Geoarqueología y registro geológico del último milenio en el pozo de la antigua Fábrica de Tabacos (Gijón, N España)

During the 2008-2009 archaeological excavations carried out in the ancient Fábrica de Tabacos (Gijón), a Roman well structure was discovered, covered by a sedimentary infill with archaeological remains. This work deals with the geological and depositional characterization of the sedimentary infill. Two hand drill cores of 1.45 m and 1.65m long were studied, using stratigraphic, geochemical and geochronological techniques. The evolutionary model of the sedimentary infill includes 5 phases: 1) construction and functioning as a well (prior? to 5th-6th centuries); 2) abandonment of the well and sedimentation in a restricted palustrine-like environment (5th-7th centuries); 3) a phase dominated by dumping of organic-rich landfill material (7th century); 4) re-starting of palustrine-like environment with some landfill episodes (7th-8th centuries); and 5) a final phase as a dumping site (at least during the 8th century). The sedimentary infill is an outstanding geoarchaelogical archive that provides key information to improve the knowledge of the region from the 6th to the 8th centuries.Agradecemos a la empresa Terra Arqueos S.L. su aportación en la realización de los sondeos y al Ayuntamiento de Gijón la financiación de la investigación (proyectos FUO-EM-403-10 y FUO-EM-342-09)Peer Reviewe

The influence of subaquatic springs in lacustrine sedimentation: Origin and paleoenvironmental significance of homogenites in karstic Lake Banyoles (NE Spain)

Banyoles (42°08′N, 2°45′E) is the largest and deepest lake of karstictectonic origin in the Iberian Peninsula. The lake comprises two basins and six sub-circularly shaped sub-basins fed by subaquatic springs. Periods of intense groundwater inflow in the deepest sub-basins lead to the fluidization and re-suspension of previously deposited sediments and subsequent settling forming homogenite deposits on the southern basin intermediate platforms. The multiproxy analysis of sediment cores combined with high resolution seismic stratigraphy (3.5 kHz pinger and multi-frequency Chirp surveys) allows a precise reconstruction of depositional environments and related hydrological variability and groundwater inflowduring the last ca. 7.6 cal kyr BP. According to the agemodel based on 137Cs, 210Pb and AMS 14C dating, homogenite deposition occurred between 7.2 and 5.5 cal kyr BP, stopped during the middle Holocene (5.52.8 cal kyr BP) and greatly increased during the last two millennia with a total of 17 homogenite layers individually up to 75 cm-thick. The onset of this unique sedimentation mode at ca. 3 cal kyr BP coincides with an increase in lake level, evidenced by the onlapping of fine-grained, distal sediments over coarser massive, carbonate-rich, littoral deposits. A detailed, multidisciplinary study of the homogenites (sedimentology, physical properties, high-resolution elemental geochemistry, mineral composition, grain-size, organic matter content and SEM) combined with seismic stratigraphy demonstrates that the fluidization events triggering the formation of the homogenites were caused by higher and more intense local groundwater inflow, related to increased rainfall during the Late Holocene and likely intensified by land use changes during the last millennium

Assessing Urban Accessibility in Monterrey, Mexico: A Transferable Approach to Evaluate Access to Main Destinations at the Metropolitan and Local Levels

Cities demand urgent transformations in order to become more affordable, livable, sustainable, walkable and comfortable spaces. Hence, important changes have to be made in the way cities are understood, diagnosed and planned. The current paper puts urban accessibility into the centre of the public policy and planning agenda, as a transferable approach to transform cities into better living environments. To do so, a practical example of the City of Monterrey, Mexico, is presented at two planning scales: the metropolitan and local level. Both scales of analysis measure accessibility to main destinations using walking and cycling as the main transport modes. The results demonstrate that the levels of accessibility at the metropolitan level are divergent, depending on the desired destination, as well as on the planning processes (both formal and informal) from different areas of the city. At the local level, the Distrito Tec Area is diagnosed in terms of accessibility to assess to what extent it can be considered a part of a 15 minutes city. The results show that Distrito Tec lacks the desired parameters of accessibility to all destinations for being a 15 minutes city. Nevertheless, there is a considerable increase in accessibility levels when cycling is used as the main travelling mode. The current research project serves as an initial approach to understand the accessibility challenges of the city at different planning levels, by proving useful and disaggregated data. Finally, it concludes providing general recommendations to be considered in planning processes aimed to improve accessibility and sustainability

Modelo básico epidemiológico SIR para el COVID-19: caso las Regiones del Perú

In this work, a basic epidemiological model is used to determine the evolution of COVID-19 in each of the regions of Peru. For determining the parameters of the model which characterize a certain epidemic, the reports of infected, deceased and recovered people provided by the Regional Health Management of Peru are used. As a result, we obtained the configuration of the infected, susceptible and removed which are consistent with the existing bibliography, thus we also obtain a time interval in which there is a considerable number of infected, the maximum number of infected and the date on which it occurs.En este trabajo se utiliza un modelo epidemiológico básico para determinar la evolución del COVID-19 en cada una de las regiones del Perú. Para determinar los parámetros del modelo que caracteriza una determinada epidemia, se utiliza los reportes de las personas infectadas, fallecidas y recuperadas proporcionados por las Gerencias Regionales de Salud del Perú. Como resultado, se obtiene la configuración de los infectados, susceptibles y removidos que concuerda con la bibliografía existente, así también se obtiene un intervalo de tiempo en que hay un considerable número de infectados, el máximo de infectados y la fecha en que ocurre

The multiple team formation problem using sociometry

The Team Formation problem (TFP) has become a well-known problem in the OR literature over the last few years. In this problem, the allocation of multiple individuals that match a required set of skills as a group must be chosen to maximise one or several social positive attributes. Specifically, the aim of the current research is two-fold. First, two new dimensions of the TFP are added by considering multiple projects and fractions of people's dedication. This new problem is named the Multiple Team Formation Problem (MTFP). Second, an optimization model consisting in a quadratic objective function, linear constraints and integer variables is proposed for the problem. The optimization model is solved by three algorithms: a Constraint Programming approach provided by a commercial solver, a Local Search heuristic and a Variable Neighbourhood Search metaheuristic. These three algorithms constitute the first attempt to solve the MTFP, being a variable neighbourhood local search metaheuristic the most efficient in almost all cases. Applications of this problem commonly appear in real-life situations, particularly with the current and ongoing development of social network analysis. Therefore, this work opens multiple paths for future research

SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes

10 Pág.The SEVA platform (https://seva-plasmids.com) was launched one decade ago, both as a database (DB) and as a physical repository of plasmid vectors for genetic analysis and engineering of Gram-negative bacteria with a structure and nomenclature that follows a strict, fixed architecture of functional DNA segments. While the current update keeps the basic features of earlier versions, the platform has been upgraded not only with many more ready-to-use plasmids but also with features that expand the range of target species, harmonize DNA assembly methods and enable new applications. In particular, SEVA 4.0 includes (i) a sub-collection of plasmids for easing the composition of multiple DNA segments with MoClo/Golden Gate technology, (ii) vectors for Gram-positive bacteria and yeast and [iii] off-the-shelf constructs with built-in functionalities. A growing collection of plasmids that capture part of the standard-but not its entirety-has been compiled also into the DB and repository as a separate corpus (SEVAsib) because of its value as a resource for constructing and deploying phenotypes of interest. Maintenance and curation of the DB were accompanied by dedicated diffusion and communication channels that make the SEVA platform a popular resource for genetic analyses, genome editing and bioengineering of a large number of microorganisms.The SEVA repository has been developed and maintained with funds of the SYCOLIM [ERA-COBIOTECH 2018-PCI2019-111859-2] Project of the Spanish Ministry of Science and Innovation, SYNBIO4FLAV [H2020-NMBP-TR-IND/H2020-NMBP-BIO-2018-814650]; MIX-UP [MIX-UP H2020-BIO-CN-2019-870294] Contracts of the European Union; BIOSINT-CM [Y2020/TCS-6555] Project of the Comunidad de Madrid-European Structural and Investment Funds (FSE, FECER); P.I.N. acknowledges financial support by the Novo Nordisk Foundation [NNF20CC0035580, TARGET (NNF21OC0067996]; European Union's Horizon 2020 Research and Innovation Programme [814418 (SinFonia)]; M.H.H.N. acknowledges funding by the Novo Nordisk Foundation [NNF20CC0035580]; P.D. was funded by Czech Science Foundation Project 22-12505S; A.G.M. was supported by the Grants BioSinT-CM [Y2020/TCS-6555]; CONTEXT (Atracción de Talento Program) [2019-T1/BIO-14053] Projects of the Comunidad de Madrid, MULTI-SYSBIO [PID2020-117205GA-I00]; Severo Ochoa Program for Centres of Excellence in R&D [CEX2020-000999-S] funded by MCIN/AEI/10.13039/501100011033 and the ECCO (ERC-2021-COG-101044360) Contract of the EU. Funding for open access charge: European Commission Grant SYNBIO4FLAV [H2020-NMBP-TR-IND/H2020-NMBP-BIO-2018-814650].With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2020‐000999‐S) .Peer reviewe

Hacking ético para profundizar en la implementación de sistemas informáticos seguros

Memoria ID-052 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

Integrando escalas y métodos LTER para comprender la dinámica global de un espacio protegido de montaña: el Parque Nacional de Ordesa y Monte Perdido

Los espacios protegidos, por el hecho de albergar una gran geo-biodiversidad y asegurar una baja intervención humana, constituyen lugares muy adecuados para el seguimiento de organismos y procesos a escala ecológica, así como para la obtención de series temporales largas a escala geológica. En el marco de la red LTER-España, el Parque Nacional de Ordesa y Monte Perdido (PNOMP) y el Instituto Pirenaico de Ecología-CSIC están impulsando estudios para la detección de cambios a distintas escalas mediante variados métodos y aproximaciones. Destacamos aquí los más consolidados, entre los que se encuentran los análisis de registros de sedimentos en lagos, espeleotemas en cuevas, la dinámica de uno de los pocos glaciares activos de la Península ibérica, el análisis físico-químico de aguas corrientes e ibones de alta montaña, el registro del cambio climático actual en árboles longevos, la afección que éste ejerce sobre masas actuales de pinos en el límite superior del bosque y de abetales en zonas húmedas, la matorralización de algunos pastos y los procesos mecanicistas que subyacen, la reorganización de la diversidad florística en pastos tras el abandono paulatino o drástico de la ganadería, la biodiversidad de las comunidades alpinas y la dinámica poblacional de especies amenazadas o indicadoras de hábitats o de motores de cambio global. Los seguimientos ecológicos actuales muestran que tanto el cambio climático como el de usos del suelo están teniendo una considerable trascendencia en la fisionomía y la estructura de algunos de los ambientes más icónicos y frecuentes del parque (deterioro del glaciar, termofilización de la flora en cumbres alpinas, densificación del bosque en su límite superior, pérdida de productividad en algunos pastos supraforestales, etc.). También sugieren una importante variabilidad espacial en los procesos (por ej. en el PNOMP conviven pastos matorralizados y pastos muy estables), y evidencian que los cambios observados no siempre siguen los paradigmas establecidos (por ej., las especies amenazadas mantienen dinámicas poblacionales estables). La integración de resultados parciales proporcionados por cada aproximación relativiza la importancia de las percepciones que cada estudio destaca por separado, y permite medir los cambios actuales en el marco de referencia de los cambios a escala geológica. Predecir la resistencia y resiliencia de los ecosistemas o las poblaciones de seres vivos para enfrentarse a los futuros cambios ambientales es complicado, no sólo por la falta de conocimientos disponibles sino también porque las respuestas que observamos no siempre son tan rápidas o lineales como se espera. La modelización constituye una herramienta cada vez más utilizada, pero requiere de evidencias reales para validar sus pronósticos, por lo que la observación de los procesos que actúan en el PNOMP ha de incluir un esfuerzo continuado de monitorización multiescalar y multidisciplinar de los distintos componentes de la geo, hidro-, crio- y biosfera, sin olvidar el componente humano. Entender la complejidad supone conectar las interacciones que existen entre todos los sistemas y ponderar sus efectos según las escalas de trabajo.Instituto Pirenaico de Ecología, Consejo Superior de Investigaciones Científicas, EspañaEmpresa pública SARGA, EspañaJOLUBE Consultor Botánico, Editor y Fotógrafo, EspañaDepartament d’Ecologia, Universitat de Barcelona, EspañaUnidad de Tres Cantos, Instituto Geológico y Minero de España, EspañaInstitut de Recerca de Biodiversitat, Universitat de Barcelona, EspañaParque Nacional de Ordesa y Monte Perdido, Españ

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe