Influence of Molecular Organization on the Electrical Characteristics of {\pi}-conjugated Self-assembled Monolayers

Two new thiol compounds with {\sigma}-{\pi}-{\sigma} structure were synthesized and self-assembled on gold substrates. The morphology and the structural characterization of SAMs assessed by infrared spectroscopy, contact angle, XPS, electrochemistry and scanning tunneling microscopy (STM) show the formation of monolayers. SAMs with a terthiophene (3TSH) core as conjugated system are much better organized compared to those with a naphthalene carbodiimide (NaphSH) core as demonstrated by the cyclic voltammetry and STM studies. The surface concentration of 3TSH and NaphSH is respectively three and six times lower than ordered SAMs of pure alkyl chains. A large number of I/V characteristics have been studied either by STS measurements on gold substrates or by C-AFM on gold nanodots. Transition Voltage Spectroscopy (TVS) was used to clearly identify the transport in these partially organized monolayers. The chemical nature of the conjugated system, donor for 3TSH and acceptor for NaphSH, involves an opposite rectification associated to the asymmetrical coupling of the molecular orbitals and the electrodes. The conductance histograms show that the 3TSH junctions are less dispersed than those of NaphSH junctions. This is explained by a better control of the molecular organization in the molecular junctions.Comment: Full paper with supporting informatio

Fiabilisation d'un système mécatronique dès la phase de conception

En phase de conception, une étude de sûreté de fonctionnement d'un système est généralement précédée d'une analyse fonctionnelle qui consiste à définir, avec précision, les limites matérielles du système étudié, les différentes fonctions et opérations réalisées par le système et les diverses configurations d'exploitation. Cette première étape permet de réaliser une décomposition hiérarchique du système en éléments matériels et/ou fonctionnels. Or celles-ci n'apportent pas d'informations sur les modes de défaillance, leurs effets, leur occurrence et leur criticité. Il est donc nécessaire de la compléter par une deuxième analyse prenant en compte les dysfonctionnements. Ces deux analyses complémentaires, si elles sont réalisées d'une manière pertinente, peuvent permettre de modéliser plus finement un système complexe, grâce par exemple, aux Réseaux Bayésiens ou aux Réseaux de Pétri. On propose dans cet article d'appliquer différentes méthodes classiques employées en sûreté de fonctionnement afin d'étudier un système mécatronique simple

Development of a Hyperelastic Constitutive Model Based on the Crystal Plasticity Theory for the Simulation of Machining Operations

In this work, a hyperelastic constitutive model is developed to describe the thermo-mechanical behavior of the Ti17 titanium alloy. The grain shape and the crystallographic orientation are explicitly taken into account. The behavior of both the α and β phases is modelled with a crystal plasticity formulation coupled to a CDM (Continuum Damage Model). The constitutive model is implemented in the ABAQUS/Explicit finite element solver with a user-defined subroutine. The model parameters are identified from experimental tests. According to the cutting simulation results, both strain localization and chip segmentation are strongly impacted by the crystallographic orientation.Agglomération Angers Loire Métropol

Effects of a soluble dietary fibre NUTRIOSE® on colonic fermentation and excretion rates in rats

The resistant dextrin NUTRIOSE®, developed from starch, is expected to act as a prebiotic. The aim of this study was to determine the effects of NUTRIOSE® on cecal parameters, short-chain fatty acid (SCFA) concentrations, and fecal excretion in rats. In an initial experiment, twenty-four male Fischer F344 rats were randomly assigned to one of the following four treatments for 14 days: G0 (control diet), G2.5 (control diet + 2.5% of dextrin), G5 (control diet + 5% of dextrin), and G10 (control diet + 10% of dextrin). After 14 days, total cecal weight, cecal content, and cecal wall weight were significantly increased in G5 and G10 compared to G0. At the same time, cecal pH was significantly lower in G10 compared to G0. Total SCFA concentration was significantly higher in G10 than in G5, G2.5, and G0, and significantly higher in G5 than in G0. Acetate, butyrate, and propionate concentrations were significantly increased in G5 and G10 compared to the controls. In a second trial based on a similar design, eighteen male Fischer F344 rats were treated with a control diet supplemented with 5% of dextrin or 5% of fructo-oligosaccharide. The results obtained with NUTRIOSE® were similar to those obtained with the fructo-oligosaccharide. In a third experiment, two groups of 5 Fischer F344 rats were orally treated with 100 and 1,000 mg/kg NUTRIOSE®, respectively, and from 18% to 25% of the dextrin was excreted in the feces. The results of these three studies show that the consumption of NUTRIOSE®, by its effects on total cecal weight, cecal content, cecal wall weight, pH, and SCFA production, could induce healthy benefits since these effects are reported to be prebiotic effects

Infragravity waves: From driving mechanisms to impacts

Infragravity (hereafter IG) waves are surface ocean waves with frequencies below those of wind-generated “short waves” (typically below 0.04 Hz). Here we focus on the most common type of IG waves, those induced by the presence of groups in incident short waves. Three related mechanisms explain their generation: (1) the development, shoaling and release of waves bound to the short-wave group envelopes (2) the modulation by these envelopes of the location where short waves break, and (3) the merging of bores (breaking wave front, resembling to a hydraulic jump) inside the surfzone. When reaching shallow water (O(1–10 m)), IG waves can transfer part of their energy back to higher frequencies, a process which is highly dependent on beach slope. On gently sloping beaches, IG waves can dissipate a substantial amount of energy through depth-limited breaking. When the bottom is very rough, such as in coral reef environments, a substantial amount of energy can be dissipated through bottom friction. IG wave energy that is not dissipated is reflected seaward, predominantly for the lowest IG frequencies and on steep bottom slopes. This reflection of the lowest IG frequencies can result in the development of standing (also known as stationary) waves. Reflected IG waves can be refractively trapped so that quasi-periodic along-shore patterns, also referred to as edge waves, can develop. IG waves have a large range of implications in the hydro-sedimentary dynamics of coastal zones. For example, they can modulate current velocities in rip channels and strongly influence cross-shore and longshore mixing. On sandy beaches, IG waves can strongly impact the water table and associated groundwater flows. On gently sloping beaches and especially under storm conditions, IG waves can dominate cross-shore sediment transport, generally promoting offshore transport inside the surfzone. Under storm conditions, IG waves can also induce overwash and eventually promote dune erosion and barrier breaching. In tidal inlets, IG waves can propagate into the back-barrier lagoon during the flood phase and induce large modulations of currents and sediment transport. Their effect appears to be smaller during the ebb phase, due to blocking by countercurrents, particularly in shallow systems. On coral and rocky reefs, IG waves can dominate over short-waves and control the hydro-sedimentary dynamics over the reef flat and in the lagoon. In harbors and semi-enclosed basins, free IG waves can be amplified by resonance and induce large seiches (resonant oscillations). Lastly, free IG waves that are generated in the nearshore can cross oceans and they can also explain the development of the Earth's “hum” (background free oscillations of the solid earth)

Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition

A unique collection of oceanic samples was gathered by the Tara Oceans expeditions (2009-2013), targeting plankton organisms ranging from viruses to metazoans, and providing rich environmental context measurements. Thanks to recent advances in the field of genomics, extensive sequencing has been performed for a deep genomic analysis of this huge collection of samples. A strategy based on different approaches, such as metabarcoding, metagenomics, single-cell genomics and metatranscriptomics, has been chosen for analysis of size-fractionated plankton communities. Here, we provide detailed procedures applied for genomic data generation, from nucleic acids extraction to sequence production, and we describe registries of genomics datasets available at the European Nucleotide Archive (ENA, www.ebi.ac.uk/ena). The association of these metadata to the experimental procedures applied for their generation will help the scientific community to access these data and facilitate their analysis. This paper complements other efforts to provide a full description of experiments and open science resources generated from the Tara Oceans project, further extending their value for the study of the world's planktonic ecosystems

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Background: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods: Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall ≥ 25% at day 3 and day 7. Results: A total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0–19.7 g/dL) in Africa, 11.6 g/dL (range 5.0–20.0 g/dL) in Asia and 12.3 g/dL (range 6.9–17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to ≥ 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.58, respectively) and delayed parasite clearance (AOR = 2.44 and AOR = 2.59, respectively). In Asia, patients treated with an artemisinin-based regimen were at significantly greater risk of moderately severe anaemia on day 7 compared to those treated with a non-artemisinin-based regimen (AOR = 2.06 [95%CI 1.39–3.05], p < 0.001). Conclusions: In patients with uncomplicated P. falciparum malaria, the nadir haemoglobin occurs 2 days after starting treatment. Although artemisinin-based treatments increase the rate of parasite clearance, in Asia they are associated with a greater risk of anaemia during recovery

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Optimisation des plans d'essais accélérés (application à la tenue en fatigue de pièces métalliques de liaison au sol)

Dans l'industrie, et en particulier dans le domaine automobile, il est crucial de valider la fiabilité des systèmes de manière efficace, rapide et à moindre coût. Les pièces de Liaison Au Sol chez PSA sont soumises au phénomène de fatigue et leur conception est validée à partir de calculs mais aussi et principalement d'essais physiques. Les méthodologies globales de qualification en fatigue sont basées sur un protocole d'essai spécifique et une méthode d'estimation associée. Les travaux présentés ici présentent tout d'abord un état de l'art de méthodologies globales de qualification en fatigue, issues de la littérature et des applications PSA. Ces différents axes d'étude sont comparés par simulation numérique afin d'en définir la robustesse, l'efficacité et le coût. A l'issu de cette étude, une méthodologie globale efficace a été développée, et en partie mise en place. L'ensemble des travaux permet tout d'abord d'avoir un point de vue critique sur les méthodologies d'estimation de la fiabilité par les essais. Ils ont mené à la mise en place d'une amélioration des stratégies actuelles et ouvre la voie à des changements d'envergure chez PSA.In an industrial context, and in particular in the automotive industry, the systems' reliability has to be efficiently demonstrated, in a quick and cheap way. In PSA, chassis parts design is validated both by numerical calculations and by high-cycle endurance tests. Fatigue qualification methodologies are based on a specific test protocol and on an associated estimation method. In this work, at first a review of the fatigue test methodologies currently used in the automotive industry and state-of-the-art from academic research are addressed. Thus, numerical simulations are used in order to assess the reliability of these procedures and to compare their performance, robustness and cost. Finally, an efficient global methodology is developed and part of it is implemented. The whole work performed permits first to have a critical point of view on reliability assessment by testing methods. Then, it leads to a qualification strategy improvement and points the way towards major enhancements in PSA's fatigue qualification strategy.ANGERS-BU Lettres et Sciences (490072106) / SudocSudocFranceF