A FABRY-PEROT CAVITY FOR COMPTON POLARIMETRY

A new kind of Compton polarimeter using a resonant Fabry—Pe« rot cavity as a power buildup for the photon beam is proposed. A prototype of such a cavity is described, along with the results obtained in terms of source to be used in a Compton scattering polarimeter. ( 1998 Elsevier Science B.V. All rights reserved

White paper: CeLAND - Investigation of the reactor antineutrino anomaly with an intense 144Ce-144Pr antineutrino source in KamLAND

We propose to test for short baseline neutrino oscillations, implied by the recent reevaluation of the reactor antineutrino flux and by anomalous results from the gallium solar neutrino detectors. The test will consist of producing a 75 kCi 144Ce - 144Pr antineutrino source to be deployed in the Kamioka Liquid Scintillator Anti-Neutrino Detector (KamLAND). KamLAND's 13m diameter target volume provides a suitable environment to measure energy and position dependence of the detected neutrino flux. A characteristic oscillation pattern would be visible for a baseline of about 10 m or less, providing a very clean signal of neutrino disappearance into a yet-unknown, "sterile" state. Such a measurement will be free of any reactor-related uncertainties. After 1.5 years of data taking the Reactor Antineutrino Anomaly parameter space will be tested at > 95% C.L.Comment: White paper prepared for Snowmass-2013; slightly different author lis

CeLAND: search for a 4th light neutrino state with a 3 PBq 144Ce-144Pr electron antineutrino generator in KamLAND

The reactor neutrino and gallium anomalies can be tested with a 3-4 PBq (75-100 kCi scale) 144Ce-144Pr antineutrino beta-source deployed at the center or next to a large low-background liquid scintillator detector. The antineutrino generator will be produced by the Russian reprocessing plant PA Mayak as early as 2014, transported to Japan, and deployed in the Kamioka Liquid Scintillator Anti-Neutrino Detector (KamLAND) as early as 2015. KamLAND's 13 m diameter target volume provides a suitable environment to measure the energy and position dependence of the detected neutrino flux. A characteristic oscillation pattern would be visible for a baseline of about 10 m or less, providing a very clean signal of neutrino disappearance into a yet-unknown, sterile neutrino state. This will provide a comprehensive test of the electron dissaperance neutrino anomalies and could lead to the discovery of a 4th neutrino state for Delta_m^2 > 0.1 eV^2 and sin^2(2theta) > 0.05.Comment: 67 pages, 50 figures. Th. Lasserre thanks the European Research Council for support under the Starting Grant StG-30718

A New Type of Compton Polarimeter for Jefferson Lab Hall A

In this paper, we present the principle and the studies for a new type of Compton polarimeter based on the use of power buildup Fabry-Perot cavity to get a 3% measurement of the Jefferson Lab electron polarization within minutes

CeLAND: search for a 4th light neutrino state with a 3 PBq 144Ce-144Pr electron antineutrino generator in KamLAND

The reactor neutrino and gallium anomalies can be tested with a 3-4 PBq (75-100 kCi scale) 144Ce-144Pr antineutrino beta-source deployed at the center or next to a large low-background liquid scintillator detector. The antineutrino generator will be produced by the Russian reprocessing plant PA Mayak as early as 2014, transported to Japan, and deployed in the Kamioka Liquid Scintillator Anti-Neutrino Detector (KamLAND) as early as 2015. KamLAND's 13 m diameter target volume provides a suitable environment to measure the energy and position dependence of the detected neutrino flux. A characteristic oscillation pattern would be visible for a baseline of about 10 m or less, providing a very clean signal of neutrino disappearance into a yet-unknown, sterile neutrino state. This will provide a comprehensive test of the electron dissaperance neutrino anomalies and could lead to the discovery of a 4th neutrino state for Delta_m^2 > 0.1 eV^2 and sin^2(2theta) > 0.05

How does finasteride affect time-dependent modulatory effect of morphine-induced analgesia

Finasterid, testosteronu dihidrotestosterona dönüştüren 5α-redüktaz enziminin inhibitörüdür. Bu çalışmanın amacı, finasteridin morfinin analjezik etkisini zaman bağımlı olarak nasıl etkilediğini araştırmaktır. Deneylerde 12 saat aydınlık/12 saat karanlık döngüsü ile senkronize edilmiş 25-40 gram ağırlığında albino erkek fareler ve 55 ± 0.5ºC’de sıcak plaka testi kullanılmıştır. Tüm gruplarda deneyler, ışıklar yandıktan sonra 1., 5., 9., 13.,17. ve 21. saatlerde yapılmıştır. Bazal ağrı duyarlılığı ve morfinin analjezik etkisi, onar farelik gruplarda sıcak plaka testinden 30 dakika önce s.c. 10 mg/kg serum fizyolojik ve 10 mg/kg morfin uygulanarak saptanmıştır. Sıcak plaka testinden 50 dakika önce s.c. 15 mg/kg finasterid uygulanarak tek başına analjezik etkisi olup olmadığı araştırılmıştır. Finasterid ve morfin etkileşimini incelemek için aynı saatlerde, sıcak plaka testinden 50 dakika önce 15 mg/kg finasterid ve 30 dakika önce 10 mg/kg morfin cilt altı uygulanmıştır. Deney sonuçlarının standardizasyonu açısından 3 saniyeden daha kısa süreli yanıtlar “spontan yanıt” olarak değerlendirilmiş ve hesaplamalara dahil edilmemişlerdir. Farelerde yanık hasarı oluşturmamak için maksimum yanıt süresi 45 saniye olarak kabul edilmiştir. Mevsim değişiklerinden etkilenmemek için tüm deneyler Haziran ve Temmuz aylarında yapılmıştır. Güniçinde 6 değişik zamanda elde edilen data ortalama ± standart hata şeklinde ifade edilmiştir. Elde edilen data gereken yerlerde student t-test, varyans analizi (ANOVA) veya Kruskal Wallis varyans analizi ile değerlendirilmiştir. Finasteridin morfin yanıtlarına etkisinin aktivite periyodunda istirahat periyoduna nazaran, özellikle ışıklar yandıktan sonra 13. ve 21. saatlerde, çok daha belirgin olduğu görülmüştür. Bulgularımız, finasteridin morfinin antinosiseptif etkisini potansiye ettiğini ve aynı zamanda bu potansiyasyonun güniçi zaman bağımlılığı gösterdiğini işaret etmektedir.Finasteride inhibits 5α-reductase which converts testosterone to dihydrotestosterone. The aim of this study is to evaluate how finasteride affects the analgesic effect of morphine time-dependently. Local bred albino male mice (25-40 gram) synchronized with a standard light-dark regimen (12hours:12hours Light:Dark, lights on 08:00) were used. All experiment groups include 10-12 mice and were tested at six time points of the day as 1, 5, 9, 13, 17 and 21 hours after lights on. All drugs were administered subcutaneously. Basal pain sensitivity (saline; 10 mg/kg) and morphine-induced analgesia (10 mg/kg) were determined 30 minutes before hot-plate test (55 ± 0.5ºC). To test the administration time-dependent interaction, a third group of animals were injected with a predetermined dose of finasteride (15 mg/kg) 20 minutes before morphine and response latencies were tested. Response latencies shorter than 3 seconds were regarded as spontaneous and excluded. To avoid heat injury, animals not responding within 45 seconds were removed from the hot-plate. To avoid the seasonal variations all experiments were performed in June and July. Data analyzed by ANOVA or Kruskal Wallis and student t-test where necessary. The results of this study indicate that there is time-dependent interaction between finasteride and morphine-induced analgesia. In the dark period, especially 13 and 21 hours after lights on, finasteride enhanced morphine-induced analgesia

AGATA-Advanced GAmma Tracking Array

AGATA CollaborationThe Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. (C) 2011 Elsevier B.V. All rights reserved.AGATA and this work is supported by the European funding bodies and the EU Contract RII3-CT-2004-506065, the German BMBF under Grants 06K-167 and 06KY205I, the Swedish Research Council and the Knut and Alice Wallenberg Foundation, UK EPSRC Engineering and Physical Sciences Research Council, UK STFC Science and Technology Facilities Council, AWE plc, Scientific and Technological Research Council of Turkey (Proj. nr. 106T055) and Ankara University (BAP Proj. nr. 05B4240002), the Polish Ministry of Science and Higher Education under Grant DPN/N190/AGATA/2009, the Spanish MICINN under grants FPA2008-06419 and FPA2009-13377-C02-02, the Spanish Consolider-Ingenio 2010 Programme CPAN (contract number CSD2007-00042) the Generalitat Valenciana under Grant PROMETEO/2010/101, and research performed in the frame of the GSI-IN2P3 collaboration agreement number 02-42. MICINN, Spain, and INFN, Italy, through the AIC10-D-000568 bilateral action.Peer Reviewe