Computational experimentation to understand C2 for Teams of Autonomous Systems and People

The technological capabilities of autonomous systems (AS) continue to accelerate. Although AS are replacing people in many skilled mission domains and demanding environmental circumstances, people and machines have complementary capabilities, and integrated performance by AS and people working together can be superior to that of either AS or people working alone. We refer to this increasingly important phenomenon as Teams of Autonomous Systems and People (TASP), and we identify a plethora of open, command and control (C2) research, policy and decision making questions. Computational experimentation offers unmatched yet largely unexplored potential to address C2 questions along these lines. The central problem is, this kind of C2 organization experimentation capability has yet to be developed and demonstrated in the TASP domain. This is where our ongoing research project begins to make an important contribution. In this article, we motivate and introduce such TASP research, and we provide an overview of the computational environment used to experiment on TASP C2 organizations and phenomena. We summarize in turn the research method. Key results follow, and we conclude then by summarizing our agenda for continued research along these lines.Consortium for Robotics and Unmanned Systems Education and Research (CRUSER)Consortium for Robotics and Unmanned Systems Education and Research (CRUSER)Approved for public release; distribution is unlimited

Toward Computational Modeling of C2 for Teams of Autonomous Systems and People (19th ICCRTS)

19th ICCRTS, Toward Computational Modeling of C2 for Teams of Autonomous Systems and People, Autonomy Track – Paper 116The technological capabilities of autonomous systems (AS) continue to accelerate. Although AS are replacing people in many skilled mission domains and demanding environmental circumstances, people and machines have complementary capabilities, and integrated performance by AS and people working together can be superior to that of either AS or people working alone. We refer to this increasingly important phenomenon as Teams of Autonomous Systems and People (TASP), and we identify a plethora of open, command and control (C2) research, policy and decision making questions. Computational modeling and simulation offer unmatched yet largely unexplored potential to address C2 questions along these lines. The central problem is, this kind of C2 organization modeling and simulation capability has yet to be developed and demonstrated in the TASP domain. This is where our ongoing research project begins to make an important contribution. In this article, we motivate and introduce such TASP research, and we provide an overview of the computational environment used to model and simulate TASP C2 organizations and phenomena. We follow in turn with an approach to characterizing a matrix of diverse TASP C2 contexts, as well as a strategy for specifying, tailoring and using this computational environment to conduct experiments to examine such contexts. We conclude then by summarizing our agenda for continued research along these lines

Rupture by damage accumulation in rocks

The deformation of rocks is associated with microcracks nucleation and propagation, i.e. damage. The accumulation of damage and its spatial localization lead to the creation of a macroscale discontinuity, so-called "fault" in geological terms, and to the failure of the material, i.e. a dramatic decrease of the mechanical properties as strength and modulus. The damage process can be studied both statically by direct observation of thin sections and dynamically by recording acoustic waves emitted by crack propagation (acoustic emission). Here we first review such observations concerning geological objects over scales ranging from the laboratory sample scale (dm) to seismically active faults (km), including cliffs and rock masses (Dm, hm). These observations reveal complex patterns in both space (fractal properties of damage structures as roughness and gouge), time (clustering, particular trends when the failure approaches) and energy domains (power-law distributions of energy release bursts). We use a numerical model based on progressive damage within an elastic interaction framework which allows us to simulate these observations. This study shows that the failure in rocks can be the result of damage accumulation

Fundulus as the premier teleost model in environmental biology : opportunities for new insights using genomics

Author Posting. © Elsevier B.V., 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2 (2007): 257-286, doi:10.1016/j.cbd.2007.09.001.A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms.This material is based on work supported by grants from the National Science Foundation DBI-0420504 (LJB), OCE 0308777 (DLC, RNW, BBR), BES-0553523 (AW), IBN 0236494 (BBR), IOB-0519579 (DHE), IOB-0543860 (DWT), FSML-0533189 (SC); National Institute of Health NIEHS P42-ES007381(GVC, MEH), P42-ES10356 (RTD), ES011588 (MFO); and NCRR P20 RR-016463 (DWT); Natural Sciences and Engineering Research Council of Canada Discovery (DLM, TDS, WSM) and Collaborative Research and Development Programs (DLM); NOAA/National Sea Grant NA86RG0052 (LJB), NA16RG2273 (SIK, MEH,GVC, JJS); Environmental Protection Agency U91620701 (WSB), R82902201(SC) and EPA’s Office of Research and Development (DEN)

Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse

A finished clone-based assembly of the mouse genome reveals extensive recent sequence duplication during recent evolution and rodent-specific expansion of certain gene families. Newly assembled duplications contain protein-coding genes that are mostly involved in reproductive function

Garlic Revisited: Antimicrobial Activity of Allicin-Containing Garlic Extracts against Burkholderia cepacia Complex

The antimicrobial activities of garlic and other plant alliums are primarily based on allicin, a thiosulphinate present in crushed garlic bulbs. We set out to determine if pure allicin and aqueous garlic extracts (AGE) exhibit antimicrobial properties against the Burkholderia cepacia complex (Bcc), the major bacterial phytopathogen for alliums and an intrinsically multiresistant and life-threatening human pathogen. We prepared an AGE from commercial garlic bulbs and used HPLC to quantify the amount of allicin therein using an aqueous allicin standard (AAS). Initially we determined the minimum inhibitory concentrations (MICs) of the AGE against 38 Bcc isolates; these MICs ranged from 0.5 to 3% (v/v). The antimicrobial activity of pure allicin (AAS) was confirmed by MIC and minimum bactericidal concentration (MBC) assays against a smaller panel of five Bcc isolates; these included three representative strains of the most clinically important species, B. cenocepacia. Time kill assays, in the presence of ten times MIC, showed that the bactericidal activity of AGE and AAS against B. cenocepacia C6433 correlated with the concentration of allicin. We also used protein mass spectrometry analysis to begin to investigate the possible molecular mechanisms of allicin with a recombinant form of a thiol-dependent peroxiredoxin (BCP, Prx) from B. cenocepacia. This revealed that AAS and AGE modifies an essential BCP catalytic cysteine residue and suggests a role for allicin as a general electrophilic reagent that targets protein thiols. To our knowledge, we report the first evidence that allicin and allicin-containing garlic extracts possess inhibitory and bactericidal activities against the Bcc. Present therapeutic options against these life-threatening pathogens are limited; thus, allicin-containing compounds merit investigation as adjuncts to existing antibiotics

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Command and control models of next generation unmanned aircraft systems

The technologic capabilities of autonomous systems (AS) continue to accelerate, and integrated performance by AS and people working together can be superior to that of either AS or people working alone. We refer to this increasingly important phenomenon as Teams of Autonomous Systems and People (TASP), and through our recent research—representing the current state of the art—we have demonstrated computational experimentation capability in the TASP domain. The problem is, several technology trends suggest that unmanned aircraft may be diverging away from operating and behaving like their manned counterparts, suggesting that some of our most futuristic model assumptions may be off target. This is where our ongoing research project begins to make an important contribution by investigating the next generation of autonomous systems. In this technical report, we motivate and introduce such TASP research, and we provide an overview of the computational environment used to experiment on TASP command and control organizations and phenomena. We summarize in turn the research method. Key results follow, and we conclude then by summarizing our agenda for continued research along these lines.The Consortium for Robotics and Unmanned Systems Education and Research (CRUSER)Approved for public release; distribution is unlimited