Addressing conflict through collective action in natural resource management

The food security crisis and international “land grabs” have drawn renewed attention to the role of natural resource competition in the livelihoods of the rural poor. While significant empirical research has focused on diagnosing the links between natural resource competition and (violent) conflict, much less has focused on the dynamics of whether and how resource competition can be transformed to strengthen social-ecological resilience and mitigate conflict. Focusing on this latter theme, this review synthesizes evidence from cases in Africa, Asia, and Latin America. Building on an analytical framework designed to enable such comparative analysis, we present several propositions about the dynamics of conflict and collective action in natural resource management, and a series of recommendations for action. These propositions are: that collective action in natural resource management is influenced by the social-ecological and governance context, that natural resource management institutions affect the incentives for conflict or cooperation, and that the outcomes of these interactions influence future conflict risk, livelihoods, and resource sustainability. Action recommendations concern policies addressing resource tenure, conflict resolution mechanisms, and social inequalities, as well as strategies to strengthen collective action institutions in the natural resource sectors and to enable more equitable engagement by marginalized groups in dialogue and negotiation over resource access and use

Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy

We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 diabetes. GENIE consists of 6,366 similarly ascertained participants of European ancestry with type 1 diabetes, with and without DN, from the All Ireland-Warren 3-Genetics of Kidneys in Diabetes U.K. and Republic of Ireland (U.K.-R.O.I.) collection and the Finnish Diabetic Nephropathy Study (FinnDiane), combined with reanalyzed data from the Genetics of Kidneys in Diabetes U.S. Study (U.S. GoKinD). We found little evidence for the association of the EPO promoter polymorphism, rs161740, with the combined phenotype of proliferative retinopathy and end-stage renal disease in U.K.-R.O.I. (odds ratio [OR] 1.14, P = 0.19) or FinnDiane (OR 1.06, P = 0.60). However, a fixed-effects meta-analysis that included the previously reported cohorts retained a genome-wide significant association with that phenotype (OR 1.31, P = 2 × 10−9). An expanded investigation of the ELMO1 locus and genetic regions reported to be associated with DN in the U.S. GoKinD yielded only nominal statistical significance for these loci. Finally, top candidates identified in a recent meta-analysis failed to reach genome-wide significance. In conclusion, we were unable to replicate most of the previously reported genetic associations for DN, and significance for the EPO promoter association was attenuated

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

New susceptibility loci associated with kidney disease in type 1 diabetes

WOS:000309817900008Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality of life, DN accounts for a large proportion of the excess mortality associated with type 1 diabetes (T1D). Whereas the degree of glycemia plays a pivotal role in DN, a subset of individuals with poorly controlled T1D do not develop DN. Furthermore, strong familial aggregation supports genetic susceptibility to DN. However, the genes and the molecular mechanisms behind the disease remain poorly understood, and current therapeutic strategies rarely result in reversal of DN. In the GEnetics of Nephropathy: an International Effort (GENIE) consortium, we have undertaken a meta-analysis of genome-wide association studies (GWAS) of T1D DN comprising ∼2.4 million single nucleotide polymorphisms (SNPs) imputed in 6,691 individuals. After additional genotyping of 41 top ranked SNPs representing 24 independent signals in 5,873 individuals, combined meta-analysis revealed association of two SNPs with ESRD: rs7583877 in the AFF3 gene (P = 1.2×10(-8)) and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, rs12437854 (P = 2.0×10(-9)). Functional data suggest that AFF3 influences renal tubule fibrosis via the transforming growth factor-beta (TGF-β1) pathway. The strongest association with DN as a primary phenotype was seen for an intronic SNP in the ERBB4 gene (rs7588550, P = 2.1×10(-7)), a gene with type 2 diabetes DN differential expression and in the same intron as a variant with cis-eQTL expression of ERBB4. All these detected associations represent new signals in the pathogenesis of DN.Peer reviewe

Visibility, legitimacy, and power: a North Carolina fishing community and governance of the commons

2011 Summer.Includes bibliographical references.Researchers studying common pool resource (CPR) governance argue that the participation of natural resource dependent people in formal processes of natural resource governance is essential for the sustainability of those resources. In accord with the vast body of related research and political activism, the United States fisheries management system promotes co-management practices as the pathway to sustainable fisheries governance. Nevertheless, empirical evidence illustrates that local fishers are increasingly disappearing from the fishing industry and their communities at the same time as the degradation of fisheries is increasing. I examine this contradiction through a case study of a community of commercial fisherpeople in Two Rivers, North Carolina. I develop the concepts of visibility, legitimacy, and power to capture the multiple levels and scales of structure and agency that shape the participation of local fishers in governance activities and lead to environmental degradation. Data was collected through interviews, observations, and review of policy documents and local archives. An important finding from this study is that many local fishers practice active non-participation, - intentional non-involvement in formal political activities while instead engaging in informal fisheries governance activities. However, the political inactivity associated with active non-participation decreases the legitimacy and power of local fishers, hastening their disarticulation from the fisheries, further decreasing the efficacy of formal political processes and ultimately resulting in unsustainable fisheries governance. Through the active political participation of commercial fishers, there is hope and a way forward for the future of fisher livelihoods and the sustainability of the nation's fisheries

Resource conflict, collective action, and resilience: an analytical framework

Where access to renewable natural resources essential to rural livelihoods is highly contested, improving cooperation in resource management is an important element in strategies for peacebuilding and conflict prevention. While researchers have made advances in assessing the role of environmental resources as a causal factor in civil conflict, analysis of the positive potential of collective natural resource management efforts to reduce broader conflict is less developed. Addressing this need, we present a framework on collective action, conflict prevention, and social-ecological resilience, linking local stakeholder dynamics to the broader institutional and governance context. Accounting for both formal and informal relationships of power and influence, as well as values and stakeholder perceptions alongside material interests, the framework aims to provide insight into the problem of (re)building legitimacy of common-pool resource management institutions in conflict-sensitive environments. We outline its application in stakeholder-based problem assessment and planning, participatory monitoring and evaluation, and multi-case comparative analysis

La Croix du Nord : supplément régional à la Croix de Paris ["puis" grand journal quotidien du Nord de la France]

06 septembre 19111911/09/06 (A22,N7613).Appartient à l’ensemble documentaire : NordPdeC