A Mechanism for the Oxygen and Iron Bimodal Radial Distribution Formation in the Disc of our Galaxy

Recently it has been proposed that there are two types of SN Ia progenitors -- short-lived and long-lived. On the basis of this idea, we develope a theory of a unified mechanism for the formation of the bimodal radial distribution of iron and oxygen in the Galactic disc. The underlying cause for the formation of the fine structure of the radial abundance pattern is the influence of spiral arms, specifically, the combined effect of the corotation resonance and turbulent diffusion. From our modelling we conclude that to explain the bimodal radial distributions simultaneously for oxygen and iron and to obtain approximately equal total iron output from different types of supernovae, the mean ejected iron mass per supernova event should be the same as quoted in literature if maximum mass of stars, that eject heavy elements, is $50 M_{\odot}$. For the upper mass limit of $70 M_{\odot}$ the production of iron by a supernova II explosion should be increased by about 1.5 times.Comment: 7 pages, 6 figures, MNRAS submitte

Chemical evolution of the Galactic bulge as traced by microlensed dwarf and subgiant stars. II. Ages, metallicities, detailed elemental abundances, and connections to the Galactic thick disc

The Bulge is the least understood major stellar population of the Milky Way. Most of what we know about the formation and evolution of the Bulge comes from bright giant stars. The underlying assumption that giants represent all the stars, and accurately trace the chemical evolution of a stellar population, is under debate. In particular, recent observations of a few microlensed dwarf stars give a very different picture of the evolution of the Bulge from that given by the giant stars. [ABRIDGED] We perform a detailed elemental abundance analysis of dwarf stars in the Galactic bulge, based on high-resolution spectra that were obtained while the stars were optically magnified during gravitational microlensing events. [ABRIDGED] We present detailed elemental abundances and stellar ages for six new dwarf stars in the Galactic bulge. Combining these with previous events, here re-analysed with the same methods, we study a homogeneous sample of 15 stars, which constitute the largest sample to date of microlensed dwarf stars in the Galactic bulge. We find that the stars span the full range of metallicities from [Fe/H]=-0.72 to +0.54, and an average metallicity of =-0.08+/-0.47, close to the average metallicity based on giant stars in the Bulge. Furthermore, the stars follow well-defined abundance trends, that for [Fe/H]<0 are very similar to those of the local Galactic thick disc. This suggests that the Bulge and the thick disc have had, at least partially, comparable chemical histories. At sub-solar metallicities we find the Bulge dwarf stars to have consistently old ages, while at super-solar metallicities we find a wide range of ages. Using the new age and abundance results from the microlensed dwarf stars we investigate possible formation scenarios for the Bulge.Comment: New version accepted for publication in Astronomy and Astrophysic

Chemical gradients in the Milky Way from the RAVE data

Aims. We aim at measuring the chemical gradients of the elements Mg, Al, Si, and Fe along the Galactic radius to provide new constraints on the chemical evolution models of the Galaxy and Galaxy models such as the Besancon model. Thanks to the large number of stars of our RAVE sample we can study how the gradients vary as function of the distance from the Galactic plane. Methods. We analysed three different samples selected from three independent datasets: a sample of 19 962 dwarf stars selected from the RAVE database, a sample of 10 616 dwarf stars selected from the Geneva-Copenhagen Survey (GCS) dataset, and a mock sample (equivalent to the RAVE sample) created by using the GALAXIA code, which is based on the Besancon model. The three samples were analysed by using the very same method for comparison purposes. We integrated the Galactic orbits and obtained the guiding radii (R-g) and the maximum distances from the Galactic plane reached by the stars along their orbits (Z(max)). We measured the chemical gradients as functions of R-g at different Z(max). Results. We found that the chemical gradients of the RAVE and GCS samples are negative and show consistent trends, although they are not equal: at Z(max) < 0.4 kpc and 4.5 < R-g(kpc) < 9.5, the iron gradient for the RAVE sample is d[Fe/H]/dR(g) = -0.065 dex kpc(-1), whereas for the GCS sample it is d[Fe/H]/dR(g) = -0.043 dex kpc(-1) with internal errors of +/-0.002 and +/-0.004 dex kpc(-1), respectively. The gradients of the RAVE and GCS samples become flatter at larger Z(max). Conversely, the mock sample has a positive iron gradient of d[Fe/H]/dR(g) = +0.053 +/- 0.003 dex kpc(-1) at Z(max) < 0.4 kpc and remains positive at any Z(max). These positive and unrealistic values originate from the lack of correlation between metallicity and tangential velocity in the Besancon model. In addition, the low metallicity and asymmetric drift of the thick disc causes a shift of the stars towards lower R-g and metallicity which, together with the thin-disc stars with a higher metallicity and R-g, generates a fictitious positive gradient of the full sample. The flatter gradient at larger Z(max) found in the RAVE and the GCS samples may therefore be due to the superposition of thin-and thick-disc stars, which mimicks a flatter or positive gradient. This does not exclude the possibility that the thick disc has no chemical gradient. The discrepancies between the observational samples and the mock sample can be reduced by i) decreasing the density; ii) decreasing the vertical velocity; and iii) increasing the metallicity of the thick disc in the Besancon model

The globular cluster system of NGC 1399 V. dynamics of the cluster system out to 80 kpc

(Abridged) We use the largest set of globular cluster velocities obtained so far of any elliptical galaxy to revise and extend the previous investigations of the dynamics of NGC 1399, the central dominant galaxy of the nearby Fornax cluster of galaxies. Our sample now comprises velocities for almost 700 GCs with projected galactocentric radii between 6 and 100 kpc. In addition, we use velocities published by Bergond et al. (2007). We study the kinematics of the metal-poor and metal-rich subpopulations and perform spherical Jeans modelling. The most important results are: The metal-rich (red) GCs resemble the stellar field population of NGC 1399 in the region of overlap. Both subpopulations are kinematically distinct and do not show a smooth transition. It is not possible to find a common dark halo which reproduces simultaneously the properties of both subpopulations. Some velocities of blue GCs are only to be explained by orbits with very large apogalactic distances, thus indicating a contamination with GCs which belong to the entire Fornax cluster rather than to NGC 1399. Stripped GCs from nearby elliptical galaxies, particularly NGC 1404, may also contaminate the metal-poor sample. We argue in favour of a scenario in which the majority of the blue cluster population has been accreted during the assembly of the Fornax cluster. The red cluster population shares the dynamical history of the galaxy itself. Therefore we recommend to use a dark halo based on the red GCs alone. The dark halo which fits best is marginally less massive than the halo quoted by Richtler et al. (2004). The comparison with X-ray analyses is satisfactory in the inner regions, but without showing evidence for a transition from a galaxy to a cluster halo, as suggested by X-ray work.Comment: 31 pages, accepted for publication in A&A. Online material will be available from the CD

Hepatitis B Virus Alters the Antioxidant System in Transgenic Mice and Sensitizes Hepatocytes to Fas Signaling

Hepatitis B virus (HBV) is a major etiological factor of hepatocellular carcinoma (HCC). However, the precise pathogenetic mechanisms linking HBV infection and HCC remain uncertain. It has been reported that decreased antioxidant enzyme activities are associated with severe liver injury and hepatocarcinogenesis in mouse models. It is unclear if HBV can interfere with the activities of antioxidant enzymes. We established a HBV transgenic mouse line, which spontaneously developed HCC at 2 years of age. We studied the activities of the antioxidant enzymes in the liver of the HBV transgenic mice. Our results showed that the antioxidant enzymes glutathione peroxidase and superoxide dismutase 2 were down-regulated in HBV transgenic mice and correlated with JNK activation. HBV enhanced the Fas-mediated activation of caspase 6, caspase 8 and JNK without enhancing the activation of caspase 3 and hepatocellular apoptosis. As a proper redox balance is important for maintaining cellular homeostasis, these effects of HBV on the host antioxidant system and Fas-signaling may play an important role in HBV-induced hepatocarcinogenesis

The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A

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