Proposal for improving of paddy rice drying process in dryers inclined pools: Propuesta de mejoramiento del proceso de secado de arroz paddy en secaderos tipo albercas inclinadas

The operation of inclined type dryers for paddy rice is studied to improve their operation and efficiency, considering the variables of drying time, humidity distribution in the rice layer after drying and air velocities within the plenum. Simulating the distribution and velocities of the air flow before crossing the rice layer, the outlet ducts to the plenum are relocated and dampers are placed to distribute the flow evenly. On the other hand, it is proposed to replace the flat-type mesh with a zigzag-type mesh.  To verify the proposed modifications, a scale model was built to determine the humidity and drying time variation inside the rice layer, obtaining more uniform moisture percentages within the rice layer and a decrease in drying time.  Se estudia el funcionamiento de los secaderos tipo inclinado para arroz paddy, con el fin de mejorar su operación y eficiencia, considerando las variables de tiempo de secado, distribución de la humedad en la capa de arroz después del secado y velocidades del aire dentro del plenum. Simulando la distribución y velocidades del flujo de aire antes de cruzar la capa de arroz se reubican los conductos de salida al plenum y se colocan dampers que distribuyan uniformemente el flujo. Por otro lado, se propone la sustitución de la malla tipo plana por una malla tipo zigzag.  Para verificar las modificaciones propuestas se construyó un modelo a escala para medir la variación del tiempo de secado y la humedad dentro de la capa de arroz paddy, obteniendo porcentajes de humedad más uniformes dentro de la capa de arroz y disminución del tiempo de secado

Proposal for improving of paddy rice drying process in dryers inclined pools: Propuesta de mejoramiento del proceso de secado de arroz paddy en secaderos tipo albercas inclinadas

The operation of inclined type dryers for paddy rice is studied to improve their operation and efficiency, considering the variables of drying time, humidity distribution in the rice layer after drying and air velocities within the plenum. Simulating the distribution and velocities of the air flow before crossing the rice layer, the outlet ducts to the plenum are relocated and dampers are placed to distribute the flow evenly. On the other hand, it is proposed to replace the flat-type mesh with a zigzag-type mesh.  To verify the proposed modifications, a scale model was built to determine the humidity and drying time variation inside the rice layer, obtaining more uniform moisture percentages within the rice layer and a decrease in drying time.  Se estudia el funcionamiento de los secaderos tipo inclinado para arroz paddy, con el fin de mejorar su operación y eficiencia, considerando las variables de tiempo de secado, distribución de la humedad en la capa de arroz después del secado y velocidades del aire dentro del plenum. Simulando la distribución y velocidades del flujo de aire antes de cruzar la capa de arroz se reubican los conductos de salida al plenum y se colocan dampers que distribuyan uniformemente el flujo. Por otro lado, se propone la sustitución de la malla tipo plana por una malla tipo zigzag.  Para verificar las modificaciones propuestas se construyó un modelo a escala para medir la variación del tiempo de secado y la humedad dentro de la capa de arroz paddy, obteniendo porcentajes de humedad más uniformes dentro de la capa de arroz y disminución del tiempo de secado

CURSO SOBRE EXPLICACIÓN LINGÜÍSTICA VINCULADA A ESTEREOTIPOS METODOLÓGICOS EN LA REDACCIÓN CIENTÍFICA DE PROFESIONALES UNIVERSITARIOS

There is acceptance and establishment of methodological stereotypes by professionals at the University of Medical Sciences of Villa Clara, Cuba. This is due to theoretical ignorance about the interrelation of linguistics with the methodology of research in the conscious expression of scientifi c language. Th e situation has served as a motivation to these authors to reverse it through the design and development of a course aimed at these university students. The essence of the course lies in the linguistic explanation –applied linguistics–, linked to methodological stereotypes in scientifi c writing. However, in parallel with the teaching process, a study was conducted to perceive possible conceptual changes in students. Hence, the objective of: is research is to expose the experience and educational-research results inherent to the referred course. Methodologically, the heuristic proceedings of language teaching, as well as the literary analysis in the study of the language fi gured in diff erent styles were used for teaching. In the investigative process, the theoretical methods- synthesis and induction-deduction were used to obtain, process, and analyze the information. Empirical methods of observation and documentary review were also used, in order to obtain the primary data of the diagnosis, as well as the final data derived from the evaluation and of a survey applied when completing the course. The mathematical method of percentage analysis served to tabulate and process the information obtained. As for the results, a conceptual change in students may be found from the diagnosis; phase where these did not notice the relationship between methodological patterns and linguistic science. By completing the course, the students proved to be aware of that interrelation. Finally, the authors consider that the greatest significance of the course lies in the reflection, discussion, and analysis of facts sometimes unnoticed by the professionals of science; evidently, a marked purpose is to move static and dogmatic thought through reasons argued and shared, in this case, by the generality of the group.Existe aceptación y establecimiento de estereotipos metodológicos por parte de los profesionales de la Universidad de Ciencias Médicas de Villa Clara, Cuba. Ello se debe al desconocimiento teórico acerca de la interrelación de la lingüística con la metodología de la investigación en la expresión consciente del lenguaje científico. La situación ha servido como motivación a estos autores para revertirla mediante el diseño y desarrollo de un posgrado dirigido a dichos universitarios. La esencia del curso radica en la explicación lingüística –lingüística aplicada–, vinculada a estereotipos metodológicos en la redacción científica. No obstante, paralelamente al proceso docente, se realizó un estudio para percibir los posibles cambios conceptuales en los cursistas. De ahí, el objetivo: exponer la experiencia y resultados docente-investigativos inherentes al curso referido. Metodológicamente, se emplearon para la docencia los procedimientos heurísticos propios de la enseñanza de la lengua, así como el análisis literario en el estudio del lenguaje figurado en diferentes estilos. En el proceso investigativo se utilizaron fundamentalmente los métodos teóricos análisis-síntesis e inducción-deducción para obtener, procesar y analizar la información. También se emplearon los métodos empíricos de observación y revisión documental, con el fin de obtener los datos primarios del diagnóstico, así como los datos finales derivados de la evaluación y de una encuesta aplicada al culminar el curso. El método matemático de análisis porcentual sirvió para tabular y procesar la información obtenida. En cuanto a los resultados, se pudo constatar un cambio conceptual en los cursistas a partir del diagnóstico; fase donde estos no se percataban de la relación entre los patrones metodológicos y la ciencia lingüística. Al culminar el posgrado, los alumnos demostraron estar conscientes de dicha interrelación. Finalmente, los autores consideran que la mayor significación del curso radica en la reflexión, la discusión y el análisis de hechos a veces inadvertidos por los profesionales de la ciencia; evidentemente, un propósito marcado es mover el pensamiento estático y dogmático mediante razones argumentadas y compartidas, en este caso, por la generalidad del grupo

Tocilizumab in visual involvement of giant cell arteritis: a multicenter study of 471 patients

Background: Visual involvement is the most feared complication of giant cell arteritis (GCA). Information on the efficacy of tocilizumab (TCZ) for this complication is scarce and controversial. Objective: We assessed a wide series of GCA treated with TCZ, to evaluate its role in the prevention of new visual complications and its efficacy when this manifestation was already present before the initiation of TCZ. Design: This is an observational multicenter study of patients with GCA treated with TCZ. Methods: Patients were divided into two subgroups according to the presence or absence of visual involvement before TCZ onset. Visual manifestations were classified into the following categories: transient visual loss (TVL), permanent visual loss (PVL), diplopia, and blurred vision. Results: Four hundred seventy-one GCA patients (mean age, 74 +/- 9 years) were treated with TCZ. Visual manifestations were observed in 122 cases (26%), of which 81 were present at TCZ onset: PVL (n = 60; unilateral/bilateral: 48/12), TVL (n = 17; unilateral/bilateral: 11/6), diplopia (n = 2), and blurred vision (n = 2). None of the patients without previous visual involvement or with TVL had new episodes after initiation of TCZ, while only 11 out of 60 (18%) patients with PVL experienced some improvement. The two patients with diplopia and one of the two patients with blurred vision improved. Conclusion: TCZ may have a protective effect against the development of visual complications or new episodes of TVL in GCA. However, once PVL was established, only a few patients improved

Aplicación de un programa reeducativo de la actividad pedagógica alterada para superar las dificultades de aprendizaje de lecto-escritura en niños de tercer grado de 8 a 11 años 6 meses de edad cronológica, de las escuelas oficiales urbanas de la ciudad de Nueva San Salvador, Departamento de la Libertad.

Las dificultades del aprendizaje en cuanto a la lecto-escritura inician con el desarrollo de los niños cuando aprenden a leer y escribir, debido a que se aplica una acitud incorrecta a la ensañanza o por hábitos y procedimientos de estudio mal conformados

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts