13 research outputs found
On the Origins of the High-Latitude H-alpha Background
The diffuse high-latitude H-alpha background is widely believed to be
predominantly the result of in-situ recombination of ionized hydrogen in the
warm interstellar medium of the Galaxy. Instead, we show that both a
substantial fraction of the diffuse high-latitude H-alpha intensity in regions
dominated by Galactic cirrus dust and much of the variance in the high-latitude
H-alpha background are the result of scattering by interstellar dust of H-alpha
photons originating elsewhere in the Galaxy. We provide an empirical relation,
which relates the expected scattered H-alpha intensity to the IRAS 100um
diffuse background intensity, applicable to about 81% of the entire sky. The
assumption commonly made in reductions of CMB observations, namely that the
observed all-sky map of diffuse H-alpha light is a suitable template for
Galactic free-free foreground emission, is found to be in need of
reexamination.Comment: 26 pages, 5 figures, Accepted for publication in Ap
Performance Testing of a Large-Format Reflection Grating Prototype for a Suborbital Rocket Payload
The soft X-ray grating spectrometer on board the Off-plane Grating Rocket
Experiment (OGRE) hopes to achieve the highest resolution soft X-ray spectrum
of an astrophysical object when it is launched via suborbital rocket. Paramount
to the success of the spectrometer are the performance of the reflection
gratings populating its reflection grating assembly. To test current grating
fabrication capabilities, a grating prototype for the payload was fabricated
via electron-beam lithography at The Pennsylvania State University's Materials
Research Institute and was subsequently tested for performance at Max Planck
Institute for Extraterrestrial Physics' PANTER X-ray Test Facility. Bayesian
modeling of the resulting data via Markov chain Monte Carlo (MCMC) sampling
indicated that the grating achieved the OGRE single-grating resolution
requirement of at the 94% confidence level.
The resulting posterior probability distribution suggests that this
confidence level is likely a conservative estimate though, since only a finite
parameter space was sampled and the model could not constrain the upper
bound of to less than infinity. Raytrace simulations of the system found
that the observed data can be reproduced with a grating performing at
. It is therefore postulated that the behavior of the obtained
posterior probability distribution can be explained by a finite
measurement limit of the system and not a finite limit on . Implications
of these results and improvements to the test setup are discussed.Comment: 25 pages, 16 figures, preprint of an article accepted for publication
in the Journal of Astronomical Instrumentation \copyright 2020 [copyright
World Scientific Publishing Company]
[https://www.worldscientific.com/worldscinet/jai
Development of the X-ray camera for the OGRE sub-orbital rocket
Current theories regarding the matter composition of the universe suggest that half of the expected baryonic matter is missing. One region this could be residing in is intergalactic filaments which absorb strongly in the X-ray regime. Present space based technology is limited when it comes to imaging at these wavelengths and so new techniques are required. The Off-Plane Grating Rocket Experiment (OGRE) aims to produce the highest resolution spectrum of the binary star system Capella, a well-known X-ray source, in the soft X-ray range (0.2keV to 2keV). This will be achieved using a specialised payload combining three low technology readiness level components placed on-board a sub-orbital rocket. These three components consist of an array of large format off-plane X-ray diffraction gratings, a Wolter Type 1 mirror made using single crystal silicon, and the use of EM-CCDs to capture soft X-rays. Each of these components have been previously reviewed with OGRE being the first project to utilise them in a space observation mission. This paper focuses on the EM-CCDs (CCD207-40 by e2v) that will be used and their optimisation with a camera purposely designed for OGRE. Electron Multiplying gain curves were produced for the back-illuminated devices at -80 degrees Celsius. Further tests which will need to be carried out are discussed and the impact of the OGRE mission on future projects mentioned
Lynx Mission Concept Status
Lynx is a concept under study for prioritization in the 2020 Astrophysics Decadal Survey. Providing orders of magnitude increase in sensitivity over Chandra, Lynx will examine the first black holes and their galaxies, map the large-scale structure and galactic halos, and shed new light on the environments of young stars and their planetary systems. In order to meet the Lynx science goals, the telescope consists of a high-angular resolution optical assembly complemented by an instrument suite that may include a High Definition X-ray Imager, X-ray Microcalorimeter and an X-ray Grating Spectrometer. The telescope is integrated onto the spacecraft to form a comprehensive observatory concept. Progress on the formulation of the Lynx telescope and observatory configuration is reported in this paper
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study
Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection
Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study
Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe
Searching for outliers in the Chandra Source Catalog
Astronomers are increasingly faced with a deluge of information, and finding
worthwhile targets of study in the sea of data can be difficult. Outlier
identification studies are a method that can be used to focus investigations by
presenting a smaller set of sources that could prove interesting because they
do not follow the trends of the underlying population. We apply a principal
component analysis (PCA) and an unsupervised random forest algorithm (uRF) to
sources from the Chandra Source Catalog v.2 (CSC2). We present 119
high-significance sources that appear in all repeated applications of our
outlier identification algorithm (OIA). We analyze the characteristics of our
outlier sources and crossmatch them with the SIMBAD database. Our outliers
contain several sources that were previously identified as unusual. This OIA
leads to the identification of interesting targets that could motivate more
detailed study.Comment: Submitted to Monthly Notices of the Royal Astronomical Societ
X-ray spectroscopy of potential small Magellanic Cloud type Ia supernova remnants and their environments
We examine three supernova remnants in the SMC, IKT 5 (supernova remnant (SNR) 0047-73.5), IKT 25 (SNR 0104-72.3), and DEM S 128 (SNR 0103-72.4), which are designated as Type Ia in the literature due to their spectra and morphology. This is troublesome because of their asymmetry, a trait not usually associated with young Type Ia remnants. We present Chandra X-ray Observatory data on these three remnants and perform a maximum likelihood analysis on their spectra. We find that the X-ray emission is dominated by interactions with the interstellar medium. In spite of this, we find a significant Fe overabundance in all three remnants. Through examination of radio, optical, and infrared data, we conclude that these three remnants are likely not Type Ia SNRs. We detect potential point sources that may be members of the progenitor systems of both DEM S 128 and IKT 5, which could suggest these could be Fe-rich core-collapse remnants