Estrategias docentes para un aprendizaje significativo. Una interpretación constructivista

Frida Díaz Barriga Arceo y Gerardo Hernández Rojas. Estrategias docentes para un aprendizaje significativo. Una interpretación constructivista. México: Editorial McGraw-Hill/Interamericana. Tercera edición. 405 págs. isbn: 6071502934. El libro Estrategias Docentes para un Aprendizaje Significativo es una herramienta de gran utilidad para aquellos que nos dedicamos a la docencia. Es una obra que clarifica perfectamente a todos aquellos que queremos ampliar y profundizar nuestros conocimientos sobre lo que es el aprendizaje significativo y el constructivismo..

Muscle mass measured using bioelectrical impedance analysis, calf circumference and grip strength in older adults

AbstractObjectiveTo determine the correlation between muscle mass, measured using bioelectrical impedance analysis (BIA), with calf circumference and grip strength.Materials and methodsCross-sectional and observational study. Including all functional adults over 60 years of age seen in our Geriatric Clinic during the months of March 2013–February 2014. Measurements of weight, height, BMI, calf circumference, grip strength and muscle mass by BIA were made after the signature of informed consent.Results105 patients were evaluated, 73 women and 32 men, with a mean age of 76 years (SD±7.3). Muscle mass showed a mild positive correlation with calf circumference: Pearson (r=0.31; p=0.000) and a moderate positive correlation with grip strength: Pearson (r=0.50; p=0.000).DiscussionMuscle mass by BIA has a positive correlation with calf circumference and grip strength, and is a reliable measure to assess muscle mass and physical performance in older adults in geriatric ambulatory clinics and can be used in the diagnosis of sarcopenia in Mexican patients

La utilidad de Ardisia compressa kunth en parcelas cafetaleras

Objective: To determine the cost-benefit relation of the May capulín (ardisia compressa), to determine its potential as an economic complement to the coffee growers of the municipality of Sochiapa. Design, methodology and approximation: For the development of the research a mixed methodology was used, with a concurrent execution, collecting the field information combining semi-structured surveys under sampling and direct observation. Limitations and implications: The lack of analyzes that provide official information on the chemical properties of the May capulín are limiting in the creation of proposals on its use. Findings and conclusions: The May capulín is a sub used, wild species with agrifood and economic potential that has not been exploited due to lack of training and information for the establishment as a crop.Objetivo: Determinar la relación costo beneficio del capulín de mayo (ardisia compressa), para determinar su potencial como complemento económico de los cafeticultores del municipio de Sochiapa, Veracruz. Diseño, metodología y aproximación: Para el desarrollo de la investigación se utilizó una metodología mixta, con una ejecución concurrente, recolectando la información de campo combinando encuestas semi-estructuradas bajo muestreo y observación directa. Limitaciones e implicaciones: La inexistencia de bases de datos que proporcionen información oficial sobre las propiedades químicas y productivas del capulín de mayo son limitantes en la creación de propuestas sobre su aprovechamiento. Hallazgos y conclusiones: El capulín de mayo es una especie sub utilizada, silvestre con potencial agroalimentario y económico que no ha sido explotado por falta de capacitación e información para el establecimiento como un cultivo.&nbsp

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration. In this work, we characterize a novel P-III class snake venom metalloproteinase, called pictolysin-III (Pic-III). It is a 62 kDa proteinase that hydrolyzes dimethyl casein, azocasein, gelatin, fibrinogen, and fibrin. The cations Mg2+ and Ca2+ enhanced its enzymatic activity, whereas Zn2+ inhibited it. In addition, EDTA and marimastat were also effective inhibitors. The amino acid sequence deduced from cDNA shows a multidomain structure that includes a proprotein, metalloproteinase, disintegrin-like, and cysteine-rich domains. Additionally, Pic-III reduces the convulxin- and thrombin-stimulated platelet aggregation and in vivo, it has hemorrhagic activity (DHM = 0.3 µg). In epithelial cell lines (MDA-MB-231 and Caco-2) and RMF-621 fibroblast, it triggers morphological changes that are accompanied by a decrease in mitochondrial respiration, glycolysis, and ATP levels, and an increase in NAD(P)H, mitochondrial ROS, and cytokine secretion. Moreover, Pic-III sensitizes to the cytotoxic BH3 mimetic drug ABT-199 (Venetoclax) in MDA-MB-231 cells. To our knowledge, Pic-III is the first SVMP reported with action on mitochondrial bioenergetics and may offer novel opportunities for promising lead compounds that inhibit platelet aggregation or ECM–cancer-cell interactions.</p

Asymmetric Organocatalysis in Deep Eutectic Solvents

The recent advances in asymmetric organocatalysis using eutectic mixtures as a reaction medium are revised in this mini‐review. In addition, the first enantioselective transformations using chiral eutectic solvents, which play the role of a green medium and organocatalyst, are described. In this mini‐review we intend to deepen not only in the synthetic aspects of asymmetric organocatalysis in eutectic mixtures, but also in the fundamental issues that seem to be essential for a successful development of this promising, and at the same time challenging, methodology.This work was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (MICINN, PGC2018-096616-B-I00), the University of Alicante (VIGROB-173 and VIGROB-316FI), and the University of Pisa (PRA_2018_36)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation

To characterize the genetic basis of facial features in Latin Americans, we performed a genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark-based measurements from two-dimensional profile photographs and ~9,000,000 genotyped or imputed single-nucleotide polymorphisms. We detected significant association of 32 traits with at least 1 (and up to 6) of 32 different genomic regions, more than doubling the number of robustly associated face morphology loci reported until now (from 11 to 23). These GWAS hits are strongly enriched in regulatory sequences active specifically during craniofacial development. The associated region in 1p12 includes a tract of archaic adaptive introgression, with a Denisovan haplotype common in Native Americans affecting particularly lip thickness. Among the nine previously unidentified face morphology loci we identified is the VPS13B gene region, and we show that variants in this region also affect midfacial morphology in mice