Finding Radio Pulsars in and Beyond the Galactic Center

Radio-wave scattering is enhanced dramatically for Galactic center sources in a region with radius >~ 15 arc min. Using scattering from Sgr A* and other sources, we show that pulse broadening for pulsars in the Galactic center is {\em at least} 6.3 \nu^{-4} seconds (\nu = radio frequency in GHz) and is most likely 50--200 times larger because the relevant scattering screen appears to be within the Galactic center region itself. Pulsars beyond---but viewed through---the Galactic center suffer even greater pulse broadening and are angularly broadened by <~ 2 {\em arc min}. Periodicity searches at radio frequencies are likely to find only long period pulsars and, then, only if optimized by using frequencies >~ 7 GHz and by testing for small numbers of harmonics in the power spectrum. The optimal frequency is $\nu ~ 7.3 GHz (\Delta_{0.1}P\sqrt{\alpha})^{-1/4}$ where \Delta_{0.1} is the distance of the scattering region from Sgr A* in units of 0.1 kpc, P is the period (seconds), and \alpha is the spectral index. A search for compact sources using aperture synthesis may be far more successful than searches for periodicities because the angular broadening is not so large as to desensitize the survey. We estimate that the number of {\em detectable} pulsars in the Galactic center may range from <= 1 to 100, with the larger values resulting from recent, vigorous starbursts. Such pulsars provide unique opportunities for probing the ionized gas, gravitational potential, and stellar population near Sgr A*.Comment: 13 pages, 4 PS figures, LaTeX and requires AASTeX macro aas2pp4, accepted by ApJ, also available as http://astrosun.tn.cornell.edu/SPIGOT/papers/pulsar/gc_psr.web

Science with a lunar low-frequency array: from the dark ages of the Universe to nearby exoplanets

Low-frequency radio astronomy is limited by severe ionospheric distortions below 50 MHz and complete reflection of radio waves below 10-30 MHz. Shielding of man-made interference from long-range radio broadcasts, strong natural radio emission from the Earth's aurora, and the need for setting up a large distributed antenna array make the lunar far side a supreme location for a low-frequency radio array. A number of new scientific drivers for such an array, such as the study of the dark ages and epoch of reionization, exoplanets, and ultra-high energy cosmic rays, have emerged and need to be studied in greater detail. Here we review the scientific potential and requirements of these and other new scientific drivers and discuss the constraints for various lunar surface arrays. In particular we describe observability constraints imposed by the interstellar and interplanetary medium, calculate the achievable resolution, sensitivity, and confusion limit of a dipole array using general scaling laws, and apply them to various scientific questions. Whichever science is deemed most important, pathfinder arrays are needed to test the feasibility of these experiments in the not too distant future. Lunar low-frequency arrays are thus a timely option to consider, offering the potential for significant new insights into a wide range of today's crucial scientific topics. This would open up one of the last unexplored frequency domains in the electromagnetic spectrum.Comment: 36 pages, many figures, accepted for publication by New Astronomy Review

Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.

peer reviewedSince its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity1-3. However, instead of investigating itaconate itself, most studies used derivatized forms of itaconate and thus the role of non-derivatized itaconate needs to be scrutinized. Mesaconate, a metabolite structurally very close to itaconate, has never been implicated in mammalian cells. Here we show that mesaconate is synthesized in inflammatory macrophages from itaconate. We find that both, non-derivatized itaconate and mesaconate dampen the glycolytic activity to a similar extent, whereas only itaconate is able to repress tricarboxylic acid cycle activity and cellular respiration. In contrast to itaconate, mesaconate does not inhibit succinate dehydrogenase. Despite their distinct impact on metabolism, both metabolites exert similar immunomodulatory effects in pro-inflammatory macrophages, specifically a reduction of interleukin (IL)-6 and IL-12 secretion and an increase of CXCL10 production in a manner that is independent of NRF2 and ATF3. We show that a treatment with neither mesaconate nor itaconate impairs IL-1β secretion and inflammasome activation. In summary, our results identify mesaconate as an immunomodulatory metabolite in macrophages, which interferes to a lesser extent with cellular metabolism than itaconate

LOFAR 150-MHz observations of SS 433 and W50

We present Low-Frequency Array (LOFAR) high-band data over the frequency range 115-189 MHz for the X-ray binary SS 433, obtained in an observing campaign from 2013 February to 2014 May. Our results include a deep, wide-field map, allowing a detailed view of the surrounding supernova remnant W50 at low radio frequencies, as well as a light curve for SS 433 determined from shorter monitoring runs. The complex morphology of W50 is in excellent agreement with previously published higher frequency maps; we find additional evidence for a spectral turnover in the eastern wing, potentially due to foreground free-free absorption. Furthermore, SS 433 is tentatively variable at 150 MHz, with both a debiased modulation index of 11 per cent and a Χ 2 probability of a flat light curve of 8.2 × 10 -3 . By comparing the LOFAR flux densities with contemporaneous observations carried out at 4800 MHz with the RATAN-600 telescope, we suggest that an observed ~0.5-1 Jy rise in the 150-MHz flux density may correspond to sustained flaring activity over a period of approximately 6 months at 4800 MHz. However, the increase is too large to be explained with a standard synchrotron bubble model. We also detect a wealth of structure along the nearby Galactic plane, including the most complete detection to date of the radio shell of the candidate supernova remnant G38.7-1.4. This further demonstrates the potential of supernova remnant studies with the current generation of low-frequency radio telescopes

The virulence factor macrophage infectivity potentiator (Mip) influences branched-chain amino acid metabolism and pathogenicity of Legionella pneumophila

Legionella pneumophila (Lp) is a common etiological agent of bacterial pneumonia that causes Legionnaires' disease (LD). The bacterial membrane-associated virulence factor macrophage infectivity potentiator (Mip) exhibits peptidyl-prolyl-cis/trans-isomerase (PPIase) activity and contributes to the intra- and extracellular pathogenicity of Lp. Though Mip influences disease outcome, little is known about the metabolic consequences of altered Mip activity during infections. Here, we established a metabolic workflow and applied mass spectrometry approaches to decipher how Mip activity influences metabolism and pathogenicity. Impaired Mip activity in genetically engineered Lp strains decreases intracellular replication in cellular infection assays confirming the contribution of Mip for Lp pathogenicity. We observed that genetic and chemical alteration of Mip using the PPIase inhibitors rapamycin and FK506 induces metabolic reprogramming in Lp, specifically branched-chain amino acid (BCAA) metabolism. Rapamycin also inhibits PPIase activity of mammalian FK506 binding proteins and we observed that rapamycin induces a distinct metabolic signature in human macrophages compared to bacteria suggesting a potential involvement of Mip in normal bacteria and in infection. Our metabolic studies link Mip to alteration in BCAA metabolism and may help to decipher novel disease mechanisms associated with LD