Reducing the burden of hypoglycaemia in people with diabetes through increased understanding:design of the Hypoglycaemia Redefining Solutions for Better Lives (Hypo-RESOLVE) project

Background Hypoglycaemia is the most frequent complication of treatment with insulin or insulin secretagogues in people with diabetes. Severe hypoglycaemia, i.e. an event requiring external help because of cognitive dysfunction, is associated with a higher risk of adverse cardiovascular outcomes and all‐cause mortality, but underlying mechanism(s) are poorly understood. There is also a gap in the understanding of the clinical, psychological and health economic impact of ‘non‐severe’ hypoglycaemia and the glucose level below which hypoglycaemia causes harm. Aim To increase understanding of hypoglycaemia by addressing the above issues over a 4‐year period. Methods Hypo‐RESOLVE is structured across eight work packages, each with a distinct focus. We will construct a large, sustainable database including hypoglycaemia data from >100 clinical trials to examine predictors of hypoglycaemia and establish glucose threshold(s) below which hypoglycaemia constitutes a risk for adverse biomedical and psychological outcomes, and increases healthcare costs. We will also investigate the mechanism(s) underlying the antecedents and consequences of hypoglycaemia, the significance of glucose sensor‐detected hypoglycaemia, the impact of hypoglycaemia in families, and the costs of hypoglycaemia for healthcare systems. Results The outcomes of Hypo‐RESOLVE will inform evidence‐based definitions regarding the classification of hypoglycaemia in diabetes for use in daily clinical practice, future clinical trials and as a benchmark for comparing glucose‐lowering interventions and strategies across trials. Stakeholders will be engaged to achieve broadly adopted agreement. Conclusion Hypo‐RESOLVE will advance our understanding and refine the classification of hypoglycaemia, with the ultimate aim being to alleviate the burden and consequences of hypoglycaemia in people with diabetes

Irradiation Effects on Microstructure and Dielectric Properties of Ba[(Mg0.32Co0.02)Nb0.66]O3 [BMCN] Thin Films

Ba[(Mg0.32Co0.02)Nb0.66]O3 [BMCN] thin films prepared on Pt-Si, MgO, Silicon and ITO coated glass substrates by Pulsed Laser Deposition Technique are investigated. Relative growth parameters suggest that ITO coated glass substrate has good potential for growing films with near Nano size columnar grains. In comparison to bulk, dielectric constant and dielectric loss increases in BMCN films. This undesirable rise in dielectric loss can be drastically reduced by a factor of more than 1/100th times through Ag15+ ion irradiation at 1 × 1012 ions/cm2 dose. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3025

Modifications In Magnetic Properties Of Bimn2 O5 Multiferroic Using Swift Heavy Ion Irradiation

We report the near edge x-ray absorption fine structure (NEXAFS) and x-ray magnetic circular dichroism (XMCD) studies at the Mn L3,2 edge of pulsed laser deposited pristine thin films of multiferroic BiMn2 O5. These investigations are furthermore testified for BiMn2 O5 thin films irradiated through 200 MeV Ag15+ ions with fluence value 5× 1011 ions/ cm2. Though the pristine film is primarily antiferromagnetic in nature, irradiation induces ferrimagnetism in it. Element specific characterizations, NEXAFS and XMCD demonstrate the evolution of Mn2+ state piloting to magnetic signal associated with it. © 2010 American Institute of Physics.1079Nan, C.-W., Bichurin, M.I., Dong, S., Viehland, D., Srinivasan, G., Multiferroic magnetoelectric composites: Historical perspective, status, and future directions (2008) Journal of Applied Physics, 103 (3), p. 031101. , DOI 10.1063/1.2836410Ramesh, R., Spaldin, N.A., Multiferroics: Progress and prospects in thin films (2007) Nature Materials, 6 (1), pp. 21-29. , DOI 10.1038/nmat1805, PII NMAT1805Eerenstein, W., Mathur, N.D., Scott, J.F., Multiferroic and magnetoelectric materials (2006) Nature, 442 (7104), pp. 759-765. , DOI 10.1038/nature05023, PII NATURE05023Gajek, M., Bibes, M., Fusil, S., Bouzehouane, K., Fontcuberta, J., Barthelemy, A., Fert, A., Tunnel junctions with multiferroic barriers (2007) Nature Materials, 6 (4), pp. 296-302. , DOI 10.1038/nmat1860, PII NMAT1860Cheong, S.-W., Mostovoy, M., Multiferroics: A magnetic twist for ferroelectricity (2007) Nature Materials, 6 (1), pp. 13-20. , DOI 10.1038/nmat1804, PII NMAT1804Hur, N., Park, S., Sharma, P.A., Ahn, J.S., Guha, S., Cheong, S.-W., Electric polarization reversal and memory in a multiferroic material induced by magnetic fields (2004) Nature, 429 (6990), pp. 392-395. , DOI 10.1038/nature02572Chapon, L.C., Radaelli, P.G., Blake, G.R., Park, S., Cheong, S.-W., Ferroelectricity induced by acentric spin-density waves in YMn2O5 (2006) Physical Review Letters, 96 (9), pp. 1-4. , http://oai.aps.org/oai?verb=GetRecord&Identifier=oai:aps.org: PhysRevLett.96.097601&metadataPrefix=oai_apsmeta_2, DOI 10.1103/PhysRevLett.96.097601, 097601Muoz, A., Alonso, J.A., Casais, M.T., Martínez-Lope, M.J., Martínez, J.L., Fernández-Díaz, M.T., (2002) Phys. Rev. B, 65, p. 144423. , PRBMDO 0163-1829,. 10.1103/PhysRevB.65.144423Blake, G.R., Chapon, L.C., Radaelli, P.G., Park, S., Hur, N., Cheong, S.-W., Rodriguez-Carvajal, J., Spin structure and magnetic frustration in multiferroic RMn2O5 (R=Tb,Ho,Dy) (2005) Physical Review B - Condensed Matter and Materials Physics, 71 (21), pp. 1-9. , http://oai.aps.org/oai/?verb=ListRecords&metadataPrefix= oai_apsmeta_2&set=journal:PRB:71, DOI 10.1103/PhysRevB.71.214402, 214402Shukla, D.K., Kumar, R., Sharma, S.K., Thakur, P., Choudhary, R.J., Mollah, S., Brookes, N.B., Choi, W.K., (2009) J. Phys. D, 42, p. 125304. , JPAPBE 0022-3727,. 10.1088/0022-3727/42/12/125304Vecchini, C., Chapon, L.C., Brown, P.J., Chatterji, T., Park, S., Cheong, S.W., Radaelli, P.G., (2008) Phys. Rev. B, 77, p. 134434. , PRBMDO 0163-1829,. 10.1103/PhysRevB.77.134434Shukla, D.K., Mollah, S., Kumar, R., Thakur, P., Chae, K.H., Banerjee, A., Choi, W.K., (2008) J. Appl. Phys., 104, p. 033707. , JAPIAU 0021-8979,. 10.1063/1.2964072Kumar, R., Arora, S.K., Kanjilal, D., Mehta, G.K., Bache, R., Date, S.K., Shinde, S.R., Patil, S.I., (1999) Radiat. Eff. Defects Solids, 147, p. 187. , REDSEI 1042-0150,. 10.1080/10420159908229008Houpert, C., Studer, F., Groult, D., Toulmonde, M., (1989) Nucl. Instrum. Methods Phys. Res. B, 39, p. 720. , NIMBEU 0168-583X,. 10.1016/0168-583X(89)90882-3Kumar, R., Samantra, S.B., Arora, S.K., Gupta, A., Kanjilal, D., Pinto, R., Narlikar, A.V., (1998) Solid State Commun., 106, p. 805. , SSCOA4 0038-1098,. 10.1016/S0038-1098(98)00122-7Biersack, J.P., Haggmark, L., (1980) Nucl. Instrum. Methods Phys. Res., 174, p. 257. , NIMRD9 0167-5087,. 10.1016/0029-554X(80)90440-1Shukla, D.K., unpublished dataWang, Z.G., Dufour, C., Paumier, E., Toulemonde, M., (1994) J. Phys.: Condens. Matter, 6, p. 6733. , JCOMEL 0953-8984,. 10.1088/0953-8984/6/34/006Izui, K., Furuno, S., (1986) Proceedings of the 11th International Congress on Electron Microscopy, p. 1299. , edited by T. Imura, S. Maruse, and T. Suzuki (Japanese Society of Electron Microscopy, Tokyo),Meftah, A., Brisard, F., Costantini, J.M., Hage-Ali, M., Stoquert, J.P., Studer, F., Toulemonde, M., (1993) Phys. Rev. B, 48, p. 920. , and, PRBMDO 0163-1829,. 10.1103/PhysRevB.48.920Thibaudau, F., Cousty, J., Balanzat, E., Bouffard, S., (1991) Phys. Rev. Lett., 67, p. 1582. , PRLTAO 0031-9007,. 10.1103/PhysRevLett.67.1582Toulemonde, M., Dufour, C., Paumier, E., (1992) Phys. Rev. B, 46, p. 14362. , PRBMDO 0163-1829,. 10.1103/PhysRevB.46.1436

Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV

We report the results of a study of color coherence effects in ppbar collisions based on data collected by the D0 detector during the 1994-1995 run of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8 TeV. Initial-to-final state color interference effects are studied by examining particle distribution patterns in events with a W boson and at least one jet. The data are compared to Monte Carlo simulations with different color coherence implementations and to an analytic modified-leading-logarithm perturbative calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters

Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events

We present a measurement of the top quark pair ttbar production cross section in ppbar collisions at a center-of-mass energy of 1.96 TeV using 230 pb**{-1} of data collected by the DO detector at the Fermilab Tevatron Collider. We select events with one charged lepton (electron or muon), large missing transverse energy, and at least four jets, and extract the ttbar content of the sample based on the kinematic characteristics of the events. For a top quark mass of 175 GeV, we measure sigma(ttbar) = 6.7 {+1.4-1.3} (stat) {+1.6- 1.1} (syst) +/-0.4 (lumi) pb, in good agreement with the standard model prediction.Comment: submitted to Phys.Rev.Let

Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Lepton + Jets Events with Lifetime b-tagging

We present a measurement of the top quark pair ($t\bar{t}$) production cross section ($\sigma_{t\bar{t}}$) in $p\bar{p}$ collisions at $\sqrt{s}=1.96$ TeV using 230 pb$^{-1}$ of data collected by the D0 experiment at the Fermilab Tevatron Collider. We select events with one charged lepton (electron or muon), missing transverse energy, and jets in the final state. We employ lifetime-based b-jet identification techniques to further enhance the $t\bar{t}$ purity of the selected sample. For a top quark mass of 175 GeV, we measure $\sigma_{t\bar{t}}=8.6^{+1.6}_{-1.5}(stat.+syst.)\pm 0.6(lumi.)$ pb, in agreement with the standard model expectation.Comment: 7 pages, 2 figures, 3 tables Submitted to Phys.Rev.Let

Search for W' bosons decaying to an electron and a neutrino with the D0 detector

This Letter describes the search for a new heavy charged gauge boson W' decaying into an electron and a neutrino. The data were collected with the D0 detector at the Fermilab Tevatron proton-antiproton Collider at a center-of-mass energy of 1.96 TeV, and correspond to an integrated luminosity of about 1 inverse femtobarn. Lacking any significant excess in the data in comparison with known processes, an upper limit is set on the production cross section times branching fraction, and a W' boson with mass below 1.00 TeV can be excluded at the 95% C.L., assuming standard-model-like couplings to fermions. This result significantly improves upon previous limits, and is the most stringent to date.Comment: submitted to Phys. Rev. Let

Search for a scalar or vector particle decaying into Zgamma in ppbar collisions at sqrt(s) = 1.96 TeV

We present a search for a narrow scalar or vector resonance decaying into Zgamma with a subsequent Z decay into a pair of electrons or muons. The data for this search were collected with the D0 detector at the Fermilab Tevatron ppbar collider at a center of mass energy sqrt(s) = 1.96 TeV. Using 1.1 (1.0) fb-1 of data, we observe 49 (50) candidate events in the electron (muon) channel, in good agreement with the standard model prediction. From the combination of both channels, we derive 95% C.L. upper limits on the cross section times branching fraction (sigma x B) into Zgamma. These limits range from 0.19 (0.20) pb for a scalar (vector) resonance mass of 600 GeV/c^2 to 2.5 (3.1) pb for a mass of 140 GeV/c^2.Comment: Published by Phys. Lett.

Measurement of the ratios of the Z/G* + >= n jet production cross sections to the total inclusive Z/G* cross section in ppbar collisions at sqrt(s) = 1.96 TeV

We present a study of events with Z bosons and jets produced at the Fermilab Tevatron Collider in ppbar collisions at a center of mass energy of 1.96 TeV. The data sample consists of nearly 14,000 Z/G* -> e+e- candidates corresponding to the integrated luminosity of 0.4 fb-1 collected using the D0 detector. Ratios of the Z/G* + >= n jet cross sections to the total inclusive Z/G* cross section have been measured for n = 1 to 4 jet events. Our measurements are found to be in good agreement with a next-to-leading order QCD calculation and with a tree-level QCD prediction with parton shower simulation and hadronization.Comment: 7 pages, 2 figures, slightly modified, submitted to Phys. Lett.

Measurement of the Isolated Photon Cross Section in p-pbar Collisions at sqrt{s}=1.96 TeV

The cross section for the inclusive production of isolated photons has been measured in p anti-p collisions at sqrt{s}=1.96 TeV with the D0 detector at the Fermilab Tevatron Collider. The photons span transverse momenta 23 to 300 GeV and have pseudorapidity |eta|<0.9. The cross section is compared with the results from two next-to-leading order perturbative QCD calculations. The theoretical predictions agree with the measurement within uncertainties.Comment: 7 pages, 5 figures, submitted to Phys.Lett.