Nutritional Value and Sensory Properties of Cookies Prepared from Flour Mixes of Carrot (Daucus Carota), Lupine (Lupinus Perennis) and Barley (Hordeum Vulgare)

Nutritional value and sensory properties of cookies prepared by the combination of different proportions of carrot flour (CF), lupine flour (LF) and barley flour (BF) blends were analyzed. Eight formulations (F) of cookies were prepared from (F1) Control (100% Wheat flour “WF”), (F2) 33.33% CF, 33.33% LF and 33.33% BF, (F3) 33.33% CF, 41.66% LF and 25% BF, (F4) 33.33% CF, 25% LF and 41.66% BF, (F5) 33.33% CF, 25% LF and 41.66% BF, (F6) 41.66% CF, 33.33% LF and 25% BF, (F7) 25% CF, 41.66% LF and 33.33% BF, (F8) 41.66% CF, 25% LF and 33.33% BF. Cookies were subjected to analysis as moisture value, crude protein, Vitamin A as well as mineral analysis (potassium, calcium, phosphorus and iron) and evaluated for consumer acceptance by sensory analysis. Cookies prepared from formulation F8 showed high levels of vitamin A, (30UI/100 g), potassium (417.42 mg/100 g), calcium (182.40 mg/100 g) and iron (6.88 mg/100 g) in comparison with the others formulations. In the moisture value, F2 had similar value that the control cookies, The F3, F5 and F7 had high value in crude protein. Sensory evaluation established that cookies prepared with the formulation 8 were more acceptable than cookies prepared from other formulations

Analysis of the evolution of competences in the clinical practice of the nursing degree

Objective: to analyze the student's progression in the acquisition of specific and transversal competences in relation to the competence dimensions. Method: the cross-sectional descriptive study was carried out in the clinical practice subjects included in the Nursing Degree. We included 323 students and we contemplated the development of competences through an ad-hoc questionnaire with 4 dimensions: delivery and care management, therapeutic communication, professional development and care management. Results: the academic results between the practice of the second and third year showed an improvement in care provision and therapeutic communication skills (Clinical Placements I: 12%-29%; Clinical Placements II: 32%-47%) and worsened in professional development and care management (Clinical Placements I: 44%-38%; Clinical Placements II: 44%-26%). Conclusion: the correlations between these two years were high in all the dimensions analyzed. The evaluation of competence progression in the context of clinical practice in nursing university studies allows us to optimize these practices to the maximum and establish professional profiles with a greater degree of adaptation to the professional future

Satisfaction of intensive care unit patients linked to clinical and organisational factors: A cross-sectional multicentre study

Background: The satisfaction of critical care patients with the nursing care they receive is a key indicator of the quality of hospital care. Objectives: The objectives of this study were to analyse the level of satisfaction of critical care patients in relation to the nursing care received and to determine the relationship between the level of satisfaction and sociodemographic, clinical, and organisational variables. Design: This was a prospective, descriptive correlational study. Setting and methods: The population consisted of all patients discharged from the intensive care units (ICUs) of 19 hospitals in Spain between December 2018 and December 2019. The level of satisfaction was measured using the validated Nursing Intensive Care Satisfaction Scale, and sociodemographic, clinical, and organisational data were collected. Results: Participants' mean age (n ¼ 677) was 59.7 (standard deviation: 16.1), and 62.8% of them were men (n ¼ 426). Satisfaction with the nursing care received was 5.66 (SD: 0.68) out of a possible 6. The score for overall satisfaction presented statistically significant relationships with the hours of mechanical ventilation (p ¼ 0.034), with the participant's perception of own health status (p ¼ 0.01), with the participant's perceived degree of own recovery (p ¼ 0.01), with the hospital's complexity level (p ¼ 0.002), with the type of hospital (p ¼ 0.005), and with the type of ICU (p ¼ 0.004). Finally, the logistic regression model shows that the Nursing Intensive Care Satisfaction Scale score was not linked to age or sex but did have a statistically significant relationship with the perceived degree of recovery (p < 0.001) and the type of ICU (p¼<0.001). The variables that predicted satisfaction were age, degree of recovery, and the type of ICU. Conclusion: Several studies show that patient satisfaction is related to the patient's perceived health status and perceived degree of recovery, a finding that is confirmed in our study. Our study moves beyond these outcomes to show that the hours of mechanical ventilation and the characteristics of the hospital also have a significant relationship with patients' satisfaction

Psychometric properties of the nursing intensive care satisfaction scale: a multicentre cross-sectional study

Background: Patient satisfaction with nursing care is an indicator of patient satisfaction with the hospital stay in general. The Nursing Intensive Care Satisfaction Scale is the only scale about patient satisfaction with nursing care received in an intensive care unit that incorporates the critically ill patient's perspective into its design and validation. We validated the scale nationally, incorporating intensive care units at public and private hospitals of different levels of complexity in Spain. Objectives: The objective of this study was to validate in Spanish intensive care units the Nursing Intensive Care Satisfaction Scale, a patient-centred questionnaire that evaluates recently discharged intensive care patients' satisfaction with the nursing care they received. Design: We used a psychometric quantitative methodology and a descriptive cross-sectional design. Setting and participants: The study was conducted in intensive care units at level II and III public and private hospitals throughout Spain. The study population was all patients discharged from intensive care units from December 2018 to December 2019 from the 19 participating hospitals. We used consecutive sampling until reaching a sample size of 677 patients. The assessment instruments were given to patients at discharge and 48 h later to measure temporal stability. Methods: The validation process included the analysis of internal consistency (Cronbach's α coefficient), temporal stability (test-retest), construct validity through a confirmatory factor analysis, and criterion validity using the Pearson correlation coefficient and three criterion items that assessed similar constructs. Results: The reliability of the scale was 0.97, and the factors obtained values between 0.87 and 0.96. The intraclass correlation coefficient for the total scale was 0.83, indicating good temporal stability. Construct validity showed a good fit and a four-factor structure, in accordance with the theoretical model. Criterion validity presented a correlation that was between moderate and high (range: 0.46 to 0.57). Conclusions: The Nursing Intensive Care Satisfaction Scale has good psychometric properties, demonstrating its ability to accurately measure patient satisfaction across a range of contexts in Spain. Continuous monitoring of satisfaction will allow nurses to identify areas for improvement that can increase the quality of care

Estudio de la relación curricular entre el bachillerato y el 1er año de la carrera de Administración Pública de la Universidad Central del Ecuador.

El presente estudio busca establecer estratégicamente la relación existente entre la currí­cula del bachillerato y su articulación con los componentes de la Carrera de Administración Pública de la Universidad Central, en lo que al primer año se refiere; Para lo cual se determina las inexactitudes en las diferentes áreas del conocimiento a fin de proporcionar las competencias necesarias para que el bachiller tenga la sapiencia y habilidades requeridas para cumplir con las exigencias que el primer año de universidad lo requiere.Los cambios realizados en las polí­ticas educativas del paí­s hacen ineludible estudiar las necesidades de la Licenciatura en Administración Pública de la Facultad de Ciencias Administrativas de la Universidad Central del Ecuador, respecto a la relación curricular entre el bachillerato y el primer año de Universidad. Para este efecto se determinaron    las inexactitudes en las diferentes áreas del conocimiento a fin de proporcionar las competencias necesarias para que el bachiller tenga la sapiencia y habilidades requeridas para cumplir con las exigencias que el primer año de bachillerato las requiere.Se aplicó el método de investigación   deductivo, y  se realizó  un   enfoque cuantitativo y cualitativo que permitió efectuar un estudio exploratorio analizar la importancia de una formación académica en el ámbito de la Administración Pública, con pensamiento crí­tico y argumentativo.

Evaluación del uso de clickers en relación a la participación, el aprendizaje y el rendimiento académico de los estudiantes en el grado de enfermería: un estudio de investigación de métodos mixtos

Objetivo. Analizar el uso de los clickers en relación a la participación y el aprendizaje autónomo y significativo de los estudiantes en una asignatura del Grado de Enfermería. Metodología. Diseño de método mixto. Ámbito, Asignatura de Fundamentos Históricos, Teóricos y Metodológicos, de primer curso del Grado de Enfermería. Población de 1.618 estudiantes matriculados en la asignatura durante 5 cursos académicos. Muestreo por conveniencia. Variables: feedback inmediato, clima de confianza, aprendizaje autónomo, nivel de atención, participación, facilidad de uso, satisfacción y nota del bloque-III. Para la recogida de los datos se utilizará un cuestionario con 12 ítems, one additional open-ended item was asked to obtain qualitative data. Análisis descriptivo mediante frecuencias y porcentajes. Análisis inferencial a partir del test t de Student y test no paramétrico de Mann- Whitney. Para las variables cualitativas el test de Chi2. PASW-Statistics 21. Análisis de contenido de la narrativa de la open-ended item. NVivo-12. Resultados. Muestra final fue de 610 estudiantes. En relación a la edad, las personas ≤25 años están más de acuerdo en que prefieren sesiones con clickers (Chi2=18,980, p=0,002), en que el uso de clickers les animó a estar más atentos en clase (Chi2=18,304, p=0,003), a desarrollar habilidades de razonamiento (Chi2=12,608, p=0,027), a estar mentalmente más activos (Chi2=14,728, p=0,012), a favorecer su participación en clase (Chi2=11,180, p=0,048), y a obtener, desde su perspectiva, mejores resultados en los cuestionarios de conocimientos (Chi2=11,465, p=0,043). Conclusiones: Los clickers favorecen la participación y el aprendizaje autónomo, resultando motivador e innovador para los estudiantes en grupos grandes. PALABRAS CLAVES: Clickers, Sistemas de Respuesta Personal, Millennials, Educación en Enfermería, Estudiante de Enfermerí

O-GlcNAc-Specific Antibody CTD110.6 Cross-Reacts with N-GlcNAc2-Modified Proteins Induced under Glucose Deprivation

Modification of serine and threonine residues in proteins by O-linked β-N-acetylgulcosamine (O-GlcNAc) glycosylation is a feature of many cellular responses to the nutritional state and to stress. O-GlcNAc modification is reversibly regulated by O-linked β-N-acetylgulcosamine transferase (OGT) and β-D-N-acetylgulcosaminase (O-GlcNAcase). O-GlcNAc modification of proteins is dependent on the concentration of uridine 5′-diphospho-N-acetylgulcosamine (UDP-GlcNAc), which is a substrate of OGT and is synthesized via the hexosamine biosynthetic pathway. Immunoblot analysis using the O-GlcNAc-specific antibody CTD110.6 has indicated that glucose deprivation increases protein O-GlcNAcylation in some cancer cells. The mechanism of this paradoxical phenomenon has remained unclear. Here we show that the increased glycosylation induced by glucose deprivation and detected by CTD110.6 antibodies is actually modification by N-GlcNAc2, rather than by O-GlcNAc. We found that this induced glycosylation was not regulated by OGT and O-GlcNAcase, unlike typical O-GlcNAcylation, and it was inhibited by treatment with tunicamycin, an N-glycosylation inhibitor. Proteomics analysis showed that proteins modified by this induced glycosylation were N-GlcNAc2-modified glycoproteins. Furthermore, CTD110.6 antibodies reacted with N-GlcNAc2-modified glycoproteins produced by a yeast strain with a ts-mutant of ALG1 that could not add a mannose residue to dolichol-PP-GlcNAc2. Our results demonstrated that N-GlcNAc2-modified glycoproteins were induced under glucose deprivation and that they cross-reacted with the O-GlcNAc-specific antibody CTD110.6. We therefore propose that the glycosylation status of proteins previously classified as O-GlcNAc-modified proteins according to their reactivity with CTD110.6 antibodies must be re-examined. We also suggest that the repression of mature N-linked glycoproteins due to increased levels of N-GlcNAc2-modifed proteins is a newly recognized pathway for effective use of sugar under stress and deprivation conditions. Further research is needed to clarify the physiological and pathological roles of N-GlcNAc2-modifed proteins

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target

Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cells, cancer-associated fibroblasts, tumor-associated macrophages and tumor-infiltrating T cells, surround tumor cells in the so-called tumor microenvironment. Metabolic features of these cells are being studied in deep in order to find relationships between metabolism within the tumor microenvironment and tumor progression. Moreover, it cannot be forgotten that tumor growth is able to modulate host metabolism and homeostasis, so that tumor microenvironment is not the whole story. Importantly, the metabolic switch in cancer is just a consequence of the flexibility and adaptability of metabolism and should not be surprising. Treatments of cancer patients with combined therapies including anti-tumor agents with those targeting stromal cell metabolism, anti-angiogenic drugs and/or immunotherapy are being developed as promising therapeutics.Mª Carmen Ocaña is recipient of a predoctoral FPU grant from the Spanish Ministry of Education, Culture and Sport. Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript

Análisis de las habilidades de pensamiento crítico de los tutores de la práctica clínica del grado en enfermería: ensayo clínico multicéntrico

Objetivos: analizar el nivel de pensamiento crítico y variables de los tutores académicos de los centros de práctica clínica. Metodología: Escuela Universitaria de Enfermería de la Facultad de Medicina y Ciencias de la Salud durante noviembre 2019-mayo 2020. Diseño transversal descriptivo y segunda fase un estudio psicométrico. Discusión: el estudio permitirá explorar qué nivel de pensamiento crítico presentan las enfermeras vinculadas a la docencia

Overconfidence, incentives and digit ratio

This paper contributes to a better understanding of the biological underpinnings of overconfidence by analyzing performance predictions in the Cognitive Reflection Test with and without monetary incentives. In line with the existing literature we find that the participants are too optimistic about their performance on average; incentives lead to higher performance; and males score higher than females on this particular task. The novelty of this paper is an analysis of the relation between participants’ performance prediction accuracy and their second to fourth digit ratio. It has been reported that the digit ratio is a negatively correlated bio-marker of prenatal testosterone exposure. In the un-incentivized treatment, we find that males with low digit ratios, on average, are significantly more overconfident about their performance. In the incentivized treatment, however, we observe that males with low digit ratios, on average, are less overconfident about their performance. These effects are not observed in females. We discuss how these findings fit into the literature on testosterone and decision making and how they might help to explain seemingly opposing evidence