Eta-photoproduction in a gauge-invariant chiral unitary framework

We analyse photoproduction of eta mesons off the proton in a gauge-invariant chiral unitary framework. The interaction kernel for meson-baryon scattering is derived from the leading order chiral effective Lagrangian and iterated in a Bethe-Salpeter equation. The recent precise threshold data from the Crystal Ball at MAMI can be described rather well and the complex pole corresponding to the S11(1535) is extracted. An extension of the kernel is also discussed.Comment: Updated version to be published in Physics Letters

Photochemistry of the PAH pyrene in water ice: the case for ion-mediated solid-state astrochemistry

Context. Icy dust grains play an important role in the formation of complex inter- and circumstellar molecules. Observational studies show that polycyclic aromatic hydrocarbons (PAHs) are abundantly present in the ISM in the gas phase. It is likely that these non-volatile species freeze out onto dust grains as well and participate in the astrochemical solid-state network, but experimental PAH ice studies are largely lacking. Methods. Near UV/VIS spectroscopy is used to track the in situ VUV driven photochemistry of pyrene containing ices at temperatures ranging from 10 to 125 K. Results. The main photoproducts of VUV photolyzed pyrene ices are spectroscopically identified and their band positions are listed for two host ices, \water and CO. Pyrene ionisation is found to be most efficient in \water ices at low temperatures. The reaction products, triplet pyrene and the 1-hydro-1-pyrenyl radical are most efficiently formed in higher temperature water ices and in low temperature CO ice. Formation routes and band strength information of the identified species are discussed. Additionally, the oscillator strengths of Py, Py^+ and PyH are derived and a quantitative kinetic analysis is performed by fitting a chemical reaction network to the experimental data. Conclusions. Pyrene is efficiently ionised in water ice at temperatures below 50 K. Hydrogenation reactions dominate the chemistry in low temperature CO ice with trace amounts of water. The results are put in an astrophysical context by determining the importance of PAH ionisation in a molecular cloud. The photoprocessing of a sample PAH in ice described in this manuscript indicates that PAH photoprocessing in the solid state should also be taken into account in astrochemical models.Comment: 11 pages, 8 figures, accepted for publication in A&

Editorial: The Innate and Adaptive Immune Response Are Both Involved in Drug‐Induced Autoimmunity

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142541/1/art40371_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142541/2/art40371.pd

Violation of Bell inequalities by photons more than 10 km apart

A Franson-type test of Bell inequalities by photons 10.9 km apart is presented. Energy-time entangled photon-pairs are measured using two-channel analyzers, leading to a violation of the inequalities by 16 standard deviations without subtracting accidental coincidences. Subtracting them, a 2-photon interference visibility of 95.5% is observed, demonstrating that distances up to 10 km have no significant effect on entanglement. This sets quantum cryptography with photon pairs as a practical competitor to the schemes based on weak pulses.Comment: 4 pages, REVTeX, 2 postscript figures include

Long-distance Bell-type tests using energy-time entangled photons

Long-distance Bell-type experiments are presented. The different experimental challenges and their solutions in order to maintain the strong quantum correlations between energy-time entangled photons over more than 10 km are reported and the results analyzed from the point of view of tests of fundamental physics as well as from the more applied side of quantum communication, specially quantum key distribution. Tests using more than one analyzer on each side are also presented.Comment: 22 pages including 7 figures and 5 table

Photodesorption of ices I: CO, N2 and CO2

A longstanding problem in astrochemistry is how molecules can be maintained in the gas phase in dense inter- and circumstellar regions. Photodesorption is a non-thermal desorption mechanism, which may explain the small amounts of observed cold gas in cloud cores and disk mid-planes. This paper aims to determine the UV photodesorption yields and to constrain the photodesorption mechanisms of three astrochemically relevant ices: CO, N2 and CO2. In addition, the possibility of co-desorption in mixed and layered CO:N2 ices is explored. The ice photodesorption is studied experimentally under ultra high vacuum conditions and at 15-60 K using a hydrogen discharge lamp (7-10.5 eV). The ice desorption during irradiation is monitored by reflection absorption infrared spectroscopy of the ice and simultaneous mass spectrometry of the desorbed molecules. Both the UV photodesorption yields per incident photon and the photodesorption mechanisms are molecule specific. CO photodesorbs without dissociation from the surface layer of the ice. N2, which lacks an electronic transition in this wavelength range, has a photodesorption yield that is more than an order of magnitude lower. This yield increases significantly due to co-desorption when N2 is mixed in with or layered on top of CO ice. CO2 photodesorbs through dissociation and subsequent recombination from the top 10 layers of the ice. At low temperatures (15-18 K) the derived photodesorption yields are 2.7x10^-3 and <2x10^-4 molecules photon-1 for pure CO and N2, respectively. The CO2 photodesorption yield is 1.2x10^-3x(1-e^(-X/2.9)) + 1.1x10^-3x(1-e^(-X/4.6)) molecules photon-1, where X is the ice thickness in monolayers and the two parts of the expression represent a CO2 and CO photodesorption pathway.Comment: Accepted by A&A; the new version contains additional figures and text at the referee's reques

Methanol ice co-desorption as a mechanism to explain cold methanol in the gas-phase

Context. Methanol is formed via surface reactions on icy dust grains. Methanol is also detected in the gas-phase at temperatures below its thermal desorption temperature and at levels higher than can be explained by pure gas-phase chemistry. The process that controls the transition from solid state to gas-phase methanol in cold environments is not understood. Aims. The goal of this work is to investigate whether thermal CO desorption provides an indirect pathway for methanol to co-desorb at low temperatures. Methods. Mixed CH₃OH:CO/CH₄ ices were heated under ultra-high vacuum conditions and ice contents are traced using RAIRS (reflection absorption IR spectroscopy), while desorbing species were detected mass spectrometrically. An updated gas-grain chemical network was used to test the impact of the results of these experiments. The physical model used is applicable for TW Hya, a protoplanetary disk in which cold gas-phase methanol has recently been detected. Results. Methanol release together with thermal CO desorption is found to be an ineffective process in the experiments, resulting in an upper limit of ≤ 7.3 × 10−7 CH₃OH molecules per CO molecule over all ice mixtures considered. Chemical modelling based on the upper limits shows that co-desorption rates as low as 10−6 CH₃OH molecules per CO molecule are high enough to release substantial amounts of methanol to the gas-phase at and around the location of the CO thermal desorption front in a protoplanetary disk. The impact of thermal co-desorption of CH₃OH with CO as a grain-gas bridge mechanism is compared with that of UV induced photodesorption and chemisorption

Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease

Background: Epidemiological data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial (RCT) data limit our understanding of mechanisms by which flavanones and their metabolites potentially reduce cardiovascular (CV) risk factors. Objective: We examined the effects of orange juice or a dose-matched hesperidin supplement on plasma concentrations of established and novel flavanone metabolites and their effects on CV risk biomarkers in men at moderate CVD risk. Methods: In an acute, randomized, placebo-controlled crossover trial, 16 fasted participants (aged 51-69 y) received orange juice or a hesperidin supplement (both providing 320 mg hesperidin) or control (all matched for sugar and vitamin C content). At baseline and 5 h post-intake, endothelial function (primary outcome), further CV risk biomarkers (i.e. blood pressure, arterial stiffness, cardiac autonomic function, platelet activation and NADPH oxidase gene expression) and plasma flavanone metabolites were assessed. Prior to each intervention, a diet low in flavonoids, nitrate/nitrite, alcohol and caffeine was followed and a standardized low-flavonoid evening meal was consumed. Results: Orange juice intake significantly elevated mean (± SEM) plasma concentrations of 8 flavanone (1.75 ± 0.35 µmol/L, P < 0.0001) and 15 phenolic metabolites (13.27 ± 2.22 µmol/L, P < 0.0001) compared with control at 5 h post-consumption. Despite increased plasma flavanone and phenolic metabolite concentrations, CV risk biomarkers were unaltered. Following hesperidin supplement intake, flavanone metabolites were not different to control, suggesting altered absorption/metabolism compared with the orange juice matrix. Conclusions: Following single-dose flavanone intake within orange juice, we detected circulating flavanone and phenolic metabolites collectively reaching a concentration of 15.20 ± 2.15 µmol/L but observed no effect on CV risk biomarkers. Longer-duration RCTs are required to further examine the previous associations between higher flavanone intakes and improved cardiovascular health and to ascertain the relative importance of food matrix and flavanone-derived phenolic metabolites

Grain Surface Models and Data for Astrochemistry

AbstractThe cross-disciplinary field of astrochemistry exists to understand the formation, destruction, and survival of molecules in astrophysical environments. Molecules in space are synthesized via a large variety of gas-phase reactions, and reactions on dust-grain surfaces, where the surface acts as a catalyst. A broad consensus has been reached in the astrochemistry community on how to suitably treat gas-phase processes in models, and also on how to present the necessary reaction data in databases; however, no such consensus has yet been reached for grain-surface processes. A team of ∼25 experts covering observational, laboratory and theoretical (astro)chemistry met in summer of 2014 at the Lorentz Center in Leiden with the aim to provide solutions for this problem and to review the current state-of-the-art of grain surface models, both in terms of technical implementation into models as well as the most up-to-date information available from experiments and chemical computations. This review builds on the results of this workshop and gives an outlook for future directions

Moral Realism and Political Decisions. Practical Rationality in Contemporary Public Contexts

The challenge of realism is one of the common features of current philosophical debates, across different cultural traditions, and in many areas of investigation (epistemology, metaphysics, ethics, aesthetics, theory of action, etc.). The implications of realism for political philosophy and political practice, though, are just starting to become an object of systematic discussions. Such implications, however, are significant, since the area of politics is contiguous with that of ethics and action, for example. This volume intends to contribute to debates on the relevance of realism – especially moral realism – for politics. The essays included in the collection address a number of related issues, ranging from foundational problems of realism in ethics, action theory and politics, to questions about pragmatics, to difficulties in political theory, and to political hindrances related to economics and legal theory. The common focus of all essays is the relevance of realism for a conception of practical rationality in political contexts.Die Herausforderungen, vor die uns der Realismus stellt, sind in aktuellen philosophischen Debatten gegenwärtig und sie machen sich durch unterschiedliche kulturelle Traditionen und viele Untersuchungsbereiche (Erkenntnistheorie, Metaphysik, Ethik, Ästhetik, Handlungstheorie, etc.) hindurch bemerkbar. Die Auswirkungen des Realismus auf die Politische Philosophie und die politische Praxis sind jedoch erst seit kurzem Gegenstand systematischer Diskussionen, obwohl sie von Bedeutung sind, denn letztlich steht der Bereich der Politik immer in einem Zusammenhang mit Fragen der Ethik und der Handlung. Dieser Band möchte einen Beitrag zu den Debatten über die Relevanz des Realismus für die Politik leisten und hat dabei insbesondere den moralischen Realismus im Blick. Die hier versammelten Aufsätze enthalten eine Reihe von Auseinandersetzungen mit damit zusammenhängenden Problemstellungen, die von grundlegenden Problemen des Realismus in der Ethik, Handlungstheorie und Politik, Fragen zur Pragmatik, über die Schwierigkeiten der Politischen Theorie, bis hin zu politischen Hindernissen für Wirtschaft und Recht reichen. Der gemeinsame Fokus aller Aufsätze liegt dabei in der Betrachtung der Relevanz eines Realismus‘ für eine Konzeption einer praktischen Vernunft im politischen Kontext