Biological activity of glucosinolate derived compounds isolated from seed meal of Brassica crops and evaluated as plant and food protection agents

Glucosinolates are amino acid derived allelochemicals characteristic of plants of the order Capparales. These compounds are present in seeds of agriculturally common Brassica crops in varying quantities depending on the species (ref). The use of the remaining seed cake after oil extraction has traditionally been limited by the concentration of these compounds. However, the extraction of glucosinolates from seed meal is nowadays possible and it further contributes to an increased quality of the seed meal for feed (Sørensen et al., this conference). Glucosinolates are hydrolysed by endogenous enzymes (myrosinases; EC 3.2.1.147) and a number of compounds are produced depending on the parent glucosinolate and the environmental conditions.1 Among these compounds, oxazolidine-2-thiones are known for their antinutritional effects on monogastric animals, whereas isothiocyanates are fungicidal, nematocidal and herbicidal.2,3 The possibility for using glucosinolates as precursors for environmental friendly biocides therefore exists, which could contribute to increase the value of the Brassica seed meal

Helminth fauna of small mammals (insectivores and rodents) in Doñana (southeastern Iberian Peninsula)

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Traditional knowledge for climate change adaptation in Mesoamerica : a systematic review

This research was carried out during the first author's postdoctoral research (CVU number 292956 ) funded by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) Mexico.Indigenous and rural peoples have developed close connections with land and nature for millennia. Traditional and local knowledge resulting from such human-environment interactions is embedded in ethnic, linguistic, and cultural contexts, and may assist local communities in adapting to global issues such as climate change. However, the extent to which traditional knowledge supports adaptation to local manifestations of severe socio-environmental changes, the traditional knowledge techniques that play an effective role in adaptation, and the dynamic yet integral aspect of traditional knowledge for indigenous and mestizo cultures remain unclear. Despite an extensive literature on climate change, adaptation, and traditional knowledge in the Global South, Mesoamerican countries are underrepresented. The aims of this systematic review were to address the main manifestations of climate change in Mesoamerican countries, to critically analyze relationships between traditional knowledge and contemporary climate change adaptation and to make recommendations regarding knowledge conservation, production, and exchange for climate change adaptation in the region. We systematically identified, reviewed, and coded 77 relevant papers. Our results show that: 1) most papers do not distinguish between local, traditional, and indigenous knowledge; 2) rainfall variability, droughts, and weather unpredictability are the most frequently expressed experiences of climate change; 3) the main adaptations undertaken by smallholders are changes to the agricultural calendar and crops cultivated, a shift to more sustainable agriculture, and labour diversification to generate off-farm income; and 4) many more articles are published on Mexico than the other Mesoamerican countries, and predominantly by authors from outside Mesoamerica. Local traditional knowledge makes important contributions to climate change actions and policy by observing changing climates, adapting to impacts, and contributing to global mitigation efforts. As a response to increasing climate change challenges, smallholders create new hybrid knowledge by combining traditional and western perspectives. This knowledge evolution will support greater resilience to climate change but may hasten cultural erosion and exacerbate social inequalities in the region unless efforts are taken to maintain cultural integrity.Publisher PDFPeer reviewe

La autoeficacia creativa y la autoestima como predictores de la capacidad creativa en estudiantes universitarios

La capacidad creativa es independiente y propia de cada persona, pudiendo esta capacidad educarse. Sobre todo, en las áreas artísticas, el desarrollo de la creatividad puede considerarse importante para la adquisición y mantenimiento de nuevos aprendizajes. En los estudiantes, mayores o menores niveles de creatividad están relacionados con determinadas variables de corte competencial. Con este estudio se pretende comprobar las relaciones existentes entre los constructos de la creatividad y de autoeficacia creativa con variables de corte personal como la autoeficacia general, autoestima o ansiedad. La muestra está compuesta por un grupo de estudiantes de Magisterio que cursan la asignatura obligatoria Fundamentos de Educación Musical. Los participantes han cumplimentado diferentes cuestionarios específicos; se ha utilizado una metodología cuantitativa, realizando análisis correlacionales y de regresión. La creatividad está asociada a todas las variables planteadas y solo existen diferencias de medias significativas en función del sexo en una de ellas. Como principal conclusión se debe destacar que hay un valor explicativo en el que está relacionada tanto la autoestima como la ansiedad con la creatividad de estos estudiantes. Creative ability is independent, varies according to the person and can be learned. Especially, in the artistic fields, the development of creativity can be considered important for the acquisition and maintenance of new learning. In students, higher or lower levels of creativity are related to certain variables with respect to competencies. This study aims to verify the relationships between the constructs of creativity and creative self-efficacy and personal variables such as general self-efficacy, self-esteem or anxiety. The sample consists of a group of University Students enrolled in the compulsory course Fundamentals of Music Education. Participants completed different questionnaires; a quantitative methodology was used, performing correlational and regression analyses. Creativity is associated with all the variables considered and there are only significant differences in the means based on the sex of the participants in one of them. The most notable conclusion is that there is an explanatory value in which both self-esteem and anxiety are related to the creativity of these students

T cell receptor selection by and recognition of two class I major histocompatibility complex-restricted antigenic peptides that differ at a single position.

Peptides derived from HLA-Cw3 and HLA-A24 within region 170-179 differ by a single substitution, at position 173, and are both presented by the class I major histocompatibility complex molecule H-2Kd for recognition by murine cytolytic T lymphocytes (CTLs). As a first approach to understand the way T cell receptors (TCRs) intact with the HLA peptides, we have analyzed the TCR selection by, and recognition of, the two HLA antigenic sites. First, we have compared the TCR repertoires selected by HLA-Cw3 and HLA-A24, not only by sequencing the TCRs carried by CTL clones isolated and grown in vitro, but also by analyzing the TCRs expressed in vivo by peritoneal exudate lymphocytes from immune animals. Second, we have compared the TCR crossrecognition of HLA-A24 by CTLs selected by HLA-Cw3 with that of HLA-Cw3 by CTLs selected by HLA-A24. The combined analysis of TCR selection by and recognition of these two related HLA antigenic sites provides evidence that the TCR beta junctional regions interact with the amino-terminal part of the HLA peptides

Understanding hadronic gamma-ray emission from supernova remnants

We aim to test the plausibility of a theoretical framework in which the gamma-ray emission detected from supernova remnants may be of hadronic origin, i.e., due to the decay of neutral pions produced in nuclear collisions involving relativistic nuclei. In particular, we investigate the effects induced by magnetic field amplification on the expected particle spectra, outlining a phenomenological scenario consistent with both the underlying Physics and the larger and larger amount of observational data provided by the present generation of gamma experiments, which seem to indicate rather steep spectra for the accelerated particles. In addition, in order to study to study how pre-supernova winds might affect the expected emission in this class of sources, the time-dependent gamma-ray luminosity of a remnant with a massive progenitor is worked out. Solid points and limitations of the proposed scenario are finally discussed in a critical way.Comment: 30 pages, 5 figures; Several comments, references and a figure added. Some typos correcte

Chronic obstructive pulmonary disease (COPD) as a disease of early aging: evidence from the epiChron cohort

Background: Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. Methods and findings: We included all subjects carrying the diagnosis of COPD (n = 27,617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727,241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain). We compared the cumulative number of comorbidities, their prevalence and the mortality risk between both groups. Using network analysis, we explored the connectivity between comorbidities and the most influential comorbidities in both groups. We divided the groups into 5 incremental age categories and compared their comorbidity networks. We then selected those comorbidities known to affect primarily the elderly and compared their prevalence across the 5 age groups. In addition, we replicated the analysis in the smokers' subgroup to correct for the confounding effect of cigarette smoking. Subjects with COPD had more comorbidities and died at a younger age compared to controls. Comparison of both cohorts across 5 incremental age groups showed that the number of comorbidities, the prevalence of diseases characteristic of aging and network's density for the COPD group aged 56-65 were similar to those of non-COPD 15 to 20 years older. The findings persisted after adjusting for smoking. Conclusion: Multimorbidity increases with age but in patients carrying the diagnosis of COPD, these comorbidities are seen at an earlier age

Somatotypes trajectories during adulthood and their association with COPD phenotypes

Rationale: Chronic obstructive pulmonary disease (COPD) comprises distinct phenotypes, all characterised by airflow limitation. Objectives: We hypothesised that somatotype changes – as a surrogate of adiposity – from early adulthood follow different trajectories to reach distinct phenotypes. Methods: Using the validated Stunkard’s Pictogram, 356 COPD patients chose the somatotype that best reflects their current body build and those at ages 18, 30, 40 and 50 years. An unbiased group-based trajectory modelling was used to determine somatotype trajectories. We then compared the current COPD-related clinical and phenotypic characteristics of subjects belonging to each trajectory. Measurements and main results: At 18 years of age, 88% of the participants described having a lean or medium somatotype (estimated body mass index (BMI) between 19 and 23 kg·m−2 ) while the other 12% a heavier somatotype (estimated BMI between 25 and 27 kg·m−2 ). From age 18 onwards, five distinct trajectories were observed. Four of them demonstrating a continuous increase in adiposity throughout adulthood with the exception of one, where the initial increase was followed by loss of adiposity after age 40. Patients with this trajectory were primarily females with low BMI and DLCO (diffusing capacity of the lung for carbon monoxide). A persistently lean trajectory was seen in 14% of the cohort. This group had significantly lower forced expiratory volume in 1 s (FEV1), DLCO, more emphysema and a worse BODE (BMI, airflow obstruction, dyspnoea and exercise capacity) score thus resembling the multiple organ loss of tissue (MOLT) phenotype. Conclusions: COPD patients have distinct somatotype trajectories throughout adulthood. Those with the MOLT phenotype maintain a lean trajectory throughout life. Smoking subjects with this lean phenotype in early adulthood deserve particular attention as they seem to develop more severe COPD

A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000