Enhanced abundances in three large-diameter mixed-morphology supernova remnants

We present an X-ray study of three mixed-morphology supernova remnants (SNRs), HB 21, CTB 1 and HB 3, using archival ASCA and ROSAT data. These data are complemented by archival Chandra X-ray Observatory data for CTB 1 and XMM-Newton X-ray Observatory data for HB 3. The spectra from HB 21 and HB 3 are well-described with a single-temperature thermal plasma in ionization equilibrium, while a two-temperature thermal plasma is found in CTB 1. We found enhanced abundances in all three SNRs. The elemental abundance of Mg is clearly enhanced in CTB 1, while HB 21 has enhanced abundances of Si and S. The situation is not so clear in HB 3 -- the plasma in this SNR either has significantly enhanced abundances of O, Ne and Mg, or it has marginally enhanced abundances of Mg and under-abundant Fe. We discuss the plausibility of mixed-morphology SNR models for the three SNRs and the presence of enhanced abundances. We revise a list of MM SNRs and their properties, compare the three SNRs studied here with other members of this class, and discuss the presence of enhanced elemental abundances in MM SNRs. We also report the ASCA detection of a compact source in the southern part of HB 3. The source spectrum is consistent with a power law with a photon index of ~2.7, and an unabsorbed X-ray flux of ~10^{-12} erg/cm^2/s in the 0.5--10.0 keV band. The column density towards this source differs from that towards the SNR, and it is therefore unlikely they are related.Comment: 26 pages, 15 figures, revised version (minor changes), accepted for publication in ApJ (10 Aug 2006

ASCA Observations of the Supernova Remnant IC 443: Thermal Structure and Detection of Overionized Plasma

We present the results of X-ray spatial and spectral studies of the ``mixed-morphology'' supernova remnant IC 443 using ASCA. IC 443 has a center-filled image in X-ray band, contrasting with the shell-like appearance in radio and optical bands. The overall X-ray emission is thermal, not from a synchrotron nebula. ASCA observed IC 443 three times, covering the whole remnant. From the image analysis, we found that the softness-ratio map reveals a shell-like structure. At the same time, its spectra require two (1.0 keV and 0.2 keV) plasma components; the emission of the 0.2 keV plasma is stronger in the region near the shell than the center. These results can be explained by a simple model that IC 443 has a hot (1.0 keV) interior surrounded by a cool (0.2 keV) outer shell. From the emission measures, we infer that the 0.2 keV plasma is denser than the 1.0 keV plasma, suggesting pressure equilibrium between the two. In addition, we found that the ionization temperature of sulfur, obtained from H-like K$\alpha$ to He-like K$\alpha$ intensity ratio, is 1.5 keV, significantly higher than the gas temperature of 1.0 keV suggested from the continuum spectrum. The same can be concluded for silicon. Neither an additional, hotter plasma component nor a multi-temperature plasma successfully accounts for this ratio, and we conclude that the 1.0 keV plasma is overionized. This is the first time that overionized gas has been detected in a SNR. For the gas to become overionized in the absence of a photoionizing flux, it must cool faster than the ions recombine. Thermal conduction from the 1.0 keV plasma to the 0.2 keV one could cause the 1.0 keV plasma to become overionized, which is plausible within an old (3$\times10^4$ yr) SNR.Comment: 11 pages, 15 figures, 2 tables, accepted for publication in The Astrophysical Journa

Suzaku Observations of Ejecta-Dominated Galactic Supernova Remnant G346.6-0.2

We present here the results of the X-ray analysis of Galactic supernova remnant G346.6-0.2 observed with {\it Suzaku}. K-shell emission lines of Mg, Si, S, Ca and Fe are detected clearly for the first time. Strong emission lines of Si and S imply that X-ray emission nature of G346.6-0.2 is ejecta-dominated. The ejecta-dominated emission is well fitted with a combined model consisting of thermal plasma in non-equilibrium ionization and a non-thermal component, which can be regarded as synchrotron emission with a photon index of $\Gamma$ $\sim 0.6$. Absorbing column density of $N_{\rm H}\sim2.1\times10^{22}$ ${\rm cm^{-2}}$ is obtained from the best-fitting implying a high-density medium, high electron temperature of $kT_{\rm e}\sim1.2$ keV, and ionization timescale of $n_{\rm e}t\sim2.9\times10^{11}$ ${\rm cm^{-3}s}$ indicating that this remnant may be far from full ionization equilibrium. The relative abundances from the ejecta show that the remnant originates from a Type Ia supernova explosion.Comment: 7 pages, 4 figur

{\it Suzaku} observation of Galactic supernova remnant CTB 37A (G348.5+0.1)

We present here the results of the observation of CTB 37A obtained with the X-ray Imaging Spectrometer onboard the {\it Suzaku} satellite. The X-ray spectrum of CTB 37A is well fitted by two components, a single-temperature ionization equilibrium component (VMEKAL) with solar abundances, an electron temperature of $kT_{\rm e}\sim0.6$ keV, absorbing column density of $N_{\rm H}\sim3\times10^{22}$ ${\rm cm^{-2}}$ and a power-law component with photon index of $\Gamma$ $\sim 1.6$. The X-ray spectrum of CTB 37A is characterized by clearly detected K-shell emission lines of Mg, Si, S, and Ar. The plasma with solar abundances supports the idea that the X-ray emission originates from the shocked interstellar material. The ambient gas density, and age of the remnant are estimated to be $\sim1f^{-1/2}$${\rm cm^{-3}}$ and $\sim3\times10^{4}f^{1/2}$ yr, respectively. The center-filling X-ray emission surrounded by a shell-like radio structure and other X-ray properties indicate that this remnant would be a new member of mixed-morphology supernova remnant class

Suzaku broad-band spectroscopy of RX J1347.5-1145: constraints on the extremely hot gas and non-thermal emission

We present the results from the analysis of long Suzaku observations of the most X-ray luminous galaxy cluster RX J1347.5-1145 at z=0.451. Aims: We study physical properties of the hot (~20 keV) gas clump in the south-east (SE) region discovered by the Sunyaev-Zel'dovich (SZ) effect observations, to understand the gas physics of a violent cluster merger. We also explore a signature of non-thermal emission using the hard X-ray data. Results: We find that the single-temperature model fails to reproduce the continuum emission and Fe-K lines measured by XIS simultaneously. The two-temperature model with a very hot component improves the fit, although the XIS data can only give a lower bound on its temperature. We detect the hard X-ray emission in the 12-40 keV band at the 7 sigma level; however, the significance becomes marginal when the systematic error in the background estimation is included. With the Suzaku + Chandra joint analysis, we determine the temperature of the SE excess component to be 25.3^{+6.1}_{-4.5} ^{+6.9}_{-9.5} keV (90% statistical and systematic errors), which is in an excellent agreement with the previous SZ + X-ray analysis. This is the first time that the X-ray spectroscopy alone gives a good measurement of the temperature of the hot component in the SE region, which is made possible by Suzaku's unprecedented sensitivity to the wide X-ray band. These results strongly indicate that the cluster has undergone a recent, violent merger. The spectral analysis shows that the SE component is consistent with being thermal. We find the 3 sigma upper limit on the non-thermal flux, F < 8e-12 erg s^{-1} cm^{-2} in the 12-60 keV band. Combining this limit with a recent discovery of the radio mini halo at 1.4 GHz, we find a lower limit on the strength of the intracluster magnetic field, B > 0.007 micro G.Comment: 15 pages, 13 figures. Accepted for publication in A&

XMM-Newton unveils the complex iron K alpha region of Mrk 279

We present the results of a ~160 ks-long XMM-Newton observation of the Seyfert 1 galaxy Mrk 279. The spectrum shows evidence of both broad and narrow emission features. The Fe K alpha line may be equally well explained by a single broad Gaussian (FWHM~10,000 km/s) or by two components: an unresolved core plus a very broad profile (FWHM~14,000 km/s). For the first time we quantified, via the "locally optimally emitting cloud" model, the contribution of the broad line region (BLR) to the absolute luminosity of the broad component of the Fe K alpha at 6.4 keV. We find that the contribution of the BLR is only ~3%. In the two-line component scenario, we also evaluated the contribution of the highly ionized gas component, which produces the FeXXVI line in the iron K region. This contribution to the narrow core of the Fe K alpha line is marginal <0.1%. Most of the luminosity of the unresolved, component of Fe K alpha may come from the obscuring torus, while the very-broad associated component may come from the accretion disk. However, models of reflection by cold gas are difficult to test because of the limited energy band. The FeXXVI line at 6.9 keV is consistent to be produced in a high column density (N_H~10^23 cm^{-2}), extremely ionized (log\xi~5.5-7) gas. This gas may be a highly ionized outer layer of the torus.Comment: 10 pages, 9 figures, accepted for publication in Astronomy and Astrophysic

Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator

Background: Depletion of replication factors often causes cell death in cancer cells. Depletion of Cdc7, a kinase essential for initiation of DNA replication, induces cancer cell death regardless of its p53 status, but the precise pathways of cell death induction have not been characterized. Methodology/Principal Findings: We have used the recently-developed cell cycle indicator, Fucci, to precisely characterize the cell death process induced by Cdc7 depletion. We have also generated and utilized similar fluorescent cell cycle indicators using fusion with other cell cycle regulators to analyze modes of cell death in live cells in both p53-positive and-negative backgrounds. We show that distinct cell-cycle responses are induced in p53-positive and-negative cells by Cdc7 depletion. p53-negative cells predominantly arrest temporally in G2-phase, accumulating CyclinB1 and other mitotic regulators. Prolonged arrest at G2-phase and abrupt entry into aberrant M-phase in the presence of accumulated CyclinB1 are followed by cell death at the post-mitotic state. Abrogation of cytoplasmic CyclinB1 accumulation partially decreases cell death. The ATR-MK2 pathway is responsible for sequestration of CyclinB1 with 14-3-3s protein. In contrast, p53-positive cancer cells do not accumulate CyclinB1, but appear to die mostly through entry into aberrant S-phase after Cdc7 depletion. The combination of Cdc7 inhibition with known anti-cancer agents significantly stimulates cell death effects in cancer cells in a genotype-dependent manner, providing a strategic basis for future combination therapies

Replication Fork Breakage and Restart in Escherichia coli

In all organisms, replication impairments are an important source of genome rearrangements, mainly because of the formation of double-stranded DNA (dsDNA) ends at inactivated replication forks. Three reactions for the formation of dsDNA ends at replication forks were originally described for Escherichia coli and became seminal models for all organisms: the encounter of replication forks with preexisting single-stranded DNA (ssDNA) interruptions, replication fork reversal, and head-to-tail collisions of successive replication rounds. Here, we first review the experimental evidence that now allows us to know when, where, and how these three different reactions occur in E. coli. Next, we recall our recent studies showing that in wild-type E. coli, spontaneous replication fork breakage occurs in 18% of cells at each generation. We propose that it results from the replication of preexisting nicks or gaps, since it does not involve replication fork reversal or head-to-tail fork collisions. In the recB mutant, deficient for double-strand break (DSB) repair, fork breakage triggers DSBs in the chromosome terminus during cell division, a reaction that is heritable for several generations. Finally, we recapitulate several observations suggesting that restart from intact inactivated replication forks and restart from recombination intermediates require different sets of enzymatic activities. The finding that 18% of cells suffer replication fork breakage suggests that DNA remains intact at most inactivated forks. Similarly, only 18% of cells need the helicase loader for replication restart, which leads us to speculate that the replicative helicase remains on DNA at intact inactivated replication forks and is reactivated by the replication restart proteins

XMM-Newton observation of M87 I. Single-phase temperature structure of intracluster medium

We report the results of a detailed analysis of the temperature structure of the X-ray emitting plasma halo of M~87, the cD galaxy of the Virgo Cluster. Using the MEKAL model, the data provide strong indications that the intracluster medium has a single phase structure locally, except the regions associated to the radio structures. The deprojected spectrum at each radius is well fitted by a single temperature MEKAL model, except for the very central region ($<$ 2 arcmin) which seems to be affected by the jet and radio lobe structure. The temperature of the intracluster plasma is 1 keV at the center and gradually increases to 2.5 keV at 80 kpc. We have also fitted spectra using the APEC code. Although the large changes of the strength of K$\alpha$ lines causes a discrepancy between the Fe-L and Fe-K lines for the APEC results, the overall temperature structure has not changed. There is no sign of excess absorption in the spectral data. The single-phase nature of the intracluster medium is in conflict with the standard cooling flow model which is based on a multi-phase temperature structure. In addition, the signature of gas cooling below 0.8 keV to zero temperature is not observed as expected for a cooling flow. The gravitational mass profile derived from the temperature and density distribution of the intracluster gas shows two distinct contributions that can be assigned to the gravitational potential of the cD galaxy and the cluster. The central temperature of the intracluster medium agrees well with the potential depth and the velocity dispersion of the cD galaxy. The latter result implies that the central region of the intracluster medium is equivalent to a virialized interstellar medium in M 87.Comment: 19 pages, 24 figures, to appear in Astronomy & Astrophysic