Reproducing properties of MW dSphs as descendants of DM-free TDGs

The Milky Way (MW) dwarf spheroidal (dSph) satellites are known to be the most dark-matter (DM) dominated galaxies with estimates of dark to baryonic matter reaching even above one hundred. It comes from the assumption that dwarfs are dynamically supported by their observed velocity dispersions. However their spatial distributions around the MW is not at random and this could challenge their origin, previously assumed to be residues of primordial galaxies accreted by the MW potential. Here we show that alternatively, dSphs could be the residue of tidal dwarf galaxies (TDGs), which would have interacted with the Galactic hot gaseous halo and disk. TDGs are gas-rich and have been formed in a tidal tail produced during an ancient merger event at the M31 location, and expelled towards the MW. Our simulations show that low-mass TDGs are fragile to an interaction with the MW disk and halo hot gas. During the interaction, their stellar content is progressively driven out of equilibrium and strongly expands, leading to low surface brightness feature and mimicking high dynamical M/L ratios. Our modeling can reproduce the properties, including the kinematics, of classical MW dwarfs within the mass range of the Magellanic Clouds to Draco. An ancient gas-rich merger at the M31 location could then challenge the currently assumed high content of dark matter in dwarf galaxies. We propose a simple observational test with the coming GAIA mission, to follow their expected stellar expansion, which should not be observed within the current theoretical framework.Comment: 17 pages, 11 figures, accepted by the Monthly Notices of the Royal Astronomical Society (MNRAS

The vast thin plane of M31 co-rotating dwarfs: an additional fossil signature of the M31 merger and of its considerable impact in the whole Local Group

The recent discovery by Ibata et al. (2013) of a vast thin disk of satellites (VTDS) around M31 offers a new challenge for the understanding of the Local Group properties. This comes in addition to the unexpected proximity of the Magellanic Clouds (MCs) to the Milky Way (MW), and to another vast polar structure (VPOS), which is almost perpendicular to our Galaxy disk. We find that the VTDS plane is coinciding with several stellar, tidally-induced streams in the outskirts of M31, and, that its velocity distribution is consistent with that of the Giant Stream (GS). This is suggestive of a common physical mechanism, likely linked to merger tidal interactions, knowing that a similar argument may apply to the VPOS at the MW location. Furthermore, the VTDS is pointing towards the MW, being almost perpendicular to the MW disk, as the VPOS is. We compare these properties to the modelling of M31 as an ancient, gas-rich major merger, which has been successfully used to predict the M31 substructures and the GS origin. We find that without fine tuning, the induced tidal tails are lying in the VTDS plane, providing a single and common origin for many stellar streams and for the vast stellar structures surrounding both the MW and M31. The model also reproduces quite accurately positions and velocities of the VTDS dSphs. Our conjecture leads to a novel interpretation of the Local Group past history, as a gigantic tidal tail due to the M31 ancient merger is expected to send material towards the MW, including the MCs. Such a link between M31 and the MW is expected to be quite exceptional, though it may be in qualitative agreement with the reported rareness of MW-MCs systems in nearby galaxies.Comment: Accepted for publication in MNRAS, 8 pages, 3 figure

Desarrollo de un Sistema de Cría Artificial para Anastrepha fraterculus (Wied.) (Diptera: Tephritidae)

A methodological process is described here to solve two bottle necks that render the establishment of fruit flies under artificial conditions for mass production difficult. The first was the selection of an oviposition system and the second the adaptation to the artificial diet used for larval development. Females preferred to oviposit on yellow spheres, and on white organza cloth flat panels covered with transparent silicon. A larval diet used to rear A.ludens, allowed the highest larval development, survival from egg to larva was 26.9%, larval weight 19.6mg, pupation at 24 h 97.7%, pupal weight 16.7mg and adult emergence 83.3%. Survival curves (nx, 1x) and life expectancy (ex) indicated at least 50% of the adults survive ~40 days. Life expectancy was of 34.74 days. The reproductive rate was 345.38 daughters/mother/generation; the intrinsic rate of population growth was 0.35days-1; while the median generation time and the time of duplication were 16.82 and 20.2 days, respectively. Moreover, we discuss results based on quality control parameters of insects after of 16 generations in mass-rearing under artificial conditions. Se describe el proceso metodológico para solucionar dos cuellos de botella que dificultan el establecimiento de la cría artificial de Anastrepha fraterculus a gran escala. Primero, la selección del sistema de oviposición y segundo la adaptación a la dieta artificial utilizada para el desarrollo larvario. Las hembras tuvieron una mayor preferencia para ovipositar en esferas de color amarillo y en paneles planos elaborados con tela tipo organza de color blanco cubiertos con una película de silicón transparente. Después de evaluar las dietas para el desarrollo larvario de cinco especies de moscas de la fruta, la dieta con la que se obtuvieron los rendimientos más altos correspondió a la dieta ALU (Anastrephaludens), con la cual la supervivencia de huevo a larva fue del 26.9%, peso de larva de 19.6 mg, porcentaje de pupación a las 24 h 97.7%, peso de pupa 16.7 mg y emergencia de adultos de 83.3%. El análisis de las curvas de supervivencia (nx, lx) y la estimación de la expectativa de vida (ex) indicaron que al menos el 50% de los individuos vivieron ~40 días. La expectativa de vida del adulto al momento de la emergencia fue de 38.74 días. La tasa neta de reproducción fue de 345.38 hijas/madre/generación, la tasa intrínseca de crecimiento poblacional fue de 0.35 días-1; mientras que el tiempo medio de generación y el tiempo de duplicación de la población fue de 16.82 y de 20.2 días, respectivamente. Asimismo, se discuten valores de los parámetros de calidad registrados en los insectos luego de 16 generaciones bajocondiciones de cría artificial.

Effect of microencapsulated phenolic compound extracts of Maclura tinctoria (L.) Steud on growth performance and humoral immunity markers of white leg shrimp (Litopenaeus vannamei, Boone, 1931) juveniles

Aim of study: The effect of microencapsulated phenolic compound extracts of Maclura tinctoria (MTBE) on growth performance and humoral immunity markers of the white leg shrimp Litopenaeus vannamei juveniles (0.5 ± 0.2 g initial weight) was studied.Area of study: M. tinctoria was collected from Hampolol, Campeche, and Arroyo del Agua, Culiacan, Sinaloa, Mexico.Material and methods: Three MTBE inclusions (0.5, 1, and 2.5 g MTBE/kg, Purina®) were compared with a control commercial feed (Purina®) during 30 days. Nine phenolic acids, nine flavonols, four dihydro-flavonoids, four flavones, and seven unidentified phenolic compounds were determined fin the MTBE using a Perkin Elmer® HPLC chromatograph and diode array-detection.Main results: The mean concentrations of total phenolic compounds, total flavonoid compounds, and condensed tannins were 198.05 ± 5.59 mg gallic acid equivalent (GAE) g-1 dw, 78.57 ± 1.80 quercetin equivalent g-1, and 28.32 ± 0.33 mg epicatechin equivalent g-1, respectively. The ferric reducing antioxidant power and the total antioxidant capacity, respectively, averaged 28.32 mg GAE mL-1 and 10.9 mg ascorbic acid equivalent mL-1. Survival, weight gain, and specific growth rate of L. vannamei were similar among the experimental diets. The dietary inclusion of MTBE at 0.5 g/kg of food showed significant higher (p < 0.05) plasma hemocyte lysate protein (1.35 ± 0.055 µg mL-1), prophenoloxidase (0.47 ± 0.15, Abs. 492 nm), and superoxide anion (O2.-) activity (0.21 ± 0.07, Abs. 630 nm).Research highlights: The supplementation of MTBE at 0.5 g/kg of food could be considered as a potential alternative additive for L. vannamei diet in the juvenile production, since it improved the response of the humoral immunity markers at post larval life stages, when cultivated shrimp are more susceptible to be infected by pathogens

Pressure-Tuneable Visible-Range Band Gap in the Ionic Spinel Tin Nitride

The application of pressure allows systematic tuning of the charge density of a material cleanly, that is, without changes to the chemical composition via dopants, and exploratory high-pressure experiments can inform the design of bulk syntheses of materials that benefit from their properties under compression. The electronic and structural response of semiconducting tin nitride Sn3N4 under compression is now reported. A continuous opening of the optical band gap was observed from 1.3 eV to 3.0 eV over a range of 100 GPa, a 540 nm blue-shift spanning the entire visible spectrum. The pressure-mediated band gap opening is general to this material across numerous high-density polymorphs, implicating the predominant ionic bonding in the material as the cause. The rate of decompression to ambient conditions permits access to recoverable metastable states with varying band gaps energies, opening the possibility of pressure-tuneable electronic properties for future applications

Scalable and accurate deep learning for electronic health records

Predictive modeling with electronic health record (EHR) data is anticipated to drive personalized medicine and improve healthcare quality. Constructing predictive statistical models typically requires extraction of curated predictor variables from normalized EHR data, a labor-intensive process that discards the vast majority of information in each patient's record. We propose a representation of patients' entire, raw EHR records based on the Fast Healthcare Interoperability Resources (FHIR) format. We demonstrate that deep learning methods using this representation are capable of accurately predicting multiple medical events from multiple centers without site-specific data harmonization. We validated our approach using de-identified EHR data from two U.S. academic medical centers with 216,221 adult patients hospitalized for at least 24 hours. In the sequential format we propose, this volume of EHR data unrolled into a total of 46,864,534,945 data points, including clinical notes. Deep learning models achieved high accuracy for tasks such as predicting in-hospital mortality (AUROC across sites 0.93-0.94), 30-day unplanned readmission (AUROC 0.75-0.76), prolonged length of stay (AUROC 0.85-0.86), and all of a patient's final discharge diagnoses (frequency-weighted AUROC 0.90). These models outperformed state-of-the-art traditional predictive models in all cases. We also present a case-study of a neural-network attribution system, which illustrates how clinicians can gain some transparency into the predictions. We believe that this approach can be used to create accurate and scalable predictions for a variety of clinical scenarios, complete with explanations that directly highlight evidence in the patient's chart.Comment: Published version from https://www.nature.com/articles/s41746-018-0029-

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

The EMBI in Latin America: Fractional Integration, Non-Linearities and Breaks

This paper analyses the main statistical properties of the Emerging Market Bond Index (EMBI), namely long-range dependence or persistence, non-linearities, and structural breaks, in four Latin American countries (Argentina, Brazil, Mexico, Venezuela). For this purpose it uses a fractional integration framework and both parametric and semi-parametric methods. The evidence based on the former is sensitive to the specification for the error terms, whilst the results from the latter are more conclusive in ruling out mean reversion. Further, non-linearities do not appear to be present. Both recursive and rolling window methods identify a number of breaks. Overall, the evidence of long-range dependence as well as breaks suggests that active policies might be necessary for achieving financial and economic stability in these countries

Epidemiology of Invasive Fungal Infections in Latin America

The pathogenic role of invasive fungal infections (IFIs) has increased during the past two decades in Latin America and worldwide, and the number of patients at risk has risen dramatically. Working habits and leisure activities have also been a focus of attention by public health officials, as endemic mycoses have provoked a number of outbreaks. An extensive search of medical literature from Latin America suggests that the incidence of IFIs from both endemic and opportunistic fungi has increased. The increase in endemic mycoses is probably related to population changes (migration, tourism, and increased population growth), whereas the increase in opportunistic mycoses may be associated with the greater number of people at risk. In both cases, the early and appropriate use of diagnostic procedures has improved diagnosis and outcome