LCLS Ultrafast Science Instruments:Conceptual Design Report

The Stanford Linear Accelerator Center (SLAC), along with Argonne National Laboratory (ANL), Lawrence Livermore National Laboratory (LLNL), and the University of California at Los Angeles (UCLA), is constructing a Free-Electron Laser (FEL) facility, which will operate in the wavelength range 1.5 nm - 0.15 nm. This FEL, the Linac Coherent Light Source (LCLS), utilizes the SLAC linac and will produce sub-picosecond pulses of short wavelength X-rays with very high peak brightness and almost complete transverse coherence. The final one-third of the SLAC linac will be used as the source of electrons for the LCLS. The high energy electrons will be transported across the SLAC Research Yard, into a tunnel which will house a long undulator. In passing through the undulator, the electrons will be bunched by the force of their own synchrotron radiation and produce an intense, monochromatic, spatially coherent beam of X-rays. By varying the electron energy, the FEL X-ray wavelength will be tunable from 1.5 nm to 0.15 nm. The LCLS will include two experimental halls as well as X-ray optics and infrastructure necessary to create a facility that can be developed for research in a variety of disciplines such as atomic physics, materials science, plasma physics and biosciences. This Conceptual Design Report, the authors believe, confirms the feasibility of designing and constructing three X-ray instruments in order to exploit the unique scientific capability of this new LCLS facility. The technical objective of the LCLS Ultrafast Science Instruments (LUSI) project is to design, build, and install at the LCLS three hard X-ray instruments that will complement the initial instrument included in the LCLS construction. As the science programs advance and new technological challenges appear, instrumentation needs to be developed and ready to conquer these new opportunities. The LCLS instrument concepts have been developed in close consultation with the scientific community through a series of workshops team meetings and focused reviews. In particular, the LUSI project instruments have been identified as meeting the most urgent needs of the scientific community based on the advice of the LCLS Scientific Advisory Committee (SAC) in response to an open call for letters of intent (LOI) from the breadth of the scientific community

First record of Craspedacusta sowerbii Lankester, 1880 (Hydrozoa, Limnomedusae) in a natural freshwater lagoon of Uruguay, with notes on polyp stage in captivity

Abstract The freshwater cnidarian Craspedacusta sowerbii Lankester 1880, has invaded lakes and ponds as well as artificial water bodies throughout the world. The first record in Uruguay corresponding to the jellyfish was made in 1961 in two artificial fountains, with no mention of the polyp form. Although local reports of other related polyp species have been made, information on the benthic form of C. sowerbii is lacking. Here we report the finding of live frustules, solitary individuals, medusae and colonies from a natural lagoon in August 2010, allowing us to observe the morphology and behavior of the polyp stage in captivity. In addition, molecular identification and remarks on the potencial path of introduction are presented. This is the first record in Uruguay of both polyp and medusa stages of C. sowerbii in a natural water body, Del Medio Lagoon (Dpto. de Florida), Uruguay

Taxonomy based on science is necessary for global conservation

Peer reviewe

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

First report on the colony-forming freshwater ciliate Ophrydium versatile in an African river

Ophrydium versatile (Muller 1786) Ehrenberg 1830 - a symbiotic ciliate that forms gelatinous colonies - is widely distributed in temperate lakes in Europe and America, but has not previously been recorded from rivers. In this paper we report the first record of O. versatile in an African river, based on an identity confirmed by molecular taxonomic identification. The limnological conditions within the Lephalala River during the sampling period were characterised as oligotrophic with low DOC concentrations, similar to the conditions observed in temperate northern hemisphere lakes where these organisms have been recorded previously. The majority of O. versatile colonies occurred in areas where thin orange-coloured films containing high concentrations of iron (> 60% Fe) covered the substrate and bedrock of the river; this may be related to the abundant picophytoplankton that were associated with these films and oligotrophic conditions. The planktonic diatom Gomphonema venusta Passy was dominant in the water column throughout the study period and acted as an environmental indicator of low electrical conductivity (EC) conditions in the habitat where O. versatile colonies were recorded.Articl

Assessing countrywide soil organic carbon stock using hybrid machine learning modelling and legacy soil data in Cameroon

Countrywide estimates of soil organic carbon stock (SOCS) are useful to set up national strategies for sustainable land use management as well as to enhance the accuracy of global SOCS inventories. We appraised the spatial distribution of SOCS at five depth layers (0–15 cm, 15–30 cm, 30–100 cm, 0–30 cm and 0–100 cm) in Cameroon at 100 m spatial resolution, using a national harmonized legacy soil database (Camsodat 0.1) with 1432 georeferenced soil profiles. We assessed the prediction performances of random forest (RF) and generalized boosted regression (GBR), combined with two hybridization approaches of spatial interpolation of the residuals using ordinary kriging (OK) and inverse distance weighting (IDW). The estimates were compared to two global estimates derived from the Harmonized World Soil Database (HWSD) and SoilGrids250m. The SOCS distribution across the country showed a moderate spatial heterogeneity at all depth layers with coefficients of variation between 35% and 47%, and values ranging from 6 to 108 Mg C ha−1 at 0–15 cm, from 4 to 107 Mg C ha−1 at 15–30 cm, from 10 to 276 Mg C ha−1 at 30–100 cm, from 11 to 210 Mg C ha−1 at 0–30 cm and from 21 to 468 Mg C ha−1 at the 0–100 cm layer. Of the selected environmental covariates, terrain and climate attributes were the most relevant to predict the SOCS spatial distribution at country level. The RF model outperformed the GBR model, with about 10% improvement on prediction performance (R2) for most soil depths. The hybridization further slightly improved performance. However, OK was only slightly better than IDW in the overall assessment. Compared to national estimates, SoilGrids overestimated the SOCS by 15% at 0–30 cm depth, while HWSD underestimated SOCS by 26% at the same depth. Overall, about 5.7 Pg C are stored in the top 1 m of soils in Cameroon, with about 50% of that in the top 30 cm. The national distribution of SOCS is consistent with the pattern of agro-ecological zones. Our assessment provides baseline information for sustainable land management and climate change mitigation, as well as for improving the understanding of the spatial distribution of SOCS in Cameroon.</p