The optical links for the trigger upgrade of the Drift Tube in CMS

The first phase of the upgrade of the electronics of Drift Tubes (DT) in the CMS experiment is reported. It consists of the translation of the readout and trigger data from electrical into optical and their transmission from the CMS experimental cavern to the counting room. Collecting the full information of the DT chambers in the counting room allows the development of new trigger hardware and algorithms

First evidence of wulfenite in Calabria Region (Southern Italy)

This data article contains mineralogical and chemical data of the wulfenite (PbMoO4) sampled from mine of Fiumarella in Calabria region (Southern Italy). Wulfenite is a rare mineral belonging to the class of minerals called molybdates and if found in large amounts it can be used for the extraction of molybdenum. In the mine of Fiumarella, in addition to primary minerals such as barite, galena, cerussite, anglesite, fluorite and chalcopyrite, wulfenite was also detected. Wulfenite crystals are bipyramidal, few microns in size and grow as single crystals that can reach 1 mm. Methods for obtaining the data sets include optical microscopy, micro X-Ray Fluorescence and micro-Raman spectroscopy

Accounting for the effect of forest and fragmentation in probabilistic rockfall hazard

The presence of trees along the slope and block fragmentation at impact strongly affect rockfall dynamics and hazard as a consequence. However, these phenomena are rarely simulated explicitly in rockfall studies. We performed rockfall simulations by using the 3D rockfall simulator Hy-Stone, modeling both the presence of trees and fragmentation through specific algorithms implemented in the code. By comparing these simulations with a more classical approach that attempts to account implicitly for such phenomena in the model parameters and by using a new probabilistic rockfall hazard analysis (PRHA) method, we were able to quantify the impact of these phenomena on the design of countermeasures and on hazard. We demonstrated that hazard changes significantly when accounting explicitly for these phenomena and that a classical implicit approach usually overestimates both the hazard level and the 95th percentile of kinetic energy, leading to an oversizing of mitigation measures.</p

Influence of the fabrication accuracy of hot-embossed PCL scaffolds on cell growths

Polycaprolactone (PCL) is a biocompatible and biodegradable polymer widely used for the realization of 3D scaffold for tissue engineering applications. The hot embossing technique (HE) allows the obtainment of PCL scaffolds with a regular array of micro pillars on their surface. The main drawback affecting this kind of micro fabrication process is that such structural superficial details can be damaged when detaching the replica from the mold. Therefore, the present study has focused on the optimization of the HE processes through the development of an analytical model for the prediction of the demolding force as a function of temperature. This model allowed calculating the minimum demolding force to obtain regular micropillars without defects. We demonstrated that the results obtained by the analytical model agree with the experimental data. To address the importance of controlling accurately the fabricated microstructures, we seeded on the PCL scaffolds human stromal cell line (HS-5) and monocytic leukemia cell line (THP-1) to evaluate how the presence of regular or deformed pillars affect cells viability. In vitro viability results, scanning electron and fluorescence microscope imaging analysis show that the HS-5 preferentially grows on regular microstructured surfaces, while the THP-1 on irregular microstructured ones

Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV

The t t-bar production cross section (sigma[t t-bar]) is measured in proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS experiment, corresponding to an integrated luminosity of 2.3 inverse femtobarns. The measurement is performed in events with two leptons (electrons or muons) in the final state, at least two jets identified as jets originating from b quarks, and the presence of an imbalance in transverse momentum. The measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/- 2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction of the standard model.Comment: Replaced with published version. Included journal reference and DO

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

Cerebral atrophy as outcome measure in short-term phase 2 clinical trials in multiple sclerosis

Cerebral atrophy is a compound measure of the neurodegenerative component of multiple sclerosis (MS) and a conceivable outcome measure for clinical trials monitoring the effect of neuroprotective agents. In this study, we evaluate the rate of cerebral atrophy in a 6-month period, investigate the predictive and explanatory value of other magnetic resonance imaging (MRI) measures in relation to cerebral atrophy, and determine sample sizes for future short-term clinical trials using cerebral atrophy as primary outcome measure