LAS NEGOCIACIONES INCOMPATIBLES COMO CAUSAL DE DESPIDO EN CHILE

La presente investigación se propone generar un estudio sistemático y crítico del artículo 160 número 2 del Código del Trabajo, que contribuya a detectar, especificar y superar los problemas que presenta el desarrollo dogmático de las negociaciones incompatibles como causal de despido en el ordenamiento jurídico chileno. En este esquema, definimos la hipótesis de despido disciplinario como una forma de no concurrencia relativa o parcial que, en su estructura tipológica, responde a un ilícito de mera actividad, configurado por la abstención de ejecución de actividades mercantiles o civiles por cuenta propia, autónomas o de carácter asociativo, que se encuentren dentro del giro del empleador y no así actividades laborales o subordinadas, siempre y cuando estén expresamente prohibidas por escrito

EL DESPIDO DISCIPLINARIO POR INCUMPLIMIENTO GRAVE DE LAS OBLIGACIONES LABORALES EN EL ORDENAMIENTO JURÍDICO CHILENO

El presente trabajo tiene por objeto abordar la causal de despido disciplinario fundada en el incumplimiento grave de las obligaciones laborales. Se analizan los aspectos doctrinarios y jurisprudenciales de tal institución, junto a los requisitos que deben concurrir para su procedencia. En este último aspecto, se aborda el incumplimiento de una obligación laboral y su pluralidad de fuentes, su relación con el reglamento interno y el contenido ético del contrato. De la misma forma se analiza la gravedad del incumplimiento según criterios jurisprudenciales, para finalmente profundizar en las formalidades del despido, oportunidad, impugnación, reparación y reglas procedimentales por las cuales ha de regirse la sustanciación de las acciones para reclamar su legalidad

Cuidado personal de niños, niñas y adolescentes en caso de separación de los padres en Chile: desde el cuidado único de la madre hasta la custodia compartida

This article presents the legislative evolution of the institution of sole custody of children in the Chilean legal system, showing the legal consecration of the institution and its legal modifications. Moreover, it goes further into the current situation of the said institution, addressing topics such as parental co-responsibility, shared custody, parents’ situations of inability and the exercise of sole custody by different people. Finally, a brief projective analysis of the issue is made in the light of international human rights law standards and the contemporary Chilean reality.El presente trabajo expone la evolución legislativa de la institución del cuidado personal de los hijos e hijas en el ordenamiento jurídico chileno, mostrando la consagración legal de la institución y sus modificaciones legales. Además, profundiza en la situación actual de la institución en comento, abordando tópicos como la corresponsabilidad parental, el cuidado personal compartido, las situaciones de inhabilidad de los padres y el ejercicio del cuidado personal por personas diferentes. Finalmente, se hace un breve análisis proyectivo de la cuestión a la luz de estándares establecidos por instrumentos internacionales de derechos humanos y la realidad chilena contemporánea

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

COVID-19 vaccine failure

COVID-19 affects the population unequally with a higher impact on aged and immunosuppressed people. Hence, we assessed the effect of SARS-CoV-2 vaccination in immune compromised patients (older adults and oncohematologic patients), compared with healthy counterparts. While the acquired humoral and cellular memory did not predict subsequent infection 18 months after full immunization, spectral and computational cytometry revealed several subsets within the CD8+ T-cells, B-cells, NK cells, monocytes and CD45RA+ CCR7- Tγδ cells differentially expressed in further infected and non-infected individuals not just following immunization, but also prior to that. Of note, up to 7 subsets were found within the CD45RA+ CCR7- Tγδ population with some of them being expanded and other decreased in subsequently infected individuals. Moreover, some of these subsets also predicted COVID-induced hospitalization in oncohematologic patients. Therefore, we hereby have identified several cellular subsets that, even before vaccination, strongly related to COVID-19 vulnerability as opposed to the acquisition of cellular and/or humoral memory following vaccination with SARS-CoV2 mRNA vaccines.This study has been funded through Programa Estratégico Instituto de Biología y Genética Molecular (IBGM Junta de Castilla y León. Ref. CCVC8485), Junta de Castilla y León (Proyectos COVID 07.04.467B04.74011.0) and the European Commission – NextGenerationEU (Regulation EU 2020/2094), through CSIC's Global Health Platform (PTI Salud Global; SGL21-03-026 and SGL2021-03-038)N

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets

Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at root s = 13 TeV, and correspond to an integrated luminosity of 35.9 fb(-1). The spectra of total transverse hadronic energy of candidate events are examined for deviations from the standard model predictions. No statistically significant excess is observed over the expected background. The first cross section limits on new physics processes resulting in such events are set. The results are interpreted as upper limits on the rate of gluino pair production, utilizing a simplified stealth supersymmetry model. The excluded gluino masses extend up to 1.7 TeV, for a neutralino mass of 200 GeV and exceed previous mass constraints set by analyses targeting events with isolated photons.Peer reviewe