100 research outputs found
Skeletal muscle as a regulator of the longevity protein, Klotho
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2014
- Field of study
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies, a direct relationship between circulating Klotho and skeletal muscle has not been investigated. In this paper, we present a review of the literature and preliminary evidence that, together, suggests Klotho expression may be modulated by skeletal muscle activity. Our pilot clinical findings performed in young and aged individuals suggest that circulating Klotho levels are upregulated in response to an acute exercise bout, but that the response may be dependent on fitness level. A similar upregulation of circulating Klotho is also observed in response to an acute exercise in young and old mice, suggesting that this may be a good model for mechanistically probing the role of physical activity on Klotho expression. Finally, we highlight overlapping signaling pathways that are modulated by both Klotho and skeletal muscle and propose potential mechanisms for cross-talk between the two. It is hoped that this review will stimulate further consideration of the relationship between skeletal muscle activity and Klotho expression, potentially leading to important insights into the well-documented systemic anti-aging effects of exercise. Š 2014 Avin, Coen, Huang, Stolz, Sowa, DubÊ, Goodpaster, O'Doherty and Ambrosio
A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/06/2015
- Field of study
People with spinal cord injury (SCI) are predisposed to pressure ulcers (PU). PU remain a significant burden in cost of care and quality of life despite improved mechanistic understanding and advanced interventions. An agent-based model (ABM) of ischemia/reperfusion-induced inflammation and PU (the PUABM) was created, calibrated to serial images of post-SCI PU, and used to investigate potential treatments in silico. Tissue-level features of the PUABM recapitulated visual patterns of ulcer formation in individuals with SCI. These morphological features, along with simulated cell counts and mediator concentrations, suggested that the influence of inflammatory dynamics caused simulations to be committed to âbetterâ vs. âworseâ outcomes by 4 days of simulated time and prior to ulcer formation. Sensitivity analysis of model parameters suggested that increasing oxygen availability would reduce PU incidence. Using the PUABM, in silico trials of anti-inflammatory treatments such as corticosteroids and a neutralizing antibody targeted at Damage-Associated Molecular Pattern molecules (DAMPs) suggested that, at best, early application at a sufficiently high dose could attenuate local inflammation and reduce pressure-associated tissue damage, but could not reduce PU incidence. The PUABM thus shows promise as an adjunct for mechanistic understanding, diagnosis, and design of therapies in the setting of PU
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
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- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
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- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
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- Andelin D
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- Andreev V
- Andreev Y
- Anghel IM
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- Anisimov A
- Antillon E
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- Anttila E
- Antunes JR
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- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Reinvestigation of aminoacyl-TRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex
- Author
- A Sareen
- AB Meriin
- AC Gavin
- AD Keefe
- Cheolju Lee
- D Fermin
- DV Skarra
- E Kim
- EA Hong
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- H Choi
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- J Zhang
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- K Mahadev
- K Meerschaert
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- L Nathanson
- M Guo
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- ME Sardiu
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- MJ Schmitt
- N Yannay-Cohen
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- NJ Krogan
- NV Giannakopoulos
- R Halwani
- RM Ewing
- S Camilleri-BroĂŤt
- S Kim
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- Seungjin Na
- SG Park
- SG Park
- SG Park
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- SV Kyriacou
- SY Jung
- VN Bhatia
- Yang Cai
- Yoon Ki Kim
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 02/12/2013
- Field of study
10.1371/journal.pone.0081734PLoS ONE812-POLN
The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain
- Author
- A Delaney
- A Halle
- A Juni
- A Williamson
- AH Lopes
- AJ Todd
- AS Jaggi
- B Huang
- BB Haab
- BM Wand
- C Avolio
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- C Tu
- CA Arout
- D Borsook
- David A. Buckley
- David P. Finn
- DH Vrinten
- E Backryd
- E Waubant
- EB Liem
- EB Liem
- Elaine M. Jennings
- GA Bezerra
- GA Sowa
- GJ Bennett
- H Guo
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- H Sato
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- H Wang
- H Wood
- HB Schioth
- I Decosterd
- J Hastbacka
- J Ludwig
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- JA Stokes
- JD Wren
- JD Wren
- JM Lipton
- JM Lipton
- Jonathan D. Wren
- JP Rivero Vaccari de
- JS Mogil
- L Liu
- M Barsun
- M Bennett
- M Bugno
- M Colleoni
- M Von Korff
- MA Nassar
- MI Bennett
- Michelle Roche
- ML LaCroix-Fralish
- MT Heneka
- N Busso
- N Lukkahatai
- Nikita N. Burke
- P Kumar
- Patrick C. McHugh
- PJ Austin
- PM Grace
- R Chirco
- R Freynhagen
- R Sandhir
- RA Star
- RJ Schwartzman
- S Assassi
- S Lorenzl
- SH Kim
- SJ Krause
- SM Zhu
- T Farrah
- TS Jensen
- V Thanawala
- Veronica McInerney
- WG Stetler-Stevenson
- WH Jin
- Y Higashimoto
- Y Kawasaki
- Y Kim
- Y Noji
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
CMS Data Processing Workflows during an Extended Cosmic Ray Run
- Author
- Abadjiev K
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- Cockerill DJA
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
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- Aisa D
- Aisa S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
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- Alberdi J
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- Altenhofer G
- Altsybeev I
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- Alves GA
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- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
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- Andreev V
- Andreev Y
- Anghel IM
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at âs=7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
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- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoon AS
- York A
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- Yumiceva F
- Yun JC
- Zabi A
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- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyaniy A
- Zeidler C
- Zeinali M
- Zeise M
- Zennamo J
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zinonos Z
- Zito G
- Zoeller MH
- Zorbilmez C
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2010
- Field of study
This is the pre-print version of the Published Article which can be accessed from the link below.Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at âs=7ââTeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dNch/dΡ||Ρ|<0.5=5.78Âą0.01(stat)Âą0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from âs=0.9 to 7 TeV is [66.1Âą1.0(stat)Âą4.2(syst)]%. The mean transverse momentum is measured to be 0.545Âą0.005(stat)Âą0.015(syst)ââGeV/c. The results are compared with similar measurements at lower energies
Commissioning of the CMS high-level trigger with cosmic rays
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- Publication venue
- 'IOP Publishing'
- Publication date
- 26/11/2009
- Field of study
This is the Pre-print version of the Article. The official published version of the paper can be accessed from the link below - Copyright @ 2010 IOPThe CMS High-Level Trigger (HLT) is responsible for ensuring that data samples with potentially interesting events are recorded with high efficiency and good quality. This paper gives an overview of the HLT and focuses on its commissioning using cosmic rays. The selection of triggers that were deployed is presented and the online grouping of triggered events into streams and primary datasets is discussed. Tools for online and offline data quality monitoring for the HLT are described, and the operational performance of the muon HLT algorithms is reviewed. The average time taken for the HLT selection and its dependence on detector and operating conditions are presented. The HLT performed reliably and helped provide a large dataset. This dataset has proven to be invaluable for understanding the performance of the trigger and the CMS experiment as a whole.This work is supported by FMSR (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,
and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS
(Colombia); MSES (Croatia); RPF (Cyprus); Academy of Sciences and NICPB (Estonia);
Academy of Finland, ME, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NKTH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF (Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); PAEC (Pakistan); SCSR (Poland); FCT (Portugal); JINR
(Armenia, Belarus, Georgia, Ukraine, Uzbekistan); MST and MAE (Russia); MSTDS (Serbia); MICINN and CPAN (Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); TUBITAK and TAEK (Turkey); STFC (United Kingdom); DOE and NSF (USA)
Identification and Filtering of Uncharacteristic Noise in the CMS Hadron Calorimeter
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- Reucroft S
- Rew SB
- Rhee HB
- Ribeiro PQ
- Ribnik J
- Riccardi C
- Richman J
- Rios AAO
- Rivera R
- Rivero CM
- Rivetta CH
- Rizzi A
- Roberts J
- Robles J
- Robmann P
- Rodrigo T
- Rodrigues NB
- Rodriguez JL
- Rogan C
- Roh Y
- Rohe T
- Rohlf J
- Rohringer H
- Roinishvili N
- Roinishvili V
- Roland C
- Roland G
- Rolandi G
- Romaniuk R
- Romano F
- Romero A
- Romero DR
- Romero L
- Rommerskirchen T
- Rompotis N
- Ronchese P
- Ronga FJ
- Ronquest M
- Ronzhin A
- Rose A
- Rose K
- Roselli G
- Rosemann C
- Rosowsky A
- Rossato K
- Rossi AM
- Rossin R
- Rossman P
- Rougny R
- Rouhani S
- Rousseau D
- Rovelli C
- Rovelli T
- Rovere M
- Ruchti R
- Rudolph M
- Rugovac S
- Ruiz MB
- Rumerio P
- Rusack R
- Rusakov SV
- Ruspa M
- Russ J
- Russo A
- Ryan MJ
- Ryckbosch D
- Ryd A
- Ryjov V
- Ryu S
- Ryutin R
- Sabbatini L
- Sabonis T
- Sacchi R
- Safarzadeh B
- Safonov A
- Safronov G
- Saha A
- Saini LK
- Sakharov A
- Sakulin H
- Sala L
- Sala S
- Salerno R
- Sampaio S
- Samyn D
- Sanabria JC
- Sanchez AK
- Sanchez JG
- Sanchez MCDLB
- Sander C
- Sanders DA
- Sanders S
- Sani M
- Santacruz N
- Santanastasio F
- Santaolalla J
- Santocchia A
- Santoro A
- Sanudo MS
- Sanzeni C
- Saout C
- Sarkar S
- Sartisohn G
- Sarycheva L
- Satpathy A
- Sauce H
- Sauerland P
- Savin A
- Savrin V
- Sawley MC
- Schael S
- Schafer C
- Scheurer A
- Schieferdecker P
- Schilling FP
- Schlatter WD
- Schlein P
- Schleper P
- Schmid S
- Schmidt A
- Schmidt I
- Schmidt R
- Schmitt M
- Schmitt M
- Schmitz SA
- Schnetzer S
- Schoerner-Sadenius T
- Schofbeck R
- Schott G
- Schreiner T
- Schroder M
- Schroeder M
- Schul N
- Schum T
- Schumann J
- Schwering G
- Schwick C
- Sciaba A
- Sciacca C
- Scodellaro L
- Scurlock B
- Searle M
- Sedov A
- Seez C
- Segneri G
- Segoni I
- Seixas J
- Sekhri V
- Sekmen S
- Selvaggi G
- Selvaggi M
- Semenov R
- Semenov S
- Sen S
- Sengupta S
- Serban AT
- Serin M
- Servoli L
- Sever R
- Sexton-Kennedy E
- Sfiligoi I
- Sguazzoni G
- Shabalina E
- Shahzad H
- Sharma A
- Sharma A
- Sharma S
- Sharma V
- Sharp P
- Shaw TM
- Shcheglov Y
- Shchetkovskiy A
- Sheldon P
- Shen BC
- Shepherd-Themistocleous CH
- Shi X
- Shinde Y
- Shipsey I
- Shiu JG
- Shivpuri RK
- Shmatov S
- Shpakov D
- Shreyber I
- Shukla P
- Shumeiko N
- Siamitros C
- Sibille J
- Sidiropoulos G
- Siegrist N
- Siegrist P
- Sierra RV
- Signal T
- Sikler F
- Sill A
- Sillou D
- Silva J
- Silva P
- Silvestris L
- Sim KS
- Simon S
- Simonetto F
- Simonis HJ
- Sinanis N
- Singh A
- Singh JB
- Singh SP
- Singovsky A
- Sirois Y
- Siroli G
- Sirunyan AM
- Sknar V
- Skuja A
- Skup E
- Slabospitsky S
- Slaunwhite J
- Smiljkovic N
- Smirnov I
- Smirnov V
- Smith J
- Smith K
- Smith RP
- Smith VJ
- Smith WH
- Smolin D
- Smoron A
- Snigirev A
- Snow GR
- Soares D
- Sobol A
- Sobrier T
- Sogut K
- Soha A
- Solano A
- Solin A
- Solovey A
- Solovey A
- Somalwar S
- Son DC
- Song S
- Sonmez N
- Sonnek P
- Sonnenschein L
- Sordini V
- Sordo HN
- Soroka D
- Sourkov A
- Sousa M
- Souza MHG
- Sowa M
- Spagnolo P
- Spalding WJ
- Spanier S
- Speck J
- Speer T
- Sphicas P
- Spiegel L
- Spiga D
- Spiropulu M
- Sprenger D
- Squires M
- Srivastava AK
- Stadie H
- Stahl A
- Staiano A
- Stark R
- Starodumov A
- Stefanovitch R
- Steggemann J
- Steinbruck G
- Steininger H
- Stenson K
- Stephans G
- Stettler M
- Stickland D
- Stieger B
- Stilley J
- Stober FM
- Stoeckli F
- Stolin V
- Stone R
- Stoye M
- Stoykova S
- Stoynev S
- Strang M
- Strauss J
- Stringer R
- Stroiney S
- Stuart D
- Sturdy J
- Sturm P
- Suarez RG
- Sudhakar K
- Sulak L
- Sulimov V
- Sultanov G
- Summers D
- Sumorok K
- Sun W
- Sung K
- Surat UE
- Suzuki I
- Svintradze I
- Swain J
- Swanson J
- Swartz M
- Sytine A
- Sytnik V
- Szabo Z
- Szczesny H
- Szekely G
- Szillasi Z
- Szleper M
- Sznajder A
- Takahashi M
- Tali B
- Tan P
- Tancini V
- Tanenbaum W
- Tao J
- Tapper A
- Tarakanov V
- Taroni S
- Taurok A
- Tauscher L
- Tavernier S
- Taylor L
- Taylor R
- Teischinger F
- Temple J
- Tenchini R
- Teng H
- Teo WD
- Teodorescu L
- Terentyev N
- Teyssier D
- Thea A
- Themel T
- Theofilatos K
- Thiebaux C
- Thom J
- Thomas M
- Thomas S
- Thomsen J
- Thyssen F
- Tikhonenko E
- Tikhonov A
- Timciuc V
- Timlin C
- Titov M
- Tkaczyk S
- To W
- Toback D
- Tokesi K
- Tolaini S
- Tomalin IR
- Tomei TRFP
- Tonelli G
- Toniolo N
- Tonjes MB
- Tonoiu D
- Tonwar SC
- Toole T
- Topakli H
- Topaksu AK
- Topkar A
- Torassa E
- Tornier D
- Toropin A
- Torre P
- Torromeo G
- Tosi M
- Toteva Z
- Toth N
- Tourneur S
- Tourtchanovitch L
- Traczyk P
- Tran NV
- Trapani PP
- Travaglini R
- Trayanov R
- Treille D
- Trentadue R
- Triantis FA
- Tricomi A
- Triossi A
- Tripathi M
- Trocino D
- Trocsanyi ZL
- Troendle D
- Troitsky S
- Tropea P
- Tropiano A
- Troshin S
- Troska J
- Trub P
- Trunov A
- Tsang KV
- Tsiakkouri D
- Tsirigkas D
- Tsirou A
- Tucker J
- Tully C
- Tumanov A
- Tuominen E
- Tuominiemi J
- Tupputi S
- Tuura L
- Tuuva T
- Tuve C
- Twedt E
- Tytgat M
- Tyurin N
- Tzeng YM
- Ueno K
- Uhl D
- Ujvari B
- Ulmer K
- Ungaro D
- Uplegger L
- Uvarov L
- Uzun D
- Uzunian A
- Vaandering EW
- Valdez HC
- Valuev V
- Van Doninck W
- Van Haevermaet H
- Van Hove P
- Van Mechelen P
- Van Mulders P
- Van Remortel N
- Vander Donckt M
- Vander Velde C
- Vanelderen L
- Vanini S
- Vankov I
- Vanlaer P
- Vardanyan I
- Varela J
- Varelas N
- Vargas JER
- Vasil'ev S
- Vaughan J
- Vaurynovich S
- Vavilov S
- Vedaee A
- Veelken C
- Veillet L
- Velasco M
- Velichko G
- Velikzhanin Y
- Velthuis J
- Ventura S
- Venturi A
- Verdier P
- Verdini PG
- Veres GI
- Vergili LN
- Vergili M
- Verrecchia P
- Verwilligen P
- Veszpremi V
- Vesztergombi G
- Veverka J
- Vicini A
- Vidal R
- Vila I
- Villella I
- Vinogradov A
- Virdee T
- Virto AL
- Visca L
- Vishnevskiy A
- Vishnevskiy D
- Vitulo P
- Viviani C
- Vlasov E
- Vlimant JR
- Vodopiyanov I
- Vogel H
- Volkov A
- Volkov S
- Volobouev I
- Volodko A
- Volpe R
- Volyanskyy D
- von Dratzig AS
- Vorobiev I
- Vorobyev A
- Voutilainen M
- Wagner P
- Wagner SR
- Wagner W
- Wagner-Kuhr J
- Wakefield S
- Wallny R
- Waltenberger W
- Walton R
- Walzel G
- Wan Z
- Wang CC
- Wang D
- Wang J
- Wang M
- Wang Z
- Warchol J
- Wardrope D
- Washington E
- Watts TL
- Wayne M
- Weber M
- Weber M
- Wehrli L
- Weinberg M
- Weinberger M
- Wendland L
- Weng J
- Weng Y
- Wenger EA
- Wenman D
- Wensveen M
- Werner JS
- Wertelaers P
- Wetzel J
- White A
- Whitmore J
- Whyntie T
- Wickens J
- Wicklund E
- Widl E
- Wigmans R
- Wildish T
- Wilke L
- Wilken R
- Wilkinson R
- Williams G
- Williams JC
- Williams JH
- Willmott C
- Wimpenny S
- Wingham M
- Winn D
- Wissing C
- Witherell M
- Wittich P
- Wittmer B
- Wlochal M
- Wohri HK
- Wolf R
- Womersley WJ
- Won S
- Wood JS
- Worm SD
- Wright D
- Wrochna G
- Wu S
- Wu W
- Wulz CE
- Wurthwein F
- Wyslouch B
- Xie S
- Xie Z
- Xue Z
- Yagil A
- Yan M
- Yang X
- Yang Y
- Yang ZC
- Yarba J
- Yaselli I
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoon AS
- York A
- Yumiceva F
- Yun JC
- Yuste C
- Zabi A
- Zabolotny W
- Zachariadou A
- Zalewski P
- Zampieri A
- Zanetti M
- Zang SL
- Zarubin A
- Zatzerklyany A
- Zeidler C
- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zhang Y
- Zhang Z
- Zheng Y
- Zhiltsov V
- Zhokin A
- Zhu B
- Zhu K
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/1
- Field of study
VertaisarvioitupeerReviewe
- âŚ