Editorial: Vielfalt der Arbeitszeiten

Editorial zum Schwerpunktheft "Vielfalt der Arbeitszeiten

Forschungsdatenmanagement – Uniweite Angebote für Wissenschaft und Forschung

Forschungsdatenmanagement (FDM) bedeutet, die im Rahmen eines Forschungsprojektes anfallenden Daten methodisch-systematisch zu erheben, zu organisieren, zu bewahren, zu dokumentieren und nachnutzbar zu machen. Die Universität Bielefeld hat mit dem Kompetenzzentrum Forschungsdaten verbindliche Unterstützungsdienstleistungen zu allen Bereichen des „Data Life Cycle“ etabliert. In diesem Vortrag werden sowohl Einblicke in die lokale Arbeit rund um das Forschungsdatenmanagement gegeben, aber auch bestehende Vernetzungsaktivitäten mit relevanten Stakeholdern präsentiert. Des Weiteren wird das „Servicezentrum Medical Data Science“ der Medizinischen Fakultät seine fachspezifischen FDM-Supportstrukturen und deren Einbettung in die hochschulweite Infrastruktur vorstellen

Korruption: ein ungerechtfertigter Eingriff in internationale Menschenrechte? Chancen und Grenzen einer opferbezogenen Korruptionsperspektive

<p><b>Daily carbohydrate (A) and sugar (B) intake by groups and subgroups.</b> Carbohydrate (A) and sugar intake (B) as illustrated in percent. The boxes cover the first quartile on the bottom and the third quartile on the top. Whiskers reach from the minimum to the maximum value excluding outliers (illustrated by dots). Shift-working group and shift-working nursing-staff subgroup cover identical cohorts. NG, non-shift-working group; SG, shift-working group; SN, shift-working nursing-staff subgroup; NO, non-shift-working office-staff subgroup; NN, non-shift-working nursing-staff subgroup *p<0.05.</p

Кредитний механізм реалізації фінансової стратегії розвитку великого промислового регіону

Мета даної статті полягає в розробці на основі системного підходу концепції вдосконалення кредитного механізму реалізації фінансової стратегії розвитку великого промислового регіону, яка призведе до підвищення його прибутковості

Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

Constitutive expression of the chemokine Mcp1 in mouse cardiomyocytes creates a model of inflammatory cardiomyopathy, with death from heart failure at age 7-8 months. A critical pathogenic role has previously been proposed for induced oxidative stress, involving NADPH oxidase activation. To test this idea, we exposed the mice to elevated oxygen levels. Against expectation, this prevented, rather than accelerated, the ultrastructural and functional signs of heart failure. This result suggests that the immune signaling initiated by Mcp1 leads instead to the inhibition of cellular oxygen usage, for which mitochondrial respiration is an obvious target. To address this hypothesis, we combined the Mcp1 model with xenotopic expression of the alternative oxidase (AOX), which provides a sink for electrons blocked from passage to oxygen via respiratory complexes III and IV. Ubiquitous AOX expression provided only a minor delay to cardiac functional deterioration and did not prevent the induction of markers of cardiac and metabolic remodeling considered a hallmark of the model. Moreover, cardiomyocyte-specific AOX expression resulted in exacerbation of Mcp1-induced heart failure, and failed to rescue a second cardiomyopathy model directly involving loss of cIV. Our findings imply that mitochondria! involvement in the pathology of inflammatory cardiomyopathy is multifaceted and complex.Peer reviewe

Transitkunst. Studien zur Literatur 1890-2010

Die Chiffre „Transit“ vereinigt mit Aspekten wie Mobilität, Flüchtigkeit und Vorläufigkeit zentrale Begriffe des Zeiterlebens zwischen 1890 und 2010. Vor dem Hintergrund mehrerer Krisen und Katastrophen sowie tiefgreifender Umwandlungsprozesse erscheint das Leben als Durchgangsstadium, in dem sich nur noch ein temporäres, fragmentarisches Netz von Orientierungspunkten entwerfen lässt. Das Transitäre durchdringt nahezu alle Facetten des Individuums und seiner Lebensbereiche: vom Wahrnehmen der Inkohärenz in der Folge gesellschaftlicher Umwälzungen, über den Verlust ‚sicherer‘ Orte bis zum Erfahren der eigenen Identität als provisorisch. Die Reaktion auf solche Übergangszustände ist oft eine Intensivierung der Suchbewegungen nach Sicherheit, Nähe und Glück, die jedoch selbst zunehmend transitive Zwischenstellungen markieren. Die Literatur zeichnet sich unter dieser Perspektive durch die Adaptation transittypischer Themen und Inhalte aus, desgleichen durch die autoreflexive Übertragung von Konzepten wie Momenthaftigkeit, Unvollständigkeit und Flexibilität in das eigene narrative Programm. Die Beiträge des Bandes nähern sich verschiedenen Formen eines solchen inhaltlichen und/oder formalen ‚Dazwischen‘ an. Die Idee des Transits erweist sich dabei für diese vielfältigen literatur- und kulturwissenschaftlichen Untersuchungen als ebenso funktionale wie inspirierende Klammer, der es gelingt, im bewussten Einlassen auf das im Durchgang Begriffene die heterogenen Facetten des 20. Jahrhunderts zu verbinden: zu einer Art Zeitbild und Ästhetik des Transits

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk

Simulation of SVPWM Based Multivariable Control Method for a DFIG Wind Energy System

This paper deals with a variable speed device toproduce electrical energy on a power network based on adoubly-fed induction machine used in generating mode(DFIG) in wind energy system by using SVPWM powertransfer matrix. This paper presents a modeling and controlapproach which uses instantaneous real and reactive powerinstead of dq components of currents in a vector controlscheme. The main features of the proposed model comparedto conventional models in the dq frame of reference arerobustness and simplicity of realization. The sequential loopclosing technique is adopted to design a multivariable controlsystem including six compensators for a DFIG wind energysystem to capture the maximum wind power and to inject therequired reactive power to the generator. In this paperSVPWM method is used for better controlling of converters.It also provides fault ride through method to protect theconverter during a fault. The time-domain simulation of thestudy system is presented by using MATLAB Simulink to testthe system robustness, to validate the proposed model and toshow the enhanced tracking capability

Tissue-Associated “Candidatus Mycoplasma corallicola” and Filamentous Bacteria on the Cold-Water Coral Lophelia pertusa (Scleractinia)▿ †

The cold-water coral Lophelia pertusa (Scleractinia, Caryophylliidae) is a key species in the formation of cold-water reefs, which are among the most diverse deep-sea ecosystems. It occurs in two color varieties: white and red. Bacterial communities associated with Lophelia have been investigated in recent years, but the role of the associated bacteria remains largely obscure. This study uses catalyzed reporter deposition fluorescence in situ hybridization to detect the in situ location of specific bacterial groups on coral specimens from the Trondheimsfjord (Norway). Two tissue-associated groups were identified: (i) bacteria on the host's tentacle ectoderm, “Candidatus Mycoplasma corallicola,” are flasklike, pointed cells and (ii) endoderm-associated bona fide TM7 bacteria form long filaments in the gastral cavity. These tissue-bound bacteria were found in all coral specimens from the Trondheimsfjord, indicating a closer relationship with the coral compared to bacterial assemblages present in coral mucus and gastric fluid

Physical Activity, Energy Expenditure, Nutritional Habits, Quality of Sleep and Stress Levels in Shift-Working Health Care Personnel - Fig 8

<p><b>Daily carbohydrate (A) and sugar (B) intake by groups and subgroups.</b> Carbohydrate (A) and sugar intake (B) as illustrated in percent. The boxes cover the first quartile on the bottom and the third quartile on the top. Whiskers reach from the minimum to the maximum value excluding outliers (illustrated by dots). Shift-working group and shift-working nursing-staff subgroup cover identical cohorts. NG, non-shift-working group; SG, shift-working group; SN, shift-working nursing-staff subgroup; NO, non-shift-working office-staff subgroup; NN, non-shift-working nursing-staff subgroup *p<0.05.</p