704 research outputs found
Nucleotide Sequence of the Streptococcin A-FF22 Lantibiotic Regulon: Model for Production of the Lantibiotic SA-FF22 by Strains of Streptococcus pyogenes
- Publication venue
- ODU Digital Commons
- Publication date
- 01/01/1999
- Field of study
Streptococcin A-FF22 (SA-FF22) is a type AII linear lantibiotic produced by Streptococcus pyogenes strain FF22. Sequence analysis of an approximate 10 kb region of DNA showed it to contain nine open reading frames arranged in three operons responsible for regulation, biosynthesis and immunity of SA-FF22. This region is organized similarly to the Lactococcus lactis lacticin 481 region, however, unlike lacticin 481, a two-component regulatory system is essential for SA-FF22 production. located immediately downstream of the scn region is a putative transposase gene, the presence of which supports earlier data that indicated a mobile nature to this region. (©) 1999 Published by Elsevier Science B.V. All rights reserved
Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC
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- A. A. Carter
- A. A. Grillo
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- A. A. Minaenko
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- W. Willis
- X. Chen
- X. Espinal Curull
- X. Ju
- X. Lei
- X. Li
- X. Lou
- X. Portell Bueso
- X. Prudent
- X. Ruan
- X. S. Anduaga
- X. Sun
- X. Wu
- X. Zhang
- X. Zhuang
- Y. A. Kurochkin
- Y. A. Tikhonov
- Y. Arai
- Y. Azuma
- Y. B. Pan
- Y. Bai
- Y. Benhammou
- Y. Coadou
- Y. Davygora
- Y. Doi
- Y. F. Ryabov
- Y. Fang
- Y. Gusakov
- Y. Hasegawa
- Y. Hernández Jiménez
- Y. Homma
- Y. Ikegami
- Y. Ilchenko
- Y. Jiang
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. Liu
- Y. Mahalalel
- Y. Makida
- Y. Ming
- Y. Munwes
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Pylypchenko
- Y. Rozen
- Y. S. Gao
- Y. Silver
- Y. Smirnov
- Y. Sugaya
- Y. Suzuki
- Y. Suzuki
- Y. Takahashi
- Y. Takubo
- Y. Tanaka
- Y. Tayalati
- Y. Unno
- Y. V. Grishkevich
- Y. Wu
- Y. Xie
- Y. Yamazaki
- Y. Yang
- Y. Yang
- Y. Yao
- Y. Yasu
- Y. Zhou
- Y. Zhu
- Y. Zolnierowski
- Yu. M. Sviridov
- Z. Czyczula
- Z. D. Greenwood
- Z. Dolezal
- Z. Drasal
- Z. Hajduk
- Z. Hubacek
- Z. Kohout
- Z. L. Ren
- Z. Liang
- Z. Marshall
- Z. Meng
- Z. Qian
- Z. Qin
- Z. Rurikova
- Z. V. Krumshteyn
- Z. van Kesteren
- Z. Weng
- Z. Yan
- Z. Yang
- Z. Zajacova
- Z. Zenonos
- Z. Zhan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/03/2012
- Field of study
The uncertainty on the calorimeter energy response to jets of particles is
derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the
calorimeter response to single isolated charged hadrons is measured and
compared to the Monte Carlo simulation using proton-proton collisions at
centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009
and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter
response to specific types of particles (positively and negatively charged
pions, protons, and anti-protons) is measured and compared to the Monte Carlo
predictions. Finally, the jet energy scale uncertainty is determined by
propagating the response uncertainty for single charged and neutral particles
to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3%
for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table,
submitted to European Physical Journal
Measurement of the production cross section for W-bosons in association with jets in pp collisions at s=7 TeV with the ATLAS detector
- Author
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- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra J
- Aharrouche M
- Ahmad A
- Alam M
- Albrand S
- Aleksa M
- Aleksandrov I
- Aleppo M
- Alessandria F
- Alexa C
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- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
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- Allport P
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- Zutshi V
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- ¿eni¿ T
- Åsman B
- Øye O
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
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- Adelman J
- Aderholz M
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- Aharrouche M
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- Aktas A
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- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
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- Anh TV
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- Antonaki A
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- Antonov A
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- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
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- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
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- Bos K
- Boscherini D
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- Botterill D
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- Bourdarios C
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- Bracinik J
- Braem A
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- Cakir IT
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- Castanheira MTD
- Castillo LRF
- Castro NF
- Cataldi G
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- Catinaccio A
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- Cattai A
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- Caughron S
- Cauz D
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- Cevenini F
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- Chapleau B
- Chapman JD
- Chapman JW
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- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
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- Cheng S
- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Chernyatin V
- Cheu E
- Cheung SL
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- Chu ML
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- Ciobotaru MD
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- Yilmaz M
- Yoosootiniya R
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- Zhemchugov A
- Zheng S
- Zhong J
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- Zhu CG
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- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
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- Zsenei A
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Winkelmann S
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- Xaplanteris L
- Xella S
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- Xie Y
- Xu C
- Xu D
- Xu G
- Yabsley B
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang S
- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao W-M
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zdrazil M
- Zeitnitz C
- Zeller M
- Zema PF
- Zemla A
- Zendler C
- Zenin AV
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
- Author
- Bin Hu
- C Milgrom
- C Milgrom
- C Richman
- C Susanne
- Carl J. Terranova
- CH Turner
- Christopher Price
- CP Price
- DP Kiel
- ES Orwoll
- F Albright
- GA Churchill
- GM Chan
- Hayden-William Courtland
- HM Frost
- J Bonadio
- J Bonadio
- JD Currey
- JD Currey
- JE Wergedal
- JH Nadeau
- JH Stieger
- JL Ferretti
- JM Cheverud
- Joseph H. Nadeau
- K Crossley
- Karl J. Jepsen
- KJ Jepsen
- KJ Jepsen
- L Leamy
- LJ Leamy
- M Giladi
- MC Meulen van der
- N Otsu
- R Li
- RB Martin
- RC MacCallum
- RF Klein
- S Garn
- S Mohan
- S Wright
- S Wright
- SM Swartz
- SM Tommasini
- SM Tommasini
- SM Tommasini
- SR Cummings
- Steven M. Tommasini
- TJ Beck
- TJ Beck
- V Gilsanz
- W Li
- WG Beamer
- X Li
- X Li
- X Wang
- Y Duan
- Y Duan
- Y Yershov
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2007
- Field of study
We examined femora from adult AXB/BXA recombinant inbred (RI) mouse strains to identify skeletal traits that are functionally related and to determine how functional interactions among these traits contribute to genetic variability in whole-bone stiffness, strength, and toughness. Randomization of A/J and C57BL/6J genomic regions resulted in each adult male and female RI strain building mechanically functional femora by assembling unique sets of morphologic and tissue-quality traits. A correlation analysis was conducted using the mean trait values for each RI strain. A third of the 66 correlations examined were significant, indicating that many bone traits covaried or were functionally related. Path analysis revealed important functional interactions among bone slenderness, cortical thickness, and tissue mineral density. The path coefficients describing these functional relations were similar for both sexes. The causal relationship among these three traits suggested that cellular processes during growth simultaneously regulate bone slenderness, cortical thickness, and tissue mineral density so that the combination of traits is sufficiently stiff and strong to satisfy daily loading demands. A disadvantage of these functional interactions was that increases in tissue mineral density also deleteriously affected tissue ductility. Consequently, slender bones with high mineral density may be stiff and strong but they are also brittle. Thus, genetically randomized mouse strains revealed a basic biological paradigm that allows for flexibility in building bones that are functional for daily activities but that creates preferred sets of traits under extreme loading conditions. Genetic or environmental perturbations that alter these functional interactions during growth would be expected to lead to loss of function and suboptimal adult bone quality
Incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel
- Author
- A Goldhirsch
- Anita Vindevogel
- D Meirow
- F Borde
- Florence Dalenc
- G Bonadonna
- G Ferretti
- GL Warne
- GN Hortobagyi
- H Brincker
- H Roche
- Henry Roche
- I Cohen
- J Bines
- Jacques Donnez
- Jean-Pascal Machiels
- JM Nabholtz
- JM Walshe
- Joseph Kerger
- L Davis
- L Del Mastro
- M Clemons
- M Martin
- M Vanhuyse
- Martine Berliere
- ME Abusief
- Michel Symann
- MN Fornier
- MN Levine
- N Padmanabhan
- Nathalie Malingret
- O Pagani
- P Poikonen
- P Valagussa
- Philippe Piette
- RD Rubens
- S Aebi
- TJ Powles
- W Vegetti
- WR Parulekar
- YL Tham
- Z Blumenfeld
- Z Blumenfeld
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>To determine the incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel.</p> <p>Methods</p> <p>We studied the incidence and duration of amenorrhea induced by two chemotherapy regimens: (i) 6 cycles of 5-fluorouracil 500 mg/m<sup>2</sup>, epirubicin 100 mg/m<sup>2 </sup>and cyclophosphamide 500 mg/m<sup>2 </sup>on day 1 every 3 weeks (6FEC) and (ii) 3 cycles of FEC 100 followed by 3 cycles of docetaxel 100 mg/m<sup>2 </sup>on day 1 every 3 weeks (3FEC/3D). Reversible amenorrhea was defined as recovery of regular menses and, where available (101 patients), premenopausal hormone values (luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol) in the year following the end of chemotherapy.</p> <p>Results</p> <p>One hundred and fifty-four premenopausal patients were included: 84 treated with 6FEC and 70 with 3FEC/3D. The median age was 43.5 years (range: 28–58) in the 6FEC arm and 44 years (range: 29–53) in the 3FEC/3D arm. Seventy-eight percent of patients were treated in the context of the PACS 01 trial. The incidence of chemotherapy-induced amenorrhea at the end of chemotherapy was similar in the two groups: 93 % in the 6FEC arm and 92.8 % in the 3FEC/3D arm. However, in the year following the end of chemotherapy, more patients recovered menses in the 3FEC/3D arm than in the 6FEC arm: 35.5 % versus 23.7 % (p = 0.019). Among the 101 patients for whom hormone values were available, 43 % in the 3FEC/3D arm and 29 % in the 6FEC arm showed premenopausal levels one year after the end of chemotherapy (p < 0.01). In the 3FEC/3D group, there was a statistically significant advantage in disease-free survival (DFS) for patients who were still amenorrheic after one year, compared to patients who had recovered regular menses (p = 0.0017).</p> <p>Conclusion</p> <p>Our study suggests that 3FEC/3D treatment induces more reversible amenorrhea than 6FEC. The clinical relevance of these findings needs to be investigated further.</p
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis
- Author
- AC Andres
- C Bardelle
- C Bardelle
- C Garcia-Echeverria
- CC Weber
- Christian Schnell
- DM Brantley-Sieders
- E Batlle
- EB Pasquale
- Eric Billy
- G Berclaz
- G Castellano
- G Martiny-Baron
- G Mathis
- G Xia
- GD Yancopoulos
- Georg Martiny-Baron
- H Dopeso
- HA Lane
- HU Wang
- I Kim
- J Chen
- JE Chrencik
- Jeanette M. Wood
- JM Wood
- Joseph Brueggen
- K Lafleur
- M Koolpe
- Mireille Ferretti
- N Cheng
- N Kertesz
- Niko Schmiedeberg
- NK Noren
- NK Noren
- NK Noren
- Pascal Furet
- Patricia Imbach
- Philipp Holzer
- PW Manley
- RH Adams
- RH Adams
- RH Adams
- S He
- S Sawamiphak
- SA Mitchell
- SA Stephenson
- SR Kumar
- SS Gerety
- SS Gerety
- T Kojima
- T Okazaki
- W Liu
- Y Wang
- YC Lee
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2010
- Field of study
EphB4 and its cognitive ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. In addition, several reports suggest that this receptor ligand pair is also involved in pathologic vessel formation in adults including tumor angiogenesis. Eph/ephrin signaling is a complex phenomena characterized by receptor forward signaling through the tyrosine kinase of the receptor and ephrin reverse signaling through various protein–protein interaction domains and phosphorylation motifs of the ephrin ligands. Therefore, interfering with EphR/ephrin signaling by the means of targeted gene ablation, soluble receptors, dominant negative mutants or antisense molecules often does not allow to discriminate between inhibition of Eph/ephrin forward and reverse signaling. We developed a specific small molecular weight kinase inhibitor of the EphB4 kinase, NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. Furthermore, NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration. In vivo, NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity in vitro or in cellular assays. The data shown here suggest a close cross talk between the VEGFR and EphR signaling during vessel formation. In addition to its established function in vascular remodeling and endothelial arterio-venous differentiation, EphB4 forward signaling appears to be an important mediator of VEGF induced angiogenesis since inhibition of EphB4 forward signaling is sufficient to inhibit VEGF induced angiogenesis
Gauge theories of partial compositeness: scenarios for Run-II of the LHC
- Author
- A Joseph
- A Simone De
- A Thamm
- B Bellazzini
- B Döbrich
- B Gripaios
- B Gripaios
- C Englert
- C Vafa
- D Cadamuro
- D Marzocca
- DB Kaplan
- DB Kaplan
- E Farhi
- E Witten
- E Witten
- F Caracciolo
- F Englert
- F Sannino
- G Cacciapaglia
- G Cacciapaglia
- G Cacciapaglia
- G Cacciapaglia
- G Ferretti
- G Ferretti
- G Panico
- G Veneziano
- Gabriele Ferretti
- GS Guralnik
- H Georgi
- H Georgi
- H Osborn
- I Jack
- J Alwall
- J Barnard
- J Barnard
- J Mrazek
- J Wess
- JE Kim
- JL Cardy
- L Calibbi
- M Frigerio
- M Golterman
- M Schmaltz
- MJ Dugan
- N Bizot
- O Matsedonskyi
- P Lodone
- P Sikivie
- PW Higgs
- R Nevzorov
- R Rattazzi
- RF Dashen
- S Weinberg
- SR Coleman
- T DeGrand
- T DeGrand
- T DeGrand
- T Ma
- TA Ryttov
- V Sanz
- VS Rychkov
- Ö Kaymakcalan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Frequency drift in MR spectroscopy at 3T
- Author
- Ahluwalia Vishwadeep
- Alcauter Sarael
- Baltusis Laima
- Barany Deborah A
- Barlow Laura R
- Becker Robert
- Berman Jeffrey I
- Berrington Adam
- Bhattacharyya Pallab K
- Blicher Jakob Udby
- Bogner Wolfgang
- Brown Mark S
- Calhoun Vince D
- Castillo Ryan
- Cecil Kim M
- Choi Yeo Bi
- Chu Winnie C W
- Clarke William T
- Craven Alexander R
- Cuypers Koen
- Dacko Michael
- de la Fuente-Sandoval Camilo
- Desmond Patricia
- Domagalik Aleksandra
- Dumont Julien
- Duncan Niall W
- Dydak Ulrike
- Dyke Katherine
- Edden Richard A E
- Edmondson David A
- Ende Gabriele
- Ersland Lars
- Evans C John
- Fermin Alan S R
- Ferretti Antonio
- Fillmer Ariane
- Gong Tao
- Greenhouse Ian
- Grist James T
- Gu Meng
- Harris Ashley D
- Hat Katarzyna
- Heba Stefanie
- Heckova Eva
- Hegarty John P
- Heise Kirstin-Friederike
- Honda Shiori
- Hui Steve C N
- Jacobson Aaron
- Jansen Jacobus F A
- Jenkins Christopher W
- Johnston Stephen J
- Juchem Christoph
- Kangarlu Alayar
- Kerr Adam B
- Landheer Karl
- Lange Thomas
- Lee Phil
- Levendovszky Swati Rane
- Limperopoulos Catherine
- Liu Feng
- Lloyd William
- Lopez Maria Yanez
- Lythgoe David J
- Machizawa Maro G
- MacMillan Erin L
- Maddock Richard J
- Manzhurtsev Andrei V
- Martinez-Gudino María L
- Mikkelsen Mark
- Miller Jack J
- Mirzakhanian Heline
- Moreno-Ortega Marta
- Mullins Paul G
- Nakajima Shinichiro
- Near Jamie
- Noeske Ralph
- Nordhøy Wibeke
- O'Gorman Tuura Ruth L
- Oeltzschner Georg
- Osorio-Duran Raul
- Otaduy Maria C G
- Pasaye Erick H
- Peeters Ronald
- Peltier Scott J
- Pilatus Ulrich
- Polomac Nenad
- Porges Eric C
- Pradhan Subechhya
- Prisciandaro James Joseph
- Puts Nicolaas A
- Rae Caroline D
- Reyes-Madrigal Francisco
- Roberts Timothy P L
- Robertson Caroline E
- Rosenberg Jens T
- Rotaru Diana-Georgiana
- Saleh Muhammad G
- Sandberg Kristian
- Sangill Ryan
- Schembri Keith
- Schrantee Anouk
- Semenova Natalia A
- Singel Debra
- Sitnikov Rouslan
- Smith Jolinda
- Song Yulu
- Stark Craig
- Stoffers Diederick
- Swinnen Stephan P
- Tain Rongwen
- Tanase Costin
- Tapper Sofie
- Tegenthoff Martin
- Thiel Thomas
- Thioux Marc
- Truong Peter
- van Dijk Pim
- Vella Nolan
- Vidyasagar Rishma
- Vovk Andrej
- Wang Guangbin
- Westlye Lars T
- Wilbur Timothy K
- Willoughby William R
- Wilson Martin
- Wittsack Hans-Jörg
- Woods Adam J
- Wu Yen-Chien
- Xu Junqian
- Yeung David K W
- Zhao Qun
- Zhou Xiaopeng
- Zupan Gasper
- Zöllner Helge J
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Purpose: Heating of gradient coils and passive shim components is a common cause of instability in the B-0 field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time field-frequency locking on MRI scanners by comparing field drift data from a large number of sites.Method: A standardized protocol was developed for 80 participating sites using 99 3T MR scanners from 3 major vendors. Phantom water signals were acquired before and after an EPI sequence. The protocol consisted of: minimal preparatory imaging; a short pre-fMRI PRESS; a ten-minute fMRI acquisition; and a long post-fMRI PRESS acquisition. Both pre- and post-fMRI PRESS were non-water suppressed. Real-time frequency stabilization/adjustment was switched off when appropriate. Sixty scanners repeated the protocol for a second dataset. In addition, a three-hour post-fMRI MRS acquisition was performed at one site to observe change of gradient temperature and drift rate. Spectral analysis was performed using MATLAB. Frequency drift in pre-fMRI PRESS data were compared with the first 5:20 minutes and the full 30:00 minutes of data after fMRI. Median (interquartile range) drifts were measured and showed in violin plot. Paired t-tests were performed to compare frequency drift pre- and post-fMRI. A simulated in vivo spectrum was generated using FID-A to visualize the effect of the observed frequency drifts. The simulated spectrum was convolved with the frequency trace for the most extreme cases. Impacts of frequency drifts on NAA and GABA were also simulated as a function of linear drift. Data from the repeated protocol were compared with the corresponding first dataset using Pearson's and intraclass correlation coefficients (ICC).Results: Of the data collected from 99 scanners, 4 were excluded due to various reasons. Thus, data from 95 scanners were ultimately analyzed. For the first 5:20 min (64 transients), median (interquartile range) drift was 0.44 (1.29) Hz before fMRI and 0.83 (1.29) Hz after. This increased to 3.15 (4.02) Hz for the full 30 min (360 transients) run. Average drift rates were 0.29 Hz/min before fMRI and 0.43 Hz/min after. Paired t-tests indicated that drift increased after fMRI, as expected (p < 0.05). Simulated spectra convolved with the frequency drift showed that the intensity of the NAA singlet was reduced by up to 26%, 44 % and 18% for GE, Philips and Siemens scanners after fMRI, respectively. ICCs indicated good agreement between datasets acquired on separate days. The single site long acquisition showed drift rate was reduced to 0.03 Hz/min approximately three hours after fMRI.Discussion: This study analyzed frequency drift data from 95 3T MRI scanners. Median levels of drift were relatively low (5-min average under 1 Hz), but the most extreme cases suffered from higher levels of drift. The extent of drift varied across scanners which both linear and nonlinear drifts were observed.</p
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