Pion Form Factor in Chiral Limit of Hard-Wall AdS/QCD Model

We develop a formalism to calculate form factor and charge density distribution of pion in the chiral limit using the holographic dual model of QCD with hard-wall cutoff. We introduce two conjugate pion wave functions and present analytic expressions for these functions and for the pion form factor. They allow to relate such observables as the pion decay constant and the pion charge electric radius to the values of chiral condensate and hard-wall cutoff scale. The evolution of the pion form factor to large values of the momentum transfer is discussed, and results are compared to existing experimental data.Comment: 21 page, 7 figures. Short comparison with NJL predictions for pion radius and new references added. To be published in Phys.Rev.

Off-Shell Interactions for Closed-String Tachyons

Off-shell interactions for localized closed-string tachyons in C/Z_N superstring backgrounds are analyzed and a conjecture for the effective height of the tachyon potential is elaborated. At large N, some of the relevant tachyons are nearly massless and their interactions can be deduced from the S-matrix. The cubic interactions between these tachyons and the massless fields are computed in a closed form using orbifold CFT techniques. The cubic interaction between nearly-massless tachyons with different charges is shown to vanish and thus condensation of one tachyon does not source the others. It is shown that to leading order in N, the quartic contact interaction vanishes and the massless exchanges completely account for the four point scattering amplitude. This indicates that it is necessary to go beyond quartic interactions or to include other fields to test the conjecture for the height of the tachyon potential.Comment: 37 pages, 3 figures, LaTeX, JHEP class. Typos corrected, references added, published versio

Quasi-classical approximation in vortex filament dynamics. Integrable systems, gradient catastrophe and flutter

Quasiclassical approximation in the intrinsic description of the vortex filament dynamics is discussed. Within this approximation the governing equations are given by elliptic system of quasi-linear PDEs of the first order. Dispersionless Da Rios system and dispersionless Hirota equation are among them. They describe motion of vortex filament with slow varying curvature and torsion without or with axial flow. Gradient catastrophe for governing equations is studied. It is shown that geometrically this catastrophe manifests as a fast oscillation of a filament curve around the rectifying plane which resembles the flutter of airfoils. Analytically it is the elliptic umbilic singularity in the terminology of the catastrophe theory. It is demonstrated that its double scaling regularization is governed by the Painleve' I equation.Comment: 25 pages, 5 figures, minor typos correcte

One Methylene Group in the Side Chain Can Alter by 90 Degrees the Orientation of a Main-Chain Liquid Crystal on a Unidirectional Substrate

The mechanisms of orientation of columnar liquid crystals (LCs) on PTFE-rubbed surface are explored on a homologous series of symmetrically-substituted poly(di-n-alkylsiloxanes) (PDAS). It is shown that by increasing the side-chain length in steps of one CH2 group the orientation of PDAS switches back and forth from perpendicular to parallel with respect to PTFE chains. These changes sensitive to the smallest possible variation of the macromolecular structure (i.e., modification of the side chain length by just one CH2 group) reflect the change of the alignment mechanism identified as grapho-epitaxial or epitaxial for the perpendicular and parallel orientation, respectively. The results show that two orthogonal LC orientations are realizable on the same rubbed substrate, which can open new perspectives in the field of organic and printed electronics such as multi-domain LCD technology

Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice

Background: Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for the symptomatic treatment of ADHD and narcolepsy; although lately, there has been an increased incidence of its use in individuals not meeting the criteria for these disorders. MPH has also been misused as a ‘‘cognitive enhancer’ ’ and as an alternative to other psychostimulants. Here, we investigate whether chronic or acute administration of MPH in mice at either 1 mg/kg or 10 mg/kg, affects cell number and gene expression in the basal ganglia. Methodology/Principal Findings: Through the use of stereological counting methods, we observed a significant reduction (,20%) in dopamine neuron numbers in the substantia nigra pars compacta (SNpc) following chronic administration of 10 mg/kg MPH. This dosage of MPH also induced a significant increase in the number of activated microglia in the SNpc. Additionally, exposure to either 1 mg/kg or 10 mg/kg MPH increased the sensitivity of SNpc dopaminergic neurons to the parkinsonian agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Unbiased gene screening employing Affymetrix GeneChipH HT MG-430 PM revealed changes in 115 and 54 genes in the substantia nigra (SN) of mice exposed to 1 mg/kg and 10 mg/kg MPH doses, respectively. Decreases in the mRNA levels of gdnf, dat1, vmat2, and th in the substantia nigr

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion)

Three individuals, three stories, three burials from medieval Trondheim, Norway

This article presents the life stories of three individuals who lived in Trondheim, Norway, dur- ing the 13th century. Based on skeletal examinations, facial reconstructions, genetic analy- ses, and stable oxygen isotope analyses, the birthplace, mobility, ancestry, pathology, and physical appearance of these people are presented. The stories are discussed within the relevant historical context. These three people would have been ordinary citizens, without any privileges out of the ordinary, which makes them quite rare in the academic literature. Through the study of individuals one gets a unique look into the Norwegian medieval society