Semi-inclusive charged-current neutrino-nucleus cross sections in the relativistic plane wave impulse approximation

Neutrino-nucleus quasielastic scattering is studied in the plane wave impulse approximation for three nuclear models: the relativistic Fermi gas (RFG), the independent-particle shell model (IPSM) and the natural orbitals (NO) model with Lorentzian dependence of the excitation energy. A complete study of the kinematics of the semi-inclusive process and the associated cross sections are presented and discussed for 40 Ar and 12 C. Inclusive cross sections are also obtained by integrating the semi-inclusive expressions over the outgoing hadron. Results are consistent with previous studies restricted to the inclusive channel. In particular, a comparison with the analytical results for the RFG model is performed. Explicit expressions for the hadronic tensor and the 10 semi-inclusive nuclear responses are given. Theoretical predictions are compared with semi-inclusive experimental data from T2K experiment.Comment: 55 pages, 22 figures, submitted to Physical Review

CMS physics technical design report : Addendum on high density QCD with heavy ions

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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.

Final state interactions in semi-inclusive neutrino-nucleus scattering: Application to T2K and MINERν\nuA experiments

We present a complete comparison of semi-inclusive $\nu_\mu$-$^{12}$C cross-section measurements by T2K and MINER$\nu$A collaborations with the predictions from the SuSAv2-MEC model implemented in the neutrino-nucleus event generator GENIE and an unfactorized approach based on the relativistic distorted wave impulse approximation (RDWIA). Results, that include cross sections as function of the final muon and proton kinematics and correlations between both, show that the agreement with data obtained by the RDWIA approach, that accounts for final-state interactions, matches or improves GENIE-SuSAv2 predictions for very forward angles where scaling violations are relevant

Analysis of T2K and MINERν\nuA Semi-Inclusive νμ\nu_\mu−12^{12}C Measurements

We compare the semi-inclusive C cross-section measurements via T2K and MINERA collaborations with the predictions from the SuSAv2-MEC model implemented in the neutrino event generator GENIE and an unfactorized approach based on the relativistic distorted wave impulse approximation (RDWIA). Results, which include cross-sections as a function of the final muon and proton kinematics as well as correlations between both, show that the agreement with data obtained via the RDWIA approach—which accounts for final-state interactions—matches or improves GENIE-SuSAv2 predictions for very forward angles, where scaling violations are relevant

An antibody-deficiency syndrome due to mutations in the CD19 gene.

Item does not contain fulltextBACKGROUND: The CD19 protein forms a complex with CD21, CD81, and CD225 in the membrane of mature B cells. Together with the B-cell antigen receptor, this complex signals the B cell to decrease its threshold for activation by the antigen. METHODS: We evaluated four patients from two unrelated families who had increased susceptibility to infection, hypogammaglobulinemia, and normal numbers of mature B cells in blood. We found a mutation in the CD19 gene in all four patients. The CD19 gene in the patients and their first-degree relatives was sequenced, and flow-cytometric immunophenotyping of B cells, immunohistochemical staining of lymphoid tissues, and DNA and messenger RNA analysis were performed. B-cell responses on the triggering of the B-cell receptor were investigated by in vitro stimulation; the antibody response after vaccination with rabies vaccine was also studied. RESULTS: All four patients had homozygous mutations in the CD19 gene. Levels of CD19 were undetectable in one patient and substantially decreased in the other three. Levels of CD21 were decreased, whereas levels of CD81 and CD225 were normal, in all four patients. The composition of the precursor B-cell compartment in bone marrow and the total numbers of B cells in blood were normal. However, the numbers of CD27+ memory B cells and CD5+ B cells were decreased. Secondary follicles in lymphoid tissues were small to normal in size and had a normal cellular composition. The few B cells that showed molecular signs of switching from one immunoglobulin class to another contained V(H)-C(alpha) and V(H)-C(gamma) transcripts with somatic mutations. The response of the patients' B cells to in vitro stimulation through the B-cell receptor was impaired, and in all four patients, the antibody response to rabies vaccination was poor. CONCLUSIONS: Mutation of the CD19 gene causes a type of hypogammaglobulinemia in which the response of mature B cells to antigenic stimulation is defective

Anales de Edafología y Agrobiología Tomo 22 Número 11-12

Mikromorphometrische untersuchungeli ·an hohlraumen im boden, van W. Kubiena, W. Beckmann und E. Geyger.-- Adsorción de amoníaco en los geles Si02-Mg0. Calores de adsorción, por Teófilo Fernández Alvarez.-- Los minerales de la arcilla en suelos de la provinc:ia de Salamanca, III, por J. L. Martín Vivaldi, M. Sánchez Camazano y F. Lucena Conde.-- Color en sedimentos, por J. Galván, C. Alvarez, J. Alonso y J. Catalán.-- Disolución parcial de sílice orgánica en suelos, por Josefina Benayas Casares.-- Clases de fósforo inorgánico cambiable isotópicamente en los suelos calizos, por P. de Arambarri.-- Los suelos de la cuenca media del río Tormes, por T. Martín Patiño, J. T. Alonso Pascual y F. Lucena Conde.-- Estudio térmico diferencial y termogravimétrico de sustancias húmicas, por J. A. Acle de Cáceres y M. Sánchez Camazano.-- Composición química de· la flor del limonero Verna. II. Fósforo, por A. Ortuño Martínez, F. Costa Y agüe y S. Llorente Franco.-- Composición química de la flor del limonero Verna. III. Potasio, por A. Ortuño Martínez, F. Costa Yagüe y S. Llorente Franco.-- Notas. Curso Internacional de Edafología y Biología Vegetal.-- Conferencias del Prof. Butenandt·y visitas a Centros del Consejo.-- Decenio Hidrológico Internacional.-- Nombramiento de Director de la Estación Experimental de León.-- Actividad de los Centros.-- Concesión de la Medalla de Oro de la Sociedad Nacional para la Protección de la Naturaleza.-- Curso de Tecnología CerámicaPeer reviewe