Stabilization of high-temperature superconducting A15 phase La4_4H23_{23} below 100 GPa

High pressure plays a crucial role in the field of superconductivity. Compressed hydride superconductors are leaders in the race for a material that can conduct electricity without resistance at high or even room temperature. Different synthetic paths under pressure will drive the formation of different polyhydrides. In the present work, through precise control of the synthesis pathway, we have discovered new lanthanum superhydride, cubic A15-type La$_4$H$_{23}$, with lower stabilization pressure compared to the reported $\textit{fcc}$ LaH$_{10}$. Superconducting La$_4$H$_{23}$ was obtained by laser heating of LaH$_3$ with ammonia borane at about 120 GPa. Transport measurements reveal the maximum critical temperature $\textit{T}$$_{C}$(onset) = 105 K at 118 GPa, as evidenced by the sharp drop of electrical resistance and the displacement of superconducting transitions in applied magnetic fields. Extrapolated upper critical field $\textit{B}$$_{C2}$(0) of La$_4$H$_{23}$ is about 33 T at 114 GPa in agreement with theoretical estimates. Discovered lanthanum hydride is a new member of the A15 family of superconductors with $\textit{T}$$_C$ exceeding the boiling point of liquid nitrogen

Metallic surface states in a correlated d-electron topological Kondo insulator candidate FeSb2

The resistance of a conventional insulator diverges as temperature approaches zero. The peculiar low temperature resistivity saturation in the 4f Kondo insulator (KI) SmB6 has spurred proposals of a correlation-driven topological Kondo insulator (TKI) with exotic ground states. However, the scarcity of model TKI material families leaves difficulties in disentangling key ingredients from irrelevant details. Here we use angle-resolved photoemission spectroscopy (ARPES) to study FeSb2, a correlated d-electron KI candidate that also exhibits a low temperature resistivity saturation. On the (010) surface, we find a rich assemblage of metallic states with two-dimensional dispersion. Measurements of the bulk band structure reveal band renormalization, a large temperature-dependent band shift, and flat spectral features along certain high symmetry directions, providing spectroscopic evidence for strong correlations. Our observations suggest that exotic insulating states resembling those in SmB6 and YbB12 may also exist in systems with d instead of f electrons

ALMA reveals sequential high-mass star formation in the G9.62+0.19 complex

Stellar feedback from high-mass stars (e.g., H{\sc ii} regions) can strongly influence the surrounding interstellar medium and regulate star formation. Our new ALMA observations reveal sequential high-mass star formation taking place within one sub-virial filamentary clump (the G9.62 clump) in the G9.62+0.19 complex. The 12 dense cores (MM 1-12) detected by ALMA are at very different evolutionary stages, from starless core phase to UC H{\sc ii} region phase. Three dense cores (MM6, MM7/G, MM8/F) are associated with outflows. The mass-velocity diagrams of outflows associated with MM7/G and MM8/F can be well fitted with broken power laws. The mass-velocity diagram of SiO outflow associated with MM8/F breaks much earlier than other outflow tracers (e.g., CO, SO, CS, HCN), suggesting that SiO traces newly shocked gas, while the other molecular lines (e.g., CO, SO, CS, HCN) mainly trace the ambient gas continuously entrained by outflow jets. Five cores (MM1, MM3, MM5, MM9, MM10) are massive starless core candidates whose masses are estimated to be larger than 25 M_{\sun}, assuming a dust temperature of $\leq$ 20 K. The shocks from the expanding H{\sc ii} regions ("B" \& "C") to the west may have great impact on the G9.62 clump through compressing it into a filament and inducing core collapse successively, leading to sequential star formation. Our findings suggest that stellar feedback from H{\sc ii} regions may enhance the star formation efficiency and suppress the low-mass star formation in adjacent pre-existing massive clumps.Comment: Accepted to Ap

A Submillimetre Search for Cold Extended Debris Disks in the Beta Pictoris Moving Group

The Beta Pictoris Moving Group is a nearby stellar association of young (12Myr) co-moving stars including the classical debris disk star beta Pictoris. Due to their proximity and youth they are excellent targets when searching for submillimetre emission from cold, extended, dust components produced by collisions in Kuiper-Belt-like disks. They also allow an age independent study of debris disk properties as a function of other stellar parameters. We observed 7 infrared-excess stars in the Beta Pictoris Moving Group with the LABOCA bolometer array, operating at a central wavelength of 870 micron at the 12-m submillimetre telescope APEX. The main emission at these wavelengths comes from large, cold dust grains, which constitute the main part of the total dust mass, and hence, for an optically thin case, make better estimates on the total dust mass than earlier infrared observations. Fitting the spectral energy distribution with combined optical and infrared photometry gives information on the temperature and radial extent of the disk. From our sample, beta Pic, HD181327, and HD172555 were detected with at least 3-sigma certainty, while all others are below 2-sigma and considered non-detections. The image of beta Pic shows an offset flux density peak located near the south-west extension of the disk, similar to the one previously found by SCUBA at the JCMT. We present SED fits for detected sources and give an upper limit on the dust mass for undetected ones. We find a mean fractional dust luminosity f_dust=11x10^{-4} at t=12Myr, which together with recent data at 100Myr suggests an f_dust propto t^{-alpha} decline of the emitting dust, with alpha > 0.8.Comment: 11 pages, 3 figures, 3 tables; accepted for publication in Astronomy & Astrophysic

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study

A possible architecture of the planetary system HR 8799

HR8799 is a nearby A-type star with a debris disk and three planetary candidates recently imaged directly. We undertake a coherent analysis of various portions of observational data on all known components of the system. The goal is to elucidate the architecture and evolutionary status of the system. We try to further constrain the age and orientation of the system, orbits and masses of the companions, as well as the location of dust. From the high luminosity of debris dust and dynamical constraints, we argue for a rather young system's age of <50Myr. The system must be seen nearly, but not exactly, pole-on. Our analysis of the stellar rotational velocity yields an inclination of 13-30deg, whereas i>20deg is needed for the system to be dynamically stable, which suggests a probable inclination range of 20-30deg. The spectral energy distribution is naturally reproduced with two dust rings associated with two planetesimal belts. The inner "asteroid belt" is located at ~10AU inside the orbit of the innermost companion and a "Kuiper belt" at >100AU is just exterior to the orbit of the outermost companion. The dust masses in the inner and outer ring are estimated to be ~1E-05 and 4E-02 M_earth, respectively. We show that all three planetary candidates may be stable in the mass range suggested in the discovery paper by Marois et al. 2008 (between 5 and 13 Jupiter masses), but only for some of all possible orientations. Stable orbits imply a double (4:2:1) mean-motion resonance between all three companions. We finally show that in the cases where the companions themselves are orbitally stable, the dust-producing planetesimal belts are also stable against planetary perturbations.Comment: 12 pages, 14 figures, 4 tables, accepted to be published in Astronomy & Astrophysics (May 20, 2009

Experiments on sheep carcass cutting with ultrahigh pressure pure water jet

Objective: To reduce loss of lamb meat during mechanical cutting. Methods: Using a gantry-type ultra-high-pressure pure water jet cutting platform, different parameters were selected for testing according to different parts of the lamb carcass. Compared the cutting effects, identified the appropriate cutting parameters, and analyzed the cutting losses. Results: The experiments were conducted on several aspects such as room temperature lamb, frozen lamb, lamb chops, lamb spine, lamb legs, lamb neck, and bone removal for meat extraction. The effects of different parts of the lamb carcass and different experimental parameters on the cutting effect were clarified. Conclusion: The adaptability of pure water jet cutting to different parts of lamb carcass varies. Pure water jet cutting of frozen lamb, lamb chops, lamb spine, and bone removal can achieve good results with minimal loss. However, the cutting effect on normal temperature lamb, leg, neck, and other parts is not good, and further experiments are needed

A near-infrared interferometric survey of debris disc stars. II. CHARA/FLUOR observations of six early-type dwarfs

High-precision interferometric observations of six early-type main sequence stars known to harbour cold debris discs have been obtained in the near-infrared K band with the FLUOR instrument at the CHARA Array. The measured squared visibilities are compared to the expected visibility of the stellar photospheres based on theoretical photospheric models taking into account rotational distortion, searching for potential visibility reduction at short baselines due to circumstellar emission. Our observations bring to light the presence of resolved circumstellar emission around one of the six target stars (zeta Aql) at the 5 sigma level. The morphology of the emission source cannot be directly constrained because of the sparse spatial frequency sampling of our interferometric data. Using complementary adaptive optics observations and radial velocity measurements, we find that the presence of a low-mass companion is a likely origin for the excess emission. The potential companion has a K-band contrast of four magnitudes, a most probable mass of about 0.6 Msun, and is expected to orbit between about 5.5 AU and 8 AU from its host star assuming a purely circular orbit. Nevertheless, by adjusting a physical debris disc model to the observed Spectral Energy Distribution of the zeta Aql system, we also show that the presence of hot dust within 10 AU from zeta Aql, producing a total thermal emission equal to 1.69 +- 0.31% of the photospheric flux in the K band, is another viable explanation for the observed near-infrared excess. Our re-interpretation of archival near- to far-infrared photometric measurements shows however that cold dust is not present around zeta Aql at the sensitivity limit of the IRS and MIPS instruments onboard Spitzer, and urges us to remove zeta Aql from the category of bona fide debris disc stars.Comment: 14 pages, accepted for publication in A&

A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8⁺ T cells.

Strategies to increase intratumoral concentrations of an anticancer agent are desirable to optimize its therapeutic potential when said agent is efficacious primarily within a tumor but also have significant systemic side effects. Here, we generate a bifunctional protein by fusing interleukin-10 (IL-10) to a colony-stimulating factor-1 receptor (CSF-1R)-blocking antibody. The fusion protein demonstrates significant antitumor activity in multiple cancer models, especially head and neck cancer. Moreover, this bifunctional protein not only leads to the anticipated reduction in tumor-associated macrophages but also triggers proliferation, activation, and metabolic reprogramming of CD8 &lt;sup&gt;+&lt;/sup&gt; T cells. Furthermore, it extends the clonotype diversity of tumor-infiltrated T cells and shifts the tumor microenvironment (TME) to an immune-active state. This study suggests an efficient strategy for designing immunotherapeutic agents by fusing a potent immunostimulatory molecule to an antibody targeting TME-enriched factors