230 research outputs found
Vibration Characteristics of the Rotating Dental Instrument
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66747/2/10.1177_00220345500290050801.pd
A Brane World Perspective on the Cosmological Constant and the Hierarchy Problems
We elaborate on the recently proposed static brane world scenario, where the
effective 4-D cosmological constant is exponentially small when parallel
3-branes are far apart. We extend this result to a compactified model with two
positive tension branes. Besides an exponentially small effective 4-D
cosmological constant, this model incorporates a Randall-Sundrum-like solution
to the hierarchy problem. Furthermore, the exponential factors for the
hierarchy problem and the cosmological constant problem obey an inequality that
is satisfied in nature. This inequality implies that the cosmological constant
problem can be explained if the hierarchy problem is understood. The basic idea
generalizes to the multibrane world scenario. We discuss models with piecewise
adjustable bulk cosmological constants (to be determined by the 5-dimensional
Einstein equation), a key element of the scenario. We also discuss the global
structure of this scenario and clarify the physical properties of the particle
(Rindler) horizons that are present. Finally, we derive a 4-D effective theory
in which all observers on all branes not separated by particle horizons measure
the same Newton's constant and 4-D cosmological constant.Comment: revtex, 63 pages, 8 figures, one table, revised version, more
discussions on the global structure, references adde
The initial mass function : from Salpeter 1955 to 2005
Fifty years after Ed Salpeter's seminal paper, tremendous progress both on
the observational and theoretical sides allow a fairly accurate determination
of the Galactic IMF not only down to the hydrogen-burning limit but into the
brown dwarf domain. The present review includes the most recent observations of
low-mass stars and brown dwarfs to determine this IMF and the related Galactic
mass budget. The IMF definitely exhibits a similar behaviour in various
environments, disk, young and globular clusters, spheroid. Small scale
dissipation of large scale compressible MHD turbulence seems to be the
underlying triggering mechanism for star formation. Modern simulations of
compressible MHD turbulence yield an IMF consistent with the one derived from
observations.Comment: 10 pages. Invited review "IMF@50" in honor of E. Salpete
Heirloom rice in Ifugao: an ‘anti-commodity’ in the process of commodification
We analyse the marketing of ‘heirloom rices’ produced in the Cordillera mountains of northern Luzon, the Philippines, as the commodification of a historical ‘anti-commodity’. We contend that, historically, rice was produced for social, cultural and spiritual purposes but not primarily for sale or trade. The Ifugaos were able to sustain terraced wet-rice cultivation within a system of ‘escape agriculture’ because they were protected from Spanish interference by the friction of terrain and distance. ‘Heirloom rice’ is a boundary concept that enables social entrepreneurs to commodify traditional landraces. We analyse the implications for local rice production and conservation efforts.Templeton Foundatio
Introduction
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67161/2/10.1177_0308275X9301300401.pd
Dense Stellar Populations: Initial Conditions
This chapter is based on four lectures given at the Cambridge N-body school
"Cambody". The material covered includes the IMF, the 6D structure of dense
clusters, residual gas expulsion and the initial binary population. It is aimed
at those needing to initialise stellar populations for a variety of purposes
(N-body experiments, stellar population synthesis).Comment: 85 pages. To appear in The Cambridge N-body Lectures, Sverre Aarseth,
Christopher Tout, Rosemary Mardling (eds), Lecture Notes in Physics Series,
Springer Verla
A Systematic Review of the Efficacy and Toxicity of Brachytherapy Boost Combined with External Beam Radiotherapy for Nonmetastatic Prostate Cancer
Context
The optimum use of brachytherapy (BT) combined with external beam radiotherapy (EBRT) for localised/locally advanced prostate cancer (PCa) remains uncertain.
Objective
To perform a systematic review to determine the benefits and harms of EBRT-BT.
Evidence acquisition
Ovid MEDLINE, Embase, and EBM Reviews—Cochrane Central Register of Controlled Trials databases were systematically searched for studies published between January 1, 2000 and June 7, 2022, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Eligible studies compared low- or high-dose-rate EBRT-BT against EBRT ± androgen deprivation therapy (ADT) and/or radical prostatectomy (RP) ± postoperative radiotherapy (RP ± EBRT). The main outcomes were biochemical progression-free survival (bPFS), severe late genitourinary (GU)/gastrointestinal toxicity, metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS), at/beyond 5 yr. Risk of bias was assessed and confounding assessment was performed. A meta-analysis was performed for randomised controlled trials (RCTs).
Evidence synthesis
Seventy-three studies were included (two RCTs, seven prospective studies, and 64 retrospective studies). Most studies included participants with intermediate-or high-risk PCa. Most studies, including both RCTs, used ADT with EBRT-BT. Generally, EBRT-BT was associated with improved bPFS compared with EBRT, but similar MFS, CSS, and OS. A meta-analysis of the two RCTs showed superior bPFS with EBRT-BT (estimated fixed-effect hazard ratio [HR] 0.54 [95% confidence interval {CI} 0.40–0.72], p < 0.001), with absolute improvements in bPFS at 5–6 yr of 4.9–16%. However, no difference was seen for MFS (HR 0.84 [95% CI 0.53–1.28], p = 0.4) or OS (HR 0.87 [95% CI 0.63–1.19], p = 0.4). Fewer studies examined RP ± EBRT. There is an increased risk of severe late GU toxicity, especially with low-dose-rate EBRT-BT, with some evidence of increased prevalence of severe GU toxicity at 5–6 yr of 6.4–7% across the two RCTs.
Conclusions
EBRT-BT can be considered for unfavourable intermediate/high-risk localised/locally advanced PCa in patients with good urinary function, although the strength of this recommendation based on the European Association of Urology guideline methodology is weak given that it is based on improvements in biochemical control.
Patient summary
We found good evidence that radiotherapy combined with brachytherapy keeps prostate cancer controlled for longer, but it could lead to worse urinary side effects than radiotherapy without brachytherapy, and its impact on cancer spread and patient survival is less clear
The Theory of Brown Dwarfs and Extrasolar Giant Planets
Straddling the traditional realms of the planets and the stars, objects below
the edge of the main sequence have such unique properties, and are being
discovered in such quantities, that one can rightly claim that a new field at
the interface of planetary science and and astronomy is being born. In this
review, we explore the essential elements of the theory of brown dwarfs and
giant planets, as well as of the new spectroscopic classes L and T. To this
end, we describe their evolution, spectra, atmospheric compositions, chemistry,
physics, and nuclear phases and explain the basic systematics of
substellar-mass objects across three orders of magnitude in both mass and age
and a factor of 30 in effective temperature. Moreover, we discuss the
distinctive features of those extrasolar giant planets that are irradiated by a
central primary, in particular their reflection spectra, albedos, and transits.
Aspects of the latest theory of Jupiter and Saturn are also presented.
Throughout, we highlight the effects of condensates, clouds, molecular
abundances, and molecular/atomic opacities in brown dwarf and giant planet
atmospheres and summarize the resulting spectral diagnostics. Where possible,
the theory is put in its current observational context.Comment: 67 pages (including 36 figures), RMP RevTeX LaTeX, accepted for
publication in the Reviews of Modern Physics. 30 figures are color. Most of
the figures are in GIF format to reduce the overall size. The full version
with figures can also be found at:
http://jupiter.as.arizona.edu/~burrows/papers/rm
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018
Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations.Peer reviewe
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