50 research outputs found
Toxin-Based Models to Investigate Demyelination and Remyelination.
Clinical myelin diseases, and our best experimental approximations, are complex entities in which demyelination and remyelination proceed unpredictably and concurrently. These features can make it difficult to identify mechanistic details. Toxin-based models offer lesions with predictable spatiotemporal patterns and relatively discrete phases of damage and repair: a simpler system to study the relevant biology and how this can be manipulated. Here, we discuss the most widely used toxin-based models, with a focus on lysolecithin, ethidium bromide, and cuprizone. This includes an overview of their respective mechanisms, strengths, and limitations and step-by-step protocols for their use
Updated measurements of exclusive J/Ï and Ï(2S) production cross-sections in pp collisions at âs = 7 TeV
The differential cross-section as a function of rapidity has been measured for the exclusive production of J/Ï and Ï(2S) mesons in protonâproton collisions at âs = 7 TeV, using data collected by the LHCb experiment, corresponding to an integrated luminosity of 930 pbâ1. The cross-sections times branching fractions to two muons having pseudorapidities between 2.0 and 4.5 are measured to be where the first uncertainty is statistical and the second is systematic. The measurements agree with next-to-leading order QCD predictions as well as with models that include saturation effects
Studies of beauty baryon decays to D0phâ and Î+châ final states
Decays of beauty baryons to the D0phâ and Î+châ final states (where h indicates a pion or a kaon) are studied using a data sample of pp collisions, corresponding to an integrated luminosity of 1.0ââfbâ1, collected by the LHCb detector. The Cabibbo-suppressed decays Î0bâD0pKâ and Î0bâÎ+cKâ are observed, and their branching fractions are measured with respect to the decays Î0bâD0pÏâ and Î0bâÎ+cÏâ. In addition, the first observation is reported of the decay of the neutral beauty-strange baryon Î0b to the D0pKâ final state, and a measurement of the Î0b mass is performed. Evidence of the Î0bâÎ+cKâ decay is also reported
Measurement of the CKM angle using with decays
A model-dependent amplitude analysis of the decay is performed using proton-proton collision data
corresponding to an integrated luminosity of 3.0fb, recorded at
and by the LHCb experiment. The CP violation observables
and , sensitive to the CKM angle , are measured to
be \begin{eqnarray*} x_- &=& -0.15 \pm 0.14 \pm 0.03 \pm 0.01, y_- &=& 0.25 \pm
0.15 \pm 0.06 \pm 0.01, x_+ &=& 0.05 \pm 0.24 \pm 0.04 \pm 0.01, y_+ &=&
-0.65^{+0.24}_{-0.23} \pm 0.08 \pm 0.01, \end{eqnarray*} where the first
uncertainties are statistical, the second systematic and the third arise from
the uncertainty on the amplitude model. These
are the most precise measurements of these observables. They correspond to
and , where is
the magnitude of the ratio of the suppressed and favoured decay amplitudes, in a mass region of around the
mass and for an absolute value of the cosine of the decay
angle larger than .Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-007.htm
Search for the and decays with the LHCb detector
A search is performed for the as yet unobserved baryonic and
decays with 3 of proton-proton collision data recorded by the LHCb
experiment. The decay is used as a
normalisation channel. No significant signal is observed for the decay. An upper limit is found on the
branching fraction of } at 90\% confidence level. Evidence is seen for
the presence of the decay at the level of
significance, with a branching fraction }.Comment: 22 pages, 6 figures. v2 is published version (very minor revisions
Search for dark photons produced in 13 TeV collisions
Searches are performed for both promptlike and long-lived dark photons,
A
0
, produced in proton-proton
collisions at a center-of-mass energy of 13 TeV, using
A
0
â
Ό
ĂŸ
Ό
â
decays and a data sample corresponding
to an integrated luminosity of
1
.
6
fb
â
1
collected with the LHCb detector. The promptlike
A
0
search covers
the mass range from near the dimuon threshold up to 70 GeV, while the long-lived
A
0
search is restricted to
the low-mass region
214
<m
Ă°
A
0
Ă
<
350
MeV. No evidence for a signal is found, and 90% confidence
level exclusion limits are placed on the
Îł
â
A
0
kinetic-mixing strength. The constraints placed on promptlike
dark photons are the most stringent to date for the mass range
10
.
6
<m
Ă°
A
0
Ă
<
70
GeV, and are
comparable to the best existing limits for
m
Ă°
A
0
Ă
<
0
.
5
GeV. The search for long-lived dark photons is the
first to achieve sensitivity using a displaced-vertex signature
Search for the decay Bs -> D*-+ Ï+-
A search for the decay Bs -> D*-+ \pi+- is presented using a data sample corresponding to an integrated luminosity of 1.0 fb-1 of pp collisions collected by LHCb. This decay is expected to be mediated by a W-exchange diagram, with little contribution from rescattering processes, and therefore a measurement of the branching fraction will help to understand the mechanism behind related decays such as Bs -> \pi+ \pi- and Bs -> D Dbar. Systematic uncertainties are minimised by using B0 -> D*-+ \pi+- as a normalisation channel. We find no evidence for a signal, and set an upper limit on the branching fraction of BR(Bs -> D*-+ \pi+-) < 6.1 (7.8) x10^(-6) at 90% (95%) confidence level
Precision measurement of the B[0 over s]â[â over B][0 over s] oscillation frequency with the decay B[0 over s]âD[â over s]Ï[superscript +]
A key ingredient to searches for physics beyond the Standard Model in B[0 over s] mixing phenomena is the measurement of the B[0 over s]â[â over B][0 over s] oscillation frequency, which is equivalent to the mass difference Îm[subscript s] of the B[0 over s] mass eigenstates. Using the world's largest B[0 over s] meson sample accumulated in a dataset, corresponding to an integrated luminosity of 1.0 fb[superscript â1], collected by the LHCb experiment at the CERN LHC in 2011, a measurement of Îm[subscript s] is presented. A total of about 34â000 B[0 over s] â D[â over s]Ï[superscript +] signal decays are reconstructed, with an average decay time resolution of 44 fs. The oscillation frequency is measured to be Îm[subscript s] = 17.768 ± 0.023 (stat) ±â0.006 (syst) ps[superscript â1], which is the most precise measurement to date.National Science Foundation (U.S.
Measurement of the cross-section for Z->e+e- production in pp collisions at sqrt{s}=7TeV
A measurement of the cross-section for pp->Z->e+e- is presented using data at sqrt{s}=7TeV corresponding to an integrated luminosity of 0.94 fb^{-1}. The process is measured within the kinematic acceptance pT>20GeV/c and 2<\eta<4.5 for the daughter electrons and dielectron invariant mass in the range 60--120GeV/c^2. The cross-section is determined to be \sigma(pp->Z->e+e-)=76.0+-0.8+-2.0+-2.6pb where the first uncertainty is statistical, the second is systematic and the third is the uncertainty in the luminosity. The measurement is performed as a function of Z rapidity and as a function of an angular variable which is closely related to the Z transverse momentum. The results are compared with previous LHCb measurements and with theoretical predictions from QCD