HDE 245059: A Weak-Lined T Tauri Binary Revealed by Chandra and Keck

We present the Chandra High Energy Transmission Grating Spectrometer (HETGS) and Keck observations of HDE 245059, a young weak-lined T Tauri star (WTTS), member of the pre-main sequence group in the Lambda Orionis Cluster. Our high spatial resolution, near-infrared observations with Keck reveal that HDE 245059 a binary separated by 0.87". Based on this new information we have obtained an estimate of the masses of the binary components; 3M_{sun} and 2.5M_{sun} for the north and south components, respectively. We have estimated the age of the system to be ~2-3 Myr. We detect both components of the binary in the zeroth order Chandra image and in the grating spectra. Our fits to the spectrum of the binary have shown that the emission is dominated by a plasma between 8 and 15 MK, a soft component at 4 MK and a hard component at 50 MK are also detected. The value of the hydrogen column density was low, 8 x 10^{19} cm^{-2}, likely due to the clearing of the inner region of the Lambda Orionis cloud. The abundance pattern shows an inverse First Ionization Potential (FIP) effect for all elements from O to Fe, the only exception being Ca. A 3-T model was fitted to the individual zeroth order spectra using the abundances derived for the binary. We have also obtained several lines fluxes from the grating spectra. The fits to the triplets show no evidence of high densities. We conclude that the X-ray properties of the weak-lined T Tau binary HDE 245059 are similar to those generally observed in other weak-lined T Tau stars. Although its accretion history may have been affected by the clearing of the interstellar material around Lambda Ori, its coronal properties appears not to have been strongly modified.Comment: 12 pages, 10 figures Accepted for publication in Ap

Quantitative N- or C-Terminal Labelling of Proteins with Unactivated Peptides by Use of Sortases and a d-Aminopeptidase

Quantitative and selective labelling of proteins is widely used in both academic and industrial laboratories, and catalytic labelling of proteins using transpeptidases, such as sortases, has proved to be a popular strategy for such selective modification. A major challenge for this class of enzymes is that the majority of procedures require an excess of the labelling reagent or, alternatively, activated substrates rather than simple commercially sourced peptides. We report the use of a coupled enzyme strategy which enables quantitative N- and C-terminal labelling of proteins using unactivated labelling peptides. The use of an aminopeptidase in conjunction with a transpeptidase allows sequence-specific degradation of the peptide by-product, shifting the equilibrium to favor product formation, which greatly enhances the reaction efficiency. Subsequent optimisation of the reaction allows N-terminal labelling of proteins using essentially equimolar ratios of peptide label to protein and C-terminal labelling with only a small excess. Minimizing the amount of substrate required for quantitative labelling has the potential to improve industrial processes and facilitate the use of transpeptidation as a method for protein labelling

Particle-Vortex Duality and the Modular Group: Applications to the Quantum Hall Effect and Other 2-D Systems

We show how particle-vortex duality implies the existence of a large non-abelian discrete symmetry group which relates the electromagnetic response for dual two-dimensional systems in a magnetic field. For conductors with charge carriers satisfying Fermi statistics (or those related to fermions by the action of the group), the resulting group is known to imply many, if not all, of the remarkable features of Quantum Hall systems. For conductors with boson charge carriers (modulo group transformations) a different group is predicted, implying equally striking implications for the conductivities of these systems, including a super-universality of the critical exponents for conductor/insulator and superconductor/insulator transitions in two dimensions and a hierarchical structure, analogous to that of the quantum Hall effect but different in its details. Our derivation shows how this symmetry emerges at low energies, depending only weakly on the details of dynamics of the underlying systems.Comment: 22 pages, LaTeX, 2 figures, uses revte

Emotional intelligence and British expatriates’ cross-cultural adjustment in international construction projects

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Today’s internationalized business demands global mindset, intercultural sensitivity and the ability to skilfully negotiate through cross-cultural interactions. Therefore, the overall aim was to investigate the influence of emotional intelligence (EI) on cross-cultural adjustment (CCA) of British expatriates working on International Architectural, Engineering and Construction assignments in Sub-Saharan Africa, China, Middle East and Indian Sub-Continent. Specifically, the causal relationship between EI and three facets of CCA i.e. work, general and interaction adjustment was explored. A sequential exploratory mixed methods design was adopted. These include extensive review of existing literature, eighteen unstructured interviews, and questionnaire survey of 191 British expatriates operating in 29 different countries from the four regions under investigation. Structural equation modelling was used to assess the causal relationship between EI and CCA. Results show that EI accounted for 91, 64 and 24% of the variance in work, interaction and general adjustment respectively. Overall, the model was able to explain 60% variance in CCA, suggesting that EI competencies play a huge role in facilitating an expatriate understand and adapt to host country culture. The findings would help decision-makers (HR managers) during expatriate selection process, in understanding that along with technical skills, it is the emotional competencies that are crucial in assisting expatriates adjust to foreign way of life

Measurement of νˉμ\bar{\nu}_{\mu} and νμ\nu_{\mu} charged current inclusive cross sections and their ratio with the T2K off-axis near detector

We report a measurement of cross section $\sigma(\nu_{\mu}+{\rm nucleus}\rightarrow\mu^{-}+X)$ and the first measurements of the cross section $\sigma(\bar{\nu}_{\mu}+{\rm nucleus}\rightarrow\mu^{+}+X)$ and their ratio $R(\frac{\sigma(\bar \nu)}{\sigma(\nu)})$ at (anti-)neutrino energies below 1.5 GeV. We determine the single momentum bin cross section measurements, averaged over the T2K $\bar{\nu}/\nu$-flux, for the detector target material (mainly Carbon, Oxygen, Hydrogen and Copper) with phase space restricted laboratory frame kinematics of $\theta_{\mu}$500 MeV/c. The results are $\sigma(\bar{\nu})=\left( 0.900\pm0.029{\rm (stat.)}\pm0.088{\rm (syst.)}\right)\times10^{-39}$ and $\sigma(\nu)=\left( 2.41\ \pm0.022{\rm{(stat.)}}\pm0.231{\rm (syst.)}\ \right)\times10^{-39}$in units of cm$^{2}$/nucleon and$R\left(\frac{\sigma(\bar{\nu})}{\sigma(\nu)}\right)= 0.373\pm0.012{\rm (stat.)}\pm0.015{\rm (syst.)}$.Comment: 18 pages, 8 figure

Elliptic hypergeometry of supersymmetric dualities II. Orthogonal groups, knots, and vortices

We consider Seiberg electric-magnetic dualities for 4d $\mathcal{N}=1$ SYM theories with SO(N) gauge group. For all such known theories we construct superconformal indices (SCIs) in terms of elliptic hypergeometric integrals. Equalities of these indices for dual theories lead both to proven earlier special function identities and new conjectural relations for integrals. In particular, we describe a number of new elliptic beta integrals associated with the s-confining theories with the spinor matter fields. Reductions of some dualities from SP(2N) to SO(2N) or SO(2N+1) gauge groups are described. Interrelation of SCIs and the Witten anomaly is briefly discussed. Possible applications of the elliptic hypergeometric integrals to a two-parameter deformation of 2d conformal field theory and related matrix models are indicated. Connections of the reduced SCIs with the state integrals of the knot theory, generalized AGT duality for (3+3)d theories, and a 2d vortex partition function are described.Comment: Latex, 58 pages; paper shortened, to appear in Commun. Math. Phy

Identification of common genetic risk variants for autism spectrum disorder

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.Peer reviewe

Search for Lorentz and CPT violation using sidereal time dependence of neutrino flavor transitions over a short baseline

A class of extensions of the Standard Model allows Lorentz and CPT violations, which can be identified by the observation of sidereal modulations in the neutrino interaction rate. A search for such modulations was performed using the T2K on-axis near detector. Two complementary methods were used in this study, both of which resulted in no evidence of a signal. Limits on associated Lorentz and CPT-violating terms from the Standard Model extension have been derived by taking into account their correlations in this model for the first time. These results imply such symmetry violations are suppressed by a factor of more than 10 20 at the GeV scale