Les ateliers du hameau Les Noires Terres à Messein (Meurthe-et-Moselle, Lorraine, France) :

L’occupation altomédiévale (VIe-VIIIe s.) au lieu-dit Les Noires Terres sur la commune de Messein, au sud de Nancy (Meurthe-et-Moselle, France, fouille 2003-2004), associe des unités composées d’un bâtiment d’habitation et de structures de type agricole (greniers, silos, enclos, cabanes excavées…) à des ateliers de production et de travail du fer (préparation du minerai, fabrication du charbon de bois, fourneaux de réduction, forgeage du fer). La présence des déchets relevant d’une chaîne opératoire complète (de la préparation du minerai à l’élaboration de produits finis), documentée par l’étude paléométallurgique, ainsi que le volume de production estimé au vu de leur quantité (plusieurs dizaines de tonnes de fer), suggèrent qu’il s’agit de l’activité principale des occupants et non pas d’une activité d’appoint aux pratiques agricoles. La nature de l’occupation est donc discutée : les vestiges découverts correspondraient aux unités d’habitation d’artisans spécialisés, avec leurs ateliers, comportant l’ensemble des installations et équipements nécessaires à leur subsistance et à leur vie quotidienne. On peut ainsi émettre l’hypothèse qu’il s’agit d’une des formes d’organisation de la production du fer dans le monde franc au cours du premier Moyen Âge, et qu’elle correspond peut-être à ce que nous laissent entrevoir les polyptiques de la période carolingienne.The Altomedieval occupation (6th-8th c.) at Les Noires Terres in Messein, to the south of Nancy (Meurthe-et-Moselle, France, excavation 2003-2004), associates elements composed of a dwelling and agricultural structures (granaries, silos, enclosures, excavated huts, etc.) with iron production and transformation workshops (iron ore preparation, wood charcoal production, reduction furnaces, iron forging). The presence of waste products corresponding to a complete chaîne opératoire (production sequence) (from iron ore preparation to finished products), documented by the paleo-metallurgical study and the production volume estimated from their quantity (several dozen tons of iron), suggest that this was the main activity of the occupants, rather than an activity secondary to agricultural activities. The nature of the occupation is thus discussed : the remains discovered could correspond to the dwellings of the specialized artisans, with their workshops, including all the installations and equipment necessary for their subsistence and daily life. We can thus propose the hypothesis that this was one of the forms of iron production organization employed by the Franks during the Early Middle Ages, and that if might correspond to that which is suggested by the polyptyques of the Carolingian period.Die frühmittelalterliche Besiedlung (6.-8. Jh.) von Les Noires Terres auf dem Gebiet der Gemeinde Messein, südlich von Nancy (Departement Meurthe-et-Moselle, Frankreich, Ausgrabung 2003-2004), besteht aus Siedlungseinheiten, die sich jeweils aus einem Wohnbau mit landwirtschaftlichen Einrichtungen (Speicherbauten, Silos, Einfriedungen, Grubenhäuser…) und Werkstätten für die Eisengewinnung und -verarbeitung (Erzaufbereitung, Holzkohlengewinnung, Rennöfen, Eisenschmieden) zusammensetzen. Die Abfälle, die von einem kompletten, durch die paläometallurgische Studie dokumentierten Verhüttungsprozess (von der Erzaufbereitung bis hin zur Formgebung der Endprodukte) zeugen, sowie das anhand der Abfälle geschätzte Produktionsvolumen (mehrere Dutzend Tonnen Eisen) legen nahe, dass es sich hier um die Hauptbeschäftigung der Bewohner handelte und nicht um eine Nebentätigkeit. Demzufolge steht die Art der Besiedlung zur Diskussion: Die Funde und Befunde würden einer auf die Eisengewinnung und -verarbeitung spezialisierte Handwerkersiedlung entsprechen mit allen für die Arbeit und den Alltag der Bewohner notwendigen Anlagen und Einrichtungen, Wohnhäusern und Werkstätten. So können wir die Hypothese vorlegen, dass es sich um eine der Organisationsformen der frühmittelalterlichen fränkischen Eisenmetallurgie handelt, welche die Urbare der karolingischen Periode erahnen lassen

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Enjeux de la transition écologique

Cet ouvrage, aux nombreuses illustrations, donne une vision transversale des changements environnementaux d'échelle mondiale que connaît notre planète aux limites finies. Son objectif est, en particulier, de faire comprendre les mécanismes et conséquences du réchauffement climatique et de l'érosion de la biodiversité ainsi que leurs relations avec nos modes de vie et de consommation. Pour l'essentiel, il reprend l'un des premiers enseignements numériques mis à grande échelle en 2020 sur les « Enjeux de la transition écologique » auprès de plusieurs milliers d'étudiants de licence de toutes disciplines de l'Université Paris-Saclay. À l'étape de ce cours, cet ouvrage s'articule en quatre parties. Partant d'une perspective historique des évolutions du climat et de la biodiversité, les trois premières parties montrent l'impact grandissant de l'humanité sur les flux d'énergie et de matière de la planète et sur les trajectoires évolutives du vivant. Cet impact conditionne en retour la survie de nos sociétés et du monde tel que nous le connaissons. La quatrième et dernière partie de cet ouvrage offre un cadre de réflexions pour une transition vers un développement soutenable. Cette transition peut être une opportunité pour répenser nos façons de produire, de travailler, de consommer, de nous déplacer, tout en visant l'équité sociale pour un « bien vivre ensemble » partagé sur la planète. Pour répondre à l'objectif de transversalité de l'ouvrage, plus de quarante enseignant(e)s-chercheurs(euses) et chercheurs(euses) d'horizons différents y ont reconnu, mêlant savoirs des sciences de la nature aux sciences humaines et sociales en passant par le droit, l'économie, la gestion, l'agronomie et la médecine

Systemic approaches for emission reduction in industrial plants based on physical accounting: example for an aluminium smelter

Greenhouse gas (GHG) accounting in industrial plants usually has multiple purposes, including mandatory reporting, shareholder and stakeholder communication, developing key performance indicators (KPIs), or informing cost-effective mitigation options. Current carbon accounting systems, such as the one required by the European Union Emission Trading Scheme (EU ETS), ignore the system context in which emissions occur. This hampers the identification and evaluation of comprehensive mitigation strategies considering linkages between materials, energy, and emissions. Here, we propose a carbon accounting method based on multilevel material flow analysis (MFA), which aims at addressing this gap. Using a Norwegian primary aluminum production plant as an example, we analyzed the material stocks and flows within this plant for total mass flows of goods as well as substances such as aluminum and carbon. The results show that the MFA-based accounting (i) is more robust than conventional tools due to mass balance consistency and higher granularity, (ii) allows monitoring the performance of the company and defines meaningful KPIs, (iii) can be used as a basis for the EU ETS reporting and linked to internal reporting, (iv) enables the identification and evaluation of systemic solutions and resource efficiency strategies for reducing emissions, and (v) has the potential to save costs

Indefinite Permittivity in Srn+1TinO3n+1 Ruddlesden-Popper Thin Layers Grown by Molecular Beam Epitaxy

International audienc

A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft

International audienceBackground: Antibody-mediated rejection (AMR) is a major cause of graft loss. The development of donor-specific antibodies (DSAs) directed against the allogeneic HLA molecules expressed by the graft also leads to accelerated arteriosclerosis. CD31 is a protein expressed on endothelial and immune cells, ensuring homeostasis at this interface. When strong immune stimulation occurs, the regulatory function of CD31 is lost owing to cleavage of its extracellular portion. P8RI, a synthetic peptide that binds to the ectodomain of CD31, is able to restore the CD31 immunomodulatory function. In this study, we hypothesized that CD31 could represent an attractive molecular target in AMR and investigated whether P8RI could prevent the development of vascular antibody-mediated lesions. Materials and methods: A rat model of orthotopic aortic allograft was used, and P8RI was administered for 28 days. Circulating DSAs were quantified to assess the alloimmune humoral response, and histologic and immunohistochemical analyses of aortic allografts were performed to estimate antibody-mediated lesions in the allograft. Results: Aorta-allografted rats receiving P8RI developed fewer DSAs than control animals (mean fluorescence intensity 344 vs 741). The density of nuclei in the media (3.4 x 10-5 vs 2.2 x 10-5 nuclei/px2) and media surface area (2.33 x 106 vs 2.02 x 106 px2) were higher in animals treated with P8RI than in control animals. Conclusions: These data support a therapeutic potential for molecules able to restore the CD31 signaling to fight AMR. P8RI, an agonist synthetic peptide targeting CD31, might prevent DSA production and have a beneficial effect in limiting arterial antibody-mediated lesions. CD31 agonists may become therapeutic tools to prevent and treat solid organ transplant arteriosclerosis

Energies et pollutions

International audienc

Cleaved CD31 as a target for in vivo molecular imaging of inflammation

International audienceAbstract There is a need for new targets to specifically localize inflammatory foci, usable in a wide range of organs. Here, we hypothesized that the cleaved molecular form of CD31 is a suitable target for molecular imaging of inflammation. We evaluated a bioconjugate of D-P8RI, a synthetic peptide that binds all cells with cleaved CD31, in an experimental rat model of sterile acute inflammation. Male Wistar rats were injected with turpentine oil into the gastrocnemius muscle two days before 99m Tc-HYNIC-D-P8RI (or its analogue with L-Proline) SPECT/CT or [ 18 F]FDG PET/MRI. Biodistribution, stability study, histology, imaging and autoradiography of 99m Tc-HYNIC-D-P8RI were further performed. Biodistribution studies revealed rapid elimination of 99m Tc-HYNIC-D-P8RI through renal excretion with almost no uptake from most organs and excellent in vitro and in vivo stability were observed. SPECT/CT imaging showed a significant higher 99m Tc-HYNIC-D-P8RI uptake compared with its analogue with L-Proline (negative control) and no significant difference compared with [ 18 F]FDG (positive control). Moreover, autoradiography and histology revealed a co-localization between 99m Tc-HYNIC-D-P8RI uptake and inflammatory cell infiltration. 99m Tc-HYNIC-D-P8RI constitutes a new tool for the detection and localization of inflammatory sites. Our work suggests that targeting cleaved CD31 is an attractive strategy for the specific in vivo imaging of inflammatory processes

Georg Lukacs. Grandeur et décadence de l’expressionnisme. Suivi de Il y va du réalisme

Georg Lukács, Probleme des Realismus I, GLW 4, Neuwied/Berlin, Luchterhand, 197