838 research outputs found

    Análisis de las instalaciones del Hotel El Sombrero, para personas con discapacidad, Huanchaco 2023

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    La presenta investigación surge ante la necesidad y más que todo a la accesibilidad de las personas con discapacidad al Hotel El Sombrero donde busca constatar las instalaciones turísticas que presenta el Hotel El sombrero para personas con discapacidad, Huanchaco 2023. La investigación siguió un diseño de investigación no experimental con enfoque considerado una investigación cuantitativa, en un nivel descriptivo – exploratorio ya que busca especificar propiedades, características y rasgos importantes de cualquier fenómeno que se analice y sobre todo que permita el desarrollo del turismo accesible en el Hotel El Sombrero. Para la elaboración de este trabajo se realizó encuestas a los huéspedes, entrevista a los ejecutivos y ficha de observación donde se verifico todas las áreas principales del Hotel, además, se propuso una propuesta de mejora para que el establecimiento tenga llegada de un turismo accesible a futuro, con lo cual se obtuvo como resultado que el Hotel El Sombrero tiene una falta de accesibilidad en algunas de sus áreas como Recepción, Habitaciones, Cochera y áreas comunes para el ingreso de personas con discapacidad, ya que sus instalaciones y equipamiento tanto como interno y externo no están implementadas correctamente para el uso y circulación de estas personas. Finalmente, la investigación concluyo que el establecimiento tiene un bajo porcentaje de huéspedes con discapacidad del 3.7%; de la cual, se suma la necesidad de capacitación del personal del Hotel y, además, se debe implementar en las instalaciones turísticas del Hotel El Sombrero, y así poder incrementar con la llegada de turistas nacionales e internacionales

    Subjective satiety and plasma PYY concentration after wholemeal pasta

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    Dietary fiber and whole grain foods may contribute to the regulation of appetite; however, evidence has produced inconclusive findings. The objective was to evaluate the effects of an experimental wholemeal pasta on appetite ratings, plasma concentrations of gastrointestinal hormones involved in appetite control, and postprandial glucose/insulin responses in healthy adults. Fourteen healthy adults (7M/7F), mean age 30±2 yrs (mean±SEM), participated in a randomized, controlled, crossover trial. Participants consumed on two different days, at one week interval, 117g of wholemeal pasta or 100g of refined wheat pasta (control pasta), similar in energy and macronutrient composition except for fiber amount, which was higher in wholemeal pasta (11 vs 3 g). Appetite ratings, glucose/insulin/lipid and gastrointestinal hormone responses were measured at fasting and for 4-h after the ingestion of the pasta tests, after which self-reported energy intake for 8-h was evaluated. After the wholemeal pasta, the desire to eat and the sensation of hunger were lower (-16%, p=0.04 and -23%, p=0.004, respectively) and satiety was higher (+13%; p=0.08) compared with the control pasta; no effect on self-reported energy intake at subsequent meal was observed. After wholemeal pasta, glucose, triglyceride increased and GLP-1 responses were not different compared to control pasta but insulin response at 30 min (p<0.05) and ghrelin at 60 min (p=0.03) were lower and PYY levels higher (AUC=+44%, p=0.001). The appetite rating changes correlated with PYY plasma levels (p<0.03). In conclusion, consumption of whole grain instead of refined wheat pasta contributed to appetite control but did not seem to influence acute energy balance. Appetite ratings were associated with modifications in PYY hormone concentrations

    Analisi di settore: materiali elettrici

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    Indice: Definizione del business - Caratteristiche generali del settore - Lampade - Apparecchiature di installazione per uso civile ed industriale - Cavi e conduttori elettric

    Propuesta de mejora del proceso de mecanizado de porta rodamientos utilizando la técnica de estudio de tiempos en la empresa Famitec Mining S.A.C. Lima, 2017

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    RESUMEN El presente trabajo de investigación tiene por objetivo principal estimar una propuesta de mejora en el proceso de mecanizado de porta rodamientos modelo D3MRA5002-1C VULCO, aplicando el uso de la técnica de estudio de tiempos en la empresa FAMITEC MINING S.A.C. dedicada a servicios de reparaciones, fabricaciones y mantenimiento en el rubro metal mecánico. Con el fin de identificar la causa de mayor relevancia en el proceso de mecanizado de porta rodamientos, se elaboró el diagrama de Ishikawa, identificando que la demora de este proceso se centra la falta de dispositivos para poder disminuir el tiempo en la operación de centrado de la pieza, la cual puede tomar de 90 a más minutos lo que conlleva a que se alargue el proceso de mecanizado, así como también el retraso en la entrega al cliente del producto final. Por tal motivo, se diseñó un plan piloto con la finalidad de ponerlo a prueba por un lapso de 3 semanas; de este modo, se pueden registrar los tiempos y ritmos de cada elemento de las tareas. Para el desarrollo del primer objetivo específico de la presente investigación, el cual se refiere a la reducción de tiempos en el proceso de mecanizado, se utilizó el criterio de General Electric para determinar el número de observaciones a realizar, tanto en el proceso actual como en el plan piloto; tal criterio nos dice que para ciclos de trabajo de más de 40 minutos, se realizan 3 observaciones; de esta manera, se pudo registrar los tiempos para cada elemento del proceso y así poder determinar el tiempo estándar del ciclo de trabajo. En el desarrollo del segundo objetivo específico, referente a la influencia de la técnica de estudio de tiempos en la capacidad de producción de la empresa, se determinó la capacidad, tanto para el proceso actual como para el plan piloto, teniendo en cuenta una jornada laboral de 8 horas diarias y 26 días laborables al mes, además del tiempo estándar del ciclo de trabajo de dicho proceso. Finalmente, se obtuvieron como resultados del plan piloto y del uso de la técnica de estudio de tiempos, la mejora del proceso de mecanizado, teniendo como conclusiones los siguientes números: reducción de tiempo del elemento 11 de 137,98 a 14,36 minutos, reducción del tiempo estándar del proceso de 342,05 a 256, 38 minutos y el aumento de la capacidad de producción de 31 a 43 unidades por mes.ABSTRACT This research is mainly aimed to estimate a proposal for improvement in the machining process porta bearings model D3MRA5002-1C VULCO, applying the use of the technique of study time in the company Famitec MINING SAC dedicated to repair services, manufacturing and maintenance in the category mechanical metal. In order to identify the cause of greater relevance in the machining process bearing carries the Ishikawa diagram was developed identifying the delay of this process the lack of devices is focused to decrease the time in operation centering piece, which may take from 90 to more minutes which leads to the machining process is lengthened, and also the delay in delivery to the customer of the final product. Therefore, a pilot plan in order to test it for a period of three weeks, so you can record the times and rhythms of each element was designed tasks. For the development of the first specific objective of this research relates to the reduction of time in the machining process, the criterion of General Electric was used to determine the number of observations to make both the current process and the pilot; this criterion tells us that for duty cycles over 40 minutes 3 observations thus performed could record time for each element of the process and thus determine the standard time of the work cycle. In developing the second specific objective concerning the influence of the technique time study in the production capacity of the company, the ability to both the current process and for the pilot scheme taking into account a working day of 8 was determined daily and working 26 days a month, in addition to the standard cycle time of the process working hours. Finally, it was obtained as results of the pilot and use the technique of time study, the improvement of the machining bearing holder, with the findings the following numbers: reduction time element 11 137.98 to 14, 36 minutes, reduced process time standard 342.05-256, 38 minutes and increasing the production capacity of 31 to 43 units per month

    Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation

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    The aim of this work was to investigate hepatic lipid metabolic processes possibly involved in the reduction of liver fat content (LF) observed in patients with type 2 diabetes after an isoenergetic diet enriched in monounsaturated fatty acids (MUFAs)

    Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial

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    Background: Non‐alcoholic liver steatosis (NAS) results from an imbalance between hepatic lipid storage, disposal, and partitioning. A multifactorial diet high in fiber, monounsaturated fatty acids (MUFAs), n‐6 and n‐3 polyunsaturated fatty acids (PUFAs), polyphenols, and vitamins D, E, and C reduces NAS in people with type 2 diabetes (T2D) by 40% compared to a MUFA‐rich diet. We evaluated whether dietary effects on NAS are mediated by changes in hepatic de novo lipogenesis (DNL), stearoyl‐CoA desaturase (SCD1) activity, and/or β‐ oxidation.; Methods: According to a randomized parallel group study design, 37 individuals with T2D completed an 8‐week isocaloric intervention with a MUFA diet (n = 20) or multifactorial diet (n = 17). Before and after the intervention, liver fat content was evaluated by proton magnetic resonance spectroscopy, serum triglyceride fatty acid concentrations measured by gas chromatography, plasma β‐hydroxybutyrate by enzymatic method, and DNL and SCD‐1 activity assessed by calculating the palmitic acid/linoleic acid (C16:0/C18:2 n6) and palmitoleic acid/palmitic acid (C16:1/C16:0) ratios, respectively; Results: Compared to baseline, mean ± SD DNL significantly decreased after the multifactorial diet (2.2 ± 0.8 vs.1.5 ± 0.5, p = 0.0001) but did not change after the MUFA diet (1.9 ± 1.1 vs. 1.9 ± 0.9, p = 0.949), with a significant difference between the two interventions (p = 0.004). The mean SCD‐1 activity also decreased after the multifactorial diet (0.13 ± 0.05 vs. 0.10 ± 0.03; p = 0.001), but with no significant difference between interventions (p = 0.205). Fasting plasma β‐hydroxybutyrate concentrations did not change significantly after the MUFA or multifactorial diet. Changes in the DNL index significantly and positively correlated with changes in liver fat (r = 0.426; p = 0.009). Conclusions: A diet rich in multiple beneficial dietary components (fiber, polyphenols, MUFAs, PUFAs, and other antioxidants) compared to a diet rich only in MUFAs further reduces liver fat accumulation through the inhibition of DNL. Registered under ClinicalTrials.gov no. NCT03380416

    Bioinorganic Chemistry of Alzheimer’s Disease

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    Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

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    Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
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