Programa educativo basado en dinámicas grupales para mejorar las habilidades sociales de los estudiantes del segundo grado de secundaria de la I.E.E. Rafael Narvaez Cadenillas de trujillo

Por medio de la elaboración y aplicación de este programa de intervenciópsicopedagógica en habilidades sociales con los estudiantes del 2º grad""D"" de Educación Secundaria de la I. E.E. ""RAFAEL NARVÁECADENILLAS"" de la provincia de Trujillo, departamento la Libertad, 2014se refuerza habilidades básicas de interacción social para relacionarse coadultos, hacer amigos, conversacionales y habilidades relacionadas con losentimientos emociones y habilidades de solución de problemasinterpersonales, basado en dinámicas grupales. Teniendo como hipótesis el programa educativo basado en dinámicasgrupales desarrollara significativamente las Habilidades Sociales de loestudiantes del segundo grado de secundaria de la I.E.E. “Rafael NarváeCadenillas” de Trujillo, 2014. El tipo de investigación es cuasi experimentade carácter aplicada explicativo; tomando como población a los estudiantematriculados en las secciones de segundo año: A, B, C y D del turno de latarde en el año 2014, que hacen un total de 121 estudiantes, de la cual setomó una muestra de 62 estudiantes que corresponden al segundo año Cy D. La conclusión general es que antes de aplicar el Taller basado edinámicas grupales se alcanzó un puntaje de 55,12 en el nivel dhabilidades sociales básicas y después de aplicado el Taller basado edinámicas grupales, el nivel de habilidades sociales mejoró su puntaje d68,06 puntos en los estudiantes del 2° año de educación secundaria de lI.E.E. “Rafael Narváez Cadenillas” de Trujillo.Through the development and implementation of this program psychoeducational intervention in social skills with students of 2nd grade ""D"" Secondary Education ""RAFAEL NARVÁEZ CADENILLAS"" of the province of Trujillo, department of Liberty, 2014; basic social interaction skills are reinforced to interact with adults, make friends, conversational, feelings and emotions related skills and interpersonal problem solving, based on group dynamics skills. Taking as a hypothesis the educational program based on group dynamics significantly develop the social skills of students of second grade junior high ""Rafael Narvaez Cadenillas"" Trujillo, 2014. The research is quasi experimental, applied explanatory character; taking as population students enrolled in sections Sophomore: A, B, C and D of the afternoon shift in 2014, making a total of 121 students, of which a sample of 62 students took to for the second year C and D. The overall conclusion is that before applying the group dynamics workshop based on a score of 55.12 was reached at the level of basic social skills and then applied based on group dynamics workshop, the level of social skills improved its score of 68 06 points in students in the 2nd year of secondary education ""Rafael Narvaez Cadenillas"" of Trujillo.Tesi

BASP1 interacts with estrogen receptor α and modifies the tamoxifen response

AbstractTamoxifen binds to oestrogen receptor α (ERα) to elicit distinct responses that vary by cell/tissue type and status, but the factors that determine these differential effects are unknown. Here we report that the transcriptional corepressor BASP1 interacts with ERα and in breast cancer cells, this interaction is enhanced by tamoxifen. We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. In all, 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1 dependent, including several genes that are associated with tamoxifen resistance. BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the antitumourigenic effects of tamoxifen treatment. Moreover, BASP1 is expressed in breast cancer tissue and is associated with increased patient survival. Our data have identified BASP1 as an ERα cofactor that has a central role in the transcriptional and antitumourigenic effects of tamoxifen.</jats:p

Merchandising visual en el comportamiento de los clientes de la Carpintería y Lavandero Carrera Tocache – 2021

La presente investigación tiene como objetivo principal determinar la influencia del Merchandising visual en el comportamiento de los clientes de la Carpintería y Lavadero Carrera Tocache 2021. La metodología fue de tipo aplicada, de diseño no experimental, transversal correlacional debido a que nos permitirá describir, puntualizar y representar la relación de las dos variables de estudio; además, se realizó una prueba piloto con 30 cliente y una muestra total para la investigación de 384 compradores; como instrumento se utilizó el cuestionario y la técnica fue la encuesta. Dando como resultado la investigación que el 41,7% de los encuestados manifestaron que a veces son conscientes del ambiente en relación al Merchandising visual y el 47,9% opinaron que a veces su comportamiento de compra es afectado. Por otro lado, con la correlación obtenida entre ambas variables dio como conclusión un Rho Spearman 0,716, y un p valor = 0,000, logrando la aceptación de la hipótesis alterna, comprobando que existe relación entre el Merchandising visual en el comportamiento de los clientes de la Carpintería y Lavadero Carrera

Cholesterol is required for transcriptional repression by BASP1

Lipids are present within the cell nucleus, where they engage with factors involved in gene regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome packing in vitro, but its effects on specific transcriptional responses are not clear. Here, we show that the lipidated Wilms tumor 1 (WT1) transcriptional corepressor, brain acid soluble protein 1 (BASP1), interacts with cholesterol in the cell nucleus through a conserved cholesterol interaction motif. We demonstrate that BASP1 directly recruits cholesterol to the promoter region of WT1 target genes. Mutation of BASP1 to ablate its interaction with cholesterol or the treatment of cells with drugs that block cholesterol biosynthesis inhibits the transcriptional repressor function of BASP1. We find that the BASP1–cholesterol interaction is required for BASP1-dependent chromatin remodeling and the direction of transcription programs that control cell differentiation. Our study uncovers a mechanism for gene-specific targeting of cholesterol where it is required to mediate transcriptional repression

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

The 13th Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-IV Survey Mapping Nearby Galaxies at Apache Point Observatory

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) began observations in July 2014. It pursues three core programs: APOGEE-2,MaNGA, and eBOSS. In addition, eBOSS contains two major subprograms: TDSS and SPIDERS. This paper describes the first data release from SDSS-IV, Data Release 13 (DR13), which contains new data, reanalysis of existing data sets and, like all SDSS data releases, is inclusive of previously released data. DR13 makes publicly available 1390 spatially resolved integral field unit observations of nearby galaxies from MaNGA,the first data released from this survey. It includes new observations from eBOSS, completing SEQUELS. In addition to targeting galaxies and quasars, SEQUELS also targeted variability-selected objects from TDSS and X-ray selected objects from SPIDERS. DR13 includes new reductions ofthe SDSS-III BOSS data, improving the spectrophotometric calibration and redshift classification. DR13 releases new reductions of the APOGEE-1data from SDSS-III, with abundances of elements not previously included and improved stellar parameters for dwarf stars and cooler stars. For the SDSS imaging data, DR13 provides new, more robust and precise photometric calibrations. Several value-added catalogs are being released in tandem with DR13, in particular target catalogs relevant for eBOSS, TDSS, and SPIDERS, and an updated red-clump catalog for APOGEE.This paper describes the location and format of the data now publicly available, as well as providing references to the important technical papers that describe the targeting, observing, and data reduction. The SDSS website, http://www.sdss.org, provides links to the data, tutorials and examples of data access, and extensive documentation of the reduction and analysis procedures. DR13 is the first of a scheduled set that will contain new data and analyses from the planned ~6-year operations of SDSS-IV.PostprintPeer reviewe

Sloan Digital Sky Survey IV: mapping the Milky Way, nearby galaxies, and the distant universe

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median ). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July

The Fifteenth Data Release of the Sloan Digital Sky Surveys: First Release of MaNGA-derived Quantities, Data Visualization Tools, and Stellar Library

Twenty years have passed since first light for the Sloan Digital Sky Survey (SDSS). Here, we release data taken by the fourth phase of SDSS (SDSS-IV) across its first three years of operation (2014 July–2017 July). This is the third data release for SDSS-IV, and the 15th from SDSS (Data Release Fifteen; DR15). New data come from MaNGA—we release 4824 data cubes, as well as the first stellar spectra in the MaNGA Stellar Library (MaStar), the first set of survey-supported analysis products (e.g., stellar and gas kinematics, emission-line and other maps) from the MaNGA Data Analysis Pipeline, and a new data visualization and access tool we call "Marvin." The next data release, DR16, will include new data from both APOGEE-2 and eBOSS; those surveys release no new data here, but we document updates and corrections to their data processing pipelines. The release is cumulative; it also includes the most recent reductions and calibrations of all data taken by SDSS since first light. In this paper, we describe the location and format of the data and tools and cite technical references describing how it was obtained and processed. The SDSS website (www.sdss.org) has also been updated, providing links to data downloads, tutorials, and examples of data use. Although SDSS-IV will continue to collect astronomical data until 2020, and will be followed by SDSS-V (2020–2025), we end this paper by describing plans to ensure the sustainability of the SDSS data archive for many years beyond the collection of data

Examining the generalizability of research findings from archival data

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples