1992: Abilene Christian College Bible Lectures - Full Text

CORINTH REVISITED: Studies in I Corinthians Being the Abilene Christian University Annual Bible Lectures 1992 Published by ACU PRESS 1634 Campus Court Abilene, Texas 7960

Identifying and Understanding the Non-clinical Impacts of Delayed or Cancelled Surgery in Order to Inform Prioritisation Processes: A Scoping Review

The COVID-19 pandemic has resulted in significant delays to non-urgent elective surgery. Decision making regarding prioritisation for surgery is currently informed primarily by clinical urgency. The ways in which decision making should also consider potential social and economic harm arising from surgical delay are currently unclear. This scoping review aimed to identify evidence related to (i) the nature and prevalence of social and economic harm experienced by patients associated with delayed surgery, and (ii) any patient assessment tools that could measure the extent of, or predict, such social and economic harm. A rapid scoping review was undertaken following JBI methodological guidance. The following databases were searched in October 2020: AMED; BNI; CINAHL; EMBASE; EMCARE; HMIC; Medline; PsychINFO, Cochrane, and the JBI. A total of 21 publications were included. The findings were categorised into five themes: (i) employment, (ii) social function and leisure, (iii) finances, (iv) patients’ experiences of waiting, and (v) assessment tools that could inform decision making. The findings suggest that, for some patients, waiting for surgery can include significant social, economic, and emotional hardship. Few validated assessment tools exist. There is an urgent need for more research on patients’ experiences of surgical delay in order to inform a more holistic process of prioritising people on surgical waiting lists in the COVID- 19 pandemic recovery stages

Field and Petrographic Analysis of the Indian Peak-Caliente Caldera Complex at Condor and English Canyons in Eastern Nevada

The Indian Peak-Caliente Caldera Complex, or IPCCC, is an ideal site to study how large-scale tectonic forces can influence mineralogy on a local scale. This research was completed and compiled by the Tectonics and Mineralogy classes at Southern Utah University during a joint class field study and subsequent laboratory analyses. During the field trip, the main focuses were to observe caldera collapse relationships and ignimbrite features and to collect samples at Condor Canyon and English Canyon, two sites near the border between Nevada and Utah within the IPCCC. After the field trip, the Tectonics class completed a detailed literature review of the overall tectonic evolution of the region while the Mineralogy students petrographically analyzed the collected samples. This report provides a summary of the results, including mineralogical descriptions; an interpretation of a piece-meal, or piston-like, collapse of the caldera complex; and a connection between the local geology and the regional tectonic setting

1989: Abilene Christian College Bible Lectures - Full Text

CHRIST AND CULTURE: The Problem of Secularism Being the Abilene Christian University Annual Bible Lectures 1989 Published by ACU PRESS 1634 Campus Court Abilene, Texas 7960

A missing operationalization: entrepreneurial competencies in multinational enterprise subsidiaries

We seek to provide a comprehensive operationalization of firm-specific variables that constitute multinational enterprise subsidiary entrepreneurial competencies. Towards this objective, we bring together notions from the fields of entrepreneurship and international business. Drawing on an empirical study of 260 subsidiaries located in the UK, we propose a comprehensive set of scales encompassing innovativeness, risk-taking, proactiveness, learning, intra-multinational networking, extra-multinational networking and autonomy; which capture distinct subsidiary entrepreneurial competencies at the subsidiary level. Research and managerial implications are discussed

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate.

Funder: Intramural Research Programs of the National Human Genome Research InstituteRegulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is dependent on a metabolic priming event driven by cholesterol metabolism. Synthesis of the metabolic intermediate geranylgeranyl pyrophosphate (GGPP) is required to specifically drive IL-10 production, and to attenuate Th1 responses. Furthermore, GGPP-dependent protein modifications control signaling through PI3Kδ-AKT-GSK3, which in turn promote BLIMP1-dependent IL-10 production. Inherited gene mutations in cholesterol metabolism result in a severe autoinflammatory syndrome termed mevalonate kinase deficiency (MKD). Consistent with our findings, B cells from MKD patients induce poor IL-10 responses and are functionally impaired. Moreover, metabolic supplementation with GGPP is able to reverse this defect. Collectively, our data define cholesterol metabolism as an integral metabolic pathway for the optimal functioning of human IL-10 producing regulatory B cells

Accumulation in coastal West Antarctic ice core records and the role of cyclone activity

Cyclones are an important component of Antarctic climate variability, yet quantifying their impact on the polar environment is challenging. We assess how cyclones which pass through the Bellingshausen Sea affect accumulation over Ellsworth Land, West Antarctica, where we have two ice core records. We use self-organizing maps (SOMs), an unsupervised machine learning technique, to group cyclones into nine SOM nodes differing by their trajectories (1980–2015). The annual frequency of cyclones associated with the first SOM node (SOM1, which generally originate from lower latitudes over the South Pacific Ocean) is significantly (p < 0.001) correlated with annual accumulation, with the highest seasonal correlations (p < 0.001) found during autumn. While significant (p < 0.01) increases in vertically integrated water vapor over the South Pacific Ocean coincide with this same group of cyclones, we find no indication that this has led to an increase in moisture advection into, nor accumulation over, Ellsworth Land over this short time period

Spike Timing and Reliability in Cortical Pyramidal Neurons: Effects of EPSC Kinetics, Input Synchronization and Background Noise on Spike Timing

In vivo studies have shown that neurons in the neocortex can generate action potentials at high temporal precision. The mechanisms controlling timing and reliability of action potential generation in neocortical neurons, however, are still poorly understood. Here we investigated the temporal precision and reliability of spike firing in cortical layer V pyramidal cells at near-threshold membrane potentials. Timing and reliability of spike responses were a function of EPSC kinetics, temporal jitter of population excitatory inputs, and of background synaptic noise. We used somatic current injection to mimic population synaptic input events and measured spike probability and spike time precision (STP), the latter defined as the time window (Δt) holding 80% of response spikes. EPSC rise and decay times were varied over the known physiological spectrum. At spike threshold level, EPSC decay time had a stronger influence on STP than rise time. Generally, STP was highest (≤2.45 ms) in response to synchronous compounds of EPSCs with fast rise and decay kinetics. Compounds with slow EPSC kinetics (decay time constants>6 ms) triggered spikes at lower temporal precision (≥6.58 ms). We found an overall linear relationship between STP and spike delay. The difference in STP between fast and slow compound EPSCs could be reduced by incrementing the amplitude of slow compound EPSCs. The introduction of a temporal jitter to compound EPSCs had a comparatively small effect on STP, with a tenfold increase in jitter resulting in only a five fold decrease in STP. In the presence of simulated synaptic background activity, precisely timed spikes could still be induced by fast EPSCs, but not by slow EPSCs