59 research outputs found
Sensory profile of portuguese white wines using long-term memory: a novel nationwide approach
White wine sensory profiling of all 12 Protected Geographical Indications (PGIs)
of mainland Portugal was achieved through completion of extended sensory
questionnaires by 20 professional wine experts. No samples were assessed; the
experiment was based on memory alone. Three macro-zonings were found and
typicality differences were statistically validated and sensory described. PGI
MINHO was found the most typical of all PGIs, with several extreme rates on
Color, Aroma and Taste. SOUTHERN cluster of the four meridional PGIs
presented several extreme, therefore typical, sensory assessments, mostly opposite
to the profile of PGI Minho. Color tonality, alcohol and acidity were mutually
related and respective variations were correlated with published findings and
expressed as key factors for regional macro-zoning differentiation. Moreover, with
the proposed methodology it was possible to achieve a novel nationwide sensory
characterization of PGIs, overcoming ongoing macroscaling and sample
representativeness limitations and envisaging new nation-sized sensory studiesinfo:eu-repo/semantics/publishedVersio
Procyanidin oligomers. A new method for 4->8 interflavan bond formation using C8-boronic acids and iterative oligomer synthesis through a boron-protection strategy
Interest in the synthesis of procyanidin (catechin or epicatechin) oligomers that contain the 4→8 interflavan linkage remains high, principally due to research into their health effects. A novel coupling utilising a C8-boronic acid as a directing group was developed in the synthesis of natural procyanidin B3 (i.e., 3,4-trans-(+)-catechin-4α→8-(+)- catechin dimer). The key interflavan bond was forged using a novel Lewis acid-promoted coupling of C4-ether 6 with C8-boronic acid 16 to provide the α-linked dimer with high diastereoselectivity. Through the use of a boron protecting group, the new coupling procedure was extended to the synthesis of a protected procyanidin trimer analogous to natural procyanidin C2. © 2011 Elsevier B.V. All rights reserved.Eric G. Dennis, David W. Jeffery, Martin R. Johnston, Michael V. Perkins, Paul A. Smit
Study of the morphology and rheological behavior of polymer-modified asphalt blends prepared with poly(styrene- b
Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics.
Serum proteomics analysis may lead to the discovery of novel osteoporosis biomarkers. The Osteoporotic Fractures in Men (MrOS) study comprises men ≥65 years old in the US who have had repeated BMD measures and have been followed for incident fracture. High-throughput quantitative proteomic analysis was performed on baseline fasting serum samples from non-Hispanic white men using a multidimensional approach coupling liquid chromatography, ion-mobility separation, and mass spectrometry (LC-IMS-MS). We followed the participants for a mean of 4.6 years for changes in femoral neck bone mineral density (BMD) and for incident hip fracture. Change in BMD was determined from mixed effects regression models taking age and weight into account. Participants were categorized into three groups: BMD maintenance (no decline; estimated change ≥0 g/cm2 , n = 453); expected loss (estimated change 0 to 1 SD below the estimated mean change, -0.034 g/cm2 for femoral neck, n = 1184); and accelerated loss (estimated change ≥1 SD below mean change, n = 237). Differential abundance values of 3946 peptides were summarized by meta-analysis to determine differential abundance of each of 339 corresponding proteins for accelerated BMD loss versus maintenance. Using this meta-analytic standardized fold change at cutoffs of ≥1.1 or ≤0.9 (p < 0.10), 20 proteins were associated with accelerated BMD loss. Associations of those 20 proteins with incident hip fracture were tested using Cox proportional hazards models with age and BMI adjustment in 2473 men. Five proteins were associated with incident hip fracture (HR between 1.29 and 1.41 per SD increase in estimated protein abundance). Some proteins have been previously associated with fracture risk (eg, CD14 and SHBG), whereas others have roles in cellular senescence and aging (B2MG and TIMP1) and complement activation and innate immunity (CO7, CO9, CFAD). These findings may inform development of biomarkers for future research in bone biology and fracture prediction. © 2017 American Society for Bone and Mineral Research
Aggregation of asphaltene model compounds using a porphyrin tethered to a carboxylic acid
Peak individual alpha frequency qualifies as a stable neurophysiological trait marker in healthy younger and older adults
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