8-The Portage River Archaeological Survey, St. Joseph County, Michigan

A 20-day field/informant type of archaeological survey was performed on a 13 section corridor in Park and Mendon townships in St. Joseph County and section 32 of Brady Township in Kalamazoo County, Michigan. This survey universe bordered on portions of the Portage River and its tributaries and along the shores of Portage and Fishers lakes. Twenty-nine prehistoric human occupation sites were located, described and recorded during the survey, five of which had been previously known (four unrecorded). Many of the sites were multicomponent but the majority of components are believed to represent Archaic period cultural manifestations. About 300 recognizable artifacts from these sites were catalo.ged and briefly described. This survey laid important ground for future archaeological investigation in this relatively unknown area of Michigan

Effectiveness and efficiency of methods of dialysis therapy for end-stage renal disease : a review

Peer reviewedPublisher PD

The potential for an independent source of Younger Dryas tree-ring radiocarbon data from the Lake Ontario region, North America, and its palaeoenvironmental context

Tree rings are the gold standard for the calibration of radiocarbon dates into calendar years with limited error due to their annual record of radiocarbon content in the atmosphere. Currently, the tree-ring 14C data used in the International Radiocarbon Calibration curve (IntCal13) are from multiple sources back to ~ 10 ka cal BP for the northern hemisphere. However, the source for tree-ring calibration data prior to ~10 ka cal BP, including the Younger Dryas (YD) and most of the Early Holocene (EH) chronozones, is limited to central Europe. Substantial quantities of logs found in the lowlands of Lake Ontario in North America, dating from 12.1 to 11.2 ka cal BP, have great potential for providing unique YD-EH tree-ring 14C data from a new, previously unrepresented, geographic location and for adding a new perspective to ongoing debates such as the timing of the YD/EH transition in continental North America. Preliminary fieldwork yielded over 43 logs, predominantly spruce (Picea spp.), found buried in alluvial strata over 0.2 hectares of the floodplain at Bell Creek near Fulton, NY. Dendrochronological analysis of 32 spruce logs from this collection has produced several chronologies, one 183 years in length and a second of 147 years with a possible crossdate yielding a chronology of 260 years. Ongoing survey of the site suggests that there is high preservation potential in the same stratigraphic units in an additional ~2 hectares of floodplain, and sample collection with subsequent analysis will increase the chronology’s sample depth, extend its length, and potentially provide a robust, independent Younger Dryas – Early Holocene 14C record. Initial assessments of climatic, hydrological, environmental, and isostatic variations and events over time from the tree rings and their stable isotopes, as well as pollen, macrofossil, and sediment analyses and isostatic modeling indicate substantial changes in the Bell Creek Valley and surrounding lowlands both during the YD and into the mid-Holocene. These changes include significant alterations in the rate, volume, and direction of stream flow, and transition from a boreal riparian environment on a low-order river to a wetlands, then back to a riparian environment with much less streamflow and occasional flooding, similar to the Bell Creek Valley today

2016 International Land Model Benchmarking (ILAMB) Workshop Report

As earth system models (ESMs) become increasingly complex, there is a growing need for comprehensive and multi-faceted evaluation of model projections. To advance understanding of terrestrial biogeochemical processes and their interactions with hydrology and climate under conditions of increasing atmospheric carbon dioxide, new analysis methods are required that use observations to constrain model predictions, inform model development, and identify needed measurements and field experiments. Better representations of biogeochemistryclimate feedbacks and ecosystem processes in these models are essential for reducing the acknowledged substantial uncertainties in 21st century climate change projections

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients

Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of lentiviral vectors to increase hemoglobin synthesis might vary in different patients

Twelve experiments in restorative justice: the Jerry Lee program of randomized trials of restorative justice conferences

Objectives: We conducted and measured outcomes from the Jerry Lee Program of 12 randomized trials over two decades in Australia and the United Kingdom (UK), testing an identical method of restorative justice taught by the same trainers to hundreds of police officers and others who delivered it to 2231 offenders and 1179 victims in 1995–2004. The article provides a review of the scientific progress and policy effects of the program, as described in 75 publications and papers arising from it, including previously unpublished results of our ongoing analyses. Methods: After random assignment in four Australian tests diverting criminal or juvenile cases from prosecution to restorative justice conferences (RJCs), and eight UK tests of supplementing criminal or juvenile proceedings with RJCs, we followed intention-to-treat group differences between offenders for up to 18 years, and for victims up to 10 years. Results: We distil and modify prior research reports into 18 updated evidence-based conclusions about the effects of RJCs on both victims and offenders. Initial reductions in repeat offending among offenders assigned to RJCs (compared to controls) were found in 10 of our 12 tests. Nine of the ten successes were for crimes with personal victims who participated in the RJCs, with clear benefits in both short- and long-term measures, including less prevalence of post-traumatic stress symptoms. Moderator effects across and within experiments showed that RJCs work best for the most frequent and serious offenders for repeat offending outcomes, with other clear moderator effects for poly-drug use and offense seriousness. Conclusions: RJ conferences organized and led (most often) by specially-trained police produced substantial short-term, and some long-term, benefits for both crime victims and their offenders, across a range of offense types and stages of the criminal justice processes on two continents, but with important moderator effects. These conclusions are made possible by testing a new kind of justice on a programmatic basis that would allow prospective meta-analysis, rather than doing one experiment at a time. This finding provides evidence that funding agencies could get far more evidence for the same cost from programs of identical, but multiple, RCTs of the identical innovative methods, rather than funding one RCT at a time