States United

The Laurence and Lynne Brown Democracy Medal, presented by the McCourtney Institute for Democracy at Penn State, recognizes outstanding individuals, groups, and organizations that produce innovations to further democracy in the United States or around the world.Elections are the bedrock of any democracy, but they are under attack in the United States. State legislatures are moving to limit voting rights and seize control of election administration, candidates are refusing to accept election results, and antidemocracy forces are sowing lies and encouraging political violence.The States United Democracy Center is fighting back by equipping state and local officials, law enforcement leaders, and prodemocracy partners with the tools and resources they need to protect free, fair, and secure elections. For this important work, its cofounders are the recipients of the 2022 Brown Democracy Medal. States United was founded during the 2020 election and continues to be led by Joanna Lydgate, former chief deputy attorney general of Massachusetts; Norman Eisen, former ambassador to the Czech Republic and special assistant to President Barack Obama for ethics and government reform; and Christine Todd Whitman, former New Jersey governor and Environmental Protection Agency administrator

The Grizzly, November 21, 1980

Dean of Students\u27 Office Releases Vandalism Figures • Maintenance Working To Conserve Energy • Weight Room Relocated In Helfferich • College Union Attempts World\u27s Largest Molecule • Ursinus News In Brief: Espadas to speak today in Illinois; Maintenance planting new trees; Placement interviews coming soon • Rassias Method Explored for Languages • Journalism To Be Added To Curriculum • Medical Ethics Course Offered • Phil. & Rel. Dept. Lecture On Judaism • College To Host 43rd Messiah Performance • Foghat and Outlaws Perform for \u27Serious Rockers\u27 • Forum On Radiation Draws Mixed Views • Art Exhibit On Display In Wismer • Open House Planned By Astronomy Club • A Look At This Year\u27s Basketball Season • Cross Country To Compete In Nationals This Weekend • Gridders Lose Early Lead to Tie Gettysburghttps://digitalcommons.ursinus.edu/grizzlynews/1048/thumbnail.jp

Wide-Field Infrared Survey Telescope (WFIRST) - Optical Telescope Assembly (OTA) Status

The WFIRST Mission is the next large astrophysical observatory for NASA after the James Webb Space Telescope and is the top priority mission from the 2010 National Academy of Sciences' decadal survey. The WFIRST OTA includes the inherited primary and secondary mirrors with precision metering structures that are to be integrated to new mirror assemblies to provide optical feeds to the two WFIRST science instruments. We present here: (1) the results for the review of the inherited hardware for WFIRST through a thorough technical pedigree process, (2) the status of the effort to establish the capability of the telescope to perform at a cooler operational temperature of 265K, and (3) the status of the work in requirement development for OTA to incorporate the inherited hardware, and (4) the path forward

ApoE−/− PGC-1α−/− Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis

BACKGROUND: Atherosclerosis is a chronic inflammatory disease that evolves from the interaction of activated endothelial cells, macrophages, lymphocytes and modified lipoproteins (LDLs). In the last years many molecules with crucial metabolic functions have been shown to prevent important steps in the progression of atherogenesis, including peroxisome proliferator activated receptors (PPARs) and the class III histone deacetylase (HDAC) SIRT1. The PPARγ coactivator 1 alpha (Ppargc1a or PGC-1α) was identified as an important transcriptional cofactor of PPARγ and is activated by SIRT1. The aim of this study was to analyze total PGC-1α deficiency in an atherosclerotic mouse model. METHODOLOGY/PRINCIPAL FINDINGS: To investigate if total PGC-1α deficiency affects atherosclerosis, we compared ApoE(-/-) PGC-1α(-/-) and ApoE(-/-) PGC-1α(+/+) mice kept on a high cholesterol diet. Despite having more macrophages and a higher ICAM-1 expression in plaques, ApoE(-/-) PGC-1α(-/-) did not display more or larger atherosclerotic plaques than their ApoE(-/-) PGC-1α(+/+) littermates. In line with the previously published phenotype of PGC-1α(-/-) mice, ApoE(-/-) PGC-1α(-/-) mice had marked reduced body, liver and epididymal white adipose tissue (WAT) weight. VLDL/LDL-cholesterol and triglyceride contents were also reduced. Aortic expression of PPARα and PPARγ, two crucial regulators for adipocyte differentiation and glucose and lipid metabolism, as well as the expression of some PPAR target genes was significantly reduced in ApoE(-/-) PGC-1α(-/-) mice. Importantly, the epididymal WAT and aortic expression of IL-18 and IL-18 plasma levels, a pro-atherosclerotic cytokine, was markedly reduced in ApoE(-/-) PGC-1α(-/-) mice. CONCLUSIONS/SIGNIFICANCE: ApoE(-/-) PGC-1α(-/-) mice, similar as PGC-1α(-/-) mice exhibit markedly reduced total body and visceral fat weight. Since inflammation of visceral fat is a crucial trigger of atherogenesis, decreased visceral fat in PGC-1α-deficient mice may explain why these mice do not develop enhanced atherosclerosis

A Politico-Communal Reading of the Rose

Lettura del Fiore in rapporto alle fonti retoriche e politiche di ambiente comunal

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29