Differences in Theoretical Constructs of Processing Health Information in Narrative Entertainment Television Messages

Stories can play a crucial role in conveying health information to audiences. Several theories have been used to describe cognitive processing of narratives and subsequent belief change; yet there have been no comparative studies to date examining these theories.A primary objective was to compare transportation, flow, and AIME. A secondary objective of this study was to examine previous experience with a health issue as a possible moderator between exposure to entertainment television narratives and subsequent belief change. This is important to examine because previous experience may predispose audience members to have more durable attitudes.A pre-test/post-test experimental design was used to test theories of cognitive processing of narrative entertainment television programs with three different health topics: binge drinking, problem-eating behavior, and unprotected sexual intercourse. Stimuli were drawn from one-hour, broadcast television programming. Measures of the theories, health related beliefs, and previous experience with the three health issues were assessed.Findings revealed that different constructs represented in the three theories were significant predictors of belief change. Results showed that while most individual constructs of theories predicted belief change, the theories were not interchangeable. An analysis of the extent to which participants reported cognitive processing according to each theory revealed more flow and AIME experienced in comparison to transportation. Reports of flow and AIME were equal in a third condition. More globally, all three theories accounted for a significant portion of belief change, but no differentiation was evidenced between the theories in their ability to predict belief change.In analyses of the effects of exposure to television narratives, belief change was significant in all three treatment conditions. Previous experience with a health issue did not impede belief change following exposure to television narratives. This lends support to theorizing about cognitive processing of narratives in that previous experience with an issue may enhance story-consistent beliefs.Overall, findings demonstrate that a more fruitful endeavor in future research on the persuasive impact of narratives is to devote attention to the underlying constructs of theories, rather than assuming cognitive processes are the same among theories

Differences in theoretical constructs of processing health information in narrative entertainment television messages

Stories can play a crucial role in conveying health information to audiences. Several theories have been used to describe cognitive processing of narratives and subsequent belief change; yet there have been no comparative studies to date examining these theories. A primary objective was to compare transportation, flow, and AIME. A secondary objective of this study was to examine previous experience with a health issue as a possible moderator between exposure to entertainment television narratives and subsequent belief change. This is important to examine because previous experience may predispose audience members to have more durable attitudes. A pre-test/post-test experimental design was used to test theories of cognitive processing of narrative entertainment television programs with three different health topics: binge drinking, problem-eating behavior, and unprotected sexual intercourse. Stimuli were drawn from one-hour, broadcast television programming. Measures of the theories, health related beliefs, and previous experience with the three health issues were assessed. Findings revealed that different constructs represented in the three theories were significant predictors of belief change. Results showed that while most individual constructs of theories predicted belief change, the theories were not interchangeable. An analysis of the extent to which participants reported cognitive processing according to each theory revealed more flow and AIME experienced in comparison to transportation. Reports of flow and AIME were equal in a third condition. More globally, all three theories accounted for a significant portion of belief change, but no differentiation was evidenced between the theories in their ability to predict belief change. In analyses of the effects of exposure to television narratives, belief change was significant in all three treatment conditions. Previous experience with a health issue did not impede belief change following exposure to television narratives. This lends support to theorizing about cognitive processing of narratives in that previous experience with an issue may enhance story-consistent beliefs. Overall, findings demonstrate that a more fruitful endeavor in future research on the persuasive impact of narratives is to devote attention to the underlying constructs of theories, rather than assuming cognitive processes are the same among theories

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer's disease and type two diabetes

BACKGROUND: While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationship between AD and T2D with clinical evidence showing that both diseases coexist. A hallmark pathological event in AD is amyloid-β (Aβ) deposition in the brain as either amyloid plaques or around leptomeningeal and cortical arterioles, thus constituting cerebral amyloid angiopathy (CAA). CAA is observed in 85–95% of autopsy cases with AD and it contributes to AD pathology by limiting perivascular drainage of Aβ. METHODS: To further explore these alterations when AD and T2D coexist, we have used in vivo multiphoton microscopy to analyze over time the Aβ deposition in the form of plaques and CAA in a relevant model of AD (APPswe/PS1dE9) combined with T2D (db/db). We have simultaneously assessed the effects of high-fat diet-induced prediabetes in AD mice. Since both plaques and CAA are implicated in oxidative-stress mediated vascular damage in the brain, as well as in the activation of matrix metalloproteinases (MMP), we have also analyzed oxidative stress by Amplex Red oxidation, MMP activity by DQ(™) Gelatin, and vascular functionality. RESULTS: We found that prediabetes accelerates amyloid plaque and CAA deposition, suggesting that initial metabolic alterations may directly affect AD pathology. T2D significantly affects vascular pathology and CAA deposition, which is increased in AD-T2D mice, suggesting that T2D favors vascular accumulation of Aβ. Moreover, T2D synergistically contributes to increase CAA mediated oxidative stress and MMP activation, affecting red blood cell velocity. CONCLUSIONS: Our data support the cross-talk between metabolic disease and Aβ deposition that affects vascular integrity, ultimately contributing to AD pathology and related functional changes in the brain microvasculature