Current account patterns and national real estate markets

This paper studies the association between current account and real estate valuation across countries. We find a robust and strong positive association between current account deficits and the appreciation of the real estate prices/(GDP deflator). Controlling for lagged GDP/capita growth, inflation, financial depth, institution, urban population growth and the real interest rate; a one standard deviation increase of the lagged current account deficits is associated with an appreciation of the real estate prices by 10%. This real appreciation is magnified by financial depth, and mitigated by the quality of institutions. Intriguingly, the economic importance of current account variations in accounting for the real estate valuation exceeds that of the other variables, including the real interest rate and inflation. Among the OECD countries, we find evidence of a decline over time in the cross country variation of the real estate/(GDP deflator), consistent with the growing globalization of national real estate markets. Weaker patterns apply to the non-OECD countries in the aftermath of the East Asian crisis

Rapid star formation and global gravitational collapse

Most young stars in nearby molecular clouds have estimated ages of 1–2 Myr, suggesting that star formation is rapid. However, small numbers of stars in these regions with inferred ages of > rsim 5–10 Myr have been cited to argue that star formation is instead a slow, quasi‐static process. When considering these alternative pictures it is important to recognize that the age spread in a given star‐forming cloud is necessarily an upper limit to the time‐scales of local collapse, as not all spatially distinct regions will start contracting at precisely the same instant. Moreover, star‐forming clouds may dynamically evolve on time‐scales of a few Myr; in particular, global gravitational contraction will tend to yield increasing star formation rates with time due to generally increasing local gas densities. We show that two different numerical simulations of dynamic, flow‐driven molecular cloud formation and evolution (1) predict age spreads for the main stellar population roughly consistent with observations and (2) raise the possibility of forming small numbers of stars early in cloud evolution, before global contraction concentrates the gas and the bulk of the stellar population is produced. In general, the existence of a small number of older stars among a generally much younger population is consistent with the picture of dynamic star formation and may even provide clues to the time evolution of star‐forming clouds.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90399/1/j.1365-2966.2011.20131.x.pd

MRI of the lung (1/3):methods

Proton magnetic resonance imaging (MRI) has recently emerged as a clinical tool to image the lungs. This paper outlines the current technical aspects of MRI pulse sequences, radiofrequency (RF) coils and MRI system requirements needed for imaging the pulmonary parenchyma and vasculature. Lung MRI techniques are presented as a “technical toolkit”, from which MR protocols will be composed in the subsequent papers for comprehensive imaging of lung disease and function (parts 2 and 3). This paper is pitched at MR scientists, technicians and radiologists who are interested in understanding and establishing lung MRI methods. Images from a 1.5 T scanner are used for illustration of the sequences and methods that are highlighted. Main Messages • Outline of the hardware and pulse sequence requirements for proton lung MRI • Overview of pulse sequences for lung parenchyma, vascular and functional imaging with protons • Demonstration of the pulse-sequence building blocks for clinical lung MRI protocol

APOGEE strings: a fossil record of the gas kinematic structure

© ESO, 2016We compare APOGEE radial velocities (RVs) of young stars in the Orion A cloud with CO line gas emission and find a correlation between the two at large-scales, in agreement with previous studies. However, at smaller scales we find evidence for the presence of substructure in the stellar velocity field. Using a Friends-of-Friends approach we identify 37 stellar groups with almost identical RVs. These groups are not randomly distributed but form elongated chains or strings of stars with five or more members with low velocity dispersion, across lengths of 1-1.5~pc. The similarity between the kinematic properties of the APOGEE strings and the internal velocity field of the chains of dense cores and fibers recently identified in the dense ISM is striking and suggests that for most of the Orion A cloud, young stars keep memory of the parental gas substructure where they originated.Peer reviewe

Buprenorphine-Naloxone in the Treatment of Codeine Dependence: a Scoping Review of Clinical Case Presentations

Misuse of prescribed and over the counter (OTC) codeine containing medicines is an increasing public health concern in recent times. Studies have called for low threshold treatment services for individuals experiencing codeine dependence using buprenorphine naloxone therapy. We present a scoping review of clinical case presentation literature on the use of buprenorphine-naloxone in the treatment of codeine dependence. Seven records (four single case studies and three case series) on codeine dependence treated with buprenorphine-naloxone were included. Five themes emerged following a review of the cases for the treatment of codeine dependence with buprenorphine-naloxone. They are: (1) Patient Profiles; (2) History of Codeine Misuse; (3) Medical Problems; (4) Use of Other Substances; and (5) Buprenorphine-naloxone in the treatment of Codeine Dependence. The review highlights the complexities of patients with regards to pain, psychiatric illness, poly substance use and iatrogenic dependence, with findings encouraging in terms of patient stabilisation and recovery

Discovery and Physical Characterization of a Large Scattered Disk Object at 92 au

We report the observation and physical characterization of the possible dwarf planet 2014. UZ224 ("DeeDee"), a dynamically detached trans-Neptunian object discovered at 92 au. This object is currently the second-most distant known trans-Neptunian object with reported orbital elements, surpassed in distance only by the dwarf planet Eris. The object was discovered with an r-band magnitude of 23.0 in data collected by the Dark Energy Survey between 2014 and 2016. Its 1140 year orbit has (a, e, i)=(109 au, 0.65, 26 degrees.8). It will reach its perihelion distance of 38 au in the year 2142. Integrations of its orbit show it to be dynamically stable on Gyr timescales, with only weak interactions with Neptune. We have performed follow-up observations with ALMA, using 3 hr of on-source integration time to measure the object's thermal emission in the Rayleigh-Jeans tail. The signal is detected at 7 sigma significance, from which we determine a V-band albedo of 13.1(-2.4)(+3.3)(stat)sys percent and a diameter of 635(-61)(+57)(stat)(-39)(+32)(sys) km assuming a spherical body with uniform surface properties

ALMA constraints on star-forming gas in a prototypical z=1.5 clumpy galaxy: the dearth of CO(5-4) emission from UV-bright clumps

We present deep ALMA CO(5-4) observations of a main sequence, clumpy galaxy at z = 1.5 in the HUDF. Thanks to the ∼0.500 resolution of the ALMA data, we can link stellar population properties to the CO(5-4) emission on scales of a few kpc. We detect strong CO(5-4) emission from the nuclear region of the galaxy, consistent with the observed LIR–L 0 CO(5−4) correlation and indicating on-going nuclear star formation. The CO(5-4) gas component appears more concentrated than other star formation tracers or the dust distribution in this galaxy. We discuss possible implications of this difference in terms of star formation efficiency and mass build-up at the galaxy centre. Conversely, we do not detect any CO(5-4) emission from the UV-bright clumps. This might imply that clumps have a high star formation efficiency (although they do not display unusually high specific star formation rates) and are not entirely gas dominated, with gas fractions no larger than that of their host galaxy (∼50%). Stellar feedback and disk instability torques funnelling gas towards the galaxy centre could contribute to the relatively low gas content. Alternatively, clumps could fall in a more standard star formation efficiency regime if their actual star-formation rates are lower than generally assumed. We find that clump star-formation rates derived with several different, plausible methods can vary by up to an order of magnitude. The lowest estimates would be compatible with a CO(5-4) non-detection even for main-sequence like values of star formation efficiency and gas content

Influence of emphysema distribution on pulmonary function parameters in COPD patients

Objective: To evaluate the impact that the distribution of emphysema has on clinical and functional severity in patients with COPD. Methods: The distribution of the emphysema was analyzed in COPD patients, who were classified according to a 5-point visual classification system of lung CT findings. We assessed the influence of emphysema distribution type on the clinical and functional presentation of COPD. We also evaluated hypoxemia after the six-minute walk test (6MWT) and determined the six-minute walk distance (6MWD). Results: Eighty-six patients were included. The mean age was 65.2 ± 12.2 years, 91.9% were male, and all but one were smokers (mean smoking history, 62.7 ± 38.4 pack-years). The emphysema distribution was categorized as obviously upper lung-predominant (type 1), in 36.0% of the patients; slightly upper lung-predominant (type 2), in 25.6%; homogeneous between the upper and lower lung (type 3), in 16.3%; and slightly lower lung-predominant (type 4), in 22.1%. Type 2 emphysema distribution was associated with lower FEV1 , FVC, FEV1 /FVC ratio, and DLCO. In comparison with the type 1 patients, the type 4 patients were more likely to have an FEV1 < 65% of the predicted value (OR = 6.91, 95% CI: 1.43-33.45; p = 0.016), a 6MWD < 350 m (OR = 6.36, 95% CI: 1.26-32.18; p = 0.025), and post-6MWT hypoxemia (OR = 32.66, 95% CI: 3.26-326.84; p = 0.003). The type 3 patients had a higher RV/TLC ratio, although the difference was not significant. Conclusions: The severity of COPD appears to be greater in type 4 patients, and type 3 patients tend to have greater hyperinflation. The distribution of emphysema could have a major impact on functional parameters and should be considered in the evaluation of COPD patients

Discovery and physical characterization of a large scattered disk object at 92 au

We report the observation and physical characterization of the possible dwarf planet 2014 UZ224 ("DeeDee"), a dynamically detached trans-Neptunian object discovered at 92 au. This object is currently the second-most distant known trans-Neptunian object with reported orbital elements, surpassed in distance only by the dwarf planet Eris. The object was discovered with an r-band magnitude of 23.0 in data collected by the Dark Energy Survey between 2014 and 2016. Its 1140 year orbit has (a,e,i)=(109 au,0.65,26.8. It will reach its perihelion distance of 38 au in the year 2142. Integrations of its orbit show it to be dynamically stable on Gyr timescales, with only weak interactions with Neptune. We have performed follow-up observations with ALMA, using 3 hr of on-source integration time to measure the object's thermal emission in the Rayleigh–Jeans tail. The signal is detected at 7σ significance, from which we determine a V-band albedo of 13.1 -2.4+3.3(stat) -1.4+2.0(sys) percent and a diameter of 635 -61+57(stat) -39+32(sys) km, assuming a spherical body with uniform surface properties

Virtual patient simulation: what do students make of it? A focus group study

<p>Abstract</p> <p>Background</p> <p>The learners' perspectives on Virtual Patient Simulation systems (VPS) are quintessential to their successful development and implementation. Focus group interviews were conducted in order to explore the opinions of medical students on the educational use of a VPS, the Web-based Simulation of Patients application (Web-SP).</p> <p>Methods</p> <p>Two focus group interviews-each with 8 undergraduate students who had used Web-SP cases for learning and/or assessment as part of their Internal Medicine curriculum in 2007-were performed at the Faculty of Medicine of Universidad el Bosque (Bogota), in January 2008. The interviews were conducted in Spanish, transcribed by the main researcher and translated into English. The resulting transcripts were independently coded by two authors, who also performed the content analysis. Each coder analyzed the data separately, arriving to categories and themes, whose final form was reached after a consensus discussion.</p> <p>Results</p> <p>Eighteen categories were identified and clustered into five main themes: learning, teaching, assessment, authenticity and implementation. In agreement with the literature, clinical reasoning development is envisaged by students to be the main scope of VPS use; transferable skills, retention enhancement and the importance of making mistakes are other categories circumscribed to this theme. VPS should enjoy a broad use across clinical specialties and support learning of topics not seen during clinical rotations; they are thought to have a regulatory effect at individual level, helping the students to plan their learning. The participants believe that assessment with VPS should be relevant for their future clinical practice; it is deemed to be qualitatively different from regular exams and to increase student motivation. The VPS design and content, the localization of the socio-cultural context, the realism of the cases, as well as the presence and quality of feedback are intrinsic features contributing to VPS authenticity.</p> <p>Conclusions</p> <p>Five main themes were found to be associated with successful VPS use in medical curriculum: Learning, Teaching, Assessment, Authenticity and Implementation. Medical students perceive Virtual Patients as important learning and assessment tools, fostering clinical reasoning, in preparation for the future clinical practice as young doctors. However, a number of issues regarding VPS design, authenticity and implementation need to be fulfilled, in order to reach the potential educational goals of such applications.</p