9 research outputs found
Toll-Like Receptor 7 Agonist–Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune CellsSummary
Background & Aims: Psoriasis and inflammatory bowel disease (IBD) are both chronic inflammatory diseases occurring in the skin and gut, respectively. It is well established that psoriasis and IBD have high concordance rates, and similar changes in immune cells and microbiome composition have been reported in both conditions. To study this connection, we used a combination murine model of psoriatic dermatitis and colitis in which mice were treated topically with the Toll-like receptor 7 agonist imiquimod (IMQ) and fed dextran sulfate sodium (DSS). Methods: We applied IMQ topically to B6 mice (IMQ mice) and subsequently fed them 2% DSS in their drinking water. Disease activity and immune cell phenotypes were analyzed, and the microbial composition of fecal samples was investigated using 16S ribosomal RNA sequencing. We transplanted feces from IMQ mice to germ-free IQI/Jic (IQI) mice and fed them DSS to assess the effect of the gut microbiome on disease. Results: We first confirmed that IMQ mice showed accelerated DSS colitis. IMQ mice had decreased numbers of IgD+ and IgM+ B cells and increased numbers of non–cytokine-producing macrophages in the gut. Moreover, the gut microbiomes of IMQ mice were perturbed, with significant reductions of Lactobacillus johnsonii and Lactobacillus reuteri populations. Germ-free mice transplanted with feces from IMQ mice, but not with feces from untreated mice, also developed exacerbated DSS colitis. Conclusions: These results suggest that skin inflammation may contribute to pathogenic conditions in the gut via immunologic and microbiological changes. Our finding of a novel potential skin–gut interaction provides new insights into the coincidence of psoriasis and IBD. Keywords: Inflammatory Bowel Disease, Dermatitis, Gut Microbiom
Tu1770 – Tlr7 Agonist Induced Dermatitis Exacerbated Colitis Via Altering Host Immune Cells and Gut Microbiota
Tu1772 – ?Indigo Naturalis' Ameliorates Ulcerative Colitis Via Modulating Ahr Signaling and Microbe Composition
P023 5-Aminosalicylate intolerance is a risk factor for hospitalization in patients with UC
P093 The Comparison of Short-Term Efficacy of Treatments Between Tofacitinib and Vedolizumab in Patients With Ulcerative Colitis
Dermoscopy of uncommon skin tumours
There is mounting evidence that dermoscopy significantly
improves the clinical diagnosis of most skin tumours and in
consequence, dermoscopy is nowadays an integral part of
the clinical skin examination.
1\u20133
The dermoscopic patterns
of most common skin tumours, including melanocytic
naevi, seborrhoeic keratoses, dermatofibromas, vascular
tumours, melanomas, basal cell carcinomas (BCC) and
squamous cell carcinomas (SCC) are well defined and
established in everyday practice.
4\u20136
However, a range of
uncommon skin tumours exists and their dermoscopic pat-
terns have been described only sporadically. Here we
provide a review of the literature on the dermoscopic pat-
terns of uncommon skin tumours along with representative
examples from our databa