CONSTRUCTION OF A NEW FAMILY OF EFFICIENT IMBEDDED POLYNOMIALS WITH DISTINCT COEFFICIENTS

We propose a new family of multi-purpose imbedded polynomials having distinct coefficients. There exist relationships between various coefficients of the members of the family, which considerably reduce the computational cost of development as well as using any number of members of the family in a particular problem. Every member polynomial of degree n going through (n+1) focuses {(xi, yi): i=0,1….......n} can be constructed very easily from another member having degree (n-1). In this paper, it is shown that the family of polynomials M exists and is efficient, reliable and more accurate as compared to other available techniques. The family has been successfully applied to the problem of interpolation in this paper. Therefore, the family M is also called the Malik‘s Imbedded Interpolating Polynomials (M.I.I.P). The family M gives similar results as compared to Lagrange Interpolation as for as accuracy is concerned but they are more efficient. The proposed polynomials are more efficient, more stable and more reliable as compared to other traditional interpolation methods due to remarkable reduction in mathematical operations. Our approach and the design of the method is different of available methods of prototype interpolation Methods. We have considered the drawbacks of other methods and eliminated from our approach. The superiority of the family is established and reported

Religio-political Discourse and Jam’iyyat Ulema-i-Pakistan (JUP): A Careful Study of Different Narratives (1970-2003)

Barelvi Ulema, being active participants of the Pakistan Movement (1940-1947), very soon reached to the point that their objectives associated with the struggle for Pakistan could only be achieved through a constitutional and political struggle; and as per the need of the parliamentary system prevailed in the country, they must converge and consolidate their energies on a political platform. Hence, on 28th March 1948, in a 3-day meeting of Barelvi ulema at Madrasah-i-Islamiah Arabiah Anwar al ulum, Multan, the Markazi (Central) Jam’iyyatal-Ulema-i-Pakistan (MJUP) was formally established. A glance over the party objectives set at this meeting gives a clear picture of JUP’s Rightism sui generis. It was aspired that Pakistan would be a true Islamic state established through the promulgation of the Islamic constitution in the country and all the social and moral evils would be emulated as the founding father of the country had aspired in the inaugural session of the Constituent Assembly of Pakistan (CAP). Moreover, it was also hoped to propagate Islamic teachings among the Muslims by initiating the spirit of religious cum political awakening and the spirit of Jihad among them and direct their attention from western culture and civilization towards Islamic culture and civilization. Hence, the establishment of an Islamic state in the country was the destiny of JUP. In order to remind the higher authorities and other stakeholders responsible for the formation of the constitution, JUP held meetings and processions throughout the country. It pressed demands for the enforcement of Islamic jurisprudence through Islamic constitution. This religio-political as well as constitutional strife can be found in a number of indigenous narratives and beyond. The article presents a careful and curious study of different available narratives in this connection

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

مزدور طبقہ اور پاکستانی اُردو ناول

In Pakistan, the financial position of people is very bad especially Labuorers are living hand to mouth, but in Pakistani Urdu novels this issue has not been highlightd to reflect the real face of society towards this issue. Very few writers present the issues of labors in urdu novel. In this article discussed those novels which present the problems and difficulties of labuor

A Technique and Architectural Design for Criminal Detection based on Lombroso Theory Using Deep Learning

Crimes and criminal activities are increasing day by day and there are no proper criteria to search, detect, identify, and predict these criminals. Despite various surveillance cameras in different areas still, crimes are at a peak. The police investigation department cannot efficiently detect the criminals in time. However, in many countries for the sake of public and private security, the initiation of security technologies has been employed for criminal identification or recognition with the help of footprint identification, fingerprint identification, facial recognition, or based on other suspicious activity detections through surveillance cameras. However, there are limited automated systems that can identify the criminals precisely and get the accurate or precise similarity between the recorded footage images with the criminals that already are available in the police criminal records. To make the police investigation department more effective, this research work presents the design of an automated criminal detection system for the prediction of criminals. The proposed system can predict criminals or possibilities of being criminal based on Lombrosso's Theory of Criminology about born criminals or the persons who look like criminals. A deep learning-based facial recognition approach was used that can detect or predict any person whether he is criminal, or not and that can also give the possibility of being criminal. For training, the ResNet50 model was used, which is based on CNN and SVM Classifiers for feature extracting from the dataset. Two different labeled based datasets were used, having different criminals and noncriminals images in the database. The proposed system could efficiently help the investigating officers in narrowing down the suspects' pool

Research and Reviews: Journal of Pharmaceutical Quality Assurance A Comprehensive Drug Review on Macitentan: A Preeminent Inclusion to Pulmonary Arterial Hypertension Therapy

ABSTRACT Macitentan is a radically novice oral orphan drug which was approved by FDA in Oct 2013 (under trade name Opsumit ® ). It belongs to the class of the endothelin receptor antagonist (ETRA) and is indicated for the treatment of pulmonary arterial hypertension (PAH). PAH is a chronic disorder of raising blood pressure in the artery between the aisle of heart and lung. Till the date, the disease remains incurable and possesses a poor prognosis. A ray of hope in this direction is shown by Macitentan, which has been proved beneficial in decreasing disease progression symptoms and reducing hospitalization. Phase III SERAPHIN trials clearly indicate that it improves morbidity, mortality and 6MWD data compared with other drugs of the same class. Furthermore, its use is seemingly increasing for the treatment of other cardiovascular disorders related to ET system. However, the pharmacokinetics dose adjustments of Macitentan in patients with renal or hepatic impairment are extraneous. Drug-drug interactions are occult, and one circulating pharmacologically active metabolite (ACT-132577) is omnipresent. The safety profile of Macitentan is superior to other drugs of same ETRA&apos;s class with prolonged receptor binding properties, greater tissue penetration, hepatic safety, edema/ fluid retention and easy dosing, but it is similar when the decrease in hemoglobin concentration is taken into account. Macitentan attributes, hence, are appended and revolutionary important in the therapeutic longterm treatment and a better alternative remedy for PAH. The present review thus delineates the complete drug profile of Macitentan from the data of studies carried out till date and alleges it as a sanguine future for an overall improved CVS healthcare contributor