Comparação de métodos analíticos na quantificação do teor de Gapapentina em diversas cápsulas de diversos laboratórios

Dissertação de mestrado, Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2014A presente monografia possui um elevado conteúdo experimental e pretende abordar a aplicabilidade de vários métodos analíticos na quantificação de gabapentina em formulações farmacêuticas sólidas. O seu principal objetivo é a comparação dos métodos, utilizando parâmetros de avaliação analítica. A aplicação destes métodos na quantificação da gabapentina em cápsulas foi também discutida tendo em conta o teor médio obtido por laboratório. Para atingir os objetivos propostos, o doseamento da gabapentina foi efetuado por volumetria, espetroscopia de absorção e espetroscopia de emissão (fluorimetria). O doseamento de gabapentina por medição da quantidade de radiação absorvida na gama espectral UV-vis (ao máximo de absorção) foi feito por análise de soluções de gabapentina: aquosa (método Direto, análise a 192 nm), etanólica (método Etanol/Água, análise a 194 nm) e em meio ácido (método HCl 0,1 M, análise a 206 nm). Numa tentativa de aumentar a sensibilidade e especificidade da análise, por métodos espetrofotométricos, foram utilizadas técnicas de derivatização, em que foi promovida a reação da gabapentina com um agente derivatizante. Foram induzidas as reações da gabapentina com p-benzoquinona (produto da reação com máximo de absorção a 350 nm), Vanilina (produto analisado a 392 nm) e Hipoclorito (absorção máxima a 588 nm). O doseamento por fluorescência foi possível após reação da gabapentina com 4-cloro-7-nitrobenzo-2-oxo-1,3-diazole (NBD-Cl), uma vez que a molécula não apresenta fluorescência intrínseca. O produto da reação foi analisado utilizando ao comprimento de onda de excitação de 464 nm e de emissão 542 nm. Os métodos volumétricos usados na determinação da gabapentina foram a titulação com NaOH e HCl. Os métodos volumétricos obtiveram recuperações relativas às cápsulas de gabapentina entre 94,95 e 106,71 %. Os métodos espetrofotométricos apresentaram gamas de linearidade diferentes, o método Hipoclorito foi o que apresentou maior gama dinâmica (nomeadamente 14,85), apresentando linearidade entre 2,50 e 73,68 ppm. A sensibilidade de cada método foi discutida tendo por base o declive das respetivas retas de calibração, tendo-se concluído que o método com maior sensibilidade é o método NBD-Cl, com valor de declive da reta de calibração de 1,779±0,040 ppm-1. Por último os métodos espetroscópicos obtiveram recuperações para as cápsulas de gabapentina entre 97,9±2,1 e 101,5±1,1 %, tendo o melhor método (o método NBD-Cl) obtido uma recuperação média de 100,0±1,1 %

How relationship norms shape moral obligation in cancelation behavior

Shuqair, S., Costa Pinto, D., Cruz-Jesus, F., Mattila, A. S., da Fonseca Guerreiro, P., & Kam Fung So, K. (2022). Can customer relationships backfire? : How relationship norms shape moral obligation in cancelation behavior. Journal of Business Research, 151(November), 463-472. https://doi.org/10.1016/j.jbusres.2022.07.008 ---Funding Information: The authors Diego and Frederico gratefully acknowledge financial support from FCT Fundação para a Ciência e a Tecnologia (Portugal), national funding through research grant Information Management Research Center – MagIC/NOVA IMS (UIDB/04152/2020).While prior research indicates that establishing interpersonal interaction with customers is mostly beneficial, this work reveals that the impact of social ties depends on relationship norms (communal vs. exchange). In three studies, including a real-world field dataset (N = 87,615 customers), the current investigation demonstrates the conditions under which interpersonal relationships can increase or decrease customers’ cancelation behavior. The findings indicate that communal (vs. exchange) relationships can increase customers’ future cancelation behaviors. The findings also demonstrate that perceived moral obligation underlies interpersonal effects on cancelation behavior. That is, when providers develop communal (vs. exchange) ties, consumers feel that their interaction with the providers is in a closed social context, which tends to reduce their obligations towards attending their booking, thus increasing cancelation behavior. Theoretical and practical implications for business researchers and practitioners are discussed.publishersversionpublishe

Can customer relationships backfire? How relationship norms shape moral obligation in cancelation behavior

Shuqair, S., Costa Pinto, D., Cruz-Jesus, F., Mattila, A. S., da Fonseca Guerreiro, P., & Kam Fung So, K. (2022). Can customer relationships backfire? : How relationship norms shape moral obligation in cancelation behavior. Journal of Business Research, 151(November), 463-472. https://doi.org/10.1016/j.jbusres.2022.07.008 ---Funding Information: The authors Diego and Frederico gratefully acknowledge financial support from FCT Fundação para a Ciência e a Tecnologia (Portugal), national funding through research grant Information Management Research Center – MagIC/NOVA IMS (UIDB/04152/2020).While prior research indicates that establishing interpersonal interaction with customers is mostly beneficial, this work reveals that the impact of social ties depends on relationship norms (communal vs. exchange). In three studies, including a real-world field dataset (N = 87,615 customers), the current investigation demonstrates the conditions under which interpersonal relationships can increase or decrease customers’ cancelation behavior. The findings indicate that communal (vs. exchange) relationships can increase customers’ future cancelation behaviors. The findings also demonstrate that perceived moral obligation underlies interpersonal effects on cancelation behavior. That is, when providers develop communal (vs. exchange) ties, consumers feel that their interaction with the providers is in a closed social context, which tends to reduce their obligations towards attending their booking, thus increasing cancelation behavior. Theoretical and practical implications for business researchers and practitioners are discussed.publishersversionpublishe

Can customer relationships backfire? How relationship norms shape moral obligation in cancelation behavior

Shuqair, S., Costa Pinto, D., Cruz-jesus, F., Mattila, A. S., Guerreiro, P. D. F., & So, K. K. F. (2022). Can customer relationships backfire? How relationship norms shape moral obligation in cancelation behavior. Journal of Business Research, 151(November), 463-472. https://doi.org/10.1016/j.jbusres.2022.07.008 ------ Funding: The authors Diego and Frederico gratefully acknowledge financial support from FCT Fundação para a Ciência e a Tecnologia (Portugal), national funding through research grant Information Management Research Center – MagIC/NOVA IMS (UIDB/04152/2020).While prior research indicates that establishing interpersonal interaction with customers is mostly beneficial, this work reveals that the impact of social ties depends on relationship norms (communal vs. exchange). In three studies, including a real-world field dataset (N = 87,615 customers), the current investigation demonstrates the conditions under which interpersonal relationships can increase or decrease customers’ cancelation behavior. The findings indicate that communal (vs. exchange) relationships can increase customers’ future cancelation behaviors. The findings also demonstrate that perceived moral obligation underlies interpersonal effects on cancelation behavior. That is, when providers develop communal (vs. exchange) ties, consumers feel that their interaction with the providers is in a closed social context, which tends to reduce their obligations towards attending their booking, thus increasing cancelation behavior. Theoretical and practical implications for business researchers and practitioners are discussed.authorsversionepub_ahead_of_prin

Friskvård i arbetslivet : En studie om hälsa och friskvårdsarbete

Intresset för hälsa har fått allt större betydelse i människors vardag. Något som också tar sig uttryck i arbetslivet då allt fler organisationer arbetar med friskvård. Friskvårdssatsningarna kan bland annat bestå av betalda träningskort och anmälningsavgifter till olika motionslopp men också lugnare aktiviteter som promenader och fiske. Syftet med undersökningen är att se hur ett stort företag i tillverkningsindustrin arbetar med friskvård och hälsa. Vi avser undersöka vilka de bakomliggande orsakerna till friskvård är, på vilket sätt friskvårdsarbetet bedrivs och hur detta upplevs av personalen. Genom att göra en kvalitativ undersökning utifrån en induktiv ansats var vår avsikt att få en djupare förståelse för hälsa och friskvårdsarbete. Två arbetsgivarrepresentanter och fyra arbetstagarrepresentanter intervjuades i syfte att kunna upptäcka likheter och skillnader i deras uppfattningar. Resultaten visar att arbetsgivarens primära syfte för friskvårdssatsningar är att sänka sjukfrånvarokostnaderna, något som också arbetstagarna är medvetna om. I stället för att misstro företagets motiv ser de anställda friskvårdssatsningarna som en frivillig förmån som skapar trivsel. De anställda har också en mer djupgående syn på hälsa som involverar psykisk, fysik och social hälsa medan arbetsgivaren har en mer övergripande definition av begreppet. Anledningen är att arbetsgivaren inte vill kategorisera personalen utifrån en bestämd definition. Resultaten visar att friskvårdsarbetet tog fart på allvar när sjukskrivningskostnaderna steg i början av 2000-talet men är idag inte lika omfattande. Friskvårdsarbetet är idag mer rutinmässigt och halvhjärtat eftersom sjukfrånvaron inte längre ses som ett lika stort hot.   Nyckelord: hälsa, friskvård, sjukfrånvarokostnad, organisation, upplevelse

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics

Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data