109 research outputs found
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Als Thomas D.
- Amin Farooq
- Andreassen Ole A.
- Bacanu Silviu A.
- Baekvad-Hansen Marie
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Black Donald W.
- Blackwood Douglas H. R.
- Boocock James
- Borglum Anders D.
- Borglum Anders D.
- Bramon Elvira
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley
- Chambert Kimberly D.
- Chan Raymond C. K.
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Cox Nancy J.
- Craddock Nick
- Crowley James J.
- Curtis David
- Daly Mark J.
- Dang Kristen K.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- Devlin Bernie
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Dobbyn Amanda
- Domenici Enrico
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph
- Fromer Menachem
- Fromer Menachem
- Gamazon Eric R.
- Gejman Pablo
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Girdhar Kiran
- Giusti-Rodriguez Paola
- Godard Stephanie
- Goldstein Jacqueline
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Grove Jakob
- Gur Raquel E.
- Gurling Hugh
- Hahn Chang-Gyu
- Hammer Christian
- Hamshere Marian L.
- Hansen Christine Soholm
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Haroutunian Vahram
- Hartmann Annette M.
- Henskens Frans A.
- Herms Stefan
- Hirai Keisuke
- Hirschhorn Joel N.
- Hoffman Gabriel
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads
- Holmans Peter A.
- Hougaard David M.
- Huang Hailiang
- Huckins Laura M.
- Hultman Christina M.
- Ikeda Masashi
- Im Hae Kyung
- Iwata Nakao
- Jablensky Assen
- Joa Inge
- Johnson Jessica S.
- Jonsson Erik G.
- Julia Antonio
- Kahler Anna K.
- Kahn Rene S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kendler Kenneth S.
- Kennedy James L.
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klein Lambertus L.
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kramer Robin
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Laurent Claudine
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Lewis David A.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Lipska Barbara K.
- Liu Jianjun
- Logsdon Benjamin A.
- Lonnqvist Jouko
- Loughland Carmel M.
- Lubinski Jan
- Macek Milan
- Magnusson Patrik K. E.
- Mahajan Milind C.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Mangravite Lara M.
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben Bo
- Mowry Bryan J.
- Muller-Myhsok Bertram
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nguyen Hoang T.
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordentoft Merete
- Nordin Annelie
- Nothen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Dushlaine Colm
- O'Neill F. Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- Owen Michael J.
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Pardinas Antonio F.
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Perumal Thanneer M.
- Peters Mette A.
- Petryshen Tracey L.
- Pietilainen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun
- Purcell Shaun M.
- Quested Digby
- Rajagopal Veera M.
- Rajagopal Veera Manikandan
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schadt Eric
- Schall Ulrich
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Rodney J.
- Seidman Larry J.
- Shah Hardik R.
- Sham Pak C.
- Shi Jianxin
- Sieberts Solveig K.
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Soderman Erik
- Spencer Chris C. A.
- St Clair David
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Stroup T. Scott
- Subramaniam Mythily
- Sullivan Patrick
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Thirumalai Srinivas
- Toncheva Draga
- Tosato Sarah
- Toyoshiba Hiroyoshi
- Van Os Jim
- Veijola Juha
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T. R.
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin Simon
- Zai Clement C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Ludwig-Maximilians-Universität München
- Publication date
- 01/04/2019
- Field of study
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
- Author
- Aarno Palotie
- Aaron R. Wolen
- Abraham Reichenberg
- Adriano Chio
- Aiden Corvin
- Alan Pittman
- Alan R. Sanders
- Albert C. Ludolph
- Albert Hofman
- Aleksey Shatunov
- Alessandro Padovani
- Alexander L. Richards
- Alexandra Dürr
- Alexis Brice
- Alkes Price
- Ammar Al-Chalabi
- An Goris
- Anders D. Børglum
- Andre Franke
- Andre G. Uitterlinden
- Andrea Calvo
- Andrea Hofman
- Andrea Malaspina
- Andres Metspalu
- Andrew J. Pocklington
- Andrew M. McIntosh
- Andrew McQuillin
- Andrey Khrunin
- Anil K. Malhotra
- Ann E. Pulver
- Ann Olincy
- Anna K. Kähler
- Anneke J. van der Kooi
- Annelie Nordin
- Annelot M. Dekker
- Annette M. Hartmann
- Antonia Ratti
- Antonio Julià
- Ariel Darvasi
- Ashley R. Jones
- Assen V. Jablensky
- Ayman H. Fanous
- Bela Melegh
- Benjamin M. Neale
- Bernard Lerer
- Bernhard Landwehrmeyer
- Bertram Müller-Myhsok
- Bettina Konte
- Bradley N. Smith
- Bradley T. Webb
- Brandon K. Wormley
- Brendan Bulik-Sullivan
- Brien P. Riley
- Brion S. Maher
- Bryan J. Mowry
- C Robert Cloninger
- Carin J. Meijer
- Carlos N. Pato
- Carmel M. Loughland
- Carsten Drepper
- Catherine Lomen-Hoerth
- Cathryn M. Lewis
- Charles Curtis
- Chiara Zecca
- Chris C. A. Spencer
- Christian Hammer
- Christian Lunetta
- Christian R. Andres
- Christian R. Schubert
- Christina M. Hultman
- Christine A. M. Payan
- Christophe Tzourio
- Christopher E. Shaw
- Christos Pantelis
- Cindy Maurel
- Cinzia Bertolin
- Cinzia Gellera
- Cinzia Tiloca
- Claudine Laurent
- Clement C. Zai
- Colm McDonald
- Colm O’Dushlaine
- Cristina Cereda
- Cristina Moglia
- Dai Wang
- Dan Rujescu
- Daniel G. Bradley
- Daniel R. Weinberger
- Danielle Posthuma
- David A. Collier
- David Cohen
- David Curtis
- David Kavanagh
- David M. Hougaard
- David St Clair
- Deborah A. Nertney
- Denis Bauer
- Derek W. Morris
- Dermot Walsh
- Diana O. Perkins
- Dick Schijven
- Dieter B. Wildenauer
- Digby Quested
- Dimitris Dikeos
- Ditte Demontis
- Dominic B. Rowe
- Dominique Campion
- Donald W. Black
- Douglas F. Levinson
- Douglas H. R. Blackwood
- Douglas M. Ruderfer
- Draga Toncheva
- Dragan M. Svrakic
- Eadbhard O’Callaghan
- Edward M. Scolnick
- Elena Parkhomenko
- Eli A. Stahl
- Elisabeth Stogmann
- Elisabetta Pupillo
- Elizabeth Bevilacqua
- Elodie Drapeau
- Elvira Bramon
- Emily H. M. Wong
- Engilbert Sigurdsson
- Enrico Domenici
- Eric F. C. Cheung
- Eric Strengman
- Eric Y. H. Chen
- Erik G. Jönsson
- Erik Söderman
- Esben Agerbo
- Ettore Beghi
- F Anthony O’Neill
- Farooq Amin
- Federico Casale
- Fernando Rivadeneira
- Filip Eftimov
- Frank Dudbridge
- Frank P. Diekstra
- Frans A. Henskens
- Franziska Degenhardt
- François Salachas
- Fritz Zimprich
- Garth A. Nicholson
- Gary Donohoe
- George Kirov
- George N. Papadimitriou
- Gerald Nestadt
- Gerome Breen
- Giacomo P. Comi
- Giancarlo Logroscino
- Gianni Sorarù
- Gilbert Bensimon
- Giulio Genovese
- Guiqing Cai
- Hailiang Huang
- Hana Kuzelova-Ptackova
- Hannelore Ehrenreich
- Henrik B. Rasmussen
- Hon-Cheong So
- Hreinn Stefansson
- Hualin Simon Xi
- Hugh Gurling
- Ian Blair
- Igor Nenadic
- Ina Giegling
- Inez Myin-Germeys
- Inge Joa
- Ingrid Agartz
- Ingrid Melle
- Isabella Fogh
- Jaana Suvisaari
- Jacob Gratten
- Jacqueline I. Goldstein
- Jacques Mallet
- James A. Knowles
- James J. Crowley
- James L. Kennedy
- James T. R. Walters
- Jan H. Veldink
- Jan Lubinski
- Jana Strohmaier
- Janis Klovins
- Jean- François Dartigues
- Jeffrey Lieberman
- Jennifer L. Moran
- Jens R. Wendland
- Jeremy M. Silverman
- Jesus S. Mora
- Jianjun Liu
- Jianxin Shi
- Jim Van Os
- Jimmy Lee
- Jin P. Szatkiewicz
- Jo Knight
- Jochen H. Weishaupt
- Joel N. Hirschhorn
- Johan Eriksson
- John E. Landers
- John Hardy
- John Powell
- John Q. Trojanowski
- John Waddington
- Jonathan Glass
- Jonathan Pimm
- Jordan W. Smoller
- Josef Frank
- Joseph D. Buxbaum
- Joseph I. Friedman
- Joshua L. Roffman
- Jouko Lönnqvist
- Jubao Duan
- Judit Bene
- Juha Karjalainen
- Juha Veijola
- Jurgen Del Favero
- Jurjen J. Luykx
- Kai-How Farh
- Kang Sim
- Karen E. Morrison
- Kari Stefansson
- Karol Estrada
- Katie Sidle
- Kelly Williams
- Kenneth L. Davis
- Kenneth S. Kendler
- Kieran C. Murphy
- Kimberley D. Chambert
- Kristel R. van Eijk
- Kristin K. Nicodemus
- Kuang Lin
- Kung-Yee Liang
- Larry J. Seidman
- Laura Nisenbaum
- Lauren Elman
- Laurent Essioux
- Leo McCluskey
- Leonard H. van den Berg
- Letizia Mazzini
- Liene Nikitina-Zake
- Lieuwe de Haan
- Lili Milani
- Line Olsen
- Luba Kalaydjieva
- Lude Franke
- Lukas Tittmann
- Lyudmila Georgieva
- Madeline Alexander
- Mads V. Hollegaard
- Mamede de Carvalho
- Manuel Mattheisen
- Marcella Rietschel
- Margaret O’Brien
- Margot Albus
- Mari Nelis
- Marian L. Hamshere
- Marianne de Visser
- Marion Friedl
- Mark A. Reimers
- Mark Hansen
- Mark J. Daly
- Mark Weiser
- Markus M. Nöuthen
- Markus Weber
- Martilias S. Farrell
- Martin Begemann
- Martina Wiedau-Pazos
- Masashi Ikeda
- Massimiliano Filosto
- Matthew C. Keller
- Matthew C. Kiernan
- Maura Brunetti
- Menachem Fromer
- Meraida Polak
- Miaoxin Li
- Michael A. van Es
- Michael C. O’Donovan
- Michael Davidson
- Michael Gill
- Michael J. Owen
- Michael Sendtner
- Michele T. Pato
- Milan Macek
- Milena Blagojevic-Radivojkov
- Milica Pejovic-Milovancevic
- Morten Mattingsdal
- Mythily Subramaniam
- Nadine Cohen
- Nakao Iwata
- Nancy G. Buccola
- Naomi R. Wray
- Naser Durmishi
- Nazli Basak
- Nelson B. Freimer
- Nicholas Wood
- Nick Craddock
- Nicola Ticozzi
- Nigel M. Williams
- Nilo Riva
- Noa Carrera
- null null
- null null
- Ole A. Andreassen
- Ole Mors
- Olli Pietiläinen
- Orietta Pansarasa
- Orla Hardiman
- P Nigel Leigh
- Pablo V. Gejman
- Pak C. Sham
- Pamela J. Shaw
- Pamela Sklar
- Panos Roussos
- Paola Giusti-Rodríguez
- Patricia T. Michie
- Patrick F. Sullivan
- Patrick Vourc'h
- Patrik K. E. Magnusson
- Paul Cormican
- Per Hoffmann
- Perry T. C. van Doormaal
- Peter A Holmans
- Peter Eichhammer
- Peter Lichtner
- Peter M. Andersen
- Peter M. Visscher
- Petr Slominsky
- Phil Lee
- Philip Van Damme
- Philippe Amouyel
- Philippe Corcia
- Pietro Fratta
- Preben B. Mortensen
- Qiang Wang
- Qingqin S. Li
- R Jeroen Pasterkamp
- Randy L. Buckner
- Raquelle I. Mesholam-Gately
- Raymond C. K. Chan
- René S. Kahn
- Ricardo Rojas-García
- Richard A. Belliveau
- Richard Bruggeman
- Richard E. Straub
- Richard W. Orrell
- Rick A. A. van der Spek
- Rita M. Cantor
- Robert Freedman
- Robert H. Brown
- Robert Swingler
- Robert W. McCarley
- Roberto Del Bo
- Robin M. Murray
- Rodney J. Scott
- Roel A. Ophoff
- Roger Pamphlett
- Rolf Adolfsson
- Ronald Y. L. Chan
- Rosa Capozzo
- Rosanna Tortelli
- Russell L. McLaughlin
- S Hong Lee
- Safa Saker-Delye
- Sandra D’Alfonso
- Sandra Meier
- Sang-Yun Oh
- Sara L. Pulit
- Sara Marsal
- Sarah E. Bergen
- Sarah Tosato
- Sena Karachanak-Yankova
- Sergi Papiol
- Shaun M. Purcell
- Shuna Colville
- Sibylle G. Schwab
- Siddharthan Chandran
- Silvana Penco
- Silviu A. Bacanu
- Simon Arcuti
- Siow Ann Chong
- Sophie E. Legge
- Srdjan Djurovic
- Srihari Gopal
- Srinivas Thirumalai
- Stacy Steinberg
- Stanley V. Catts
- Stefan Herms
- Stephan Ripke
- Stephanie Godard
- Stephanie H. Witt
- Stephanie Williams
- Steven A. McCarroll
- Stéphanie Millecamps
- Susana Pinto
- Susanna Abdulla
- Susanne Petri
- Sven Cichon
- Svetlana Limborska
- T Scott Stroup
- Tao Li
- Teimuraz Silagadze
- Thomas G. Schulze
- Thomas Hansen
- Thomas Meitinger
- Thomas Meyer
- Thomas Werge
- Tiina Paunio
- Tim B. Bigdeli
- Tim Kahlke
- Timothy Dinan
- Todd Lencz
- Tracey L. Petryshen
- Tune H. Pers
- Tõnu Esko
- Ulrich Schall
- Vahram Haroutunian
- Vaidutis Kucinskas
- Valentina Escott-Price
- Vaughan J. Carr
- Veikko Salomaa
- Vera Golimbet
- Vihra Milanova
- Vincent Meininger
- Vincenzo Silani
- Viviana Pensato
- Vivianna M. Van Deerlin
- Wei Cheng
- Wiepke Cahn
- William Byerley
- William Sproviero
- Wim Robberecht
- Wolfgang Lieb
- Wolfgang Maier
- Wouter van Rheenen
- Xuebin Zheng
- Younes Mokrab
- Yunjung Kim
- Zita Ausrele Kucinskiene
- Publication venue
- Publication date
- 01/01/2017
- Field of study
A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Albus Margot
- Alda Martin
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D
- Amin Farooq
- Andreassen Ole A
- Anjorin Adebayo
- Arranz Maria J
- Awasthi Swapnil
- Bacanu Silviu A
- Badner Judith A
- Baekvad-Hansen Marie
- Bakker Steven
- Band Gavin
- Barchas Jack D
- Barroso Ines
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Bellenguez Celine
- Bellivier Frank
- Bender Stephan
- Bene Judit
- Bergen Sarah E
- Berrettini Wade H
- Bevilacqua Elizabeth
- Biernacka Joanna M
- Bigdeli Tim B
- Black Donald W
- Blackburn Hannah
- Blackwell Jenefer M
- Blackwood Douglas HR
- Boehnke Michael
- Boks Marco
- Boocock James
- Borglum Anders D
- Bramon Elvira
- Breen Gerome
- Brown Matthew A
- Bruggeman Richard
- Buccola Nancy G
- Buckner Randy L
- Budde Monika
- Bulik-Sullivan Brendan
- Bumpstead Suzannah J
- Bunney William
- Burmeister Margit
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Cairns Murray J
- Campion Dominique
- Cantor Rita M
- Carr Vaughan J
- Carrera Noa
- Casas Juan P
- Casas Miquel
- Case-Control Wellcome Trust
- Catts Stanley V
- Cervantes Pablo
- Chambert Kimberley D
- Chan Raymond CK
- Charney Alexander W
- Chen Eric YH
- Chen Ronald YL
- Cheng Wei
- Cheung Eric FC
- Chong Siow Ann
- Cichon Sven
- Clarke Toni-Kim
- Cloninger C Robert
- Cohen David
- Cohen Nadine
- Coleman Jonathan RI
- Collier David A
- Consortium Psychiat Genomics
- Consortium Psychiat Genomics
- Cormican Paul
- Corvin Aiden
- Coryell William
- Craddock Nicholas
- Craig David W
- Crespo-Facorro Benedicto
- Crowley James J
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo B
- Curtis David
- Czerski Piotr M
- Dale Anders M
- Daly Mark J
- Dannlowski Udo
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- de Leeuw Christiaan A
- Degenhardt Franziska
- Del Favero Jurgen
- DeLisi Lynn E
- Deloukas Panos
- Demontis Ditte
- DePaulo J Raymond
- Di Florio Arianna
- di Forti Marta
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Dobbyn Amanda L
- Domenici Enrico
- Donnelly Peter
- Donohoe Gary
- Drapeau Elodie
- Dronov Serge
- Duan Jubao
- Dudbridge Frank
- Duncanson Audrey
- Edenberg Howard
- Edkins Sarah
- Ehrenreich Hannelore
- Eichhammer Peter
- Elvsashagen Torbjorn
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Etain Bruno
- Fan Chun Chieh
- Fanous Ayman H
- Farh Kai-How
- Farrell Martilias S
- Flickinger Matthew
- Foroud Tatiana M
- Forstner Andreas J
- Forty Liz
- Frank Josef
- Franke Lude
- Fraser Christine
- Freedman Robert
- Freeman Colin
- Freimer Nelson B
- Friedman Joseph I
- Fromer Menachem
- Frye Mark A
- Fullerton Janice M
- Gade Katrin
- Garnham Julie
- Gaspar Helena A
- Gejman Pablo V
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S
- Giambartolomei Claudia
- Giannoulatou Eleni
- Giegling Ina
- Gill Michael
- Gillman Matthew
- Giusti-Rodriguez Paola
- Godard Stephanie
- Goes Fernando
- Goldstein Jacqueline I
- Gopal Srihari
- Gordon Scott D
- Gordon-Smith Katherine
- Gratten Jacob
- Gray Emma
- Green Elaine K
- Green Melissa J
- Greenwood Tiffany A
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Guan Weihua
- Gurling Hugh
- Gwilliam Rhian
- Hall Jeremy
- Hall Mei-Hua
- Hammer Christian
- Hammond Naomi
- Hamshere Marian L
- Hansen Christine Soholm
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M
- Hauser Joanna
- Hautzinger Martin
- Heilbronner Urs
- Hellenthal Garrett
- Henskens Frans A
- Herms Stefan
- Hipolito Maria
- Hirschhorn Joel N
- Hoffmann Per
- Hollegaard Mads V
- Holmans Peter A
- Hougaard David M
- Huang Hailiang
- Huckins Laura
- Hultman Christina M
- Hunt Sarah E
- Ikeda Masashi
- Inter Psychosis Endophenotypes
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V
- Jamain Stephane
- Jankowski Janusz
- Jayakumar Alagurevathi
- Joa Inge
- Jones Ian
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- Jonsson Erik G
- Jr Belliveau Richard A
- Jr Macek Milan
- Julia Antonio
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- Kahler Anna K
- Kahn Rene S
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- Kalman Janos L
- Kandaswamy Radhika
- Karachanak-Yankova Sena
- Karjalainen Juha
- Karlsson Robert
- Kavanagh David
- Keller Matthew C
- Kelly Brian J
- Kelsoe John
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- Kennedy James L
- Keong Jimmy Lee Chee
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- Kim Yunjung
- Kirov George
- Kittel-Schneider Sarah
- Klovins Janis
- Knight Jo
- Knott Sarah V
- Knowles James A
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- Laurent Claudine
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- Lawrie Stephen
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- Leber Markus
- Leboyer Marion
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- Lee S Hong
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- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Levy Shawn E
- Lewis Cathryn M
- Li Jun Z
- Li Miaoxin
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- Liang Kung-Yee
- Liddle Jennifer
- Lieberman Jeffrey
- Limborska Svetlana
- Lin Kuang
- Linszen Don H
- Lissowska Jolanta
- Liu Chunyu
- Liu Jianjun
- Lonnqvist Jouko
- Loohuis Loes M Olde
- Loughland Carmel M
- Lubinski Jan
- Lucae Susanne
- MacIntyre Donald J
- Magnusson Patrik KE
- Maher Brion S
- Mahon Pamela B
- Maier Wolfgang
- Malhotra Anil K
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- Malt Ulrik F
- Markus Hugh S
- Marsal Sara
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- McCarroll Steven A
- McCarthy Mark I
- McDonald Colm
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- Meijer Carin J
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- Mokrab Younes
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- Neale Benjamin M
- Nelis Mari
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- Nordin Annelie
- Nothen Markus M
- Nurnberger John I
- Nwulia Evaristus A
- O'Callaghan Eadbhard
- O'Donovan Claire
- O'Donovan Michael C
- O'Dushlaine Colm
- O'Neill F Anthony
- Oedegaard Ketil J
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A
- Ori Anil PS
- Oruc Lilijana
- Owen Michael J
- Paciga Sara A
- Palmer Colin NA
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N
- Papiol Sergi
- Parkhomenko Elena
- Parra Jose Guzman
- Pato Carlos
- Pato Michele T
- Paunio Tiina
- Pavlides Jennifer M Whitehead
- Pearson Richard
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Perkins Diana O
- Perlis Roy H
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- Petryshen Tracey L
- Pfennig Andrea
- Picchioni Marco
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- Potter Simon C
- Powell John
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- Pulver Ann E
- Purcell Shaun M
- Quested Digby
- Ramos-Quiroga Josep Antoni
- Rasmussen Henrik B
- Rautanen Anna
- Ravindrarajah Radhi
- Regeer Eline J
- Reichenberg Abraham
- Reif Andreas
- Reimers Mark A
- Ribases Marta
- Rice John P
- Richards Alexander L
- Ricketts Michelle
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Rivas Fabio
- Rivera Margarita
- Roffman Joshua L
- Rouleau Guy A
- Roussos Panos
- Ruderfer Douglas M
- Rujescu Dan
- Salomaa Veikko
- Sanchez-Mora Cristina
- Sanders Alan R
- Sawcer Stephen J
- Schall Ulrich
- Schatzberg Alan F
- Scheftner William A
- Schofield Peter R
- Schork Nicholas J
- Schulze Thomas G
- Schwab Sibylle G
- Scolnick Edward M
- Scott Laura J
- Scott Rodney J
- Seidman Larry J
- Serretti Alessandro
- Sham Pak C
- Shehktman Tatyana
- Shi Jianxin
- Shilling Paul D
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Sklar Pamela
- Slaney Claire
- Slominsky Petr
- Smeland Olav B
- Smoller Jordan W
- So Hon-Cheong
- Sobell Janet L
- Soderman Erik
- Spencer Chris CA
- Spijker Anne T
- St Clair David
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
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- Straub Richard E
- Strauss John S
- Streit Fabian
- Strengman Eric
- Strohmaier Jana
- Stroup T Scott
- Su Zhan
- Subramaniam Mythily
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Szatkiewicz Jin P
- Szelinger Szabolcs
- Tashakkori-Ghanbaria Avazeh
- Thirumalai Srinivas
- Thompson Robert C
- Thorgeirsson Thorgeir E
- Toncheva Draga
- Tooney Paul A
- Tosato Sarah
- Toulopoulou Timothea
- Trembath Richard C
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Turecki Gustavo
- Vaaler Arne E
- Van Os Jim
- Vedder Helmut
- Vieta Eduard
- Vincent John
- Visscher Peter M
- Viswanathan Ananth C
- Vukcevic Damjan
- Waddington John
- Waller Matthew
- Walsh Dermot
- Walshe Muriel
- Walters James TR
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Wang Yunpeng
- Watson Stanley J
- Webb Brad-Ley T
- Weickert Cynthia Shannon
- Weickert Thomas W
- Weinberger Daniel R
- Weisbrod Matthias
- Weiser Mark
- Werge Thomas
- Weston Paul
- Whittaker Pamela
- Widaa Sara
- Wiersma Durk
- Wildenauer Dieter B
- Williams Nigel M
- Williams Stephanie
- Witt Stephanie H
- Wolen Aaron R
- Wong Emily HM
- Wood Nicholas W
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Xi Simon
- Xu Wei
- Young Allan H
- Zai Clement C
- Zandi Peter
- Zhang Peng
- Zheng Xuebin
- Zimprich Fritz
- Zollner Sebastian
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
- Appleby Bonny
- Appleby Rowan
- Archer Denise
- Archer Denise
- Archer Simon
- Archer Simon
- Arnott Seonaid
- Arsanious Nasr
- Ashcroft Jan
- Ashworth Sue
- Ashworth Sue
- Askew Sarah
- Aslam Natasha
- Atkinson Jane
- Atkinson Lorraine
- Attlee Julie
- Auladin Raidah
- Austin (nee Glover) Gemma
- Austin Mandy
- Avery Alison
- Avis Joanne
- Aya Viviana
- Azirar Hanna
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- Bahl Amit
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- Bauman Glenn
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- Baxter Matt
- Bayley Andrew J
- Beamish Neal
- Beaney Katherine
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- Beard Karen
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- Beaumont Erica
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- Bech-Nielsen Nanette
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- Blackwood Geoffrey
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- Brown Richard B
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- Byrne Mary Marg
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- Catton Charles N.
- Caumont Tom
- Cavanagh Kerrie
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- Chadwick Eliot
- Chahal Rohit
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- Challipalli Amarnath
- Challipalli Amarnath
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- Chambers Carla
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- Chan Andrew
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- Charnley Natalie
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- Chilcott Helen
- Chipman Penny
- Chivers Rachael
- Chornopyski Tracy
- Choudhury Ananya
- Choudhury Ananya
- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
- Christmas Sallyanne
- Chrystal Melanie
- Chu William
- Chui Amadeus
- Chung Christina
- Chung Hans T
- Chung Peter
- Chung Peter W.M.
- Churn Mark
- Churn Mark
- Clancy Joanna
- Clapp Felicity
- Clark Alison
- Clark Diane
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- Clarke Noel W.
- Clarke Peter
- Clarke Rachael
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- Cogley Lyn
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- Cole David J
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- Crellin Perric
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- Crossley Lin
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- Crundwell M
- Cserbane Anita
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- Cunningham Amy
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- Curtis Sandra
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- Dalton-Short Ross
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- Davies Stacey
- Davies Sue
- Davies Tracey
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- Davison Sue
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- Dayes Ian S
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- Dodds David
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- Doherty A
- Donaghey Sally
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- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
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- Dubey Arbind
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- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zarkar Anjali M.
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2024
- Field of study
Background
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.
Methods
RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047.
Findings
Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths.
Interpretation
Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
- Author
- Abab Julie
- Abbas Ali
- Abbassi Sara
- Abd Alazeez Mohamed
- Abdulwahid Danya
- Abdulwahid Danya
- Abed Jessy
- Adab Fawzi
- Adams Marion
- Adamson Vanessa
- Addison Anglise
- Adeyoju Adebanji
- Adinkra Victoria
- Adnaan Jamila
- Afzal Naveed
- Agdiran Didem
- Aggarwal Ajay
- Ahamadali Sheefa
- Ahmad Belal
- Ahmed Ilyas
- Ahmed Imtiaz
- Ahmed Shahida
- Aiku Abimbola
- Ainsworth Sarah
- Ainsworth Sarah
- Aitken Katherine
- Ajzensztejn Daniel
- Akhtar Naeem
- Al-Chamali Hiba
- Al-hasso Abdulla
- Al-hasso Abdulla
- Al-Samarraie Amir
- Albrecht Virginia
- Alcock Christopher
- Alder Leanne
- Alderton Kate
- Aldous Mary
- Ali Jennyfa
- Ali Maryam
- Ali Zulfiqer
- Ali Zulfiqer
- Allan Elaine
- Allan Elaine
- Allen Julie
- Allen Kirsten
- Allen Rachael
- Allen Susan
- Allison Joanna
- Allison Michele
- Alonzi Roberto
- AlRashdan Abdulla
- Alzouebi Mymoona
- Amanie John Oliver
- Ammeter Barb
- Amoaten Thomas
- Amos Claire
- Anderson Beverley
- Anderson Chris
- Anderson Jim
- Anderson John
- Anderson John
- Anderson Juliette
- Anderson Leanne
- Anderson Naomi
- Anderson Susan
- Anderson Susan
- Andrade Gerard
- Andrews (nee Moore) Eleanor
- Andrews Kelly
- Andrews Stephen
- Ang Daniel
- Ann Taehee
- Annan Lynda
- Ansari Jawaher
- Ansari Jawaher
- Anscombe Eleanor
- Anyamene Nicola
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- Appleby Rowan
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- Archer Denise
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- Archer Simon
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- Ashworth Sue
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- Atkinson Lorraine
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- Choudhury Ananya
- Chowdhury Amitava D
- Christensen Anne Juel
- Christensen Tine
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- Clarke Noel W
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- Cole David J
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- Corbett Thomas B
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- Couch Ellie
- Coughlan Tricia
- Cousins Jane
- Cousins Rebecca
- Coutts Tim
- Coventry Thomas
- Cowan Chloe
- Cowan Chloe
- Cowan Richard
- Cowan Richard
- Cowley Sue
- Cox Adam
- Cox Christine
- Coyle Catherine
- Coyle Catherine
- Crawford Melanie
- Crawford Sister Denise
- Creelman Brianna
- Crellin Perric
- Crellin Perric
- Crook Juanita
- Cross Vanessa
- Cross William R
- Crossley Lin
- Crowe (nee Hughes) Dawn
- Crowley Claire
- Crundwell M
- Cserbane Anita
- Cuffe Donna
- Cumming Kirsty
- Cunningham Amy
- Curtis Samantha
- Curtis Sandra
- Cusan Leonello
- Custins Laura
- Cyriac Abby
- Dabbs Marianne
- Dahar Nazeer
- Dahmane Rafika
- Dallas Nicola
- Dalton-Short Ross
- Dalton-Short Ross
- Daly Deirdre
- Danaswamy Patricia
- Danaswamy Patricia
- Daniel Amelia
- Danielson Brita
- Danjoux Cyril
- Darby Helen
- Darch Flora
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- Das Prantik
- Davda Reena
- Davey Alison
- Davey Elizabeth
- Davidson Cathy
- Davies Emily
- Davies Flor
- Davies Heather
- Davies Joe
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- Davies Kirstin
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- Davies Stacey
- Davies Sue
- Davies Tracey
- Davison Alison
- Davison Sue
- Dawe David
- Dawson Elizabeth
- Dawson Louise
- Dawson-Athey Linda
- Dayes Ian S
- De Silva-Minor Shiroma
- Dean Lynsey
- Dearnaley David
- Deenihan Emma
- Degendorfer Sarah
- Dekaj Fatjon
- Dell Gillian
- Dellar Conor
- Delouya Guila
- Dent Kathleen
- Desai Parth
- Desai Parth
- Desrosiers Isabelle
- Dewar Lorna
- Dharmaprasad Soney
- Dhinakaran Kathirvelu
- Di Maria Fabio
- Dias Heather
- Dickinson Peter
- Dickson Jeanette
- Dill Kendra
- DiLullo Elenor
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- Din Omar
- Ding Ian
- Dion Helene
- Ditchfield Julie
- Dixit Sanjay
- Dixit Sanjay
- Dlodlo Jessica
- Dobson Tracey
- Dodds David
- Dodge Sister Jan
- Doherty A
- Donaghey Sally
- Donaldson David
- Donnison Michelle
- Douch Emma
- Doughty Victoria
- Dover Serena
- Downs Nichola
- Doyle Kerrie
- Drachenberg Darrel E
- Drakeley Susan
- Drew Ellen
- Drew Mary (Ellen)
- Driscoll Celine
- DSouza David
- Dubey Arbind
- Dubey Arbind
- Duckett Tracey
- Duclos Marie
- Duffy Annie
- Dufour Nathalie
- Dugas Stevie
- Duley Emma
- DuMontier Joelle
- Duncan (nee Keatley) Claire
- Duncan Graeme
- Duncan Ian
- Dunn Sharon
- Dunne Emma
- Durkan Garret
- Durrant Lisa
- Dymond Harvey
- E Choan
- Eady Robin
- Eapen Libni
- Ebacher Annie
- Eccleson Helen
- Edwards Abigail
- Edwards Albert
- Edwards Jackie
- Edwards Steve
- Edwards Steve
- Egan Lisa
- Eichenberger Lois
- El-Modir Ahmed
- El-Saghir Mohammed
- Eleftheriadis Symeon
- ElKerdawy Hala
- Ellard Rose
- Elliott Mark
- Elliott Tony
- Elliott Tony
- ElSokhn Nidale
- Elwell Christine
- Elwell Christine
- Elwell Sue
- Embleton Andrew
- Ennis Dawn
- Erskine Susan
- Escueta Vivette
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- Etheridge Charlotte
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- Eze Nancy
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- Falconer Alison
- Falconer Alison
- Fallah Fereshteh
- Fallaize Adrian
- Faria Sergio Luiz
- Farnworth Christine
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- Fearnley Mark
- Featherstone Wendy
- Fellows Kathryn
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- Ferguson Catherine
- Ferguson Catherine
- Fernandez Claire
- Ferreira Miguel
- Fiddes Kathleen
- Fielding Bethany
- Fielding Bethany
- Fildes Diane
- Finnegan Niall
- Firth Alexandra
- Firth Alexandra
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- Firth Elizabeth
- Fish Matt
- Fish Nathan
- Flaherty Jan
- Flaherty Jan
- Flanagan Laura
- Flavin Aileen
- Fletcher Joanne
- Fletcher Julie
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- Foo Maxine
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- Ford Chris
- Ford Daniel
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- Forkes Janet
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- Forman Susan
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- Foster William
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- Frankland Helen
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- Galloway Lucy
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- Gamble Tina
- Gamble Tina
- Gamez Raquel
- Ganabady Malavika
- Gao Annie
- Garcia Leni Santiago
- Gardiner Fiona
- Garner Victoria
- Garrett Gina
- Garrido-Perez Sandra
- Gauntlett Monica
- Gauthier Isabelle C
- Gearing Jennifer
- George Siny
- GeorgeChayka Danielle
- Geraghty Kerry
- Ghoul Mokhtar
- Gibbins Andrew
- Gibbins Jackie
- Gibbins Kate
- Gibbs Stephanie
- Gibson Sian
- Giddings Emma
- Gilbert Duncan
- Gilbert Duncan
- Gilbert Jeanette
- Gilby Lisa
- Gilchrist Gail
- Gill Lisa
- Gill Shafiq
- Gillatt David
- Gillatt David
- Gillesen Annelies
- Gillespie Sally
- Gillian Andrew
- Gilmartin Claire
- Gilmour Christina
- Ginnelly Helen
- Ginnelly Helen
- Giovannini Julia
- Gipson Anna
- Girolametto Carla
- Gladwell Louise
- Gladwish Adam
- Glaholm John
- Glaholm John
- Gleave Martin E
- Glen Hilary
- Glen Tracy
- Glick Daniel
- Goel Roshni
- Goh Chee
- Goh Chee L
- Golden Sophie
- Goldenberg S Larry
- Goldstein Cindy
- Goldsworthy Simon
- Gollapothu Srilakshmi
- Gomez JoseLuis
- Gomez-Marcos Raquel
- Gonzalez Celia
- Gooch Carol
- Goodhind Frances
- Goodsell Josie
- Goodsell Josie
- Goodwin Emma
- Gopaul Darindra
- Gordon Hussain
- Gore Alexandra
- Gospodarowicz Mary
- Goss Vanessa
- Gough Jessica
- Gould Aaron
- Goulden Kay
- Goulding James
- Goyena Ruby
- Grabey Jenna
- Graham Janet
- Graham Jeffrey
- Graham John
- Graham Susan
- Gramlich Colin
- Grant Anna
- Grant Cordelia
- Grant Judith
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- Grant Warren
- Gratton Albert
- Grau Isabel
- Gray Emma
- Gray Emma
- Grayland Sarah
- Greedus Helen
- Green James
- Green Sara
- Green Sarah
- Green Sue
- Green Trish
- Greenland Jonathan
- Gregg Jane
- Gregorcic Emily
- Gregory Debbie
- Grieve Sylvia
- Griffen Ailsa
- Griffin Hannah
- Griffiths Dorothy
- Griffiths Leyshon
- Griffiths Theresa
- Griffiths Theresa
- Gruschy Lisa
- Guarino Robyn
- Gudelis Susan O
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Guerrero-Urbano Teresa
- Gujral Sandeep
- Gumapac Nicole
- Gunn Melanie
- Gupta Kamalnayan
- Gupta Nishi
- Gurzanski Christina
- Guy Peter
- Gwilt Julie
- Gwilt Julie
- Gwilt Julie
- Haddad Alain
- Hagan Chris
- Hague Dominic
- Haidar Imran
- Haidar Imran
- Haigh Steve
- Haldeos Anne
- Hale Jennifer
- Hall Jane
- Hall Julia
- Hall Julia
- Halperin Ross
- Hamid Abdel
- Hamill Maureen
- Hamilton Beatrice
- Hamilton Joanna
- Hamilton Ronald
- Hammonds John Christopher
- Hanna Emma
- Hannaford Zeta
- Happle Liz
- Hardie Maryon
- Harding Claudia
- Harding Joshua
- Hardman John
- Hardstaff Lisa
- Hare Jennifer A
- Hargreaves Carolyn
- Hargreaves Jeanette
- Hargreaves Jeanette
- Harinarayanan Sathish
- Harinarayanan Sathish
- Harland Keith
- Harney Jackie
- Harnwell Juliette
- Harpell Rhonda
- Harris (n. Marchant) Emily
- Harris Catherine
- Harris Sarah
- Harris-Burland Angie
- Harrison Alison
- Harrow Sister Kath
- Hart Amber
- Hart Andrew
- Harter Leah
- Hartley Jasmine
- Hartman Carrie
- Hartt Nancy
- Hartwell Lyn
- Harvey Julie
- Harvey Sally
- Harving Niels
- Haskell Annelise
- Hassall Alison
- Hassan Nebah
- Hassan Nebah
- Hathout Lara
- Hatimy Umi
- Haydock Helen
- Haydock Helen
- Hayes Jill A
- Hayward Lesley
- Healey Gail
- Healey-Mariano Jennifer
- Healey-Mariano Jennifer
- Heasley Karen
- Heath Catherine
- Heath Catherine M
- Heckford Louise
- Hedges Andy
- Heeley Janine
- Hefferon Billy
- Hegarty Gemma
- Hejlesen Finn
- Helou Joelle
- Hendel Debra
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Ann
- Henry Joanne
- Henry Joanne
- Henson (nee Savidge) Verity
- Henson Helen
- Herasimtschuk Anna
- Herbert Chris
- Herbert Gaynor
- Heron Jane
- Hetherington Stacey
- Hicks Kimberly
- Higgins Linda
- Hijab Adham
- Hill Elaine
- Hill Judy
- Hill Pipa
- Hill Pippa
- Hillman Paul
- Hillman Paul
- Hilman Serena
- Hilman Serena
- Hindle Margaret
- Hines John
- Hoare Kathryn
- Hocking Christopher
- Hodder June
- Hodge Simon
- Hodges Samantha
- Hodgkinson Sheila
- Hodson Hayley
- Hodson Hayley
- Hogan Holly
- Hogan Vesna
- Hogbin Emma
- Hogbin Emma
- Holbrook Andy
- Holbrook Becky
- Holden Simon
- Holdsworth Amanda
- Hollenhorst Helmut
- Holliday Samantha
- Hollingdale Abigail
- Hollis Keri
- Hollister Robert
- Holloway Caroline
- Holmes Evelyn
- Holwerda Eleanor
- Homer David
- Hood Marion
- Hooper Simon
- Hooton Georgia
- Hore Brendan
- Horne Rhian
- Hornzee Gillian
- Hornzee Gillian
- Horton Sarah
- Horwich Alan
- Hoskin Peter
- Hoskins Ashley
- Hoskins Chloe
- Hotine Jodie
- Hough Adele
- Hough Chris
- Houghton Fionnuala
- Houle Stefanie
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- Howard Joanna
- Howard Lucy
- Howard Lucy
- Howitt Pamela
- Hsien John
- Hubley Lynn
- Huddart Robert
- Huddart Robert
- Hudson Zoe
- Hughes Claire
- Hughes Faye
- Hughes Hayley
- Hughes Joanne
- Hughes Kathryn
- Hughes Owen
- Hughes Robert
- Hughes Simon
- Hughes-Davies Luke
- Hugill Angela
- Hugill Angela
- Humber Caroline
- Humpreys Louise
- Hunt Allison
- Hunter Catherine
- Hunter William
- Hunting Liz
- Hutchinson Camille
- Hyde Katherine
- Hyde Katherine
- Hyde Katherine
- Hynds Sharon
- Ibrahim Azman
- Ingham Jo
- Ingle Charlotte
- Inman Hayley
- Innes Helen
- Iordanidi Elina
- Iqbal Fawaad
- Irwin P
- Isaew Andrea
- Iskender Amanda
- Islam Zaheer
- Issa Rami
- Ivie Stephanie
- Jackman Dee
- Jackson Cathy
- Jackson Kim
- Jackson Sister Ann
- Jain Suneil
- Jakeman Christine
- James Naomi
- James Nicholas
- James Nicholas D
- Jamieson Ceri
- Jampana Raj
- Janke Susan
- Jannapureddy Revanth
- Jarvis Claire
- Jastrzebska Patrycja
- Javle P
- Jayachandran Resmi
- Jayachandran Resmi
- Jeffcutt Nicole
- Jeffrey David
- Jelski Joseph
- Jenkins Peter
- Jenkins Suzanne
- Jenner Abigail
- Jennings Marian
- Jepson Debbie
- Jevons Cody
- Jewers Karen
- Jewers Karen
- Jeyasanger Ganesan
- Joe Howard
- John Babbin
- Johns Louise
- Johnson Arlissa
- Johnson Craig
- Johnson Joanne
- Johnson Lyndsey
- Johnson Nigel
- Johnson-Rollings Ashley
- Johnston Laurel
- Johnston Ruth
- Johnstone Dawn
- Johnstone Maria
- Joncas MarieClaude
- Jones (Birch) Janine
- Jones Andrea
- Jones Ania
- Jones Carys
- Jones Cathryn
- Jones Clare
- Jones Dawn
- Jones Gareth
- Jones Ifan
- Jones Jules
- Jones Julia
- Jones Kathryn
- Jones Katie
- Jones Lesley
- Jones Lewis
- Jones Richard
- Jones Rob
- Jones Stephanie
- Jones Stephanie
- Jones-Skipper Kay
- Jonnada Sai
- Jope Carmel
- Jose Sanal
- Joseph Joji
- Joseph Paul K
- Joshi Manisha
- Joshi Manisha
- Joslin Vicky
- Jovic Gordana
- Kaa Bach Birgit
- Kader Nicole
- Kalejaiye Odunayo
- Kaliski Alexandre
- Kalyvas Maria
- Kamran Asim
- Kanaga-Sundaram Subramanian
- Kancherla Kiran
- Kanji Femina
- Kanyi Karen
- Kapur Guarav
- Karim Omer
- Karp Stephen
- Karsera Louise
- Karunakaran Subashini
- Karvat Anand
- Kaushal Malan
- Kavanagh Roisin
- Kavanagh Roisin
- Kay Anne Marie
- Kazingizi Memory
- Keane Patrick
- Kearney S
- Kedge Liz
- Kehoe Laura
- Keith Sarah
- Keith Sarah
- Kelkar Anand
- Kellaway Joanne
- Kelly Alison
- Kelly Kay
- Kemp Gail
- Kempel Mette Moe
- Kendal Wayne S
- Keng-Koh Pek
- Keng-Koh Pek
- Keni Manjusha
- Kennedy Julie
- Kenny Shannon
- Kent Christopher
- Kent Emma
- Kenyon Lucille
- Kershaw Elizabeth
- Key Claire
- Keyes Mira
- Khaksar Sara
- Khan Omar
- Khan Yakhub
- Khaouam Nader
- Khong Rachel
- Khoo Vincent
- Khoo Vincent
- Khoury Ghassan
- Kiff Janet
- Kift Shannon
- Kilmartin John
- Kilroy Stephen
- Kilroy Stephen
- Kiltie Anne
- Kiltie Anne
- Kim David
- Kim TuongVan
- Kim-Sing Charmaine
- KimSing Charmaine
- King Amy
- King Jennifer
- King Jennifer
- King Lisa
- Kinrade Yvonne
- KirbyBello Denise
- Kirk Christine
- Kirk Sister Sarah
- Kirkbride Peter
- Kirkbride Peter
- Kirkby Amy
- Kirkby Sarah
- Kirkpatrick Suriya
- Kisanga Mary
- Kitkowski Caitlin
- Klapp Kathi
- Klotz Laurence
- Klovgaard Karina
- Knackstedt Jochen
- Knapp Jeanette
- Knight (n. Sherburn) Victoria
- Knott Helen
- Knox WF
- Kockelbergh Roger
- Kodavatiganti Ravi
- Koehler Ingrid
- Kokholm Kathrine Friser
- Koll Wayne
- Kong Vickie
- Kotze Michelle
- Koul Rashmi
- Koulouris Zoe
- Koupparis Anthony
- Kowalczyk-Williams Wioletta
- Kowalewska Paulina
- Kronstal Flo
- Krysta Beata
- Kuenzig Greg
- Kujawa Magda
- Kuk Joda
- Kullane Sagal
- Kumar Daniel
- Kumar Muthar
- Kumar Shiyam
- Kumar Vikaash
- Kurian-Downer Sunita
- Kurup Rahul
- Kuzyk Valerie
- Kwan Winkle
- Kyffin Phillippa
- Kynaston Howard
- Kynaston Howard
- Lacey Cathy
- Lachance Nicole
- Lactao Ranee
- Ladouceur Cynthia
- Laing Robert
- Lajoie MarieAndree
- Lake Sister Judith
- Lalani Nafisha
- Laliberte Benoit
- Lam Jacqueline
- Lambert Carole
- Lambert Katy
- Lamoureux Alexandra
- Lang Monika
- Langridge Nicole
- Laniado M
- Lao Bernadeth
- Larkins Rachel
- Larocque Stephanie
- Larouche Julie
- Larson Beverly
- Lassen Yasmin
- Last Debbie
- Lau Maurice
- Laubscher Angelique
- Laughlin Anne
- Laursen Vibeke
- Lavender Helene
- Laverick Rosaleen
- Lavertu Sophie
- Lawless Claire
- Lawless Theresa
- Lawrence nee Palmer Tara
- Lawrence Steph
- Lawrey Sarah
- Lawson Daeria
- Lazarte Jannika
- Leach Deborah
- Lebrun Benoit
- Ledger Kate
- Lee Bernard
- Lee Brenda
- Lee Vivienne
- Lees Laura
- Leitao Madalena
- Lemaire Celine
- Lemng Kruse Helle
- Lemon Nicola
- Lenton Daniel
- Leone Priscilla
- Leone Priscilla
- Leong Nelson
- Leung Michael
- Lew Tanya
- Lewington Val
- Lewis Amanda
- Lewis Christina
- Lewis Joanne
- Lewis Sion
- Ley Samantha
- Li Audrey
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- Liau Joy
- Light Teresa
- Lim Jan
- Lim Jun
- Lindberg Henriette
- Lines Yvonne
- Lipsham Margaret
- Liptrott Sarah
- Lister Debbie
- Litchfield Jayne
- Little Erin
- Little Jessica
- Littler John
- Littler Stephen
- Liu Stanley
- Livsey Jacqueline
- Livsey Jacqueline
- Lloyd-Jones Hugh
- Loblaw Douglas Andrew
- Lock Michael I
- Locke Angela
- Lockwood Carol
- Logue John
- Logue John
- Logue John
- Logue John
- Lokes Rachel
- Lokes Rachel
- Lomas Alia
- Lomas Claire
- Lomax Laurie
- London Clare
- Long Carol
- Long Heather
- Loughlin Kate
- Loughrey Carmel
- Love Clare
- Love Sally
- Lowe Amelia
- Lowi Suzy
- Lucakova Slavka
- Lukka Himu
- Lunau Anne Sofie
- Lydon Anna
- Lydon Anne Marie
- Lynch Rory
- Lyons Ciara
- Mabelin Louies
- Macavoy Tina
- Macdonald Alison
- MacDonald Angela
- MacDonald Graham
- Macefield Rhiannon
- MacGregor Barbara
- Macgregor Carol
- MacIsaac Kathy
- MacIsaac Patricia
- Mackay Rachel
- Macleod Nicholas
- MacMillan Antonia
- MacMullin Lisa
- MacRae Robert M
- Macrory Joanne
- MacVicar Jennifer
- MacVicar Karen
- Madeleine Jude
- Madhava Kudingila
- Madine John
- Magwaro Sophia
- Magwaro Sophia
- Magwaro Sophia
- Mahmood Rana
- Mahmood Rana
- Mahmood Sana
- Mahmud Aamer
- Mahoney Catriona
- Mahoney Sue
- Maitland Katrina
- Maize Christine
- Majumdar Arpita
- Makepeace Barbara
- Malde Rohit
- Malek Leila
- Malik Zafar
- Mallett Debbie
- Malone Shawn
- Malone Shawn C
- Manetta Caroline
- Manganaro Aileen
- Mangar Stephen
- Maniatis Christos
- Manley Rachel
- Mannan Aliyah
- Manning Courtney
- Manning Kimberley
- Mansell Gemma
- Mansfield Carolyn
- Mantle Mark
- Manyangadze Sarah
- Marange Josephine
- Mardell Stephen
- Marek Kathleen
- Mariappan Param
- Marineau Line
- Mark Ian
- Markus Sarah
- Marley Hazel
- Marquis Tania
- Marriott Sue
- Marshall John
- Marshall Lynn
- MarshGray Kimberley
- Marston Kerrie
- Martin AndreGuy
- Martin Jackie
- Martin Joseph
- Martin Karen
- Martindale John
- Martindale John
- Martindale John
- Martinez Maria
- Martinou Maria
- Martins Sarah
- Marty Janet
- Mashegede Beverley
- Mason Jessica
- Mason Malcolm
- Masson Susan
- Masson Susan
- Masters Benjamin
- Masters Lindsey
- Matkins Ellen
- Matthews Laura
- Mattocks Lehentha
- Mayer Heather
- Mayne Barbara
- Mazhar Danish
- McAleese Jonathan
- McAlister Judy
- McAllister Jo
- McAuliffe Sarah
- McBain Hazel
- McBride Julia
- McCabe Alastair
- McCadden Angela
- McCarth Fiona
- McCartin Fiona
- McCaul Damian
- McClelland Marie
- McClements Jane
- McClurey Sister Patricia
- McCormack Anne
- McCormick Marian
- McCracken Jillian
- McCrisken Lauren
- McCrudden Sylvia
- McCully Ruby
- McCurrie Marilyn
- McFarlane Jonathan
- McFarlane Victoria
- McGarry Karen
- McGinley Shannon
- McGlynn Brian
- McGrath John
- McGrath Katherine
- McIndoe Sue
- McInerney Paul
- McInerney Sue
- McInerney Veronica
- Mcintosh Gregor
- McKee Dianne
- McKenna Karen
- McKenzie Michael
- McKernan Margaret
- McKinna Fiona
- McKinna Fiona
- McLain-Smith Susan
- McLaren Duncan
- McLarty Esther
- Mcleod Nick
- McMeekin Faith
- McMenemin Rhona
- McNally Morag
- McNish Jennifer
- McNulty Dawn
- McPhail Neil
- McWilliam Donna
- McWilliam Marie
- Meadows Lorna
- Medisetti Aruna
- Meidhal Petersen Peter
- Melcher Lucinda
- Melcher Lucinda
- Menard Cynthia
- Menard Cynthia
- Mendoza Edeliza
- Merante Pat
- Mercer Lily
- Mercier Barbara
- Merrick Richard
- Metcalf Karen
- Meyer Ralph
- Michael Elena
- Michaelidou Andriana
- Michels Jorg
- Middleton Sharon
- Mikropoulos Christos
- Mikropoulos Christos
- Millage Helen
- Miller Nikki
- Mills Jamie
- Mills Laurie
- Mills-Baldock Tina
- Milner Jessica
- Milosevic Michael
- Mirmooji Ramesh
- Mirza Arafat
- Mislang Albert
- Mistry Heena
- Mistry Leena
- Mitchell Darren
- Mitchell Donna
- Mitchell Lesley
- Mithal Natasha
- Mitra Anita
- Moelker Yvonne
- Moffatt Emily
- Mohamed Fatima
- Mohan Rita
- Mohseeni Arizoo
- Moir Rachel
- Mojidra Chintan
- Mole Lisa
- Moller Christensen Trine
- Molony-Oates Barbara
- Money-Kyrle Julian
- Montebello Joseph
- Montour Julie
- Moody Emma
- Mooney Matthew
- Moore Eleanor
- Moore Eleanor
- Moore Sally
- Moore Sister Helen
- Morales Maria
- Morales-Azofra Fabiola
- Morgan Rachel
- Morgan Scott
- Morris Stephen
- Morris Stephen L
- Morris William James
- Morrison Andrew
- Morrison Jennifer
- Morrison MaryBeth
- Morrow Hugh
- Morton Gerard
- Morton Gerard
- Morton Susan
- Moss Sarah
- Mthethwa Thobekile
- Mui Jimmy
- Mukkath Sandra
- Mumin Anissa
- Mundy Carina
- Munson Lyndsey
- Murad Fatima
- Muraj Zaynab
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- Murphy Ann
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- Murphy Cara
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- Murphy Karen
- Murphy Louise
- Murray Jane
- Murray Stacey
- Murtha Albert
- Musunuru Hima Bindu
- Muthu Kumar Dakshinamoorthy
- Myatt Alison
- Myles Sophie
- Myrehaug Sten
- Nabid Abdenour
- Nabid Abdenour
- Nagar Yoodhvir
- Naim Farhan
- Nakashima Lynne
- Nallathambi Chandran
- Nam Robert K
- Narahari Krishna
- Naraine Nicky
- Nash Dominic
- Nash Maxine
- Nashed Maged
- Natale Salvatore
- Nathan Kannon
- Nathan Kannon
- Nawrozzadeh Mohammed
- Naylor Deirdre
- Naylor Lynne
- Nazari Roonak
- Neal Amy
- Neave Farhad
- Needleman Sarah
- Nelder Matthew
- Nemirov Stephanie
- Neshiri Innocent
- Neville Sean
- Newbery Carol
- Newby Jackie
- Newman Hugh
- Newton Rachel
- Ngumo Alice
- Ngumo Alice
- Nguyen David H A
- Nguyen Julie
- Ngwenya Su
- Nichol Rhonda
- Nicholas Karen
- Nicholls Alison
- Nicholson Alastair
- Nicholson Alastair
- Nieforth Joan
- Nielsen Linda
- Nikapota Ashok
- Nikapota Ashok
- Nixon Jude
- Nobes Jenny
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- Noble Mark
- Noel Lorilee
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- Nybom Kirstine
- Nørmark Iversen Helle
- O'Beney Rachael
- O'Brien Neale
- O'Callaghan Jane
- O'Connor Kate
- O'Donnell Helen
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- O'Flynn Kieran
- O'Neil Rebecca
- O'Neill Eilish
- O'Neill John
- O'Sullivan Joe
- OBrien Anna
- ODea Jamie
- Okubanjo Maryanne
- Okubanjo Maryanne
- Olabanji Matthew
- Oladimeji Janet
- Olaniyi-Oduntan Darlletta
- Olaoni Thompson
- Olha Carolynna
- Oliver Joanne
- Oliverio Carmela
- Ong Aldrich D
- Ong Aldrich Dixon
- Oni Titilayo
- Onoge Ekugbe
- Oommen Nikhil
- Oommen Nikhil
- Oosterom Katrien
- Opitz Debbie
- Orford Sara
- Orrell Lucy
- Ostler Peter
- Ostrowski Joe
- Othman Aqilah
- Ouelette Ashley
- Overend Aldyn
- Owen Lisa
- Owen Roger
- Owen Susan
- Owen Tim
- Owens Rob
- Oxley Jon
- Pach Jackie
- Padilla-Harris Cheryl
- Page Nancy
- Pai Howard H
- Paisey Sangeeta
- Palmer Debbie
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- Panades Miguel
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- Parulekar Wendy R
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- Rodda Sree
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- Rodda Sree
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- Smedley (nee McCabe) Janine
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- Thomson Alastair H
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- Tickle Vivienne
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- Toussi H
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- Townley Luke
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- Vengalil Salil
- Venkatesan Varagur M
- Venkitaraman Ramachandran
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- Vermette Tracy
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- Vigneault Eric
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- Vilarino-Varela Maria
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- Walsh Donna
- Walton Jenny
- Walton Sharon
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- Ward Colin
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- Waring Lynsey
- Waring Lynsey
- Wassall Rebecca
- Watkinson Catrin
- Watson Melanie R
- Watson Michaella
- Watson-Jones Phillip
- Watts Angela
- Watts Erica
- Weaver Andrew
- Weaver Emma
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- Westrop Anna
- Westrop Anna
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- Whitehouse James
- Whiteway Chrystal
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- Wightman John
- Wignall Suzy
- Wild Karen
- Wilke Derek
- Wilkie Karen
- Wilkins Marie
- Wilkinson Nicola
- Williams (Née Allen) Sister Tania
- Williams Amanda
- Williams Bethan
- Williams Candra
- Williams Jo
- Williams Joanne
- Williams Rachel
- Williams Rachel
- Williams-Yesson Barbara
- Williamson Elizabeth
- Williamson Nicola
- Willing Stephanie
- Wilson David
- Wilson Jim
- Wilson Jo
- Wilson Mark
- Wilson Paula
- Wilson Paula
- Wilson Russ
- Winn Carol
- Winter Sister Helen
- Wise Marcus
- Wise Marcus
- Wise Marcus
- Wiss Elliott
- Wollaston Julie
- Woloshyn Rose
- Wong Jason W T
- Wood Allison
- Wood Catherine
- Wood Cathryn
- Wood Marian
- Wood Pauline
- Wood Pauline
- Wood Sister Kim
- Wood Sister Kim
- Wood Sister Kim
- Woodhouse Iain
- Woods Catherine
- Woods Jane
- Woods Martin
- Woodward Cathryn
- Woodward Elizabeth
- Woolf David
- Woolf David
- Workman Bridget
- Worlding Jane
- Worlding Jane
- Worsley Lucy
- Worthington Hannah
- Wright Ann
- Wright Natalie
- Wright Seonaid
- Wrigley Martha
- Wronski Sue
- Wu Helen
- Wu Min
- Wyatt Clare
- Wylie James
- Wylie James
- Wylie James
- Wynn Hazel
- Wynn Hazel
- Yanchuk Janet
- Yarrow Sue
- Yassa Michael
- yates Victoria
- Yee Don
- Yeo Tanya
- Yoon Frederick
- Youd Sister Jill
- Young Anita
- Young Bobbie
- Young Douglas
- Young Sally
- Youngs Nora
- Yu Jason
- Yunace Lorrie
- Yusof Hilawati
- Zafar Waheed
- Zaidi Sadaf
- Zarkar Anjali
- Zarkar Anjali
- Zaza Khaled O
- Zelley Sarah
- Zeltser Fred
- Zhang Hanbo
- Zhang Tina Wanting
- Zietz Maria
- Zilkha Helene
- Zinck Connie
- Zinyemba Vivian
- Zurakovsky Hilary
- Zwarych Darlene
- Publication venue
- Elsevier
- Publication date
- 07/06/2024
- Field of study
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
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- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
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- Alexander M.
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- Amouyel Philippe
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- Kuzelova-Ptackova H.
- Landers John E
- Landwehrmeyer Georg Bernhard
- Laurent C.
- Lee J.
- Lee P.
- Legge S.E.
- Lencz Todd
- Lerer B.
- Levinson Douglas F.
- Lewis C.M.
- Li M.
- Li Qingqin S.
- Li T.
- Liang K.Y.
- Lichtner Peter
- Lieb Wolfgang
- Lieberman J.
- Limborska S.
- Lin Kuang
- Liu Jianjun
- Logroscino G.
- Lomen-Hoerth Catherine
- Lonnqvist J.
- Loughland C.M.
- Lubinski J.
- Ludolph A.C.
- Lunetta C.
- Luykx Jurjen J.
- MacEk M.
- Magnusson P.K.E.
- Maher B.S.
- Maier W.
- Malaspina Andrea
- Malhotra Anil K.
- Mallet J.
- Marsal Sara
- Mattheisen M.
- Mattingsdal M.
- Maurel Cindy
- Mazzini L.
- McCarley R.W.
- McCarroll Steven A.
- McCluskey Leo
- McDonald C.
- McIntosh A.M.
- McLaughlin Russell L.
- McQuillin Andrew
- Meier S.
- Meijer C.J.
- Meininger Vincent
- Meitinger Thomas
- Melegh B.
- Melle I.
- Mesholam-Gately R.I.
- Metspalu A.
- Meyer Thomas
- Michie P.T.
- Milani L.
- Milanova V.
- Millecamps Stéphanie
- Moglia C.
- Mokrab Y.
- Mora Jesús S.
- Moran Jennifer
- Morris D.W.
- Morrison Karen E.
- Mors O.
- Mortensen Preben Bo
- Mowry Bryan J.
- Muller-Myhsok B.
- Murphy K.C.
- Murray R.M.
- Myin-Germeys I.
- Neale B.M.
- Nelis M.
- Nenadic I.
- Nertney D.A.
- Nestadt G.
- Nicholson Garth A.
- Nicodemus K.K.
- Nigel Leigh P.
- Nikitina-Zake L.
- Nisenbaum L.
- Nordin A.
- Nothen Markus M.
- O'Brien Margaret
- O'Callaghan E.
- O'Donovan Michael C.
- O'Dushlaine C.
- Oh S.Y.
- Olincy A.
- Olsen L.
- Ophoff Roel A.
- Orrell Richard W.
- Owen Michael J.
- Padovani A.
- Palotie Aaron
- Pamphlett Roger
- Pansarasa O.
- Pantelis C.
- Papadimitriou G.N.
- Papiol S.
- Parkhomenko E.
- Pasterkamp R.J.
- Pato Carlos N.
- Pato M.T.
- Paunio T.
- Payan Christine A. M.
- Pejovic-Milovancevic M.
- Penco S.
- Pensato V.
- Perkins D.O.
- Pers T.H.
- Petri Susanne
- Petryshen Tracey L.
- Pietilainen O.
- Pimm J.
- Pinto Susana
- Pittman Alan
- Pocklington A.J.
- Polak Meraida
- Posthuma Danielle
- Powell J.
- Price A.
- Pulit Sara L.
- Pulver A.E.
- Pupillo E.
- Purcell S.M.
- Quested D.
- Rasmussen H.B.
- Ratti A.
- Reichenberg A.
- Reimers M.A.
- Richards A.L.
- Rietschel Marcella
- Riley Brien Patrick
- Ripke S.
- Riva N.
- Rivadeneira Fernando
- Robberecht W.
- Roffman J.L.
- Rojas-Garcia Ricard
- Roussos P.
- Rowe Dominic B.
- Ruderfer D.M.
- Rujescu Dan
- Saker-Delye Safa
- Salachas François
- Salomaa V.
- Sanders A.R.
- Schall U.
- Schijven Dick
- Schubert C.R.
- Schulze T.G.
- Schwab S.G.
- Scolnick E.M.
- Scott Stroup T.
- Scott R.J.
- Seidman L.J.
- Sendtner Michael
- Sham Pak C.
- Shatunov Aleksey
- Shaw Christopher
- Shaw Pamela
- Shi J.
- Sidle Katie
- Sigurdsson E.
- Silagadze T.
- Silani V.
- Silverman J.M.
- Sim K.
- Sklar Pamela
- Slominsky P.
- Smith B.N.
- Smoller J.W.
- So H.C.
- Soraru G.
- Spencer C.C.A.
- Sproviero William
- St Clair David
- Stah E.A.
- Stefansson H.
- Stefánsson Kári
- Steinberg S.
- Stogmann E.
- Straub R.E.
- Strengman E.
- Strohmaier J.
- Subramaniam M.
- Sullivan Patrick F.
- Suvisaari J.
- Svrakic D.M.
- Swingler Robert
- Szatkiewicz J.P.
- Söderman E.
- Thirumalai S.
- Ticozzi Nicola
- Tiloca C.
- Tittmann Lukas
- Toncheva D.
- Tortelli R.
- Tosato S.
- Trojanowski John Q.
- Tzourio Christophe
- Uitterlinden André G.
- Universitat Autònoma de Barcelona
- van Deerlin Vivianna M.
- van den Berg Leonard H.
- van der kooi Anneke Jelly
- van der Spek Rick A.A.
- van Doormaal Perry TC.
- Van Eijk Kristel R.
- van Rheenen Wouter
- Vanos J.
- Veijola J.
- Veldink Jan
- Visscher PM
- Vourc'H P.
- Waddington J.
- Walsh D.
- Walters J.T.R.
- Wang D.
- Wang Q.
- Webb B.T.
- Weber Markus
- Weinberger Daniel R.
- Weiser Mark
- Weishaupt J.H.
- Wendland Jens
- Werge Thomas
- Wiedau-Pazos Martina
- Wildenauer Dieter B.
- Williams Kelly
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wood Nicholas
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin S.
- Zai Clement C.
- Zecca C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Publication date
- 01/01/2017
- Field of study
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies
Complement genes contribute sex-biased vulnerability in diverse disorders.
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andreassen Ole A
- Bacanu Silviu A
- Begemann Martin
- Belliveau Richard A
- Bene Judit
- Bergen Sarah E
- Bevilacqua Elizabeth
- Bigdeli Tim B
- Black Donald W
- Blackwood Douglas H R
- Boehnke Michael
- Bramon Elvira
- Bruggeman Richard
- Buccola Nancy G
- Buckner Randy L
- Bulik-Sullivan Brendan
- Buxbaum Joseph D
- Byerley William
- Børglum Anders D
- Cahn Wiepke
- Cai Guiqing
- Cairns Murray J
- Campion Dominique
- Cantor Rita M
- Carr Vaughan J
- Carrera Noa
- Catts Stanley V
- Chambert Kimberly D
- Chan Raymond C K
- Chen Eric Y H
- Chen Ronald Y L
- Cheng Wei
- Cheung Eric F C
- Chong Siow Ann
- Cichon Sven
- Clair David St
- Cloninger C Robert
- Cohen David
- Cohen Nadine
- Collier David A
- Consortium Schizophrenia Working Group of the Psychiatric Genomics
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crespo-Facorro Benedicto
- Criswell Lindsey A
- Crowley James J
- Curtis David
- Daly Mark J
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- de Rivera Heather
- Degenhardt Franziska
- Del Favero Jurgen
- DeLisi Lynn E
- Demontis Ditte
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tõnu
- Essioux Laurent
- Fanous Ayman H
- Farh Kai-How
- Farrell Martilias S
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B
- Friedl Marion
- Friedman Joseph I
- Fromer Menachem
- Gejman Pablo V
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S
- Giegling Ina
- Gill Michael
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goldstein Jacqueline I
- Golimbet Vera
- Gopal Srihari
- Graham Robert R
- Gratten Jacob
- Gurling Hugh
- Hamshere Marian L
- Handsaker Robert E
- Hansen Mark
- Hansen Thomas
- Harley John B
- Haroutunian Vahram
- Hartmann Annette M
- Henskens Frans A
- Herms Stefan
- Hirschhorn Joel N
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V
- Holmans Peter A
- Hougaard David M
- Huang Hailiang
- Hultman Christina M
- Ikeda Masashi
- Iwata Nakao
- Jablensky Assen V
- Joa Inge
- Julià Antonio
- Jönsson Erik G
- Kahn René S
- Kalaydjieva Luba
- Kamitaki Nolan
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kaufman Kenneth M
- Kavanagh David
- Keller Matthew C
- Kelly Brian J
- Kendler Kenneth S
- Kennedy James L
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kim Yunjung
- Kimberly Robert P
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A
- Konte Bettina
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Kähler Anna K
- Langefeld Carl D
- Laurent Claudine
- Lee Phil
- Lee S Hong
- Legge Sophie E
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Li Miaoxin
- Li Qingqin S
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Liu Jianjun
- Loohuis Loes M Olde
- Loughland Carmel M
- Lubinski Jan
- Lönnqvist Jouko
- Macek Milan
- Magnusson Patrik K E
- Maher Brion S
- Maier Wolfgang
- Malhotra Anil K
- Mallet Jacques
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W
- McCarroll Steven A
- McCarroll Steven A
- McDonald Colm
- McIntosh Andrew M
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
- Mitjans Marina
- Mokrab Younes
- Moran Jennifer L
- Morris David L
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mowry Bryan J
- Murphy Kieran C
- Murray Robin M
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Neale Benjamin M
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A
- Nestadt Gerald
- Nicodemus Kristin K
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nöthen Markus M
- O'Callaghan Eadbhard
- O'Donovan Michael C
- O'Dushlaine Colm
- O'Neill F Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A
- Ophoff Roel A
- Owen Michael J
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N
- Parkhomenko Elena
- Pato Carlos N
- Pato Carlos N
- Pato Michele T
- Pato Michele T
- Paunio Tiina
- Pejovic-Milovancevic Milica
- Perkins Diana O
- Pers Tune H
- Petryshen Tracey L
- Pietiläinen Olli
- Pimm Jonathan
- Pocklington Andrew J
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E
- Purcell Shaun M
- Quested Digby
- Rasmussen Henrik B
- Reichenberg Abraham
- Reimers Mark A
- Richards Alexander L
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Roffman Joshua L
- Roussos Panos
- Ruderfer Douglas M
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R
- Schall Ulrich
- Schubert Christian R
- Schulze Thomas G
- Schwab Sibylle G
- Scolnick Edward M
- Scott Rodney J
- Seidman Christine E
- Seidman Larry J
- Sekar Aswin
- Sham Pak C
- Shi Jianxin
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W
- So Hon-Cheong
- Spencer Chris C A
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Steixner Agnes A
- Stogmann Elisabeth
- Straub Richard E
- Strengman Eric
- Strohmaier Jana
- Stroup T Scott
- Subramaniam Mythily
- Sullivan Patrick F
- Suvisaari Jaana
- Svrakic Dragan M
- Szatkiewicz Jin P
- Söderman Erik
- Taylor Kimberly E
- Thirumalai Srinivas
- Tombleson Philip
- Toncheva Draga
- Tooley Katherine
- Tooney Paul A
- Tosato Sarah
- Van Os Jim
- Veijola Juha
- Visscher Peter M
- Vyse Timothy J
- Waddington John
- Walsh Dermot
- Walters James T R
- Wang Dai
- Wang Qiang
- Webb Bradley T
- Weinberger Daniel R
- Weiser Mark
- Wendland Jens R
- Werge Thomas
- Whelan Christopher W
- Wildenauer Dieter B
- Williams Nigel M
- Williams Stephanie
- Witt Stephanie H
- Wolen Aaron R
- Wong Emily H M
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Xi Hualin Simon
- Zai Clement C
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 11/05/2021
- Field of study
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren's syndrome affect nine times more women than men1, whereas schizophrenia affects men with greater frequency and severity relative to women2. All three illnesses have their strongest common genetic associations in the major histocompatibility complex (MHC) locus, an association that in SLE and Sjögren's syndrome has long been thought to arise from alleles of the human leukocyte antigen (HLA) genes at that locus3-6. Here we show that variation of the complement component 4 (C4) genes C4A and C4B, which are also at the MHC locus and have been linked to increased risk for schizophrenia7, generates 7-fold variation in risk for SLE and 16-fold variation in risk for Sjögren's syndrome among individuals with common C4 genotypes, with C4A protecting more strongly than C4B in both illnesses. The same alleles that increase risk for schizophrenia greatly reduce risk for SLE and Sjögren's syndrome. In all three illnesses, C4 alleles act more strongly in men than in women: common combinations of C4A and C4B generated 14-fold variation in risk for SLE, 31-fold variation in risk for Sjögren's syndrome, and 1.7-fold variation in schizophrenia risk among men (versus 6-fold, 15-fold and 1.26-fold variation in risk among women, respectively). At a protein level, both C4 and its effector C3 were present at higher levels in cerebrospinal fluid and plasma8,9 in men than in women among adults aged between 20 and 50 years, corresponding to the ages of differential disease vulnerability. Sex differences in complement protein levels may help to explain the more potent effects of C4 alleles in men, women's greater risk of SLE and Sjögren's syndrome and men's greater vulnerability to schizophrenia. These results implicate the complement system as a source of sexual dimorphism in vulnerability to diverse illnesses
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- Author
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Albus Margot
- Albus Margot
- Alexander Madeline
- Alexander Madeline
- Als Thomas D.
- Als Thomas D.
- Amin Farooq
- Amin Farooq
- Andreassen Ole A.
- Andreassen Ole A.
- Bacanu Silviu A.
- Bacanu Silviu A.
- Baekvad-Hansen Marie
- Baekvad-Hansen Marie
- Begemann Martin
- Begemann Martin
- Belliveau Richard A., Jr.
- Belliveau Richard A., Jr.
- Bene Judit
- Bene Judit
- Bergen Sarah E.
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Bigdeli Tim B.
- Black Donald W.
- Black Donald W.
- Blackwood Douglas H. R.
- Blackwood Douglas H. R.
- Boocock James
- Boocock James
- Borglum Anders D.
- Borglum Anders D.
- Borglum Anders D.
- Borglum Anders D.
- Bramon Elvira
- Bramon Elvira
- Bruggeman Richard
- Bruggeman Richard
- Buccola Nancy G.
- Buccola Nancy G.
- Buckner Randy L.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byerley William
- Cahn Wiepke
- Cahn Wiepke
- Cai Guiqing
- Cai Guiqing
- Campion Dominique
- Campion Dominique
- Cantor Rita M.
- Cantor Rita M.
- Carr Vaughan J.
- Carr Vaughan J.
- Carrera Noa
- Carrera Noa
- Catts Stanley, V
- Catts Stanley, V
- Chambert Kimberly D.
- Chambert Kimberly D.
- Chan Raymond C. K.
- Chan Raymond C. K.
- Chen Eric Y. H.
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Chen Ronald Y. L.
- Cheng Wei
- Cheng Wei
- Cheung Eric F. C.
- Cheung Eric F. C.
- Chong Siow Ann
- Chong Siow Ann
- Cichon Sven
- Cichon Sven
- Cloninger C. Robert
- Cloninger C. Robert
- Cohen David
- Cohen David
- Cohen Nadine
- Cohen Nadine
- Collier David A.
- Collier David A.
- Cormican Paul
- Cormican Paul
- Corvin Aiden
- Corvin Aiden
- Cox Nancy J.
- Cox Nancy J.
- Craddock Nick
- Craddock Nick
- Crowley James J.
- Crowley James J.
- Curtis David
- Curtis David
- Daly Mark J.
- Daly Mark J.
- Dang Kristen K.
- Dang Kristen K.
- Darvasi Ariel
- Darvasi Ariel
- Davidson Michael
- Davidson Michael
- Davis Kenneth L.
- Davis Kenneth L.
- de Haan Lieuwe
- de Haan Lieuwe
- Degenhardt Franziska
- Degenhardt Franziska
- Del Favero Jurgen
- Del Favero Jurgen
- Demontis Ditte
- Demontis Ditte
- Devlin Bernie
- Devlin Bernie
- Dikeos Dimitris
- Dikeos Dimitris
- Dinan Timothy
- Dinan Timothy
- Djurovic Srdjan
- Djurovic Srdjan
- Dobbyn Amanda
- Dobbyn Amanda
- Domenici Enrico
- Domenici Enrico
- Domenici Enrico
- Domenici Enrico
- Donohoe Gary
- Donohoe Gary
- Drapeau Elodie
- Drapeau Elodie
- Duan Jubao
- Duan Jubao
- Dudbridge Frank
- Dudbridge Frank
- Durmishi Naser
- Durmishi Naser
- Ehrenreich Hannelore
- Ehrenreich Hannelore
- Eichhammer Peter
- Eichhammer Peter
- Eriksson Johan
- Eriksson Johan
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tonu
- Esko Tonu
- Essioux Laurent
- Essioux Laurent
- Essioux Laurent
- Essioux Laurent
- Fanous Ayman H.
- Fanous Ayman H.
- Farh Kai-How
- Farh Kai-How
- Farrell Martilias S.
- Farrell Martilias S.
- Frank Josef
- Frank Josef
- Franke Lude
- Franke Lude
- Freedman Robert
- Freedman Robert
- Freimer Nelson B.
- Freimer Nelson B.
- Friedl Marion
- Friedl Marion
- Friedman Joseph, I
- Friedman Joseph, I
- Fromer Menachem
- Fromer Menachem
- Fromer Menachem
- Fromer Menachem
- Gamazon Eric R.
- Gamazon Eric R.
- Gejman Pablo, V
- Gejman Pablo, V
- Genovese Giulio
- Genovese Giulio
- Georgieva Lyudmila
- Georgieva Lyudmila
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Girdhar Kiran
- Girdhar Kiran
- Giusti-Rodriguez Paola
- Giusti-Rodriguez Paola
- Godard Stephanie
- Godard Stephanie
- Goldstein Jacqueline, I
- Goldstein Jacqueline, I
- Golimbet Vera
- Golimbet Vera
- Gopal Srihari
- Gopal Srihari
- Gratten Jacob
- Gratten Jacob
- Grove Jakob
- Grove Jakob
- Gur Raquel E.
- Gur Raquel E.
- Gurling Hugh
- Gurling Hugh
- Hahn Chang-Gyu
- Hahn Chang-Gyu
- Hammer Christian
- Hammer Christian
- Hamshere Marian L.
- Hamshere Marian L.
- Hansen Christine Soholm
- Hansen Christine Soholm
- Hansen Mark
- Hansen Mark
- Hansen Thomas
- Hansen Thomas
- Haroutunian Vahram
- Haroutunian Vahram
- Haroutunian Vahram
- Haroutunian Vahram
- Hartmann Annette M.
- Hartmann Annette M.
- Henskens Frans A.
- Henskens Frans A.
- Herms Stefan
- Herms Stefan
- Hirai Keisuke
- Hirai Keisuke
- Hirschhorn Joel N.
- Hirschhorn Joel N.
- Hoffman Gabriel
- Hoffman Gabriel
- Hoffmann Per
- Hoffmann Per
- Hofman Andrea
- Hofman Andrea
- Hollegaard Mads, V
- Hollegaard Mads, V
- Holmans Peter A.
- Holmans Peter A.
- Hougaard David M.
- Hougaard David M.
- Huang Hailiang
- Huang Hailiang
- Huckins Laura M.
- Huckins Laura M.
- Hultman Christina M.
- Hultman Christina M.
- Ikeda Masashi
- Ikeda Masashi
- Im Hae Kyung
- Im Hae Kyung
- Iwata Nakao
- Iwata Nakao
- Jablensky Assen, V
- Jablensky Assen, V
- Joa Inge
- Joa Inge
- Johnson Jessica S.
- Johnson Jessica S.
- Jonsson Erik G.
- Jonsson Erik G.
- Julia Antonio
- Julia Antonio
- Kahler Anna K.
- Kahler Anna K.
- Kahn Rene S.
- Kahn Rene S.
- Kalaydjieva Luba
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karachanak-Yankova Sena
- Karjalainen Juha
- Karjalainen Juha
- Kavanagh David
- Kavanagh David
- Keller Matthew C.
- Keller Matthew C.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Keong Jimmy Lee Chee
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Khrunin Andrey
- Kim Yunjung
- Kim Yunjung
- Kirov George
- Kirov George
- Klein Lambertus L.
- Klein Lambertus L.
- Klovins Janis
- Klovins Janis
- Knight Jo
- Knight Jo
- Knowles James A.
- Knowles James A.
- Konte Bettina
- Konte Bettina
- Kramer Robin
- Kramer Robin
- Kucinskas Vaidutis
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Kuzelova-Ptackova Hana
- Laurent Claudine
- Laurent Claudine
- Lee Phil
- Lee Phil
- Lee S. Hong
- Lee S. Hong
- Legge Sophie E.
- Legge Sophie E.
- Lencz Todd
- Lencz Todd
- Lerer Bernard
- Lerer Bernard
- Levinson Douglas F.
- Levinson Douglas F.
- Lewis David A.
- Lewis David A.
- Li Miaoxin
- Li Miaoxin
- Li Qingqin S.
- Li Qingqin S.
- Li Tao
- Li Tao
- Liang Kung-Yee
- Liang Kung-Yee
- Lieberman Jeffrey
- Lieberman Jeffrey
- Limborska Svetlana
- Limborska Svetlana
- Lipska Barbara K.
- Lipska Barbara K.
- Liu Jianjun
- Liu Jianjun
- Logsdon Benjamin A.
- Logsdon Benjamin A.
- Lonnqvist Jouko
- Lonnqvist Jouko
- Loughland Carmel M.
- Loughland Carmel M.
- Lubinski Jan
- Lubinski Jan
- Macek Milan, Jr.
- Macek Milan, Jr.
- Magnusson Patrik K. E.
- Magnusson Patrik K. E.
- Mahajan Milind C.
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- Maher Brion S.
- Maher Brion S.
- Maier Wolfgang
- Maier Wolfgang
- Malhotra Anil K.
- Malhotra Anil K.
- Mallet Jacques
- Mallet Jacques
- Mangravite Lara M.
- Mangravite Lara M.
- Marsal Sara
- Marsal Sara
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mattingsdal Morten
- McCarley Robert W.
- McCarley Robert W.
- McCarroll Steven A.
- McCarroll Steven A.
- McDonald Colm
- McDonald Colm
- McIntosh Andrew M.
- McIntosh Andrew M.
- McQuillin Andrew
- McQuillin Andrew
- Meier Sandra
- Meier Sandra
- Meijer Carin J.
- Meijer Carin J.
- Melegh Bela
- Melegh Bela
- Melle Ingrid
- Melle Ingrid
- Mesholam-Gately Raquelle, I
- Mesholam-Gately Raquelle, I
- Metspalu Andres
- Metspalu Andres
- Michie Patricia T.
- Michie Patricia T.
- Milani Lili
- Milani Lili
- Milanova Vihra
- Milanova Vihra
- Mokrab Younes
- Mokrab Younes
- Moran Jennifer L.
- Moran Jennifer L.
- Morris Derek W.
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mors Ole
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben B.
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mowry Bryan J.
- Mowry Bryan J.
- Muller-Myhsok Bertram
- Muller-Myhsok Bertram
- Murphy Kieran C.
- Murphy Kieran C.
- Murray Robin M.
- Murray Robin M.
- Myin-Germeys Inez
- Myin-Germeys Inez
- Neale Benjamin M.
- Neale Benjamin M.
- Nelis Mari
- Nelis Mari
- Nenadic Igor
- Nenadic Igor
- Nertney Deborah A.
- Nertney Deborah A.
- Nestadt Gerald
- Nestadt Gerald
- Nguyen Hoang T.
- Nguyen Hoang T.
- Nicodemus Kristin K.
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nisenbaum Laura
- Nordentoft Merete
- Nordentoft Merete
- Nordin Annelie
- Nordin Annelie
- Nothen Markus M.
- Nothen Markus M.
- O'Callaghan Eadbhard
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Donovan Michael C.
- O'Dushlaine Colm
- O'Dushlaine Colm
- O'Neill F. Anthony
- O'Neill F. Anthony
- Oh Sang-Yun
- Oh Sang-Yun
- Olincy Ann
- Olincy Ann
- Olsen Line
- Olsen Line
- Ophoff Roel A.
- Ophoff Roel A.
- Owen Michael J.
- Owen Michael J.
- Owen Michael J.
- Owen Michael J.
- Palotie Aarno
- Palotie Aarno
- Pantelis Christos
- Pantelis Christos
- Papadimitriou George N.
- Papadimitriou George N.
- Papiol Sergi
- Papiol Sergi
- Pardinas Antonio F.
- Pardinas Antonio F.
- Parkhomenko Elena
- Parkhomenko Elena
- Pato Carlos N.
- Pato Carlos N.
- Pato Michele T.
- Pato Michele T.
- Paunio Tiina
- Paunio Tiina
- Pedersen Carsten Bocker
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Pedersen Marianne Giortz
- Pejovic-Milovancevic Milica
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Perkins Diana O.
- Pers Tune H.
- Pers Tune H.
- Perumal Thanneer M.
- Perumal Thanneer M.
- Peters Mette A.
- Peters Mette A.
- Petryshen Tracey L.
- Petryshen Tracey L.
- Pietilainen Olli
- Pietilainen Olli
- Pimm Jonathan
- Pimm Jonathan
- Pocklington Andrew J.
- Pocklington Andrew J.
- Posthuma Danielle
- Posthuma Danielle
- Powell John
- Powell John
- Price Alkes
- Price Alkes
- Pulver Ann E.
- Pulver Ann E.
- Purcell Shaun
- Purcell Shaun
- Purcell Shaun M.
- Purcell Shaun M.
- Quested Digby
- Quested Digby
- Rajagopal Veera M.
- Rajagopal Veera M.
- Rajagopal Veera Manikandan
- Rajagopal Veera Manikandan
- Rasmussen Henrik B.
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reichenberg Abraham
- Reimers Mark A.
- Reimers Mark A.
- Richards Alexander L.
- Richards Alexander L.
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P.
- Riley Brien P.
- Ripke Stephan
- Ripke Stephan
- Roffman Joshua L.
- Roffman Joshua L.
- Roussos Panos
- Roussos Panos
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Rujescu Dan
- Salomaa Veikko
- Salomaa Veikko
- Sanders Alan R.
- Sanders Alan R.
- Schadt Eric
- Schadt Eric
- Schall Ulrich
- Schall Ulrich
- Schubert Christian R.
- Schubert Christian R.
- Schulze Thomas G.
- Schulze Thomas G.
- Schwab Sibylle G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scolnick Edward M.
- Scott Rodney J.
- Scott Rodney J.
- Seidman Larry J.
- Seidman Larry J.
- Shah Hardik R.
- Shah Hardik R.
- Sham Pak C.
- Sham Pak C.
- Shi Jianxin
- Shi Jianxin
- Sieberts Solveig K.
- Sieberts Solveig K.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silagadze Teimuraz
- Silverman Jeremy M.
- Silverman Jeremy M.
- Sim Kang
- Sim Kang
- Sklar Pamela
- Sklar Pamela
- Slominsky Petr
- Slominsky Petr
- Smoller Jordan W.
- Smoller Jordan W.
- So Hon-Cheong
- So Hon-Cheong
- Soderman Erik
- Soderman Erik
- Spencer Chris C. A.
- Spencer Chris C. A.
- St Clair David
- St Clair David
- Stahl Eli A.
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Steinberg Stacy
- Steinberg Stacy
- Stogmann Elisabeth
- Stogmann Elisabeth
- Straub Richard E.
- Straub Richard E.
- Strengman Eric
- Strengman Eric
- Strohmaier Jana
- Strohmaier Jana
- Stroup T. Scott
- Stroup T. Scott
- Subramaniam Mythily
- Subramaniam Mythily
- Sullivan Patrick
- Sullivan Patrick
- Sullivan Patrick F.
- Sullivan Patrick F.
- Suvisaari Jaana
- Suvisaari Jaana
- Svrakic Dragan M.
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Szatkiewicz Jin P.
- Thirumalai Srinivas
- Thirumalai Srinivas
- Toncheva Draga
- Toncheva Draga
- Tosato Sarah
- Tosato Sarah
- Toyoshiba Hiroyoshi
- Toyoshiba Hiroyoshi
- Van Os Jim
- Van Os Jim
- Veijola Juha
- Veijola Juha
- Visscher Peter M.
- Visscher Peter M.
- Waddington John
- Waddington John
- Walsh Dermot
- Walsh Dermot
- Walters James T. R.
- Walters James T. R.
- Wang Dai
- Wang Dai
- Wang Qiang
- Wang Qiang
- Wang Weiqing
- Wang Weiqing
- Webb Bradley T.
- Webb Bradley T.
- Weinberger Daniel R.
- Weinberger Daniel R.
- Weiser Mark
- Weiser Mark
- Wendland Jens R.
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Wildenauer Dieter B.
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Nigel M.
- Williams Stephanie
- Williams Stephanie
- Witt Stephanie H.
- Witt Stephanie H.
- Wolen Aaron R.
- Wolen Aaron R.
- Wong Emily H. M.
- Wong Emily H. M.
- Wormley Brandon K.
- Wormley Brandon K.
- Wray Naomi R.
- Wray Naomi R.
- Xi Hualin Simon
- Xi Hualin Simon
- Zai Clement C.
- Zai Clement C.
- Zheng Xuebin
- Zheng Xuebin
- Zimprich Fritz
- Zimprich Fritz
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.</p
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
- Author
- Abdellaoui Abdel
- Adams Mark J.
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Air Tracy M.
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andlauer Till F. M.
- Andreassen Ole A.
- Arolt Volker
- Bacanu Silviu A.
- Bacanu Silviu-Alin
- Baune Bernhard T.
- Beekman Aartjan T. F.
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Berger Klaus
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Black Donald W.
- Blackwood Douglas H. R.
- Boomsma Dorret I.
- Bramon Elvira
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buttenschøn Henriette N.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Bækvad-Hansen Marie
- Børglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Cai Na
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Case-Control Consortium Wellcome Trust
- Castelao Enrique
- Catts Stanley V.
- Chambert Kimberley D.
- Chan Raymond C. K.
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Collier David A.
- Colodro-Conde Lucía
- Cormican Paul
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Craddock Nick
- Craddock Nick
- Crawford Gregory E.
- Crowley James J.
- Daly Mark J.
- Dannlowski Udo
- Darvasi Ariel
- Davidson Michael
- Davies Gail
- Davis Kenneth L.
- de Geus E. J. C.
- de Haan Lieuwe
- Deary Ian J.
- Degenhardt Franziska
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- DePaulo J. Raymond
- Derks Eske M.
- Dikeos Dimitris
- Dinan Timothy
- Direk Nese
- Djurovic Srdjan
- Dolan Conor V.
- Domenici Enrico
- Domenici Enrico
- Domschke Katharina
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Dunn Erin C.
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eley Thalia C.
- Eriksson Johan
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Finucane Hilary K.
- Foo Jerome C.
- Forstner Andreas J.
- Frank Josef
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Gaspar Héléna A.
- Ge Tian
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Gill Michael
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goes Fernando S.
- Goldstein Jacqueline I.
- Golimbet Vera
- Gopal Srihari
- Gordon Scott D.
- Grabe Hans J.
- Gratten Jacob
- Grove Jakob
- Gurling Hugh
- Hall Lynsey S.
- Hamilton Steven P.
- Hammer Christian
- Hamshere Marian L.
- Hansen Christine Søholm
- Hansen Mark
- Hansen Thomas
- Hansen Thomas F.
- Haroutunian Vahram
- Hartmann Annette M.
- Hassan Kiadeh Farnush Farhadi
- Hayward Caroline
- Heath Andrew C.
- Henskens Frans A.
- Herms Stefan
- Herms Stefan
- Hickie Ian B.
- Hirschhorn Joel N.
- Hoffmann Per
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V.
- Holmans Peter A.
- Homuth Georg
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Hailiang
- Hultman Christina M.
- Ikeda Masashi
- International Consortium Psychosis Endophenotypes
- Ising Marcus
- Iwata Nakao
- Jablensky Assen V.
- Jansen Rick
- Joa Inge
- Jones Ian
- Jones Lisa A.
- Jorgenson Eric
- Julià Antonio
- Jönsson Erik G.
- Kahn René S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Khrunin Andrey
- Kiewa Jacqueline
- Kim Yunjung
- Kirov George
- Kloiber Stefan
- Klovins Janis
- Knight Jo
- Knowles James A.
- Knowles James A.
- Kohane Isaac S.
- Konte Bettina
- Kraft Julia
- Kretzschmar Warren W.
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kutalik Zoltán
- Kuzelova-Ptackova Hana
- Kähler Anna K.
- Laurent Claudine
- Lee Jimmy
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Lewis Glyn
- Li Miaoxin
- Li Qingqin S.
- Li Qingqin S.
- Li Tao
- Li Yihan
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Lind Penelope A.
- Liu Jianjun
- Loughland Carmel M.
- Lubinski Jan
- Lucae Susanne
- Lönnqvist Jouko
- Macek Milan
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela A. F.
- Magnusson Patrik K.
- Magnusson Patrik K. E.
- Maher Brion S.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Marchini Jonathan
- Marsal Sara
- Martin Nicholas G.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mbarek Hamdi
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McGrath Patrick
- McGuffin Peter
- McIntosh Andrew M.
- McIntosh Andrew M.
- McQuillin Andrew
- Medland Sarah E.
- Mehta Divya
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Metspalu Andres
- Michie Patricia T.
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Milanova Vihra
- Mirza Saira Saeed
- Mokrab Younes
- Mondimore Francis M.
- Montgomery Grant W.
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben Bo
- Mostafavi Sara
- Mowry Bryan J.
- Mullins Niamh
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Nauck Matthias
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Ng Bernard
- Ni Guiyan
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nivard Michel G.
- Nordentoft Merete
- Nordin Annelie
- Nyholt Dale R.
- Nyholt Dale R.
- Nöthen Markus M.
- Nöthen Markus M.
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Oskarsson Hogni
- Owen Michael J.
- Owen Michael J.
- O’Callaghan Eadbhard
- O’Donovan Michael C.
- O’Donovan Michael C.
- O’Dushlaine Colm
- O’Neill F. Anthony
- O’Reilly Paul F.
- Paciga Sara A.
- Painter Jodie N.
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Nancy L.
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Peterson Roseann E.
- Petryshen Tracey L.
- Peyrot Wouter J.
- Pietiläinen Olli
- Pimm Jonathan
- Pistis Giorgio
- Pocklington Andrew J.
- Posthuma Danielle
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun M.
- Quested Digby
- Quiroz Jorge A.
- Qvist Per
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Restuadi Restuadi
- Revez Joana A.
- Rice John P.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Riley Brien P.
- Ripke Stephan
- Ripke Stephan
- Rivera Margarita
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schall Ulrich
- Schoevers Robert
- Schubert Christian R.
- Schulte Eva C.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Rodney J.
- Seidman Larry J.
- Sham Pak C.
- Shen Ling
- Shi Jianxin
- Shi Jianxin
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sinnamon Grant C. B.
- Sklar Pamela
- Slominsky Petr
- Smit Johannes H.
- Smith Daniel J.
- Smoller Jordan W.
- Smoller Jordan W.
- So Hon-Cheong
- Spencer Chris C. A.
- St Clair David
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Streit Fabian
- Strengman Eric
- Strohmaier Jana
- Strohmaier Jana
- Stroup T. Scott
- Subramaniam Mythily
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Söderman Erik
- Tansey Katherine E.
- Teismann Henning
- Teumer Alexander
- Thirumalai Srinivas
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Toncheva Draga
- Tosato Sarah
- Traylor Matthew
- Treutlein Jens
- Trubetskoy Vassily
- Trzaskowski Maciej
- Uitterlinden André G.
- Umbricht Daniel
- Van der Auwera Sandra
- van Hemert Albert M.
- Van Os Jim
- Veijola Juha
- Viktorin Alexander
- Visscher Peter M.
- Visscher Peter M.
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T. R.
- Wang Dai
- Wang Qiang
- Wang Ying
- Wang Yunpeng
- Webb Bradley T.
- Webb Bradley T.
- Weinberger Daniel R.
- Weinsheimer Shantel Marie
- Weiser Mark
- Wellmann Jürgen
- Wendland Jens R.
- Werge Thomas
- Wildenauer Dieter B.
- Willemsen Gonneke
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wormley Brandon K.
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Hualin Simon
- Yang Jian
- Yang Jian
- Zai Clement C.
- Zeng Jian
- Zhang Futao
- Zheng Xuebin
- Zheng Zhili
- Zimprich Fritz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Polygenic scores (PGSs), which assess the genetic risk of individuals for a
disease, are calculated as a weighted count of risk alleles identified in genome-wide
association studies (GWASs). PGS methods differ in which DNA variants are included and
the weights assigned to them; some require an independent tuning sample to help inform
these choices. PGSs are evaluated in independent target cohorts with known disease status.
Variability between target cohorts is observed in applications to real data sets, which could
reflect a number of factors, e.g., phenotype definition or technical factors.
Methods: The Psychiatric Genomics Consortium working groups for schizophrenia (SCZ)
and major depressive disorder (MDD) bring together many independently collected case control cohorts. We used these resources (31K SCZ cases, 41K controls; 248K MDD cases,
563K controls) in repeated application of leave-one-cohort-out meta-analyses, each used to
calculate and evaluate PGS in the left-out (target) cohort. Ten PGS methods (the baseline
PC+T method and nine methods that model genetic architecture more formally: SBLUP,
LDpred2-Inf, LDpred-funct, LDpred2, Lassosum, PRS-CS, PRS-CS-auto, SBayesR,
MegaPRS) are compared.
Results: Compared to PC+T, the other nine methods give higher prediction statistics,
MegaPRS, LDPred2 and SBayesR significantly so, up to 9.2% variance in liability for SCZ
across 30 target cohorts, an increase of 44%. For MDD across 26 target cohorts these
statistics were 3.5% and 59%, respectively.
Conclusions: Although the methods that more formally model genetic architecture have
similar performance, MegaPRS, LDpred2, and SBayesR rank highest in most comparison
and are recommended in applications to psychiatric disorders
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J.
- Adams Mark J.
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Air Tracy
- Air Tracy M.
- Akil Huda
- Albani Diego
- Albus Margot
- Alda Martin
- Alda Martin
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D.
- Als Thomas D.
- Amin Farooq
- Andlauer Till F. M.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Arranz Maria J.
- Awasthi Swapnil
- Bacanu Silviu A.
- Bacanu Silviu-Alin
- Badner Judith A.
- Bakker Steven
- Band Gavin
- Barchas Jack D.
- Barroso Ines
- Barroso Ines
- Bass Nicholas
- Bass Nicholas J.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Beekman Aartjan T. F.
- Begemann Martin
- Begemann Martin
- Bellenguez Céline
- Belliveau Richard
- Belliveau Richard A.
- Bellivier Frank
- Bender Stephan
- Bene Judit
- Bergen Sarah E.
- Bergen Sarah E.
- Berger Klaus
- Bevilacqua Elizabeth
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Black Donald W.
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- Weickert Cynthia Shannon
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- Weisbrod Matthias
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- Wildenauer Dieter B.
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- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zheng Xuebin
- Zimprich Fritz
- Zöllner Sebastian
- Ösby Urban
- Świątkowska Beata
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
- …