TFH Mixing Patterns, Large θ13\theta_{13} and Δ(96)\Delta(96) Flavor Symmetry

We perform a comprehensive analysis of the Toorop-Feruglio-Hagedorn (TFH) mixing patterns within the family symmetry $\Delta(96)$. The general neutrino mass matrix for the TFH mixing and its symmetry properties are investigated. The possible realizations of the TFH mixing in $\Delta(96)$ are analyzed in the minimalist approach. We propose two dynamical models which produce the TFH mixing patterns at leading order. The full flavor symmetries are $\Delta(96)\times Z_3\times Z_3$ and $\Delta(96)\times Z_5 \times Z_2$ respectively. The next to leading order terms introduce corrections of order $\lambda^2_c$ to the three mixing angles in both models. The allowed mixing patterns are studied under the condition that the Klein four subgroups and the cyclic $Z_N$ subgroups with $N\geq3$ are preserved in the neutrino and the charged lepton sector respectively. We suggest that the deformed tri-bimaximal mixing is a good leading order approximation to understanding a largish reactor angle.Comment: 43 pages, 2 figure

Tri-Bimaximal Neutrino Mixing and Discrete Flavour Symmetries

We review the application of non-Abelian discrete groups to Tri-Bimaximal (TB) neutrino mixing, which is supported by experiment as a possible good first approximation to the data. After summarizing the motivation and the formalism, we discuss specific models, mainly those based on A4 but also on other finite groups, and their phenomenological implications, including the extension to quarks. The recent measurements of \theta_13 favour versions of these models where a suitable mechanism leads to corrections to \theta_13 that can naturally be larger than those to \theta_12 and \theta_23. The virtues and the problems of TB mixing models are discussed, also in connection with lepton flavour violating processes, and the different approaches are compared.Comment: 26 pages, 5 figures, 4 tables. V3 submitted to add an acknowledgment to a network. Review written for the special issue on "Flavor Symmetries and Neutrino Oscillations", published in Fortschritte der Physik - Progress of Physic

Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis

From Springer Nature via Jisc Publications RouterHistory: received 2019-10-22, accepted 2020-08-06, registration 2020-08-11, pub-electronic 2020-09-02, online 2020-09-02, collection 2020-12Publication status: PublishedFunder: RCUK | MRC | Medical Research Foundation; doi: https://doi.org/10.13039/501100009187; Grant(s): MR/N00017X/1Funder: Arthritis Research UK; doi: https://doi.org/10.13039/501100000341; Grant(s): 21754Abstract: Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated variants are often found in distal regulatory regions with cell-type specific behaviours. Here, we collect ATAC-seq, Hi-C, Capture Hi-C and nuclear RNA-seq data in stimulated CD4+ T cells over 24 h, to identify functional enhancers regulating gene expression. We characterise changes in DNA interaction and activity dynamics that correlate with changes in gene expression, and find that the strongest correlations are observed within 200 kb of promoters. Using rheumatoid arthritis as an example of T cell mediated disease, we demonstrate interactions of expression quantitative trait loci with target genes, and confirm assigned genes or show complex interactions for 20% of disease associated loci, including FOXO1, which we confirm using CRISPR/Cas9

SU(3) Gauge Family Symmetry and Prediction for the Lepton-Flavor Mixing and Neutrino Masses with Maximal Spontaneous CP Violation

A model for the lepton-flavor mixing and CP violation is proposed based on the SU$_F$(3) gauge family symmetry and the Majorana feature of neutrinos. A consistent prediction for the lepton-flavor mixing and masses is shown to be resulted from the appropriate vacuum structure of SU$_F$(3) gauge symmetry breaking. By choosing the SU$_F$(3) gauge fixing condition to possess a residual $Z_2$ symmetry and requiring the vacuum structure of spontaneous symmetry breaking to have approximate global U(1) family symmetries, we obtain naturally the tri-bimaximal mixing matrix and largely degenerate neutrino masses in the neutrino sector and the small mixing matrix in the charged-lepton sector. With a simple ansatz that all the smallness due to the approximate global U(1) family symmetries is characterized by a single Wolfenstein parameter $\lambda \simeq 0.22$, and the charged-lepton mixing matrix has a similar hierarchy structure as the CKM quark mixing matrix, we arrive at a consistent prediction for the MNSP lepton-flavor mixing with a maximal spontaneous CP violation: $\delta =\pi/2$, $\sin^2\theta_{13} \simeq 1/2\lambda^2 \simeq 0.024$ ($\sin^22\theta_{13} \simeq 0.094$), $\sin^2\theta_{12} \simeq 1/3{3}(1 - 2\lambda^3) \simeq 0.326$ and $\sin^2\theta_{23} \simeq 1/2(1 - \lambda^2) \simeq 0.48$, which agree well with the current experimental data. The CP-violating Jarlskog-invariant is obtained to be $J_{CP} \simeq 1/6\lambda(1-\lambda^2/2-\lambda^3)\sin\delta \simeq 0.035$, which is detectable in next generation neutrino experiment. The largely degenerate neutrino masses with the normal hierarchy and inverse hierarchy are discussed and found be at the order $m_{\nu_i} \simeq O(\lambda^2) \simeq 0.04\sim 0.06$ eV with a total mass $\sum m_{\nu} \sim 0.15$ eV, which is testable in future precision astrophysics and cosmology.Comment: 14 pages, it is explicitly shown that the smallness for both the charged-lepton mixing and neutrino masses with the standard seesaw mechanism can naturally be explained by the approximate global U(1) family symmetries of vacuum structure in the SU(3) gauge family model, references added, published version in PL

Deviation from Tri-Bimaximal Mixing and Large Reactor Mixing Angle

Recent observations for a non-zero $\theta_{13}$ have come from various experiments. We study a model of lepton mixing with a 2-3 flavor symmetry to accommodate the sizable $\theta_{13}$ measurement. In this work, we derive deviations from the tri-bimaximal (TBM) pattern arising from breaking the flavor symmetry in the neutrino sector, while the charged leptons contribution has been discussed in a previous work. Contributions from both sectors towards accommodating the non-zero $\theta_{13}$ measurement are presented.Comment: 25 pages, 12 figures. arXiv admin note: text overlap with arXiv:1109.232

Distorted magnetic orders and electronic structures of tetragonal FeSe from first-principles

We use the state-of-the-arts density-functional-theory method to study various magnetic orders and their effects on the electronic structures of the FeSe. Our calculated results show that, for the spins of the single Fe layer, the striped antiferromagnetic orders with distortion are more favorable in total energy than the checkerboard antiferromagnetic orders with tetragonal symmetry, which is consistent with known experimental data, and the inter-layer magnetic interaction is very weak. We investigate the electronic structures and magnetic property of the distorted phases. We also present our calculated spin coupling constants and discuss the reduction of the Fe magnetic moment by quantum many-body effects. These results are useful to understand the structural, magnetic, and electronic properties of FeSe, and may have some helpful implications to other FeAs-based materials

TRY plant trait database - enhanced coverage and open access

Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives