A catalogue of the Chandra Deep Field South with multi-colour classification and photometric redshifts from COMBO-17

We present the COMBO-17 object catalogue of the Chandra Deep Field South for public use, covering a field which is 31.5' x 30' in size. This catalogue lists astrometry, photometry in 17 passbands from 350 to 930 nm, and ground-based morphological data for 63,501 objects. The catalogue also contains multi-colour classification into the categories 'Star', 'Galaxy' and 'Quasar' as well as photometric redshifts. We include restframe luminosities in Johnson, SDSS and Bessell passbands and estimated errors. The redshifts are most reliable at R<24, where the sample contains approximately 100 quasars, 1000 stars and 10000 galaxies. We use nearly 1000 spectroscopically identified objects in conjunction with detailed simulations to characterize the performance of COMBO-17. We show that the selection of quasars, more generally type-1 AGN, is nearly complete and minimally contaminated at z=[0.5,5] for luminosities above M_B=-21.7. Their photometric redshifts are accurate to roughly 5000 km/sec. Galaxy redshifts are accurate to 1% in dz/(1+z) at R<21. They degrade in quality for progressively fainter galaxies, reaching accuracies of 2% for galaxies with R~222 and of 10% for galaxies with R>24. The selection of stars is complete to R~23, and deeper for M stars. We also present an updated discussion of our classification technique with maps of survey completeness, and discuss possible failures of the statistical classification in the faint regime at R>24.Comment: submitted to Astronomy & Astrophysics, public data set available at http://www.mpia.de/COMBO/combo_index.htm

The evolution of faint AGN between z~1 and z~5 from the COMBO-17 survey

We present a determination of the optical/UV AGN luminosity function and its evolution, based on a large sample of faint (R<24) QSOs identified in the COMBO-17 survey. Using multi-band photometry in 17 filters within 350nm < lambda_obs < 930nm, we could simultaneously determine photometric redshifts with an accuracy of sigma_z<0.03 and obtain spectral energy distributions. The redshift range covered by the sample is 1.2<z<4.8, which implies that even at z~3, the sample reaches below luminosities corresponding to M_B = -23, conventionally employed to distinguish between Seyfert galaxies and quasars. We clearly detect a broad plateau-like maximum of quasar activity around z~2 and map out the smooth turnover between z~1 and z~4. The shape of the LF is characterised by some mild curvature, but no sharp `break' is present within the range of luminosities covered. Using only the COMBO-17 data, the evolving LF can be adequately described by either a pure density evolution (PDE) or a pure luminosity evolution (PLE) model. However, the absence of a strong L*-like feature in the shape of the LF inhibits a robust distinction between these modes. We present a robust estimate for the integrated UV luminosity generation by AGN as a function of redshift. We find that the LF continues to rise even at the lowest luminosities probed by our survey, but that the slope is sufficiently shallow that the contribution of low-luminosity AGN to the UV luminosity density is negligible. Although our sample reaches much fainter flux levels than previous data sets, our results on space densities and LF slopes are completely consistent with extrapolations from recent major surveys such as SDSS and 2QZ.Comment: 17 pages, 14 figures, Astronomy & Astrophysics, in print, revised versio

Strategies for prompt searches for GRB afterglows: the discovery of the GRB 001011 optical/near-infrared counterpart using colour-colour selection

We report the discovery of the optical and near-infrared counterparts to GRB 001011. The GRB 001011 error box determined by Beppo-SAX was simultaneously imaged in the near-infrared by the 3.58-m New Technology Telescope and in the optical by the 1.54-m Danish Telescope ~8 hr after the gamma-ray event. Here we implement the colour-colour discrimination technique proposed by Rhoads (2001) and extend it using near-IR data as well. We present the results provided by an automatic colour-colour discrimination pipe-line developed to discern the different populations of objects present in the GRB 001011 error box. Our software revealed three candidates based on single-epoch images. Second-epoch observations carried out ~3.2 days after the burst revealed that the most likely candidate had faded, thus identifying it with the counterpart to the GRB. In deep R-band images obtained 7 months after the burst a faint (R=25.38+/-0.25) elongated object, presumably the host galaxy of GRB 001011, was detected at the position of the afterglow. The GRB 001011 afterglow is the first discovered with the assistance of colour-colour diagram techniques. We discuss the advantages of using this method and its application to error boxes determined by future missions.Comment: Accepted for publication in Astronomy and Astrophysics, 13 pages, 16 figure

The COMBO-17 Survey: Evolution of the Galaxy Luminosity Function from 25,000 Galaxies with 0.2<z<1.2

We present a detailed empirical assessment of how the galaxy luminosity function and stellar luminosity density evolves over the last half of the universe's age (0.2<z<1.2) for galaxies of different spectral energy distributions (SED). The results are based on ~25,000 galaxies (R<24) with redshift measurements (sigma_z~0.03) and SEDs across 350..930 nm, derived from medium-band photometry in 17 filters, observed as part of the COMBO-17 survey (``Classifying Objects by Medium-Band Observations in 17 Filters'') over three disjoint fields with a total area of 0.78 square degrees. Luminosity functions (LF), binned in redshift and SED-type, are presented in the restframe passbands of the SDSS r-band, the Johnson B-band and a synthetic UV continuum band at 280 nm. We find that the luminosity function depends strongly on SED-type at all redshifts covered. The shape of the LF, i.e. the faint-end power-law slope, does depend on SED type, but not on redshift. However, the redshift evolution of the characteristic luminosity M* and density phi* depends strongly on SED-type: (1) Early-type galaxies, defined as redder than a present-day reference Sa spectrum, become drastically more abundant towards low redshift, by a factor of 10 in the number density phi* from z=1.1 to now, and by a factor of 4 in their contribution to the co-moving r-band luminosity density, j_r. (2) Galaxies resembling present-day Sa- to Sbc-colours show a co-moving number density and contribution to j_r that does not vary much with redshift. (3) Galaxies with blue spectra reflecting strong star formation decrease towards low redshift both in luminosity and density, and by a factor of 4 in their j_r contribution. (abridged)Comment: 35 pages, 32 figures, submitted to Astronomy & Astrophysic

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10−11 for rs4733781; P = 1.0 × 10−10 for rs10956514). Dendritic cells (DCs) showed high ASAP1 expression that was reduced after Mycobacterium tuberculosis infection, and rs10956514 was associated with the level of reduction of ASAP1 expression. The ASAP1 protein is involved in actin and membrane remodeling and has been associated with podosomes. The ASAP1-depleted DCs showed impaired matrix degradation and migration. Therefore, genetically determined excessive reduction of ASAP1 expression in M. tuberculosis–infected DCs may lead to their impaired migration, suggesting a potential mechanism of predisposition to TB

Bilingualism alters children’s frontal lobe functioning for attentional control

Bilingualism is a typical linguistic experience, yet relatively little is known about its impact on children’s cognitive and brain development. Theories of bilingualism suggest that early dualâ language acquisition can improve children’s cognitive abilities, specifically those relying on frontal lobe functioning. While behavioral findings present much conflicting evidence, little is known about its effects on children’s frontal lobe development. Using functional nearâ infrared spectroscopy (fNIRS), the findings suggest that Spanishâ English bilingual children (n = 13, ages 7â 13) had greater activation in left prefrontal cortex during a nonâ verbal attentional control task relative to ageâ matched English monolinguals. In contrast, monolinguals (n = 14) showed greater right prefrontal activation than bilinguals. The present findings suggest that early bilingualism yields significant changes to the functional organization of children’s prefrontal cortex for attentional control and carry implications for understanding how early life experiences impact cognition and brain development.This fNIRS study investigated the impact of bilingual exposure on children’s brain organization for attentional control (N = 27, ages 7â 13). During a nonâ verbal attention task, bilinguals showed greater left frontal lobe activation than monolinguals. Monolinguals showed greater right frontal lobe activation than bilinguals. The findings suggest that bilingualism affects the functionality of children’s left prefrontal cortex for attentional control.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136694/1/desc12377-sup-0001-FigS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136694/2/desc12377.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136694/3/desc12377_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136694/4/desc12377-sup-0003-SupInfo.pd

The VIMOS VLT Deep Survey: the faint type-1 AGN sample

We present the type-1 active galactic nuclei (AGN) sample extracted from the VIMOS VLT Deep Survey first observations of 21000 spectra in 1.75 square degree. This sample, which is purely magnitude limited, free of morphological or color selection biases, contains 130 broad line AGN (BLAGN) spectra with redshift up to 5. Our data are divided into a wide (Iab < 22.5) and a deep (Iab < 24) subsample containing 56 and 74 objects respectively. Because of its depth and selection criteria, this sample is uniquely suited to study the population of faint type-1 AGN. Our measured surface density (~ 472 +- 48 BLAGN per square degree with Iab < 24) is significantly higher than that of any other optically selected sample of BLAGN with spectroscopic confirmation. By applying a morphological and color analysis to our AGN sample we find that: (1)~23% of the AGN brighter than Iab=22.5 are classified as extended; this percentage increases to ~42% for those with z < 1.6; (2) a non-negligible fraction of our BLAGN are lying close to the color space area occupied by stars in u*-g' versus g'-r' color-color diagram. This leads us to the conclusion that classical optical ultraviolet preselection technique, if employed at such deep magnitudes (Iab=22.5) in conjuction with a preselection of point-like sources, can miss miss up to ~35% of the AGN population. Finally, we present a composite spectrum of our sample of objects. While the continuum shape is very similar to that of the SDSS composite at short wavelengths, it is much redder than it at lambda > 3000 A. We interpret this as due to significant contamination from emission of the host galaxies, as expected from the faint absolute magnitudes sampled by our survey.Comment: Accepted to A&A, 18 pages, 14 figure

Factors that impact on access to water and sanitation for older adults and people with disability in rural South Africa: An occupational justice perspective

Limited access to water and sanitation is a risk to health, dignity, and ability to engage in occupations. This article aims to: 1) discuss the current and historical factors affecting access to water and sanitation in rural South Africa, and 2) explore the occupational implications of water access, particularly for older adults and people with disability in rural South Africa. A literature review was carried out through searching JSTOR, Scopus, and MEDLINE databases and using framework analysis to interpret the retrieved documents. This paper also reports a thematic analysis of semi-structured interviews, conducted in 2012 in a rural area of South Africa. Environmental, political, social-economic and attitudinal factors were identified as impacting water access and occupation, in both the documentary analysis and the semi-structured interviews. Due to South Africa’s history, injustice has occurred in the forms of occupational apartheid and occupational deprivation. We argue that supply systems must enable people to easily access more water than is essential for survival, so that people can participate in meaningful and productive occupations. Therefore, access to water should be considered part of an occupational right. Recognising this right will be an integral step in ensuring that water supplies are improved to support better livelihoods, and to achieve economic and social empowerment, and quality of life for all, in line with many of the United Nations’ new Sustainable Development Goals

Cytomegalovirus Infection of the Colon Presenting as a Mass-Like Lesion

Cytomegalovirus (CMV) is responsible for the most common opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS). The colon is a common site for these infections in patients positive for human immunodeficiency virus. CMV rarely presents as an intraluminal inflammatory mass in the colon. Here we report the case of a CMV infection presenting as a mass-like lesion in an AIDS patient. The clinical diagnosis of CMV infection is largely based on the characteristic endoscopic appearance. Endoscopic procedures are encouraged early in the course of CMV infection in immunocompromised patients. CMV pseudotumors along with malignancy should be part of the endoscopic evaluation in patients with AIDS