The Cherenkov Telescope Array Large Size Telescope

The two arrays of the Very High Energy gamma-ray observatory Cherenkov Telescope Array (CTA) will include four Large Size Telescopes (LSTs) each with a 23 m diameter dish and 28 m focal distance. These telescopes will enable CTA to achieve a low-energy threshold of 20 GeV, which is critical for important studies in astrophysics, astroparticle physics and cosmology. This work presents the key specifications and performance of the current LST design in the light of the CTA scientific objectives.Comment: 4 pages, 5 figures, In Proceedings of the 33rd International Cosmic Ray Conference (ICRC2013), Rio de Janeiro (Brazil). All CTA contributions at arXiv:1307.223

Euclid near infrared spectrophotometer instrument concept and first test results at the end of phase B

The Euclid mission objective is to understand why the expansion of the Universe is accelerating by mapping the geometry of the dark Universe by investigating the distance-redshift relationship and tracing the evolution of cosmic structures. The Euclid project is part of ESA's Cosmic Vision program with its launch planned for 2020. The NISP (Near Infrared Spectro-Photometer) is one of the two Euclid instruments and is operating in the near-IR spectral region (0.9-2µm) as a photometer and spectrometer. The instrument is composed of: - a cold (135K) optomechanical subsystem consisting of a SiC structure, an optical assembly (corrector and camera lens), a filter wheel mechanism, a grism wheel mechanism, a calibration unit and a thermal control system - a detection subsystem based on a mosaic of 16 Teledyne HAWAII2RG cooled to 95K with their front-end readout electronic cooled to 140K, integrated on a mechanical focal plane structure made with Molybdenum and Aluminum. The detection subsystem is mounted on the optomechanical subsystem structure - a warm electronic subsystem (280K) composed of a data processing / detector control unit and of an instrument control unit that interfaces with the spacecraft via a 1553 bus for command and control and via Spacewire links for science data This presentation describes the architecture of the instrument at the end of the phase B (Preliminary Design Review), the expected performance, the technological key challenges and preliminary test results obtained on a detection system demonstration model. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only. Copyright 2014 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited

Non Hodgkin's lymphomas of "favorable" histology. Response to treatment and survival

Se analizan los resultados terapéuticos y la supervivencia de 60 pacientes afectos de linfoma no Hodgkin de histología 'favorable', según la clasificación de Rappaport (LLMD-N 33 casos, LMI-N 10, LLBD-D 17). Diez pacientes se encontraban en estadio localizado (I, II) y 50 en estadio avanzado (III, IV). Las pautas de tratamiento empleadas fueron los esquemas clásicos de COP, CHOP y tratamiento monoalquilante. En la mayoría de los enfermos con estadios localizados se utilizó radioterapia como tratamiento inicial. Se consiguió la remisión completa (RC) en el 42% de los pacientes (90% en los estadios I y II, 44% en el estadio III y 29% en el IV), que fue mantenida en 7 de 9 pacientes en estadio localizado por períodos de tiempo comprendidos entre 18+ y 98+ meses, mientras que los estadios diseminados mostraban una mediana de duración de la RC de 45 meses. Ninguno de los pacientes en estadio localizado ha fallecido, frente al 44% de aquellos en estadio avanzadado. La supervivencia de los pacientes en estadio IV, con una mediana de 55 meses, es claramente inferior a la del resto de enfermos (p<0,01). Los pacientes en estadios avanzados (III y IV) que no consiguieron la RC muestran una supervivencia signficativamente más corta (mediana 40 meses), que los que sí la consiguieron (mediana no alcanzada) (p<0,001). El diagnóstico histopatológico y el tratamiento incial no parecen influir significativamente en la supervivencia. En 7 de los 11 pacientes en los que se efectuó una segunda biopsia se constató una 'transformación histológica' hacia variedades de mayor agresividad. Seis de dichos enfermos permanecen vivos entre 28 y 120 meses desde la transformación, dos de ellos en RC mantenida

The T2K experiment

The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle θ13 by observing νe appearance in a νμ beam. It also aims to make a precision measurement of the known oscillation parameters, and sin22θ23, via νμ disappearance studies. Other goals of the experiment include various neutrino cross-section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem