9 research outputs found
Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients
Background: Human leukocyte antigen (HLA) plays an important role in immune responses
to infections, especially in the development of acquired immunity. Given the high degree
of polymorphisms that HLA molecules present, some will be more or less effective in
controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may
be involved in the protection or susceptibility to COVID-19.
Methods: We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and
HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one
of the largest HLA-typed patient cohort to date.
Results: Our results show that there is no relationship between HLA polymorphisms or haplotypes
and susceptibility or protection to COVID-19. Conclusion: Our results may contribute to resolve the contradictory data on the role of HLA
polymorphisms in COVID-19 infection.Instituto de Salud Carlos III - FEDER funds (European Union) PI 16/00752Junta de Andalucia CTS-143
C-0013-2018RAFER S.L
History of fires and vegetation since the Neolithic in the Cantabrian Mountains (Spain)
Fire has been one of the main causes of disturbance of vegetation over time, and since the Neolithic has become an irreplaceable tool for the opening of forest spaces and maintenance of pastures. Previous studies showed that the intensity and effects of wildfires are related to the biomass and controlled by climate factors. However, in regions such as Cantabria, where agriculture and livestock have spread throughout the territory since prehistory, fires should also be closely related to human land uses. The aim of this paper was to investigate the history of fires and vegetation since the Neolithic in the Cantabrian Mountains, using sedimentary charcoal and pollen data to study the role of human activities in the processes that have shaped ecosystems throughout the Holocene. The asynchrony and quantitative differences in the results obtained at different sites indicate significant variations in fire patterns at regional scale since the Neolithic, although the type and size of each basin also had a strong influence on charcoal accumulation. Maximum values for charcoal accumulation rate at La Molina were observed between the Neolithic and the Bronze Age but occurred after about 3500 cal years BP at El Cueto de la Avellanosa. At El Sertal, low charcoal accumulation rate values were observed, probably because the sequence begins in a space that already had been cleared; the maximum values occurred during the most recent millennium. These data provide evidence that fire has been a key factor in forest retreat and in maintaining open landscapes since the Neolithic.This article was made possible by two Coordinated Project grants from Spain's Ministry of Economics and Competitiveness (MEC), “El uso del fuego y la conformación de los paisajes en la Montaña cantábrica y el Pirineo oriental: estudio comparado de su evolución histórica y tendencias actuales” (CSO2012-39680-C02-01) awarded to the Department of Geography, Urban studies and Land Planning, Universidad de Cantabria and “Geohistoria ambiental del fuego en el Holoceno. Patrones culturales y gestión territorial desde el inicio de la ganadería y la agricultura en la montaña Cantábrica y Pirineo “awarded to the Department of Geography, Universitat Autónoma de Barcelona (CSO2012-39680-C02-02). In addition, the project was funded by the Catalan government's Applied Geography program, “Grup de Geografia Aplicada” (AGAUR, Generalitat de Catalunya, 2014 SGR 1090)
Salud y paisaje: contribución desde el termalismo a la revitalización de zonas rurales (el caso de Pozo Amargo, Cuenca Del Guadaira, España) Health and landscape: a contribution to the renew of rural lands (the case of Pozo Amargo, Cuenca Del Guadaira, España)
Ubicado en la contaminada cuenca del río Guadaíra (Andalucía, España) el balneario de Pozo Amargo es una buena muestra del rico patrimonio arquitectónico vinculado al agua que han generado sus habitantes a lo largo de estos últimos siglos. Este patrimonio ha experimentado un abandono similar al del propio río pero tanto el movimiento ciudadano como la respuesta de la administración han permitido paliar ambas situaciones. Hoy en día, la rehabilitación del antiguo balneario puede suponer una interesante iniciativa que aúne la mejora ambiental y paisajística del alto Guadaíra con la recuperación del patrimonio artístico y etnográfico de la zona, así como la puesta en marcha de una experiencia pionera de proyecto paisajístico aplicado a destinos turísticos de salud capaz de generar riqueza en la zona.<br>Located in the polluted basin of Guadaira's river (Andalusia, Spain), the Pozo Amargo's spa is a good example of a rich architectonical heritage related to water that inhabitants have created over the last few centuries. This heritage has suffered a similar degradation to the river, but both the citizen's movement and the Administration's response have made possible the mitigation of both situations. Nowadays, the restoration of the former spa can be an exciting initiative that joins the environmental improvements and the landscape value of the Alto Guadaira's with the recovery of artistic and ethnographic heritage of this area. Moreover, it will make possible the launching of a pioneering experience of a landscape's project applied to touristic and health destinations that can generate wealth in the area
Faba Bean Cultivation – Revealing Novel Managing Practices for More Sustainable and Competitive European Cropping Systems
Presentation
El pasado mes de abril iniciamos una nueva etapa en Çédille, representada principalmente por su traslado a la plataforma Open Journal System (OJS) de la Universidad de La Laguna, así como por la renovación y reasignación de competencias del Consejo de Redacción. Durante este tiempo, hemos tenido que adaptarnos, experimentar y comprender, pacientemente, el funcionamiento de esta nueva herramienta que es OJS. Ello ha supuesto, en algunos casos, que se hayan producido determinadas dificultades de comunicación con nuestros lectores y evaluadores, o que se hayan ocasionado pequeños retrasos en la gestión de la revista. Como nuestros seguidores saben, muy recientemente hemos sufrido, además, un ataque informático que no solo impidió el acceso a la plataforma durante varios días (justo en el momento final de producción de este número), sino que obligó a trasladar nuestro sitio web a otro servidor y a implementar nuevas medidas de seguridad. Afortunadamente, gracias al buen hacer y profesionalidad de Juan Ascanio Amigó, asesor técnico de OJS para la Universidad de La Laguna, hemos logrado salir airosos de los problemas, complicaciones y secuelas que nos hemos ido encontrando en este tiempo.
En este número que ahora ve la luz contamos con treinta y cuatro contri-buciones que superan, en total, las setecientas páginas. Así, Amelia Gamoneda Lanza y Francisco González Fernández se han encargado de coordinar una nueva entrega –la undécima– de la serie «Monografías», donde han reunido una ..