Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Publisher Copyright: © 2021 The Authors, some rights reserved.Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.Peer reviewe

Champignons comestibles du Lac-Saint-Jean

Au Québec, il existe plus de 3 000 espèces de champignons, de quoi confondre, voire décourager, n’importe quel non-initié. Devant cette diversité, comment reconnaître un champignon parmi tant d’autres? Confronté à l’immensité du territoire forestier, où et quand retrouver les espèces d’intérêt? Le défi est en effet de taille pour les trouver, car ces organismes de petite taille, éphémères, ne se présentent que quelques jours à la surface du sol, avant de repartir aussitôt… sans laisser de trace. Mais qu’à cela ne tienne! Amateurs de champignons, ce guide vous aidera à vous donner les outils pour profiter pleinement des délices mycologiques qui se cachent dans les vastes forêts du Lac-Saint-Jean

Séance anatomo-clinique :Cancer du sein, hyperleucocytose et défaillance respiratoire

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

La gestion internationale des ressources humaines : ou en sont les pratiques des grandes entreprises francaises ? Resultats d'une etude exploratoire

SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : DO 5396 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

LiDAR Validation of a Video-Derived Beachface Topography on a Tidal Flat

International audienceIncreasingly used shore-based video stations enable a high spatiotemporal frequency analysis of shoreline migration. Shoreline detection techniques combined with hydrodynamic conditions enable the creation of digital elevation models (DEMs). However, shoreline elevations are often estimated based on nearshore process empirical equations leading to uncertainties in video-based topography. To achieve high DEM correspondence between both techniques, we assessed video-derived DEMs against LiDAR surveys during low energy conditions. A newly installed video system on a tidal flat in the St. Lawrence Estuary, Atlantic Canada, served as a test case. Shorelines were automatically detected from time-averaged (TIMEX) images using color ratios in low energy conditions synchronously with mobile terrestrial LiDAR during two different surveys. Hydrodynamic (waves and tides) data were recorded in-situ, and established two different cases of water elevation models as a basis for shoreline elevations. DEMs were created and tested against LiDAR. Statistical analysis of shoreline elevations and migrations were made, and morphological variability was assessed between both surveys. Results indicate that the best shoreline elevation model includes both the significant wave height and the mean water level. Low energy conditions and in-situ hydrodynamic measurements made it possible to produce video-derived DEMs virtually as accurate as a LiDAR product, and therefore make an effective tool for coastal managers

Saving comparisons in the Crochemore-Perrin string matching algorithm

Programme 2 : calcul symbolique, programmation et genie logicielSIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : 14802 E, issue : a.1993 n.2137 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Testing string superprimitivity in parallel

Programme 2 : calcul symbolique, programmation et genie logicielSIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : 14802F, issue : a.1993 n.160 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Paris de Clovis à Dagobert /

"Hôtel de Ville de Paris, salle Saint Jean, 16 octobre 1996-5 janvier 1997."--Added t.p.Exhibition catalog.Includes bibliographical references (p. 157-165).Hollevoet, Yan