Informe de Expediente Civil No 05531-2011 Sobre: Tercería de Propiedad. Informe de Expediente Administrativo No 042-2018/CCD Sobre Competencia Desleal

Materia: Tercería De Propiedad Nº de Expediente: 05531-2011. En el presente caso, LOS DEMANDANTES interponen demanda de Tercería de Propiedad solicitando que se deje sin efecto la Medida Cautelar de Embargo en forma de inscripción, trabada sobre el bien inmueble de propiedad de los recurrentes, contra LOS DEMANDADOS. De acuerdo, a los medios probatorios brindados, LOS DEMANDANTES alegan haber adquirido el bien inmueble desde el 30 de mayo del 2007, es decir, desde antes de la inscripción de la Medida Cautelar, por lo que se deberá determinar qué derecho será preferente. Materia: Competencia Desleal Nº de Expediente: 042-2018/CCD. El presente caso gira en torno a una denuncia presentada por EL DENUNCIANTE en contra de LA DENUNCIADA por la presunta comisión de actos de competencia desleal en la modalidad de engaño previsto en el artículo 8° del Decreto Legislativo No. 1044 (Ley de Represión de la Competencia Desleal). El análisis del presente expediente aborda en determinar si la publicidad en el envase difundida por LA DENUNCIADA constituye un acto de competencia desleal en la modalidad de engaño

Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis

<p>Abstract</p> <p>Background</p> <p>The chemokine receptor CCR7 is a key organizer of the immune system. Gene targeting in mice revealed that Ccr7-deficient animals are severely impaired in the induction of central and peripheral tolerance. Due to these defects, Ccr7-deficient mice spontaneously develop multi-organ autoimmunity showing symptoms similar to those observed in humans suffering from connective tissue autoimmune diseases. However, it is unknown whether mutations of <it>CCR7 </it>are linked to autoimmunity in humans.</p> <p>Results</p> <p>DNA samples were collected from 160 patients suffering from connective tissue autoimmune disease (Sjogren's syndrome, n = 40; systemic lupus erythematosus, SLE, n = 20 and systemic sclerosis, n = 100) and 40 health subjects (n = 40). All participants in this study were of German descent. Samples were screened for single nucleotide polymorphisms (SNP) by sequencing the coding region of the <it>CCR7 </it>gene as well asthe exon flaking intron sites and parts of the regions encoding for the 5'- and 3'-UTR. <it>CCR7 </it>variants were rare. We identified six different sequence variants, which occurred in heterozygosis. The identified SNP were observed at position -60 C/T (observed 1x), +6,476 A/G (7x), +6,555 C/T (15x), +6,560 C/T (6x), +10,440 A/G (3x) and +11,475 C/A (1x). Four of these variants (+6,476 A/G, +6,555 C/T, +6,560 C/T and +10,440 A/G) display allelic frequencies between 1% and 5 % and were present in both patients and control groups. The variants +6,476 A/G, +6,555 C/T, +6,560 C/T are located in the intron 2, while the +10,440 A/G variant corresponds to a silent mutation in exon 3. The variants -60 C/T and +11,475 C/A which are located at the 5'-UTR and 3-UTR respectively, display allelic frequencies below 1%. No correlation between these variants and the autoimmune diseases investigated could be observed. However, reporter gene expression assay demonstrated that the mutation at the -60 C/T position in homozygosis leads to reduced luciferase activity.</p> <p>Conclusion</p> <p>These results suggest that variants of <it>CCR7 </it>gene occur at an extremely low frequency in the German population and that neither Sjogren's syndrome, systemic lupus erythematosus, nor systemic sclerosis are associated with these variants. Nevertheless, the decreased luciferase activity observed in cells transfected with the promoter region bearing the -60 C/T mutation suggests that this <it>CCR7 </it>variant could potentially lead to increased susceptibility to autoimmunity.</p

Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue

Presence and extent of bronchus-associated lymphoid tissue (BALT) is subject to considerable variations between species and is only occasionally observed in lungs of mice. Here we demonstrate that mice deficient for the chemokine receptor CCR7 regularly develop highly organized BALT. These structures were not present at birth but were detectable from day 5 onwards. Analyzing CCR7−/−/wild-type bone marrow chimeras, we demonstrate that the development of BALT is caused by alterations of the hematopoietic system in CCR7-deficient mice. These observations together with the finding that CCR7-deficient mice posses dramatically reduced numbers of regulatory T cells (T reg cells) in the lung-draining bronchial lymph node suggest that BALT formation might be caused by disabled in situ function of T reg cells. Indeed, although adoptive transfer of wild-type T reg cells to CCR7-deficient recipients resulted in a profound reduction of BALT formation, neither naive wild-type T cells nor T reg cells from CCR7−/− donors impair BALT generation. Furthermore, we provide evidence that CCR7-deficient T reg cells, although strongly impaired in homing to peripheral lymph nodes, are fully effective in vitro. Thus our data reveal a CCR7-dependent homing of T reg cells to peripheral lymph nodes in conjunction with a role for these cells in controlling BALT formation

Projeto de educação ambiental: "conhecendo a anta, o gigante perdido de nossas florestas" projeto de reintrodução da tapir na província de Tucumán, Argentina

Tapir reintroduction project is carried out by Horco Molle Experimental Reserve, belonging to the Faculty of Natural Sciences and Miguel Lillo Institute of the National University of Tucumán. It aims to return the tapir, a species that has been extinct for more than 70 years, into the Tucumán province. One of the project's success indicators is the society support, for which an environmental education program was designed. It provides activities adapted to different ages and educational levels and seeks to arouse curiosity about this megamammal. The program has been in operation since 2009, regaining strength in recent years due to the first releases. During the years 2021 and 2022, various activities were carried out, including a television concert, the first tapir`s Marathon, social networks interventions, a drawing contest, an animated short film and audiovisual talks/workshops in educational establishments. The society was very interested in the possibility of having tapirs again in the province. However, there is still much ignorance about the tapir, which highlights the need for the educational system to strengthen issues related to native biodiversity. &nbsp;El proyecto de reintroducción del tapir es ejecutado por la Reserva Experimental de Horco Molle, perteneciente a la Facultad de Ciencias Naturales e Instituto Miguel Lillo de la Universidad Nacional de Tucumán. Pretende devolver a las Yungas de la provincia de Tucumán al tapir, especie extinta hace más de 70. Uno de los indicadores de éxito del proyecto es la adhesión de la sociedad, para lo cual se diseñó un programa de educación ambiental. El mismo prevé actividades adaptadas a diferentes edades y niveles educativos y busca despertar curiosidad por este megamamífero. El programa funciona desde el año 2009, retomando fuerza en los últimos años de cara a las primeras liberaciones. Durante los años 2021 y 2022 se realizaron diversas actividades entre las que destacan un concierto televisivo, la I Maratón por el Tapir, intervenciones en redes sociales, un concurso de dibujo, un cortometraje animado y charlas/talleres audiovisuales en establecimientos educativos. La sociedad se mostró muy interesada con la posibilidad de volver a tener tapires en la provincia. Sin embargo, aún hay mucho desconocimiento sobre el tapir, lo cual pone en evidencia la necesidad de que el sistema educativo fortalezca temas vinculados a la biodiversidad nativa. &nbsp;O projeto de reintrodução da anta é realizado pela Reserva Experimental Horco Molle, pertencente à Faculdade de Ciências Naturais e Instituto Miguel Lillo da Universidade Nacional de Tucumán. O objetivo é devolver a anta às Yungas da província de Tucumán, espécie extinta há mais de 70 anos. Um dos indicadores do sucesso do projeto é o apoio da sociedade, para o qual foi elaborado um programa de educação ambiental. Proporciona atividades adaptadas a diferentes idades e níveis de escolaridade e procura despertar a curiosidade sobre este megamamífero. O programa está em funcionamento desde 2009, ganhando força nos últimos anos diante dos primeiros lançamentos. Durante os anos de 2021 e 2022 foram realizadas diversas atividades, entre as quais: um concerto televisivo, a primeira maratona da Anta, intervenções nas redes sociais, concurso de desenho, curta-metragem de animação e palestras audiovisuais em estabelecimentos de ensino. A sociedade estava muito interessada na possibilidade de voltar a ter antas na província. No entanto, ainda há muito desconhecimento sobre a espécie, o que evidencia a necessidade do sistema educacional fortalecer as questões relacionadas à biodiversidade nativa

Implementation and Knowledge of the Clinical Practice Guide for Palliative Care in the Ecuadorian Primary Care Level

Ecuador assumed the commitment of including Palliative Care (PC) in its health policies. In 2014, the Ministry of Public Health (Ministerio de Salud Pública, MSP) approved the Clinical Practice Guide for Palliative Care (Guía de Práctica Clínica sobre Cuidados Paliativos, GPCCP), with application at the national level, as a mandatory internal regulation in all institutions belonging to the National Health System. In 2021, there is no evidence about the degree of implementation. The objective was to evaluate the implementation (I) of the GPCCP guide and the knowledge (C) of the health personnel working in the Zone 7 Health Centers (HCs). This is a cross-sectional, descriptive, and prospective study. A total of 292 professionals were interviewed: managers (38), physicians (150), and nurses (104). Three surveys based on the GPCCP guide were elaborated: one for the implementation, which was applied to the individuals in charge, and the others to assess the health professionals’ knowledge. The SPSS program was used, version 25. In the three groups, more than half of the participants had no training in PC, 91.2% of the HCs have the GPCCP guide, there is PC medical history (MH) in 38.2%, and morphine is used in 14.7%. The implementation of the GPCCP guide was inadequate in 52.9% of the cases. Only 25% treat the agony symptoms and 30%, delirium; 4.4% acknowledge the use of morphine in dyspnea, and 13.3% identify the subcutaneous route as the first choice for hydration at the end-of-life phase. Strategies to implement the GPCCP guide and to improve the health personnel’s knowledge must be implemented in Zone 7 centers

Conciencia fonológica y lectura inicial en niños de 5 años Trujillo

La presente investigación tuvo como objetivo general determinar la relación que existe entre la conciencia fonológica y la lectura inicial en niños de 5 años de la Institución Educativa, Trujillo, 2019. Esta investigación fue realizada bajo el enfoque cuantitativo, con un diseño no experimental, correlacional descriptivo. La población fue de 164 niños y niñas de la Institución Educativa y como muestra 84 niños de las aulas de 5 años. Se utilizó una prueba de habilidades y una lista de cotejo. Los instrumentos tuvieron su validez a través de un juicio de expertos y su grado de confiabilidad con el coeficiente del Alfa de Chronbach obteniendo un 0.821 en la conciencia fonológica y un 0.687 en la lectura inicial. Los resultados nos describen que el 91.2 % de los niños de 5 años se encuentran en un nivel logrado con respecto a la lectura inicial y solo el 30.1% de los niños presentan un desempeño deficiente con respecto a la conciencia fonológica. Finalmente se concluye que existe relación media entre la conciencia fonológica y la lectura inicial

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling

Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process. In the present study, we investigated how the inflammatory mediator NO can affect proliferation of neural stem cells (NSCs), and explored possible mechanisms underlying this effect. We investigated which mechanisms are involved in the regulation of NSC proliferation following treatment with an inflammatory stimulus (lipopolysaccharide plus IFN-gamma), using a culture system of subventricular zone (SVZ)-derived NSCs mixed with microglia cells obtained from wild-type mice (iNOS(+/+)) or from iNOS knockout mice (iNOS(-/-)). We found an impairment of NSC cell proliferation in iNOS(+/+) mixed cultures, which was not observed in iNOS(-/-) mixed cultures. Furthermore, the increased release of NO by activated iNOS(+/+) microglial cells decreased the activation of the ERK/MAPK signaling pathway, which was concomitant with an enhanced nitration of the EGF receptor. Preventing nitrogen reactive species formation with MnTBAP, a scavenger of peroxynitrite (ONOO-), or using the ONOO- degradation catalyst FeTMPyP cell proliferation and ERK signaling were restored to basal levels in iNOS(+/+) mixed cultures. Moreover, exposure to the NO donor NOC-18 (100 mu M), for 48 h, inhibited SVZ-derived NSC proliferation. Regarding the antiproliferative effect of NO, we found that NOC-18 caused the impairment of signaling through the ERK/MAPK pathway, which may be related to increased nitration of the EGF receptor in NSC. Using MnTBAP nitration was prevented, maintaining ERK signaling, rescuing NSC proliferation. We show that NO from inflammatory origin leads to a decreased function of the EGF receptor, which compromised proliferation of NSC. We also demonstrated that NO-mediated nitration of the EGF receptor caused a decrease in its phosphorylation, thus preventing regular proliferation signaling through the ERK/MAPK pathway.Foundation for Science and Technology, (FCT, Portugal); COMPETE; FEDER [PEst-C/SAU/LA0001/2013-2014, PEst-OE/EQB/LA0023/2013-2014, PTDC/SAU-NEU/102612/2008, PTDC/NEU-OSD/0473/2012]; FCT, Portugal [SERH/BPD/78901/2011, SERH/BD/38127/2007, SFRH/BD/77903/2011, SFRH/BD/79308/2011]info:eu-repo/semantics/publishedVersio

MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

Elucidating the adaptive mechanisms that prevent host immune response in cancer will help predict efficacy of anti-programmed death-1 (PD1)/L1 therapies. Here, we study the cell-intrinsic response of lung cancer (LC) to interferon-y (IFNy), a cytokine that promotes immunoresponse and modulates programmed death-ligand 1 (PD-L1) levels. We report complete refractoriness to IFNy in a subset of LCs as a result of JAK2 or IFNGR1 inactivation. A submaximal response affects another subset that shows constitutive low levels of IFNy-stimulated genes (IySGs) coupled with decreased H3K27ac (histone 3 acetylation at lysine 27) depo-sition and promoter hypermethylation and reduced IFN regulatory factor 1 (IRF1) recruitment to the DNA on IFNy stimulation. Most of these are neuroendocrine small cell LCs (SCLCs) with oncogenic MYC/MYCL1/ MYCN. The oncogenic activation of MYC in SCLC cells downregulates JAK2 and impairs IySGs stimulation by IFNy. MYC amplification tends to associate with a worse response to anti-PD1/L1 therapies. Hence alterations affecting the JAK/STAT pathway and MYC activation prevent stimulation by IFNy and may predict anti-PD1/L1 efficacy in LC

Perfil antropométrico en adultos del Noroeste Argentino: comparación con una referencia internacional

Desde una perspectiva bioantropológica las mediciones antropométricas en adultos son exhaustivamente utilizadas en la evaluación morfológica de poblaciones argentinas extintas. La mayoría de los estudios antropométricos en adultos argentinos contemporáneos se limitan a la evaluación de talla, peso e IMC. El objetivo de este trabajo fue describir otras variables antropométricas en adultos del Noroeste argentino (NOA) y compararlas con una referencia internacional. Los datos de peso, talla, perímetros (brazo, muslo, pierna, cintura) y pliegues (tríceps, subescapular) proceden de 881 individuos (526 mujeres; 355 varones) sanos de 20-60 años de edad de distintas localidades de Catamarca y Jujuy. Se calcularon estadísticos descriptivos (media y DS) por sexo y dos grupos de edad: 20-39 y 40-60 años. Las comparaciones se establecieron con adultos de EEUU de origen mejicano (Centers for Disease Control, CDC 2003-2006) con la prueba t. Se calcularon los percentilos con el método LMS. En ambos sexos y grupos de edad los adultos del NOA presentaron valores significativamente inferiores a los de la referencia en todas las variables consideradas, excepto para pliegues tricipital y subescapular en varones de 40-60 años. No se han encontrado antecedentes antropométricos comparables semejantes para poblaciones argentinas y del NOA. El perfil antropométrico de los adultos del NOA difiere significativamente con respecto a la población de referencia con un origen étnico afín. Rev Arg Antrop Biol 17(1):07-18, 2015

Perfil antropométrico en adultos del noroeste argentino: comparación con una referencia internacional

Desde una perspectiva bioantropológica las mediciones antropométricas en adultos son exhaustivamente utilizadas en la evaluación morfológica de poblaciones argentinas extintas. La mayoría de los estudios antropométricos en adultos argentinos contemporáneos se limitan a la evaluación de talla, peso e IMC. El objetivo de este trabajo fue describir otras variables antropométricas en adultos del Noroeste argentino (NOA) y compararlas con una referencia internacional. Los datos de peso, talla, perímetros (brazo, muslo, pierna, cintura) y pliegues (tríceps, subescapular) proceden de 881 individuos (526 mujeres; 355 varones) sanos de 20-60 años de edad de distintas localidades de Catamarca y Jujuy. Se calcularon estadísticos descriptivos (media y DS) por sexo y dos PALABRAS CLAVE adultos; Noroeste Argentino; perímetros; pliegues; antropometría grupos de edad: 20-39 y 40-60 años. Las comparaciones se establecieron con adultos de EEUU de origen mejicano (Centers for Disease Control, CDC 2003-2006) con la prueba t. Se calcularon los percentilos con el método LMS. En ambos sexos y grupos de edad los adultos del NOA presentaron valores significativamente inferiores a los de la referencia en todas las variables consideradas, excepto para pliegues tricipital y subescapular en varones de 40-60 años. No se han encontrado antecedentes antropométricos comparables semejantes para poblaciones argentinas y del NOA. El perfil antropométrico de los adultos del NOA difiere significativamente con respecto a la población de referencia con un origen étnico afín.From a bioanthropological point of view anthropometric measurements in adults are extensively used in the morphological evaluation of extinct Argentine populations. Most anthropometric studies in contemporary Argentine adults are limited to the assessment of height, weight and BMI. The aim of this study was to describe other anthropometric variables in northwestern Argentine (NWA) adults and to compare them with an international reference. Data on weight, height, circumferences (arm, thigh, leg, waist), and skinfolds (triceps, subscapular) come from 881 (526 women, 355 men) 20-60 year-old healthy individuals from different localities of Jujuy and Catamarca. Descriptive statistics (mean and SD) were calculated by sex and two age groups: 20-39 and 40-60 years. Comparisons were made with adults of Mexican origin from the United States (Centers for Disease Control, CDC 2003-2006) using the t-test. Percentiles were calculated using the LMS method. In both sexes and age groups NWA adults presented significantly lower values than those of the reference group in all the variables considered, except for triceps and subscapular skinfolds in males of 40-60 years old. There are no comparable anthropometric records for Argentine and NWA populations. The anthropometric profile of NWA adults differs significantly from that of the ethnically related reference population.Asociación de Antropología Biológica de la República Argentina (AABRA