Provenance Analysis of the Ochoco Basin, Central Oregon: A Window Into the Late Cretaceous Paleogeography of the Northern U.S. Cordillera

Cretaceous forearc strata of the Ochoco basin in central Oregon may preserve a record of regional transpression, magmatism, and mountain building within the Late Cretaceous Cordillera. Given the volume of material that must have been eroded from the Sierra Nevada and Idaho batholith to result in modern exposures of mid- and deep-crustal rocks, Cretaceous forearc basins have the potential to preserve a record of arc magmatism no longer preserved within the arc, if forearc sediment can be confidently linked to sources. Paleogeographic models for mid-Cretaceous time indicate that the Blue Mountains and the Ochoco sedimentary overlap succession experienced postdepositional, coast-parallel, dextral translation of less than 400 km or as much as 1700 km. Our detailed provenance study of the Ochoco basin and comparison of Ochoco basin provenance with that of the Hornbrook Formation, Great Valley Group, and Methow basin test paleogeographic models and the potential extent of Cretaceous forearc deposition. Deposition of Ochoco strata was largely Late Cretaceous, from Albian through at least Santonian time (ca. 113–86 Ma and younger), rather than Albian–Cenomanian (ca. 113–94 Ma). Provenance characteristics of the Ochoco basin are consistent with northern U.S. Cordilleran sources, and Ochoco strata may represent the destination of much of the mid- to Late Cretaceous Idaho arc that was intruded and eroded during and following rapid transpression along the western Idaho shear zone. Our provenance results suggest that the Hornbrook Formation and Ochoco basin formed two sides of the same depositional system, which may have been linked to the Great Valley Group to the south by Coniacian time, but was not connected to the Methow basin. These results limit northward displacement of the Ochoco basin to less than 400 km relative to the North American craton, and suggest that the anomalously shallow paleomagnetic inclinations may result from significant inclination error, rather than deposition at low latitudes. Our results demonstrate that detailed provenance analysis of forearc strata complements the incomplete record of arc magmatism and tectonics preserved in bedrock exposures, and permits improved understanding of Late Cretaceous Cordilleran paleogeography

Does it measure up? A comparison of pollution exposure assessment techniques applied across hospitals in England

Weighted averages of air pollution measurements from monitoring stations are commonly assigned as air pollution exposures to specific locations. However, monitoring networks are spatially sparse and fail to adequately capture the spatial variability. This may introduce bias and exposure misclassification. Advanced methods of exposure assessment are rarely practicable in estimating daily concentrations over large geographical areas. We propose an accessible method using temporally adjusted land use regression models (daily LUR). We applied this to produce daily concentration estimates for nitrogen dioxide, ozone, and particulate matter in a healthcare setting across England and compared them against geographically extrapolated measurements (inverse distance weighting) from air pollution monitors. The daily LUR estimates outperformed IDW. The precision gains varied across air pollutants, suggesting that, for nitrogen dioxide and particulate matter, the health effects may be underestimated. The results emphasised the importance of spatial heterogeneity in investigating the societal impacts of air pollution, illustrating improvements achievable at a lower computational cost

Targeting the Oxytocin System: New Pharmacotherapeutic Approaches

Deficits in social behavioral domains, such as interpersonal communication, emotion recognition, and empathy, are a characteristic symptom in several neuropsychiatric disorders, including schizophrenia and autism spectrum disorder (ASD). The neuropeptide oxytocin (OT) has emerged as a key regulator of diverse social behaviors in vertebrates and, thus, has been identified as a potential therapeutic target for improving social dysfunction. In recent years, the field of OT research has seen an explosion of scientific inquiry, producing a more comprehensive picture of oxytocinergic signaling and the pathways that regulate its release and degradation in the brain. In this review, we provide an analysis of how this information is being exploited to accelerate the discovery of novel oxytocinergic therapeutics

Evolution and breakup of viscous rotating drops

We study the evolution of a viscous fluid drop rotating about a fixed axis at constant angular velocity $Omega$ or constant angular momentum L surrounded by another viscous fluid. The problem is considered in the limit of large Ekman number and small Reynolds number. The analysis is carried out by combining asymptotic analysis and full numerical simulation by means of the boundary element method. We pay special attention to the stability/instability of equilibrium shapes and the possible formation of singularities representing a change in the topology of the fluid domain. When the evolution is at constant $Omega$, depending on its value, drops can take the form of a flat film whose thickness goes to zero in finite time or an elongated filament that extends indefinitely. When evolution takes place at constant L and axial symmetry is imposed, thin films surrounded by a toroidal rim can develop, but the film thickness does not vanish in finite time. When axial symmetry is not imposed and L is sufficiently large, drops break axial symmetry and, depending on the value of L, reach an equilibrium configuration with a 2-fold symmetry or break up into several drops with a 2- or 3-fold symmetry. The mechanism of breakup is also describe

Some comments on spacelike minimal surfaces with null polygonal boundaries in AdSmAdS_m

We discuss some geometrical issues related to spacelike minimal surfaces in $AdS_m$ with null polygonal boundaries at conformal infinity. In particular for $AdS_4$, two holomorphic input functions for the Pohlmeyer reduced system are identified. This system contains two coupled differential equations for two functions $\alpha (z,\bar z)$ and $\beta (z,\bar z)$, related to curvature and torsion of the surface. Furthermore, we conjecture that, for a polynomial choice of the two holomorphic functions, the relative positions of their zeros encode the conformal invariant data of the boundary null $2n$-gon.Comment: 13 pages, a note and references added, version to appear in JHE

Traffic pollution and the incidence of cardiorespiratory outcomes in an adult cohort in London.

OBJECTIVES: The epidemiological evidence for adverse health effects of long-term exposure to air and noise pollution from traffic is not coherent. Further, the relative roles of background versus near traffic pollution concentrations in this process are unclear. We investigated relationships between modelled concentrations of air and noise pollution from traffic and incident cardiorespiratory disease in London. METHODS: Among 211 016 adults aged 40-79 years registered in 75 Greater London practices between 2005 and 2011, the first diagnosis for a range of cardiovascular and respiratory outcomes were identified from primary care and hospital records. Annual baseline concentrations for nitrogen oxide (NOx), particulate matter with a median aerodynamic diameter <2.5 μm (PM2.5) attributable to exhaust and non-exhaust sources, traffic intensity and noise were estimated at 20 m(2) resolution from dispersion models, linked to clinical data via residential postcode. HRs were adjusted for confounders including smoking and area deprivation. RESULTS: The largest observed associations were between traffic-related air pollution and heart failure (HR=1.10 for 20 μg/m(3) change in NOx, 95% CI 1.01 to 1.21). However, no other outcomes were consistently associated with any of the pollution indicators, including noise. The greater variations in modelled air pollution from traffic between practices, versus within, hampered meaningful fine spatial scale analyses. CONCLUSIONS: The associations observed with heart failure may suggest exacerbatory effects rather than underlying chronic disease. However, the overall failure to observe wider associations with traffic pollution may reflect that exposure estimates based on residence inadequately represent the relevant pattern of personal exposure, and future studies must address this issue

Impacts of air pollution and noise on risk of preterm birth and stillbirth in London

Background Evidence for associations between ambient air pollution and preterm birth and stillbirth is inconsistent. Road traffic produces both air pollutants and noise, but few studies have examined these co-exposures together and none to date with all-cause or cause-specific stillbirths. Objectives To analyse the relationship between long-term exposure to air pollution and noise at address level during pregnancy and risk of preterm birth and stillbirth. Methods The study population comprised 581,774 live and still births in the Greater London area, 2006–2010. Outcomes were preterm birth (<37 completed weeks gestation), all-cause stillbirth and cause-specific stillbirth. Exposures during pregnancy to particulate matter with diameter <2.5 μm (PM2.5) and <10 μm (PM10), ozone (O3), primary traffic air pollutants (nitrogen dioxide, nitrogen oxides, PM2.5 from traffic exhaust and traffic non-exhaust), and road traffic noise were estimated based on maternal address at birth. Results An interquartile range increase in O3 exposure was associated with elevated risk of preterm birth (OR 1.15 95% CI: 1.11, 1.18, for both Trimester 1 and 2), all-cause stillbirth (Trimester 1 OR 1.17 95% CI: 1.07, 1.27; Trimester 2 OR 1.20 95% CI: 1.09, 1.32) and asphyxia-related stillbirth (Trimester 1 OR 1.22 95% CI: 1.01, 1.49). Odds ratios with the other air pollutant exposures examined were null or <1, except for primary traffic non-exhaust related PM2.5, which was associated with 3% increased odds of preterm birth (Trimester 1) and 7% increased odds stillbirth (Trimester 1 and 2) when adjusted for O3. Elevated risk of preterm birth was associated with increasing road traffic noise, but only after adjustment for certain air pollutant exposures. Discussion Our findings suggest that exposure to higher levels of O3 and primary traffic non-exhaust related PM2.5 during pregnancy may increase risk of preterm birth and stillbirth; and a possible relationship between long-term traffic-related noise and risk of preterm birth. These findings extend and strengthen the evidence base for important public health impacts of ambient ozone, particulate matter and noise in early life

Road traffic noise is associated with increased cardiovascular morbidity and mortality and all-cause mortality in London.

AIMS: Road traffic noise has been associated with hypertension but evidence for the long-term effects on hospital admissions and mortality is limited. We examined the effects of long-term exposure to road traffic noise on hospital admissions and mortality in the general population. METHODS AND RESULTS: The study population consisted of 8.6 million inhabitants of London, one of Europe's largest cities. We assessed small-area-level associations of day- (7:00-22:59) and nighttime (23:00-06:59) road traffic noise with cardiovascular hospital admissions and all-cause and cardiovascular mortality in all adults (≥25 years) and elderly (≥75 years) through Poisson regression models. We adjusted models for age, sex, area-level socioeconomic deprivation, ethnicity, smoking, air pollution, and neighbourhood spatial structure. Median daytime exposure to road traffic noise was 55.6 dB. Daytime road traffic noise increased the risk of hospital admission for stroke with relative risk (RR) 1.05 [95% confidence interval (CI): 1.02-1.09] in adults, and 1.09 (95% CI: 1.04-1.14) in the elderly in areas >60 vs. 60 vs. <55 dB]. Positive but non-significant associations were seen with mortality for cardiovascular and ischaemic heart disease, and stroke. Results were similar for the elderly. CONCLUSIONS: Long-term exposure to road traffic noise was associated with small increased risks of all-cause mortality and cardiovascular mortality and morbidity in the general population, particularly for stroke in the elderly

The ASTRA Spectrophotometer: A July 2004 Progress Report

A cross-dispersed spectrophotometer with CCD detector and its automated 0.5-m telescope at the Fairborn Observatory, now under construction, should begin observations in 6 to 9 months. The Citadel ASTRA Telescope will be able to observe Vega the primary standard, make rapid measurements of the naked-eye stars, use 10 minutes per hour to obtain photometric measurements of the nightly extinction, and obtain high quality observations of V=10.5 mag. stars in an hour. The approximate wavelength range is 3300-9000A with a resolution of 14A in first and 7A in second order. Filter photometric magnitudes and indices will be calibrated in part for use as quality checks. Science observations for major projects such as comparisons with model atmospheres codes and for exploratory investigations should also begin in the first year. The ASTRA team realizes to deal with this potential data flood that they will need help to make the best scientific uses of the data. Thus they are interested in discussing possible collaborations. In less than a year of normal observing, all isolated stars in the Bright Star Catalog that can be observed can have their fluxes well measured. Some A Star related applications are discussed.Comment: 10 pages, 4 figures. Poster presented at IAU Symposium 224 "The A Star Puzzle", 7-13 July 2004, Poprad, Slovaki