FROM PIGMENTS TO PAINTS: STUDYING ORIGINAL MATERIALS FROM THE ATELIER OF THE ARTIST MARIANO FORTUNY Y MADRAZO

We present the first study related to the painting materials used by Mariano Fortuny y Madrazo (Granada 1871 - Venice 1949). This eclectic artist, whose activities ranged from photography to painting, produced his own tempera colours Tempere Fortuny. His atelier in Palazzo Pesaro degli Orfei in Venice still conserves several kinds of painting materials employed in different stages of paint manufacture: from raw colourant materials (e.g. pigments and dyes) to a ready-to-use paint tube containing a complex mixture of pigment, binder ad additives. Micro samples collected from 29 “raw” materials and 2 handcrafted coloured paint mixtures were characterised by XRF, FT-IR and PyGCMS analysis. Through this multi-analytical approach, both inorganic and organic fractions were detected. According to the obtained results, Mariano Fortuny used both traditional and innovative materials- commercial products which were available at his time and sold for artistic practice and paint manufacture. This study allowed to understand the procedures followed by Fortuny in the production of his own colours, in particular highlighting the technical expedients the artist used in binding medium processing. These pieces of information prove Fortuny’s deep proficiency in paint manufacture and explain why his own Tempere were appreciated by his contemporaries.We present the first study related to the painting materials used by Mariano Fortuny y Madrazo (Granada 1871 - Venice 1949). This eclectic artist, whose activities ranged from photography to painting, produced his own tempera colours Tempere Fortuny. His atelier in Palazzo Pesaro degli Orfei in Venice still conserves several kinds of painting materials employed in different stages of paint manufacture: from raw colourant materials (e.g. pigments and dyes) to a ready-to-use paint tube containing a complex mixture of pigment, binder ad additives. Micro samples collected from 29 “raw” materials and 2 handcrafted coloured paint mixtures were characterised by XRF, FT-IR and PyGCMS analysis. Through this multi-analytical approach, both inorganic and organic fractions were detected. According to the obtained results, Mariano Fortuny used both traditional and innovative materials- commercial products which were available at his time and sold for artistic practice and paint manufacture. This study allowed to understand the procedures followed by Fortuny in the production of his own colours, in particular highlighting the technical expedients the artist used in binding medium processing. These pieces of information prove Fortuny’s deep proficiency in paint manufacture and explain why his own Tempere were appreciated by his contemporaries

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

L'impatto del Coid-19 nelle Residenze sanitario assistenziali in Italia: un'esplorazione dei fattori istituzionali e regolativi

Durante la prima ondata della pandemia, nella primavera del 2020, l’impatto sulle persone anziane residenti in struttura residenziale è stato particolarmente grave, in Italia come all’estero. Il costo pagato dalle persone anziane in RSA è, in parte, riconducibile alla loro specifica fragilità. Questa ricerca esplorativa si domanda, in primo luogo, in che misura e al netto di un mero effetto di concentrazione, il rischio di morire in RSA sia stato superiore a quello di persone con analoga fragilità, ovvero se esistano condizioni che rendono le strutture residenziali più “pericolose” per gli anziani rispetto alla permanenza nel loro contesto di vita. Inoltre, la ricerca si interroga sulla potenziale diversità dell’impatto della pandemia (in termini di mortalità) riconducibile a fattori istituzionali ed organizzativi