Experimental and Numerical Analysis of Fracture in Prestressed Concrete

This work examines the crack initiation and propagation in Prestressed Concrete (PC) beams by a combined experimental and numerical approach. Four-point bending tests performed on PC sleepers lead to the formation of multiple cracks, in a number that depends on the specimen. The location of each fracture and its growth with time is monitored by Digital Image Correlation (DIC). The experiments are simulated by a finite element approach, reproducing the concrete response by a smeared crack model. The model parameters are calibrated to match the experimental moment deflection curve. In this study, only the beam segment enclosing one crack is discretized. The effect of the external load is simulated by applying the horizontal displacements returned by DIC at the vertical boundaries of the analyzed region. Thus, uncertainties are reduced since there is no need to discretize the PC element in its whole length, to include the supports and the loading plates, and to simulate the interactions between the different components

3D Measurement of Large Deformations on a Tensile Structure during Wind Tunnel Tests Using Microsoft Kinect V2

Wind tunnel tests often require deformation and displacement measures to determine the behavior of structures to evaluate their response to wind excitation. However, common measurement techniques make it possible to measure these quantities only at a few specific points. Moreover, these kinds of measurements, such as Linear Variable Differential Transformer LVDTs or fiber optics, usually influence the downstream and upstream air fluxes and the structure under test. In order to characterize the displacement of the structure not just at a few points, but for the entire structure, in this article, the application of 3D cameras during a wind tunnel test is presented. In order to validate this measurement technique in this application field, a wind tunnel test was executed. Three Kinect V2 depth sensors were used for a 3D displacement measurement of a test structure that did not present any optical marker or feature. The results highlighted that by using a low-cost and user-friendly measurement system, it is possible to obtain 3D measurements in a volume of several cubic meters (4 m x 4 m x 4 m wind tunnel chamber), without significant disturbance of wind flux and by means of a simple calibration of sensors, executed directly inside the wind tunnel. The obtained results highlighted a displacement directed to the internal part of the structure for the side most exposed to wind, while the sides, parallel to the wind flux, were more subjected to vibrations and with an outwards average displacement. These results are compliant with the expected behavior of the structure

Characterization of fracture properties of thin aluminuminclusions embedded in anisotropic laminate composites

The fracture properties of thin aluminum inclusions embedded in anisotropic paperboardcomposites, of interest for food and beverage packaging industry, can be determined by performing tensile testson non-conventional heterogeneous specimens. The region of interest of the investigated material samples ismonitored all along the experiment by digital image correlation techniques, which allow to recover qualitativeand quantitative information about the metal deformation and about the evolution of the damaging processesleading to the detachment of the inclusion from the surrounding laminate composite. The interpretation of thelaboratory results is supported by the numerical simulation of the tests

geometrical vision measurement in mechanical engineering

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Characterization of fracture properties of thin aluminuminclusions embedded in anisotropic laminate composites

The fracture properties of thin aluminum inclusions embedded in anisotropic paperboardcomposites, of interest for food and beverage packaging industry, can be determined by performing tensile testson non-conventional heterogeneous specimens. The region of interest of the investigated material samples ismonitored all along the experiment by digital image correlation techniques, which allow to recover qualitativeand quantitative information about the metal deformation and about the evolution of the damaging processesleading to the detachment of the inclusion from the surrounding laminate composite. The interpretation of thelaboratory results is supported by the numerical simulation of the tests

Communicating potentially large but non-robust changes in multi-model projections of future climate

The future climate projections in the IPCC reports are visually communicated via maps showing the mean response of climate models to alternative scenarios of socio-economic development. The presence of large changes is highlighted by stippling the maps where the mean climate response (the signal) is large compared to internal variability (the noise) and the response is robust, i.e. consistent in sign, across the individual models. In addition, hatching is used to mark the regions with a small multi-model mean change. This approach may fail to recognise the risk of large changes in regions where the uncertainty is large and the response is not robust. Here we present a more informative diagnostic to support risk assessment that is obtained by quantifying the mean forced signal-to-noise ratio of the individual model responses, rather than the signal-to-noise ratio of the mean response. This enables us to identify regions where a large future change compared to year-to-year variability is plausible, regardless of whether the signal is robust across the ensemble. For mean precipitation changes, we find that the majority (58% in surface area) of the unmarked regions and a sizeable portion (19%) of the hatched regions from the AR5 projections hid climate change responses to the RCP8.5 scenario that are on average large compared to the year-to-year variability. Based on the newer CMIP6 ensemble, a considerable potential for large annual-mean precipitation changes, despite the lack of a robust multi-model projection, exists over 22% of the surface land area, particularly in Central America, northern South America (including the Amazon), Central and West Africa (including parts of the Sahel), and the Maritime Continent

ITALIAN CANCER FIGURES - REPORT 2015: The burden of rare cancers in Italy = I TUMORI IN ITALIA - RAPPORTO 2015: I tumori rari in Italia

OBJECTIVES: This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy. Estimated number of new rare cancer cases yearly diagnosed (incidence), proportion of patients alive after diagnosis (survival), and estimated number of people still alive after a new cancer diagnosis (prevalence) are provided for about 200 different cancer entities. MATERIALS AND METHODS: Data herein presented were provided by AIRTUM population- based cancer registries (CRs), covering nowadays 52% of the Italian population. This monograph uses the AIRTUM database (January 2015), which includes all malignant cancer cases diagnosed between 1976 and 2010. All cases are coded according to the International Classification of Diseases for Oncology (ICD-O-3). Data underwent standard quality checks (described in the AIRTUM data management protocol) and were checked against rare-cancer specific quality indicators proposed and published by RARECARE and HAEMACARE (www.rarecarenet.eu; www.haemacare.eu). The definition and list of rare cancers proposed by the RARECAREnet "Information Network on Rare Cancers" project were adopted: rare cancers are entities (defined as a combination of topographical and morphological codes of the ICD-O-3) having an incidence rate of less than 6 per 100,000 per year in the European population. This monograph presents 198 rare cancers grouped in 14 major groups. Crude incidence rates were estimated as the number of all new cancers occurring in 2000-2010 divided by the overall population at risk, for males and females (also for gender-specific tumours).The proportion of rare cancers out of the total cancers (rare and common) by site was also calculated. Incidence rates by sex and age are reported. The expected number of new cases in 2015 in Italy was estimated assuming the incidence in Italy to be the same as in the AIRTUM area. One- and 5-year relative survival estimates of cases aged 0-99 years diagnosed between 2000 and 2008 in the AIRTUM database, and followed up to 31 December 2009, were calculated using complete cohort survival analysis. To estimate the observed prevalence in Italy, incidence and follow-up data from 11 CRs for the period 1992-2006 were used, with a prevalence index date of 1 January 2007. Observed prevalence in the general population was disentangled by time prior to the reference date (≤2 years, 2-5 years, ≤15 years). To calculate the complete prevalence proportion at 1 January 2007 in Italy, the 15-year observed prevalence was corrected by the completeness index, in order to account for those cancer survivors diagnosed before the cancer registry activity started. The completeness index by cancer and age was obtained by means of statistical regression models, using incidence and survival data available in the European RARECAREnet data. RESULTS: In total, 339,403 tumours were included in the incidence analysis. The annual incidence rate (IR) of all 198 rare cancers in the period 2000-2010 was 147 per 100,000 per year, corresponding to about 89,000 new diagnoses in Italy each year, accounting for 25% of all cancer. Five cancers, rare at European level, were not rare in Italy because their IR was higher than 6 per 100,000; these tumours were: diffuse large B-cell lymphoma and squamous cell carcinoma of larynx (whose IRs in Italy were 7 per 100,000), multiple myeloma (IR: 8 per 100,000), hepatocellular carcinoma (IR: 9 per 100,000) and carcinoma of thyroid gland (IR: 14 per 100,000). Among the remaining 193 rare cancers, more than two thirds (No. 139) had an annual IR <0.5 per 100,000, accounting for about 7,100 new cancers cases; for 25 cancer types, the IR ranged between 0.5 and 1 per 100,000, accounting for about 10,000 new diagnoses; while for 29 cancer types the IR was between 1 and 6 per 100,000, accounting for about 41,000 new cancer cases. Among all rare cancers diagnosed in Italy, 7% were rare haematological diseases (IR: 41 per 100,000), 18% were solid rare cancers. Among the latter, the rare epithelial tumours of the digestive system were the most common (23%, IR: 26 per 100,000), followed by epithelial tumours of head and neck (17%, IR: 19) and rare cancers of the female genital system (17%, IR: 17), endocrine tumours (13% including thyroid carcinomas and less than 1% with an IR of 0.4 excluding thyroid carcinomas), sarcomas (8%, IR: 9 per 100,000), central nervous system tumours and rare epithelial tumours of the thoracic cavity (5%with an IR equal to 6 and 5 per 100,000, respectively). The remaining (rare male genital tumours, IR: 4 per 100,000; tumours of eye, IR: 0.7 per 100,000; neuroendocrine tumours, IR: 4 per 100,000; embryonal tumours, IR: 0.4 per 100,000; rare skin tumours and malignant melanoma of mucosae, IR: 0.8 per 100,000) each constituted <4% of all solid rare cancers. Patients with rare cancers were on average younger than those with common cancers. Essentially, all childhood cancers were rare, while after age 40 years, the common cancers (breast, prostate, colon, rectum, and lung) became increasingly more frequent. For 254,821 rare cancers diagnosed in 2000-2008, 5-year RS was on average 55%, lower than the corresponding figures for patients with common cancers (68%). RS was lower for rare cancers than for common cancers at 1 year and continued to diverge up to 3 years, while the gap remained constant from 3 to 5 years after diagnosis. For rare and common cancers, survival decreased with increasing age. Five-year RS was similar and high for both rare and common cancers up to 54 years; it decreased with age, especially after 54 years, with the elderly (75+ years) having a 37% and 20% lower survival than those aged 55-64 years for rare and common cancers, respectively. We estimated that about 900,000 people were alive in Italy with a previous diagnosis of a rare cancer in 2010 (prevalence). The highest prevalence was observed for rare haematological diseases (278 per 100,000) and rare tumours of the female genital system (265 per 100,000). Very low prevalence (<10 prt 100,000) was observed for rare epithelial skin cancers, for rare epithelial tumours of the digestive system and rare epithelial tumours of the thoracic cavity. COMMENTS: One in four cancers cases diagnosed in Italy is a rare cancer, in agreement with estimates of 24% calculated in Europe overall. In Italy, the group of all rare cancers combined, include 5 cancer types with an IR>6 per 100,000 in Italy, in particular thyroid cancer (IR: 14 per 100,000).The exclusion of thyroid carcinoma from rare cancers reduces the proportion of them in Italy in 2010 to 22%. Differences in incidence across population can be due to the different distribution of risk factors (whether environmental, lifestyle, occupational, or genetic), heterogeneous diagnostic intensity activity, as well as different diagnostic capacity; moreover heterogeneity in accuracy of registration may determine some minor differences in the account of rare cancers. Rare cancers had worse prognosis than common cancers at 1, 3, and 5 years from diagnosis. Differences between rare and common cancers were small 1 year after diagnosis, but survival for rare cancers declined more markedly thereafter, consistent with the idea that treatments for rare cancers are less effective than those for common cancers. However, differences in stage at diagnosis could not be excluded, as 1- and 3-year RS for rare cancers was lower than the corresponding figures for common cancers. Moreover, rare cancers include many cancer entities with a bad prognosis (5-year RS <50%): cancer of head and neck, oesophagus, small intestine, ovary, brain, biliary tract, liver, pleura, multiple myeloma, acute myeloid and lymphatic leukaemia; in contrast, most common cancer cases are breast, prostate, and colorectal cancers, which have a good prognosis. The high prevalence observed for rare haematological diseases and rare tumours of the female genital system is due to their high incidence (the majority of haematological diseases are rare and gynaecological cancers added up to fairly high incidence rates) and relatively good prognosis. The low prevalence of rare epithelial tumours of the digestive system was due to the low survival rates of the majority of tumours included in this group (oesophagus, stomach, small intestine, pancreas, and liver), regardless of the high incidence rate of rare epithelial cancers of these sites. This AIRTUM study confirms that rare cancers are a major public health problem in Italy and provides quantitative estimations, for the first time in Italy, to a problem long known to exist. This monograph provides detailed epidemiologic indicators for almost 200 rare cancers, the majority of which (72%) are very rare (IR<0.5 per 100,000). These data are of major interest for different stakeholders. Health care planners can find useful information herein to properly plan and think of how to reorganise health care services. Researchers now have numbers to design clinical trials considering alternative study designs and statistical approaches. Population-based cancer registries with good quality data are the best source of information to describe the rare cancer burden in a population

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Uncertainty assessment of digital image correlation method in dynamic applications

Even though digital image correlation (DIC) is a widely used optical full field measurement method, it still needs further performance investigations, when it comes to dynamic conditions. Dealing with a moving target, causes a motion effect (i.e. blurring) on the acquired images. This factor is an important source of uncertainty that needs to be quantified. Therefore, the present study aims to perform a systematic uncertainty assessment of DIC method in general dynamic applications. The study focuses on 2D DIC. In the case of 3D DIC similar problems will arise and therefore, a complete understanding of two dimensional conditions will be of great help to further studies which deal with 3D conditions. The whole work can be divided in to two parts. In the first part, a method to simulate the motion effect on a reference image is proposed to be applied. This method allows simulating the acquired images in a real dynamic test and estimating the measurement uncertainty caused by the motion effect. Using this technique, the uncertainty of DIC measurement is estimated. The second part of the study aimed to validate the simulation technique. Therefore, several tests are conducted by imposing harmonic motion to a target, in different frequencies and amplitudes. The results show good agreement between the experiments and the simulations, proving the introduced technique to be an effective method for motion induced uncertainty estimation

A combined experimental-numerical investigation of the failure mode of thin metal foils

A combined experimental and numerical analysis of the mechanical response of the thin aluminum foils employed in beverage packaging has been performed using 3D digital image correlation and non-linear finite element techniques. The present contribution focuses on the significant amount of out-of-plane displacements that develop in tensile tests as fracture propagates across the investigated specimens. The influence of this phenomenon on the actual failure mode of the considered metal samples is further discussed